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Erschienen in: Die Innere Medizin 6/2011

01.06.2011 | Schwerpunkt

Therapiestrategien bei rheumatoider Arthritis

verfasst von: Dr. H. Bastian, E. Feist, G.-R. Burmester

Erschienen in: Die Innere Medizin | Ausgabe 6/2011

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Zusammenfassung

Die rheumatoide Arthritis ist die häufigste chronisch-entzündliche rheumatische Gelenkerkrankung, die unbehandelt zu radiologisch erfassbaren progredienten Gelenkdestruktionen führt. Die Erkrankung hat eine wesentliche sozialökonomische Bedeutung, da es bei einem Großteil der betroffenen Patienten zur Manifestation im berufsfähigen Alter kommt, mit resultierender Arbeitsunfähigkeit sowie möglicher Invalidität. Für die Prognose spielt eine frühzeitige adäquate antirheumatische Basistherapie sowie ergo- und physiotherapeutische Maßnahmen eine entscheidende Rolle. In den letzten Jahren haben sich die Möglichkeiten der medikamentösen Behandlung deutlich verbessert. Dieser Fortschritt war die Grundlage für neue Therapiestrategien mit einer dem individuellen Krankheitsverlauf eng angepassten medikamentösen Behandlung mit dem Ziel einer Krankheitsremission.
Literatur
1.
Zurück zum Zitat Alamanos Y, Drosos AA (2005) Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 4:130–136PubMedCrossRef Alamanos Y, Drosos AA (2005) Epidemiology of adult rheumatoid arthritis. Autoimmun Rev 4:130–136PubMedCrossRef
2.
Zurück zum Zitat Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581PubMedCrossRef Aletaha D, Neogi T, Silman AJ et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569–2581PubMedCrossRef
3.
Zurück zum Zitat American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines (2002) Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum 46:328–346CrossRef American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines (2002) Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum 46:328–346CrossRef
4.
Zurück zum Zitat Backhaus M (2002) Value of arthrosonography in early arthritis diagnosis. Z Rheumatol 61:120–129PubMedCrossRef Backhaus M (2002) Value of arthrosonography in early arthritis diagnosis. Z Rheumatol 61:120–129PubMedCrossRef
5.
Zurück zum Zitat Backhaus M, Burmester GR, Sandrock D et al (2002) Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints. Ann Rheum Dis 61:895–904PubMedCrossRef Backhaus M, Burmester GR, Sandrock D et al (2002) Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints. Ann Rheum Dis 61:895–904PubMedCrossRef
6.
Zurück zum Zitat Backhaus M, Kamradt T, Sandrock D et al (1999) Arthritis of the finger joints: a comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging. Arthritis Rheum 42:1232–1245PubMedCrossRef Backhaus M, Kamradt T, Sandrock D et al (1999) Arthritis of the finger joints: a comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging. Arthritis Rheum 42:1232–1245PubMedCrossRef
7.
Zurück zum Zitat Bastian H, Zinke S, Egerer K et al (2010) Effects of early rituximab retreatment in rheumatoid arthritis patients with an inadequate response after the first cycle: retrospective arthritis cohort study. J Rheumatol 37:1069–1071PubMedCrossRef Bastian H, Zinke S, Egerer K et al (2010) Effects of early rituximab retreatment in rheumatoid arthritis patients with an inadequate response after the first cycle: retrospective arthritis cohort study. J Rheumatol 37:1069–1071PubMedCrossRef
8.
Zurück zum Zitat Bizzaro N, Mazzanti G, Tonutti E et al (2001) Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem 47:1089–1093PubMed Bizzaro N, Mazzanti G, Tonutti E et al (2001) Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem 47:1089–1093PubMed
9.
Zurück zum Zitat Bresnihan B, Alvaro-Gracia JM, Cobby M et al (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41:2196–2204PubMedCrossRef Bresnihan B, Alvaro-Gracia JM, Cobby M et al (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41:2196–2204PubMedCrossRef
10.
Zurück zum Zitat Buttgereit F, Doering G, Schaeffler A et al (2008) Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 371:205–214PubMedCrossRef Buttgereit F, Doering G, Schaeffler A et al (2008) Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 371:205–214PubMedCrossRef
11.
Zurück zum Zitat Campion GV, Lebsack ME, Lookabaugh J et al (1996) Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum 39:1092–1101PubMedCrossRef Campion GV, Lebsack ME, Lookabaugh J et al (1996) Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum 39:1092–1101PubMedCrossRef
12.
Zurück zum Zitat Cohen SB, Emery P, Greenwald MW et al; REFLEX Trial Group (2006) Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 54:2793–2806PubMedCrossRef Cohen SB, Emery P, Greenwald MW et al; REFLEX Trial Group (2006) Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 54:2793–2806PubMedCrossRef
13.
