Skip to main content

2022 | OriginalPaper | Buchkapitel

12. Therapeutisches Drug Monitoring und Bedside Genotyping

verfasst von : Georgios Schoretsanitis, Michael Paulzen

Erschienen in: Therapieresistenz bei Depressionen und bipolaren Störungen

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Bei PatientInnen mit medikamentöser Therapieresistenz kann der Erfolg der pharmakologischen Behandlung – je nach Medikament und klinischer Entwicklung – durch die Steuerung der Therapie mittels Personalisierungsinstrumenten wie dem Therapeutischen Drug Monitoring (TDM) sowie etablierten pharmakogenetischen Testungen optimiert werden. In diesem Buchkapitel soll ein Einblick in das TDM und die Genotypisierung (Bedside Genotyping) sowie deren sinnvoller Einsatz im klinischen Alltag bei PatientInnen mit therapieresistenten affektiven Störungen gegeben werden.
Literatur
Zurück zum Zitat Abraham AP, Vidyasagar A, Lakshmanan J, Nair S, Joseph M (2014) Phenytoin toxicity in patients with traumatic brain injury. Neurol India 62:285–289CrossRefPubMed Abraham AP, Vidyasagar A, Lakshmanan J, Nair S, Joseph M (2014) Phenytoin toxicity in patients with traumatic brain injury. Neurol India 62:285–289CrossRefPubMed
Zurück zum Zitat Alkermes, 2015. ARISTADA™ (aripiprazole lauroxil) extended-release injectable suspension for intramuscular use, Waltham, MA Alkermes, 2015. ARISTADA™ (aripiprazole lauroxil) extended-release injectable suspension for intramuscular use, Waltham, MA
Zurück zum Zitat Bousman CA, Bengesser SA, Aitchison KJ, Amare AT, Aschauer H, Baune BT, Asl BB, Bishop JR, Burmeister M, Chaumette B, Chen LS, Cordner ZA, Deckert J, Degenhardt F, DeLisi LE, Folkersen L, Kennedy JL, Klein TE, McClay JL, McMahon FJ, Musil R, Saccone NL, Sangkuhl K, Stowe RM, Tan EC, Tiwari AK, Zai CC, Zai G, Zhang J, Gaedigk A, Muller DJ (2021) Review and consensus on pharmacogenomic testing in psychiatry. Pharmacopsychiatry 54:5–17CrossRefPubMed Bousman CA, Bengesser SA, Aitchison KJ, Amare AT, Aschauer H, Baune BT, Asl BB, Bishop JR, Burmeister M, Chaumette B, Chen LS, Cordner ZA, Deckert J, Degenhardt F, DeLisi LE, Folkersen L, Kennedy JL, Klein TE, McClay JL, McMahon FJ, Musil R, Saccone NL, Sangkuhl K, Stowe RM, Tan EC, Tiwari AK, Zai CC, Zai G, Zhang J, Gaedigk A, Muller DJ (2021) Review and consensus on pharmacogenomic testing in psychiatry. Pharmacopsychiatry 54:5–17CrossRefPubMed
Zurück zum Zitat Chamberlain SR, Cavanagh J, de Boer P, Mondelli V, Jones DNC, Drevets WC, Cowen PJ, Harrison NA, Pointon L, Pariante CM, Bullmore ET (2019) Treatment-resistant depression and peripheral C-reactive protein. Br J Psychiatry 214:11–19CrossRefPubMedPubMedCentral Chamberlain SR, Cavanagh J, de Boer P, Mondelli V, Jones DNC, Drevets WC, Cowen PJ, Harrison NA, Pointon L, Pariante CM, Bullmore ET (2019) Treatment-resistant depression and peripheral C-reactive protein. Br J Psychiatry 214:11–19CrossRefPubMedPubMedCentral
Zurück zum Zitat Chang CC, Ng CC, Too CL, Choon SE, Lee CK, Chung WH, Hussein SH, Lim KS, Murad S (2017) Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population. Pharmacogenomics J 17:170–173CrossRefPubMed Chang CC, Ng CC, Too CL, Choon SE, Lee CK, Chung WH, Hussein SH, Lim KS, Murad S (2017) Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population. Pharmacogenomics J 17:170–173CrossRefPubMed
Zurück zum Zitat Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY, Taiwan SJSC (2011) Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 364:1126–1133CrossRefPubMed Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY, Taiwan SJSC (2011) Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 364:1126–1133CrossRefPubMed
Zurück zum Zitat Cun Y, Shi L, Kulski JK, Liu S, Yang J, Tao Y, Zhang X, Shi L, Yao Y (2021) Haplotypic associations and differentiation of MHC class II polymorphic alu insertions at five loci with HLA-DRB1 alleles in 12 minority ethnic populations in China. Front Genet 12:636236CrossRefPubMedPubMedCentral Cun Y, Shi L, Kulski JK, Liu S, Yang J, Tao Y, Zhang X, Shi L, Yao Y (2021) Haplotypic associations and differentiation of MHC class II polymorphic alu insertions at five loci with HLA-DRB1 alleles in 12 minority ethnic populations in China. Front Genet 12:636236CrossRefPubMedPubMedCentral
