Introduction
Objectives
Materials and methods
Clinical features
Diagnosis
Studied polymorphisms
Gene symbol | Polymorphism | Sequence of primers | Restriction enzyme | Products |
---|---|---|---|---|
IL-1β (rs1143634) | +3953
C>T
| F 5′-gTTgTC ATC Aga CTT TgA CC-3′ R 5′-TTC AgT TCA TAT ggA CCA gA-3′ | TaqI (Thermo Scientific) |
CC 137,114 bp,
CT 251,137,114 bp
TT 251 bp |
IL-1RN (rs2234663) |
86 bp VNTR
| F 5′-CTC AgC AAC ACT CCT AT-3′ R 5′-TCC Tgg TCT gCAggT AA-3′ | IL1RN*0 154 bp IL1RN*1 410 bp IL1RN*2 240 bp IL1RN*3 500 bp IL1RN*4 325 bp IL1RN*5 595 bp | |
IL-6 (rs1800795) | −174
G>C
| F 5′-ACA TgC CAA gTgCTgAgT CA-3′ R 5′-AAT CTT TgTTggAgggTg Ag-3′ | LweI (Thermo Scientific) |
GG 114,100 bp
GC 214,114,100 bp
CC 214 bp |
IL-6 (rs1800797) | −596
G>A
| F 5′-ggAgTC ACA CAC TCC ACC Tg-3′ R 5′-AAgCAg AAC CAC TCT TCC TTT ACT T-3′ | BseGI (BtsCI) (Thermo Scientific) |
GG 420 bp
GA 420,354,66 bp
AA 354, 66 bp |
TNF-α (rs1800629) | −308
G>A
| 5′-AAA TggAgg CAA Tag gTTTTgAggggCTTg-3′ 5′-TAC CCC TCA CAC TCC CCA TCC TCCCTg ATC-3′ | FaqI (BsmFI) (Thermo Scientific) | GG 86,45 bp
GA 131,86,45 bp
AA 131 bp |
Group without IVH
N = 55 (%) | Group with IVH grade 1-4
N = 45 (%) |
p value | Group without IVH and with IVH grade 1 and 2
N = 89 (%) | Group with IVH grade 3–4
N = 11 (%) |
p value | |
---|---|---|---|---|---|---|
Gender | ||||||
Male | 29 (52.73) | 25 (55.56) | 0.778a
| 47 (52.81) | 7 (63.64) | 0.719b
|
Female | 26 (47.27) | 20 (44.44) | 42 (47.19) | 4 (36.36) | ||
Gestational age (weeks) | ||||||
24 + 0–28 + 6 | 19 (34.55) | 35 (77.78) | 0.00002s
| 44 (49.44) | 10 (90.91) | 0.022b
|
29 + 0–32 + 0 | 36 (65.45) | 10 (22.22) | 45 (50.56) | 1 (9.09) | ||
Birth weight (g) | ||||||
<750 | 3 (5.45) | 11 (24.44) | 0.0003a
| 12 (13.48) | 2 (18.18) | 0.057a
|
750–1000 | 10 (18.18) | 17 (37.78) | 21 (23.60) | 6 (54.55) | ||
>1000 | 42 (76.37) | 17 (37.78) | 56 (62.92) | 3 (27.27) | ||
Apgar score (median and range) | ||||||
1st minute | 6 (1–10) | 4 (1–10) | 0.0001c
| 6 (1–10) | 3 (1–7) | 0.054c
|
5th minute | 8 (5–10) | 7 (1–9) | 0.0005c
| 7 (2–10) | 7 (1–8) | 0.009c
|
Mode of delivery | ||||||
Vaginal | 17 (29.09) | 24 (53.33) | 0.039d
| 35 (39.30) | 6 (54.55) | 0.520d
|
Cesarean section | 38 (69.09) | 21 (46.67) | 54 (60.70) | 5 (45.45) | ||
Asphyxia (pH >7.0 or BE <−12) | ||||||
Yes | 0 (0.00) | 3 (6.98) | 0.084e
| 2 (2.30) | 1 (10.00) | 0.713b
|
No | 54 (100.00) | 40 (93.02) | 85 (97.7) | 9 (90.00) | ||
Intrauterine infection | ||||||
Yes | 22 (40.00) | 33 (73.33) | 0.0009a
