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Digestive Diseases and Sciences
Erschienen in: Digestive Diseases and Sciences 8/2023

19.06.2023 | Original Article

Therapeutic Effect of Polaprezinc on Reflux Esophagitis in the Rat Model

verfasst von: Wenbo Xie, Lu An, Zhaoyang Liu, Xindi Wang, Xueqi Fu, Junfeng Ma

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2023

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Abstract

Background/Aims

To explore the protective effects and therapeutic mechanism of Esomeprazole (PPI), polaprezinc granule (PZ), and PPI + PZ on reflux esophagitis (RE) in the rat model.

Methods

Wistar rats were randomly divided into 9 groups, which contain the control group, the acid cessation group (0.7% HCl, Q3D × 4), and the acid persistence group (0.7% HCl, Q3D × 11). PPI was administered by gavage at 8 mg·kg−1 body weight and PZ was administered by gavage at 120 mg·kg−1 body weight once a day for 15 days. The gastric cardia tissue of the feeding tube was observed under the light microscope, and the levels of interleukin-8 (IL-8) and prostaglandin E2 (PGE2) were measured by ELISA. The expression of EGFR, Akt, p-Akt, and p-mTOR was detected by Western blot.

Results

The ELISA results showed that the levels of IL-8 and PGE2 were significantly increased in the model group, but decreased in all groups after treatment. In the acid cessation group, PZ treatment had the most significant effect on reducing IL-8 levels and PPI + PZ treatment had the most significant effect on reducing PGE2 levels. In the acid persistence group, the PPI treatment had the most significant effect on reducing the levels of IL-8 and PGE2, and the PZ treatment could also significantly reduce their levels, close to the normal value. Western blot results showed that the expression of PI3K/Akt/mTOR pathway protein was increased in the model group, while its expression was decreased after treatment.

Conclusions

Polaprezinc has a significant therapeutic effect on RE in rats, which can reduce the levels of IL-8 and PGE2 and downregulate the expression of PI3K/Akt/mTOR signal pathway protein. The efficacy of polaprezinc in the treatment of reflux esophagitis is comparable to that of PPI, and the combination of them is more effective in the reflux esophagitis treatment.
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Metadaten
Titel
Therapeutic Effect of Polaprezinc on Reflux Esophagitis in the Rat Model
verfasst von
Wenbo Xie
Lu An
Zhaoyang Liu
Xindi Wang
Xueqi Fu
Junfeng Ma
Publikationsdatum
19.06.2023
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 8/2023
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-023-07990-6

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