Zurück zum Zitat de Filippis R, Soldevila-Matias P, De Fazio P, Guinart D, Fuentes-Dura I, Rubio JM, Kane JM, Schoretsanitis G (2020) Clozapine-related drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review. Expert Rev Clin Pharmacol 13:875–883CrossRefPubMed de Filippis R, Soldevila-Matias P, De Fazio P, Guinart D, Fuentes-Dura I, Rubio JM, Kane JM, Schoretsanitis G (2020) Clozapine-related drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review. Expert Rev Clin Pharmacol 13:875–883CrossRefPubMed
Zurück zum Zitat Dome P, Kunovszki P, Takacs P, Feher L, Balazs T, Dede K, Mulhern-Haughey S, Barbreau S, Rihmer Z (2021) Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis. PLoS ONE 16:e0245510CrossRefPubMedPubMedCentral Dome P, Kunovszki P, Takacs P, Feher L, Balazs T, Dede K, Mulhern-Haughey S, Barbreau S, Rihmer Z (2021) Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis. PLoS ONE 16:e0245510CrossRefPubMedPubMedCentral
Zurück zum Zitat Edberg D, Hoppensteadt D, Walborn A, Fareed J, Sinacore J, Halaris A (2018) Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment. J Psychiatr Res 102:1–7CrossRefPubMed Edberg D, Hoppensteadt D, Walborn A, Fareed J, Sinacore J, Halaris A (2018) Plasma C-reactive protein levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment. J Psychiatr Res 102:1–7CrossRefPubMed
Zurück zum Zitat Fang H, Xu X, Kaur K, Dedek M, Zhu GD, Riley BJ, Espin FG, Del Tredici AL, Moreno TA (2019) A screening test for HLA-B( *)15:02 in a large united states patient cohort identifies broader risk of carbamazepine-induced adverse events. Front Pharmacol 10:149CrossRefPubMedPubMedCentral Fang H, Xu X, Kaur K, Dedek M, Zhu GD, Riley BJ, Espin FG, Del Tredici AL, Moreno TA (2019) A screening test for HLA-B( *)15:02 in a large united states patient cohort identifies broader risk of carbamazepine-induced adverse events. Front Pharmacol 10:149CrossRefPubMedPubMedCentral
Zurück zum Zitat Frederiksen T, Smith RL, Wollmann BM, Areberg J, Molden E. 2021. Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clin Pharmacokinet 60:1475–86 Frederiksen T, Smith RL, Wollmann BM, Areberg J, Molden E. 2021. Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data. Clin Pharmacokinet 60:1475–86
Zurück zum Zitat Genin E, Chen DP, Hung SI, Sekula P, Schumacher M, Chang PY, Tsai SH, Wu TL, Bellon T, Tamouza R, Fortier C, Toubert A, Charron D, Hovnanian A, Wolkenstein P, Chung WH, Mockenhaupt M, Roujeau JC (2014) HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. Pharmacogenomics J 14:281–288CrossRefPubMed Genin E, Chen DP, Hung SI, Sekula P, Schumacher M, Chang PY, Tsai SH, Wu TL, Bellon T, Tamouza R, Fortier C, Toubert A, Charron D, Hovnanian A, Wolkenstein P, Chung WH, Mockenhaupt M, Roujeau JC (2014) HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. Pharmacogenomics J 14:281–288CrossRefPubMed
Zurück zum Zitat Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, A LL, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A (2015) Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther 98:127–134CrossRefPubMedPubMedCentral Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, A LL, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A (2015) Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther 98:127–134CrossRefPubMedPubMedCentral
Zurück zum Zitat Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC (2017) Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther 102:37–44CrossRefPubMed Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC (2017) Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther 102:37–44CrossRefPubMed