| 46 (51.69) | 9 (81.82) | 0.116b
|
No | 33 (60.00) | 12 (26.67) | 43 (48.31) | 2 (18.18) | ||
Deaths | 2 (3.63) | 8 (17.77) | 0.038b
| 5 (5.6) | 5 (45.45) | 0.0004b
|
Statistical analysis
Results
Gene symbol | Group without IVH
N = 55 (%) | Group with IVH grades 1–4
N = 45 (%) |
p value | OR | Group without IVH and IVH grade 1 and 2
N = 89 (%) | Group with IVH grades 3–4
N = 11 (%) |
p value | OR |
---|---|---|---|---|---|---|---|---|
IL-1β
+3953
C>T(rs1143634) | ||||||||
Genotype | ||||||||
CC obs exp | 32 (58.18) 31.31 | 30 (66.67) 28.8 | – | References | 53 (59.55) 51.19 | 9 (81.82) 9.06 | – | References |
CT obs exp | 19 (34.55) 20.37 | 12 (26.67) 14.4 | 0.509 | 0.674 (0.253–1.761) | 29 (32.58) 32.61 | 2 (18.18) 1.82 | 0.436 | 0.406 (0.040–2.173) |
TT obs exp | 4 (7.27) 3.31 | 3 (6.66) 1.8 | 1.000 | 0.800 (0.108–5.178) | 7 (7.87) 5.19 | 0 (0.00) 0.09 | 0.716 | 0.000 (0.000–4.916) |
H-W | 0.883 | 0.535 | H-W | 0.579 | 0.946 | |||
Allele | ||||||||
C
| 83 (75.45) | 72 (80) | – | References | 135 (75.84) | 20 (90.9) | – | References |
T
| 27 (24.55) | 18 (20) | 0.553 | 0.769 (0.367–1.586) | 43 (24.15) | 2 (9.1) | 0.596 | 0.628 (0.148–2.024) |
Genotype | ||||||||
1/1 obs exp | 28 (50.91) 25.83 | 22 (48.89) 19.78 | – | References | 46 (51.69) 41.86 | 4 (36.36) 3.84 | – | References |
IL-1RN 86 bp VNTR (rs2234663) | ||||||||
1/2 obs exp | 18 (32.73) 22.34 | 15 (33.33) 19.44 | 1.000 | 1.061 (0.398–2.807) | 28 (31.46) 36.28 | 5 (45.45) 5.32 | 0.501 | 2.054 (0.401–11.17) |
1/3
| 1 (1.82) | 1 (2.22) | 1.000 | 1.273 (0.016–103.4) | 2 (2.25) | 0 (0.00) | 1.000 | 0.000 (0.000–71.11) |
2/2 obs exp | 7 (12.73) 4.83 | 7 (15.51) 4.78 | 0.920 | 1.273 (0.325–4.957) | 12 (13.48) 7.86 | 2 (18.18) 1.84 | 0.785 | 1.917 (0.154–15.15) |
2/3
| 1 (1.82) | 0 (0.00) | 1.000 | 0.00 (0.00–51.41) | 1 (1.12) | 0 (0.00) | 1.000 | 0.000 (0.000–458.3) |
H-W | 0.368 | 0.317 | H-W | 0.106 | 0.981 | |||
Allele | ||||||||
1
| 75 (68.18) | 60 (66.66) | – | References | 122 (68.53) | 13 (59.1) | – | References |
2
| 33 (30) | 29 (32.22) | 0.879 | 1.098 (0.573–2.097) | 53 (29.77) | 9 (40.9) | 0.437 | 1.594 (0.563–4.308) |
3
| 2 (1.81) | 1 (1.11) | 1.000 | 0.625 (0.010–12.31) | 3 (1.68) | 0 | 1.000 | 0.00 (0.000–24.38) |
IL-6
-174
G>C(rs1800795) | ||||||||
Genotype | ||||||||
GG obs exp | 13 (23.64) 16.32 | 8 (17.78) 8.60 | – | References | 19 (21.35) 22.75 | 2 (18.18) 3.84 | – | References |
GC obs exp | 33 (60.00) 28.36 | 28 (62.22) 20.81 |
0.718
|
1.379 (0.450–4.416)
|
52 (58.43)
44.49
| 9 (81.82) 5.32 |
0.850
|
1.644 (0.298–16.9)