Zurück zum Zitat den Broeder A, van de Putte L, Rau R et al (2002) A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis. J Rheumatol 29:2288–2298 den Broeder A, van de Putte L, Rau R et al (2002) A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis. J Rheumatol 29:2288–2298
14.
Zurück zum Zitat Døhn UM, Ejbjerg BJ, Court-Payen M et al (2006) Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints. Arthritis Res Ther 8:R110PubMedCrossRef Døhn UM, Ejbjerg BJ, Court-Payen M et al (2006) Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints. Arthritis Res Ther 8:R110PubMedCrossRef
15.
Zurück zum Zitat Doran MF, Pond GR, Crowson CS et al (2002) Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 46:625–631PubMedCrossRef Doran MF, Pond GR, Crowson CS et al (2002) Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 46:625–631PubMedCrossRef
16.
Zurück zum Zitat Drevlow BE, Lovis R, Haag MA et al (1996) Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis. Arthritis Rheum 39:257–265PubMedCrossRef Drevlow BE, Lovis R, Haag MA et al (1996) Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis. Arthritis Rheum 39:257–265PubMedCrossRef
17.
Zurück zum Zitat Edwards JCW, Szczepanski L, Szechinski J et al (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350:2572–2581PubMedCrossRef Edwards JCW, Szczepanski L, Szechinski J et al (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350:2572–2581PubMedCrossRef
18.
Zurück zum Zitat Egerer K, Feist E, Burmester G-R (2009) The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigens. Dtsch Arztebl Int 106:159–163PubMed Egerer K, Feist E, Burmester G-R (2009) The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigens. Dtsch Arztebl Int 106:159–163PubMed
20.
21.
Zurück zum Zitat Goodson N, Marks J, Lunt M, Symmons D (2005) Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s. Ann Rheum Dis 64:1595–1601PubMedCrossRef Goodson N, Marks J, Lunt M, Symmons D (2005) Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s. Ann Rheum Dis 64:1595–1601PubMedCrossRef
22.
Zurück zum Zitat Gøtzsche PC, Johansen HK (1998) Meta-analysis of short-term low dose prednisolone versus placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis. BMJ 316:811–818PubMed Gøtzsche PC, Johansen HK (1998) Meta-analysis of short-term low dose prednisolone versus placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis. BMJ 316:811–818PubMed
23.
Zurück zum Zitat Grünke M, Bastian H, Schulze-Koops H, Burmester GR (2010) New biologics and orally available compounds. What is still in the pipeline? Z Rheumatol 69:626–632PubMedCrossRef Grünke M, Bastian H, Schulze-Koops H, Burmester GR (2010) New biologics and orally available compounds. What is still in the pipeline? Z Rheumatol 69:626–632PubMedCrossRef
24.
25.
Zurück zum Zitat Klareskog L, van der Heijde D, de Jager JP et al; TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators (2004) Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363:675–681PubMedCrossRef Klareskog L, van der Heijde D, de Jager JP et al; TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators (2004) Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363:675–681PubMedCrossRef
26.
Zurück zum Zitat Koch AE (2000) The role of angiogenesis in rheumatoid arthritis: recent developments. Ann Rheum Dis 59 (Suppl 1):i65–71PubMedCrossRef Koch AE (2000) The role of angiogenesis in rheumatoid arthritis: recent developments. Ann Rheum Dis 59 (Suppl 1):i65–71PubMedCrossRef
27.
Zurück zum Zitat Kremer JM, Genant HK, Moreland LW et al (2006) Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med 144:865–876PubMed Kremer JM, Genant HK, Moreland LW et al (2006) Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med 144:865–876PubMed
28.
Zurück zum Zitat Laan RF, Jansen TL, Riel PL van (1999) Glucocorticosteroids in the management of rheumatoid arthritis. Rheumatology (Oxford) 38:6–12 Laan RF, Jansen TL, Riel PL van (1999) Glucocorticosteroids in the management of rheumatoid arthritis. Rheumatology (Oxford) 38:6–12
29.
Zurück zum Zitat Lindqvist E, Eberhardt K, Bendtzen K et al (2005) Prognostic laboratory markers of joint damage in rheumatoid arthritis. Ann Rheum Dis 64:196–201PubMedCrossRef Lindqvist E, Eberhardt K, Bendtzen K et al (2005) Prognostic laboratory markers of joint damage in rheumatoid arthritis. Ann Rheum Dis 64:196–201PubMedCrossRef
30.
Zurück zum Zitat Lipsky PE, van der Heijde DM, St Clair EW et al; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group (2000) Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 343:1594–1602PubMedCrossRef Lipsky PE, van der Heijde DM, St Clair EW et al; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group (2000) Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 343:1594–1602PubMedCrossRef
31.
Zurück zum Zitat Maetzel A, Wong A, Strand V et al (2000) Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 39:975–981 Maetzel A, Wong A, Strand V et al (2000) Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 39:975–981
32.