Zurück zum Zitat Hiemke C, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Grunder G, Haen E, Havemann-Reinecke U, Hefner G, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mossner R, Muller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Unterecker S, Waschgler R, Zernig G, Zurek G, Baumann P (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017. Pharmacopsychiatry 51:e1CrossRefPubMed Hiemke C, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Grunder G, Haen E, Havemann-Reinecke U, Hefner G, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mossner R, Muller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Unterecker S, Waschgler R, Zernig G, Zurek G, Baumann P (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017. Pharmacopsychiatry 51:e1CrossRefPubMed
Zurück zum Zitat Hoffman S, Gründer G, Paulzen M (2018) Arzneimittelmetabolismus und Therapieversagen. Mit „Therapeutischem Drug Monitoring“ Psychopharmakotherapie optimieren. NeuroTransmitter 29(1):46–57 Hoffman S, Gründer G, Paulzen M (2018) Arzneimittelmetabolismus und Therapieversagen. Mit „Therapeutischem Drug Monitoring“ Psychopharmakotherapie optimieren. NeuroTransmitter 29(1):46–57
Zurück zum Zitat Jukic MM, Smith RL, Haslemo T, Molden E, Ingelman-Sundberg M (2019) Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. Lancet Psychiatry 6:418–426CrossRefPubMed Jukic MM, Smith RL, Haslemo T, Molden E, Ingelman-Sundberg M (2019) Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. Lancet Psychiatry 6:418–426CrossRefPubMed
Zurück zum Zitat Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT (2021) Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2C9 and HLA-B genotypes and phenytoin dosing: 2020 update. Clin Pharmacol Ther 109:302–309CrossRefPubMed Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT (2021) Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2C9 and HLA-B genotypes and phenytoin dosing: 2020 update. Clin Pharmacol Ther 109:302–309CrossRefPubMed
Zurück zum Zitat Lenoir C, Daali Y, Rollason V, Curtin F, Gloor Y, Bosilkovska M, Walder B, Gabay C, Nissen MJ, Desmeules JA, Hannouche D, Samer CF (2021) Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva cocktail. Clin Pharmacol Ther 109:1668–1676CrossRefPubMedPubMedCentral Lenoir C, Daali Y, Rollason V, Curtin F, Gloor Y, Bosilkovska M, Walder B, Gabay C, Nissen MJ, Desmeules JA, Hannouche D, Samer CF (2021) Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva cocktail. Clin Pharmacol Ther 109:1668–1676CrossRefPubMedPubMedCentral
Zurück zum Zitat Manson LEN, Swen JJ, Guchelaar HJ (2020) Diagnostic test criteria for HLA Genotyping to prevent drug hypersensitivity reactions: a systematic review of actionable HLA recommendations in CPIC and DPWG guidelines. Front Pharmacol 11:567048CrossRefPubMedPubMedCentral Manson LEN, Swen JJ, Guchelaar HJ (2020) Diagnostic test criteria for HLA Genotyping to prevent drug hypersensitivity reactions: a systematic review of actionable HLA recommendations in CPIC and DPWG guidelines. Front Pharmacol 11:567048CrossRefPubMedPubMedCentral
Zurück zum Zitat McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, Carrington M, Sills GJ, Marson T, Jia X, de Bakker PI, Chinthapalli K, Molokhia M, Johnson MR, O’Connor GD, Chaila E, Alhusaini S, Shianna KV, Radtke RA, Heinzen EL, Walley N, Pandolfo M, Pichler W, Park BK, Depondt C, Sisodiya SM, Goldstein DB, Deloukas P, Delanty N, Cavalleri GL, Pirmohamed M (2011) HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 364:1134–1143CrossRefPubMedPubMedCentral McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, Carrington M, Sills GJ, Marson T, Jia X, de Bakker PI, Chinthapalli K, Molokhia M, Johnson MR, O’Connor GD, Chaila E, Alhusaini S, Shianna KV, Radtke RA, Heinzen EL, Walley N, Pandolfo M, Pichler W, Park BK, Depondt C, Sisodiya SM, Goldstein DB, Deloukas P, Delanty N, Cavalleri GL, Pirmohamed M (2011) HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 364:1134–1143CrossRefPubMedPubMedCentral