|
CC obs exp | 9 (16.36) 12.32 | 9 (20.00) 12.60 |
0.672
|
1.625 (0.379–7.013)
|
18 (20.22)
21.75
|
0 (0.00)
1.84
|
0.567
|
0.000 (0.000–6.185)
|
H-W | 0.209 | 0.081 |
H–W
|
0.282
|
0.072
| |||
Allele | ||||||||
G
| 59 (53.63) | 44 (48.88) |
–
| References |
90 (50.56)
|
13 (59.1)
|
–
| References |
C
| 51 (46.36) | 46 (51.11) |
0.599
|
1.209 (0.667–2.195)
|
88 (49.43)
|
9 (40.9)
|
0.599
|
0.708 (0.254–1.899)
|
IL-6
−596
G>A(rs1800797) | ||||||||
Genotype | ||||||||
GG obs exp | 15 (27.28) 16.91 | 8 (17.78) 11.25 |
–
| References |
21 (23.60)
24.29
|
2 (18.18)
3.84
|
–
| References |
GA obs exp | 31 (56.36) 27.17 | 29 (64.44) 22.50 |
0.388
|
1.754 (0.587–5.504)
|
51 (57.30)
44.41
|
9 (81.82)
5.32
|
0.721
|
1.853 (0.338–18.93)
|
AA obs exp | 9 (16.36) 10.91 | 8 (17.78) 11.25 |
0.647
|
1.667 (0.384–7.223)
|
17 (19.10) 20.29
|
0 (0.00)
1.84
|
0.649
|
0.000 (0.000–7.201)
|
H-W | 0.579 | 0.153 |
H–W
|
0.375
|
0.072
| |||
Allele | ||||||||
G
| 61 (55.45) | 45 (50) |
–
| References |
93 (52.24)
|
13 (59.1)
|
–
| References |
A
| 49 (44.55) | 45 (50) |
0.531
|
1.245
(0.686–2.261)
|
85 (47.75)
|
9 (40.9)
|
0.707
|
0.758 (0.271–2.031)
|
TNF-α−308G>A (rs1800629) | ||||||||
Genotype | ||||||||
GG obs exp | 42 (76.36) 42.77 | 35 (77.78) 35.56 |
–
| References |
69 (77.53)
70.12
|
8 (72.73)
8.20
|
–
| References |
GA obs exp | 13 (23.64) 11.46 | 10 (22.22) 8.89 |
1.000
|
0.923 (0.320–2.603)
|
20 (22.47)
17.75
|
3 (27.27)
2.59
|
0.973
|
1.294 (0.202–60.51)
|
AA obs exp | 0 (0.00) 0.77 | 0 (0.00) 0.56 |
–
|
–
|
0 (0.00)
1.12
|
0 (0.00)
0.20
|
–
|
–
|
H-W | 0.610 | 0.704 |
0.490
|
0.872
| ||||
Allele | ||||||||
G
| 97 (88.18) | 80 (88.88) |
–
| References |
158 (88.76)
|
19 (86.36)
|
–
| References |
A
| 13 (11.82) | 10 (11.11) |
1.000
|
0.933 (0.346–2.443)
|
20 (11.23)
|
3 (13.63)
|
0.957
|
1.247 (0.217–4.823)
|
Gene symbol | Group without IVH
N = 19 (%) | Exp | Group with IVH grades 1–4
N = 35 (%) | Exp |
p value | OR | Group without IVH and IVH grade 1 and 2
N = 44 (%) | Exp | Group with IVH grades 3–4
N = 10 (%) | Exp |
p value | OR |
---|---|---|---|---|---|---|---|---|---|---|---|---|
IL-1β
+3953
C>T(rs1143634) | ||||||||||||
Genotypes | ||||||||||||
CC
| 10 (52.63) | 10.32 | 25 (71.43) | 24.03 | – | References | 27 (61.36) | 26.27 | 8 (80.00) | 8.10 | – | References |
CT
| 8 (42.11) | 7.37 | 8 (22.86) | 9.94 | 0.243 | 0.4 (0.099–1.625) | 14 (31.82) | 15.45 | 2 (20.00) | 1.80 | 0.648 | 0.482 (0.045–2.939) |
TT
| 1 (5.26) | 1.32 | 2 (5.71) | 1.03 | 1.000 | 0.8 (0.038–51.86) | 3 (6.82) | 2.27 | 0 (0.00) | 0.10 | 0.963 | 0 (0.000–9.542) |
