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Cancer Microenvironment

Erschienen in:

24.01.2019 | Review

The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders

verfasst von: Lukas Marcelis, Thomas Tousseyn

Erschienen in: Cancer Microenvironment | Ausgabe 1/2019

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Abstract

Post-transplant lymphoproliferative disorders (PTLDs) cover a broad spectrum of lymphoproliferative lesions arising after solid organ or allogeneic hematopoietic stem cell transplantation. The composition and function of the tumor microenvironment (TME), consisting of all non-malignant constituents of a tumor, is greatly impacted in PTLD through a complex interplay between 4 factors: 1) the graft organ causes immune stimulation through chronic antigen presentation; 2) the therapy to prevent organ rejection interferes with the immune system; 3) the oncogenic Epstein-Barr virus (EBV), present in 80% of PTLDs, has a causative role in the oncogenic transformation of lymphocytes and influences immune responses; 4) interaction with the donor-derived immune cells accompanying the graft. These factors make PTLDs an interesting model to look at cancer-microenvironment interactions and current findings can be of interest for other malignancies including solid tumors. Here we will review the current knowledge of the TME composition in PTLD with a focus on the different factors involved in PTLD development.

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Titel: The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders
verfasst von: Lukas Marcelis
Thomas Tousseyn
Publikationsdatum: 24.01.2019
Verlag: Springer Netherlands
Erschienen in: Cancer Microenvironment / Ausgabe 1/2019
Print ISSN: 1875-2292
Elektronische ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-018-00219-5

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Springer Medizin

The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders

Abstract

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Springer Medizin

Abstract

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