Zurück zum Zitat Mrazek D (2010) Psychiatric pharmacogenomics. Oxford University Press, New YorkCrossRef Mrazek D (2010) Psychiatric pharmacogenomics. Oxford University Press, New YorkCrossRef
Zurück zum Zitat Mylan Institutional Inc (1997) THIORIDAZINE HYDROCHLORIDE tablet film coated, Rockford, IL Mylan Institutional Inc (1997) THIORIDAZINE HYDROCHLORIDE tablet film coated, Rockford, IL
Zurück zum Zitat Otsuka. (2016a). ABILIFY MAINTENA® (aripiprazole) for extended-release injectable suspension for intramuscular use, Tokyo, Japan Otsuka. (2016a). ABILIFY MAINTENA® (aripiprazole) for extended-release injectable suspension for intramuscular use, Tokyo, Japan
Zurück zum Zitat Otsuka. (2016b). REXULTI® (brexpiprazole) ) tablets for oral use, Tokyo, Japan Otsuka. (2016b). REXULTI® (brexpiprazole) ) tablets for oral use, Tokyo, Japan
Zurück zum Zitat Paulzen M, Kuzin M, Gründer G (2015) Arzneimittelmetabolismus und Therapieversagen. DNP - Der Neurologe & Psychiater 16:46–55CrossRef Paulzen M, Kuzin M, Gründer G (2015) Arzneimittelmetabolismus und Therapieversagen. DNP - Der Neurologe & Psychiater 16:46–55CrossRef
Zurück zum Zitat Phillips EJ, Sukasem C, Whirl-Carrillo M, Muller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M (2018) CClinical Pharmacogenetics implementation consortium guideline for HLA genotype and use of carbamazepine and oxcarbazepine: 2017 update. Clin Pharmacol Ther 103:574–581CrossRefPubMed Phillips EJ, Sukasem C, Whirl-Carrillo M, Muller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M (2018) CClinical Pharmacogenetics implementation consortium guideline for HLA genotype and use of carbamazepine and oxcarbazepine: 2017 update. Clin Pharmacol Ther 103:574–581CrossRefPubMed
Zurück zum Zitat Rogers HL, Bhattaram A, Zineh I, Gobburu J, Mathis M, Laughren TP, Pacanowski M (2012) CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration’s new dosing recommendations. J Clin Psychiatry 73:1187–1190CrossRefPubMed Rogers HL, Bhattaram A, Zineh I, Gobburu J, Mathis M, Laughren TP, Pacanowski M (2012) CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration’s new dosing recommendations. J Clin Psychiatry 73:1187–1190CrossRefPubMed
Zurück zum Zitat Sandoz. (2000) Perphenazine Tablets USP, Princeton, NJ Sandoz. (2000) Perphenazine Tablets USP, Princeton, NJ
Zurück zum Zitat Schoretsanitis G, Baumann P, Conca A, Dietmaier O, Giupponi G, Grunder G, Hahn M, Hart X, Havemann-Reinecke U, Hefner G, Kuzin M, Mossner R, Piacentino D, Steimer W, Zernig G, Hiemke C (2021a) Therapeutic drug monitoring of long-acting injectable antipsychotic drugs. Ther Drug Monit 43:79–102CrossRefPubMed Schoretsanitis G, Baumann P, Conca A, Dietmaier O, Giupponi G, Grunder G, Hahn M, Hart X, Havemann-Reinecke U, Hefner G, Kuzin M, Mossner R, Piacentino D, Steimer W, Zernig G, Hiemke C (2021a) Therapeutic drug monitoring of long-acting injectable antipsychotic drugs. Ther Drug Monit 43:79–102CrossRefPubMed
Zurück zum Zitat Schoretsanitis G, Haen E, Grunder G, Stegmann B, Schruers KR, Hiemke C, Lammertz SE, Paulzen M (2016) Pharmacokinetic drug-drug interactions of mood stabilizers and risperidone in patients under combined treatment. J Clin Psychopharmacol 36:554–561CrossRefPubMed Schoretsanitis G, Haen E, Grunder G, Stegmann B, Schruers KR, Hiemke C, Lammertz SE, Paulzen M (2016) Pharmacokinetic drug-drug interactions of mood stabilizers and risperidone in patients under combined treatment. J Clin Psychopharmacol 36:554–561CrossRefPubMed
Zurück zum Zitat Schoretsanitis G, Kuzin M, Kane JM, Hiemke C, Paulzen M, Haen E (2021b) Elevated clozapine concentrations in clozapine-treated patients with hypersalivation. Clin Pharmacokinet 60:329–335CrossRefPubMed Schoretsanitis G, Kuzin M, Kane JM, Hiemke C, Paulzen M, Haen E (2021b) Elevated clozapine concentrations in clozapine-treated patients with hypersalivation. Clin Pharmacokinet 60:329–335CrossRefPubMed