H-W | 0.933 | 0.513 | 0.823 | 0.940 | ||||||||
Allele | ||||||||||||
C
| 28 (73.68%) | 58 (82.85%) | – | References | 68 (77.27%) | 18 (90%) | – | References | ||||
T
| 10 (26.31%) | 12 (17.15%) | 0.377 | 0.579 (0.202–1.703) | 20 (22.72%) | 2 (10%) | 0.442 | 0.425 (0.044–2.078) | ||||
IL-1RN86 bp VNTR (rs2234663) | ||||||||||||
Genotypes | ||||||||||||
1/1
| 9 (47.37) | 6.72 | 18 (51.43) | 16.46 | – | References | 24 (54.55) | 20.24 | 3 (30.00) | 3.03 | – | References |
1/2
| 4 (21.05) | 8.56 | 12 (34.29) | 15.09 | 0.827 | 1.5 (0.318–8.165) | 11 (25.00) | 18.52 | 5 (50.00) | 4.95 | 0.219 | 3.636 (0.568–26.85) |
1/3
| 0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
2/2
| 5 (26.32) | 2.72 | 5 (14.29) | 3.46 | 0.579 | 0.5 (0.089–2.852) | 8 (18.18) | 4.24 | 2 (20.00) | 2.03 | 0.824 | 2 (0.140–20.59) |
2/3
| 1 (5.26) | 0 (0.00) | 0.714 | 0 (0.000–21.67) | 1 (2.27) | 0 (0.00) | 1.000 | 0 (0.000–325) | ||||
H-W | 0.078 | 0.481 | 0.029 | 0.999 | ||||||||
Allele | ||||||||||||
1
| 22 (57.89%) | 48 (61.53%) | – | References | 59 (67.04%) | 11 (55%) | – | References | ||||
2
| 15 (39.47%) | 22 (38.46%) | 0.464 | 0.672 (0.272–1.683) | 28 (31.81%) | 9 (45%) | 0.368 | 0.383 (0.039–1.952) | ||||
3
| 1 (2.63%) | 0 | 0.648 | 0.000 (0.000–18.69) | 1 (1.13%) | 0 | 1.000 | 0.000 (0.000–212.7) | ||||
IL-6−174G>C
(rs1800795) | ||||||||||||
Genotypes | ||||||||||||
GG
| 6 (31.58) | 7.58 | 5 (14.29) | 9.26 | – | References | 9 (20.45) | 13.09 | 2 (20.00) | 3.60 | – | References |
GC
| 12 (63.16) | 8.84 | 26 (74.29) |
17.49
|
0.300
|
2.6
(0.529–12.93)
|
30 (68.19)
|
21.82
|
8 (80.00)
|
4.80
|
1.000
|
1.2
(0.186–13.55)
|
CC
| 1 (5.26) | 2.58 | 4 (11.43) |
8.26
|
0.462
|
4.8
(0.294–275)
|
5 (11.36)
|
9.09
|
0 (0.00)
|
1.60
|
0.917
|
0
(0.000–12.15)
|
H-W | 0.298 |
0.016
|
0.045
|
0.108
| ||||||||
Allele | ||||||||||||
G
| 24 (63.15%) | 36 (51.42%) | – | References |
48 (54.54%)
|
12 (60%)
| – | References | ||||
C
| 14 (36.84%) | 34 (48.57%) |
0.333
|
1.619
(0.672–3.969)
|
40 (45.45%)
|
8 (40%)
|
0.808
|
0.764
(0.229–2.401)
| ||||
IL-6−596G>A
(rs1800797) | ||||||||||||
Genotypes | ||||||||||||
GG
| 6 (31.58) | 7.58 | 5 (14.29) | 9.78 | – | References |
9 (20.45)
|
13.64
|
2 (20.00)
| 3.60 | – | References |
GA
| 12 (63.16) | 8.84 | 27 (77.14) |
17.44
|
0.274
|
2.7
(0.551–13.39)
|
31 (70.45)
|
21.72
|
8 (80.00)
|
4.80
|
1.000
|
1.161
(0.180–13.11)
|
AA
| 1 (5.26) | 2.58 | 3 (8.57) |
7.78
|
0.677
|
3.6
(0.191–219.9)
|
4 (9.10)
|
8.64
|
0 (0.00)
|
1.60
|
1.000
|
0
(0.000–15.59)
|
H-W | 0.298 |
0.005
|
0.018
|
0.108
| ||||||||
Allele | ||||||||||||
G
| 24 (63.15%) | 37 (52.85%) | – | References |
49 (55.68%)
|
12 (60%)
| – | References | ||||
A
| 14 (36.84%) | 33 (47.14%) |
0.408
|
1.529
(0.634–3.750)
|
39 (44.31%)
|
8 (40%)
|
0.838
|
0.779
(0.234–2.448)
| ||||
TNF-α −308G>A(rs1800629) | ||||||||||||
Genotypes | ||||||||||||
GG
| 16 (84.21) | 16.12 | 28 (80.00) | 28.35 | – | References |
36 (81.82)
|
36.36
|
8 (80.00)
| 8.10 | – | References |
GA
| 3 (15.79) | 2.76 | 7 (20.00) |
6.30
|
1.000
|
1.333
(0.256–9.06)
|
8 (18.18)
|
7.27
|
2 (20.00)
|
1.80
|
1.000
|
1.125
(0.098–7.372)
|
AA
| 0 (0.00) | 0.12 | 0 (0.00) |
0.35
|
–
|
–
|
0 (0.00)
|
0.36
|
0 (0.00)
|
0.10
|
–
|
–
|
H-W | 0.933 |
0.806
|
0.803
|
0.940
| ||||||||
Allele | ||||||||||||
G
| 35 (92.1%) | 63 (90%) | – | References |
80 (90.9%)
| 18 (90%) | – | References | ||||
A
| 3 (2.63%) | 7 (10%) |
1.000
|
1.296
(0.273–8.236)
|
8 (9.1%)
| 2 (10%) |
1.000
|
1.25
(0.118–7.120)
|
Gene symbol | Group with IVH 1–4 infected (N = 33; %) | Exp | Group with IVH 1–4 non-infected (N = 14; %) | Exp |
p value | OR | Group with IVH 3–4 infected (N = 9; %) | Exp | Group with IVH 3–4 non-infected (N = 2; %) | Exp |
p value | OR |
---|---|---|---|---|---|---|---|---|---|---|---|---|
IL-1β +3953C>T (rs1143634) | ||||||||||||
Genotypes | ||||||||||||
CC
| 22 (66.67) | 21.28 | 8 (66.67) | 7.52 | – | References | 7 (77.78) | 7.11 | 2 (100.0) | 2 | – | References |
CT
| 9 (27.27) | 10.44 | 3 (25.00) | 3.96 | 1.000 | 1.091 (0.196–7.820) | 2 (22.22) | 1.78 | 0 (0.00) | 0 | – | – |
TT
| 2 (6.06) | 1.28 | 1 (8.33) | 0.52 | 1.000 | 0.727 (0.034–48.21) | 0 (0.00) | 0.11 | 0 (0.00) | 0 | – | – |
H-W | 0.731 | 0.703 | H–W | 0.932 | – | |||||||
Allele | ||||||||||||
C
| 53 (80.30) | 19 (79.17) | – | References | 16 (88.89) | 6 (75.00) | – | References | ||||
T
| 13 (19.70) | 5 (20.83) | 1.000 | 0.932 (0.265–3.797) | 2 (11.11) | 2 (25.00) | 0.717 | 0.375 (0.023–6.531) | ||||
Genotypes | ||||||||||||
1/1
| 15 (45.45) | 12.73 | 7 (58.33) | 7.36 | – | References | 3 (33.33) | 2.78 | 1 (50.00) | 1.13 | – | References |
IL -1RN 86 bp VNTR
(rs2234663) | ||||||||||||
1/2
| 11 (33.33) | 15.53 | 4 (33.33) | 3.27 | 1.000 | 1.283 (0.246–7.497) | 4 (44.44) | 4.44 | 1 (50.00) | 0.75 | 1.000 | 1.333 (0.013–130.5) |
1/3
| 0 (0.00) | 1 (8.33) | 0.696 | 0.000 (0.000–20.80) | 0 (0.00) | 0 (0.00) | – | – | ||||
2/2
| 7 (21.21) | 4.73 | 0 (0.00) | 0.36 | – | – | 2 (22.22) | 1.78 | 0 (0.00) | 0.13 | – | – |
IL-1RN (rs2234663)
2/3