Zurück zum Zitat Schoretsanitis G, Paulzen M, Unterecker S, Schwarz M, Conca A, Zernig G, Grunder G, Haen E, Baumann P, Bergemann N, Clement HW, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Havemann-Reinecke U, Hefner G, Helmer R, Janssen G, Jaquenoud-Sirot E, Laux G, Messer T, Mossner R, Muller MJ, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Silva Gracia M, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Waschgler R, Zurek G, Hiemke C (2018) TDM in psychiatry and neurology: a comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>. World J Biol Psychiatry 19:162–174CrossRefPubMed Schoretsanitis G, Paulzen M, Unterecker S, Schwarz M, Conca A, Zernig G, Grunder G, Haen E, Baumann P, Bergemann N, Clement HW, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Havemann-Reinecke U, Hefner G, Helmer R, Janssen G, Jaquenoud-Sirot E, Laux G, Messer T, Mossner R, Muller MJ, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Silva Gracia M, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Waschgler R, Zurek G, Hiemke C (2018) TDM in psychiatry and neurology: a comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup/>. World J Biol Psychiatry 19:162–174CrossRefPubMed
Zurück zum Zitat Steegen G, Catthoor K, Sabbe BGC, Dreesen T, Vandendriessche F, Detraux J (2021) Between response and resistance: pseudo-resistance during treatment of major depressive disorder. Tijdschr Psychiatr 63:189–196PubMed Steegen G, Catthoor K, Sabbe BGC, Dreesen T, Vandendriessche F, Detraux J (2021) Between response and resistance: pseudo-resistance during treatment of major depressive disorder. Tijdschr Psychiatr 63:189–196PubMed
Zurück zum Zitat Stingl JC, Brockmoller J, Viviani R (2013) Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function. Mol Psychiatry 18:273–287CrossRefPubMed Stingl JC, Brockmoller J, Viviani R (2013) Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function. Mol Psychiatry 18:273–287CrossRefPubMed
Zurück zum Zitat Takeda. (2017) TRINTELLIX (vortioxetine) tablets for oral use, Deerfield, IL Takeda. (2017) TRINTELLIX (vortioxetine) tablets for oral use, Deerfield, IL
Zurück zum Zitat Unterecker S, Hefner G, Baumann P, Grunder G, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Haen E, Havemann-Reinecke U, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mossner R, Muller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Waschgler R, Zernig G, Zurek G, Hiemke C (2019)Therapeutic drug monitoring in neuropsychopharmacology: summary of the consensus guidelines 2017 of the TDM task force of the AGNP. Nervenarzt 90:463–471CrossRefPubMed Unterecker S, Hefner G, Baumann P, Grunder G, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Haen E, Havemann-Reinecke U, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mossner R, Muller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Waschgler R, Zernig G, Zurek G, Hiemke C (2019)Therapeutic drug monitoring in neuropsychopharmacology: summary of the consensus guidelines 2017 of the TDM task force of the AGNP. Nervenarzt 90:463–471CrossRefPubMed
Zurück zum Zitat van Harten J (1995) Overview of the pharmacokinetics of fluvoxamine. Clin Pharmacokinet 29(Suppl 1):1–9CrossRefPubMed van Harten J (1995) Overview of the pharmacokinetics of fluvoxamine. Clin Pharmacokinet 29(Suppl 1):1–9CrossRefPubMed
Zurück zum Zitat Vanda Pharmaceuticals Inc. (2009) FANAPT® (iloperidone) tablets, Washington, DC Vanda Pharmaceuticals Inc. (2009) FANAPT® (iloperidone) tablets, Washington, DC
Zurück zum Zitat Yatham LN, Grossman F, Augustyns I, Vieta E, Ravindran A (2003) Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomised controlled trial. Br J Psychiatry 182:141–147CrossRefPubMed Yatham LN, Grossman F, Augustyns I, Vieta E, Ravindran A (2003) Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomised controlled trial. Br J Psychiatry 182:141–147CrossRefPubMed
Metadaten
Titel
Therapeutisches Drug Monitoring und Bedside Genotyping
verfasst von
Georgios Schoretsanitis
Michael Paulzen
Copyright-Jahr
2022
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-65734-8_12

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).