| 0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
H-W | 0.246 | 0.762 | 0.956 | 0.895 | ||||||||
Allele | ||||||||||||
1
| 41 (61.19) | 19 (82.61) | – | References | 10 (55.56) | 3 (75.00) | – | References | ||||
2
| 25 (38.81) | 4 (17.39) | 0.115 | 2.896 (0.819–12.92) | 8 (44.44) | 1 (25.00) | 0.899 | 2.4 (0.150–141.5) | ||||
3
| 0 (0.00) | 0 (0.00) | – | – | 0 (0.00) | 0 (0.00) | – | – | ||||
IL-6−174 G>C
(rs1800795) | ||||||||||||
Genotypes | ||||||||||||
GG
| 5 (15.15) | 7.28 | 3 (25.00) | 3.52 | – | References | 1 (11.11) | 2.78 | 1 (50.00) | 1.13 | – | References |
GC
| 21 (63.64) | 16.44 | 7 (58.33) |
5.96
|
0.777
|
1.800 (0.218–12.22)
| 8 (88.89) | 4.44 | 1 (50.00) |
0.75
|
0.691
|
8 (0.051–704)
|
CC
| 7 (21.21) | 9.28 | 2 (16.67) |
2.52
|
0.873
|
2.1 (0.162–32.92)
| 0 (0.00) | 1.78 | 0 (0.00) |
0.13
|
–
|
–
|
H-W | 0.281 |
0.832
| H–W | 0.056 |
0.895
| |||||||
Allele | ||||||||||||
G
| 31 (46.97) | 13 (54.17) |
–
| References | 10 (55.56) | 3 (75.00) |
–
| References | ||||
C
| 35 (53.03) | 11 (45.83) |
0.715
|
1.334 (0.472–3.810)
| 8 (44.44) | 1 (25.00) |
0.899
|
2.4 (0.150–141.5)
| ||||
IL-6−596 G>A
(rs1800797) | ||||||||||||
Genotypes | ||||||||||||
GG
| 5 (15.15) | 7.28 | 3 (25.00) |
4.08
|
–
| References | 1 (11.11) | 2.78 | 1 (50.00) |
1.13
|
–
| References |
GA
| 21 (63.64) | 16.44 | 8 (66.67) |
5.83
|
0.888
|
1.575 (0.196–10.42)
| 8 (88.89) | 4.44 | 1 (50.00) |
0.75
|
0.691
|
8 (0.051–704)
|
AA
| 7 (21.21) | 9.28 | 1 (8.33) |
2.08
|
0.569
|
4.2 (0.227–251.3)
| 0 (0.00) | 1.78 | 0 (0.00) |
0.13
|
–
|
–
|
H-W | 0.281 |
0.437
| 0.056 |
0.895
| ||||||||
Allele | ||||||||||||
G
| 31 (46.97) | 14 (58.33) |
–
| References | 10 (55.56) | 3 (75.00) |
–
| References | ||||
A
| 35 (53.03) | 10 (41.67) |
0.475
|
1.581 (0.557–4.583)
| 8 (44.44) | 1 (25.00) |
0.899
|
2.4 (0.150–141.5)
| ||||
TNF-α−308G>A
(rs1800629) | ||||||||||||
Genotypes | ||||||||||||
GG
| 26 (78.79) | 26.37 | 9 (75.00) |
9.19
|
–
| References | 7 (77.78) | 7.11 | 1 (50.00) |
1.13
|
–
| References |
GA
| 7 (21.21) | 6.26 | 3 (25.00) |
2.63
|
1.000
|
0.808 (0.142–5.898)
| 2 (22.22) | 1.78 | 1 (50.00) |
0.75
|
0.982
|
0.286 (0.003–33.55)
|
AA
| 0 (0.00) | 0.37 | 0 (0.00) |
0.19
|
–
|
–
| 0 (0.00) | 0.11 | 0 (0.00) |
0.13
|
–
|
–
|
H-W | 0.793 |
0.885
| 0.932 |
0.895
| ||||||||
Allele | ||||||||||||
G
| 59 (89.39) | 21 (87.50) |
–
| References | 16 (88.89) | 3 (75.00) |
–
| References | ||||
A
| 7 (10.61) | 3 (12.50) |
1.000
|
0.831 (0.169–5.441)
| 2 (11.11) | 1 (25.00) |
0.940
|
0.375 (0.015–29.43)
|