Zurück zum Zitat Maradit-Kremers H, Nicola PJ, Crowson CS et al (2005) Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 52:722–732PubMedCrossRef Maradit-Kremers H, Nicola PJ, Crowson CS et al (2005) Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 52:722–732PubMedCrossRef
33.
Zurück zum Zitat McInnes IB, O’Dell JR (2010) State-of-the-art: rheumatoid arthritis. Ann Rheum Dis 69:1898–1906PubMedCrossRef McInnes IB, O’Dell JR (2010) State-of-the-art: rheumatoid arthritis. Ann Rheum Dis 69:1898–1906PubMedCrossRef
34.
Zurück zum Zitat Nishimoto N, Miyasaka N, Yamamoto K et al (2009) Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol 19:12–19PubMedCrossRef Nishimoto N, Miyasaka N, Yamamoto K et al (2009) Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol 19:12–19PubMedCrossRef
35.
Zurück zum Zitat O’Dell JR (2002) Treating rheumatoid arthritis early: a window of opportunity? Arthritis Rheum 46:283–285CrossRef O’Dell JR (2002) Treating rheumatoid arthritis early: a window of opportunity? Arthritis Rheum 46:283–285CrossRef
36.
Zurück zum Zitat O’Dell JR (2004) Therapeutic strategies for rheumatoid arthritis. N Engl J Med 350:2591–2602CrossRef O’Dell JR (2004) Therapeutic strategies for rheumatoid arthritis. N Engl J Med 350:2591–2602CrossRef
37.
Zurück zum Zitat Ostendorf B, Scherer A, Backhaus M et al; Bildgebende Verfahren der Deutschen Gesellschaft für Rheumatologie (2003) [Imaging techniques in rheumatology: magnetic resonance imaging in rheumatoid arthritis.] Z Rheumatol 62:274–286 Ostendorf B, Scherer A, Backhaus M et al; Bildgebende Verfahren der Deutschen Gesellschaft für Rheumatologie (2003) [Imaging techniques in rheumatology: magnetic resonance imaging in rheumatoid arthritis.] Z Rheumatol 62:274–286
38.
Zurück zum Zitat Østergaard M, Ejbjerg B, Szkudlarek M (2005) Imaging in early rheumatoid arthritis: roles of magnetic resonance imaging, ultrasonography, conventional radiography and computed tomography. Best Pract Res Clin Rheumatol 19:91–116PubMedCrossRef Østergaard M, Ejbjerg B, Szkudlarek M (2005) Imaging in early rheumatoid arthritis: roles of magnetic resonance imaging, ultrasonography, conventional radiography and computed tomography. Best Pract Res Clin Rheumatol 19:91–116PubMedCrossRef
39.
Zurück zum Zitat Sandrock D, Backhaus M, Burmester G, Munz DL (2003) Imaging techniques in rheumatology: scintigraphy in rheumatoid arthritis. Z Rheumatol 62:476–480PubMedCrossRef Sandrock D, Backhaus M, Burmester G, Munz DL (2003) Imaging techniques in rheumatology: scintigraphy in rheumatoid arthritis. Z Rheumatol 62:476–480PubMedCrossRef
40.
Zurück zum Zitat Saraux A, Berthelot JM, Chalès G et al (2002) Value of laboratory tests in early prediction of rheumatoid arthritis. Arthritis Rheum 47:155–165PubMedCrossRef Saraux A, Berthelot JM, Chalès G et al (2002) Value of laboratory tests in early prediction of rheumatoid arthritis. Arthritis Rheum 47:155–165PubMedCrossRef
41.
Zurück zum Zitat Schellekens GA, Visser H, de Jong BA et al. (2000) The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 43:155–163PubMedCrossRef Schellekens GA, Visser H, de Jong BA et al. (2000) The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 43:155–163PubMedCrossRef
42.
Zurück zum Zitat Schiff M, Keiserman M, Codding C et al (2008) Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis 67:1096–1103PubMedCrossRef Schiff M, Keiserman M, Codding C et al (2008) Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis 67:1096–1103PubMedCrossRef
43.
Zurück zum Zitat Scott DL, Smolen JS, Kalden JRet al; European Leflunomide Study Group (2001) Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Ann Rheum Dis 60:913–923PubMedCrossRef Scott DL, Smolen JS, Kalden JRet al; European Leflunomide Study Group (2001) Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Ann Rheum Dis 60:913–923PubMedCrossRef
44.
Zurück zum Zitat Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, Woodworth T, Alten R; OPTION Investigators (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371:987–997PubMedCrossRef Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, Woodworth T, Alten R; OPTION Investigators (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371:987–997PubMedCrossRef
45.
Zurück zum Zitat Smolen JS, Landewé R, Breedveld FC et al (2010) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 69:964–975PubMedCrossRef Smolen JS, Landewé R, Breedveld FC et al (2010) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 69:964–975PubMedCrossRef
46.
Zurück zum Zitat Smolen JS, Van Der Heijde DM, St Clair EW et al; Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group (2006) Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial. Arthritis Rheum 54:702–710PubMedCrossRef Smolen JS, Van Der Heijde DM, St Clair EW et al; Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group (2006) Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial. Arthritis Rheum 54:702–710PubMedCrossRef
47.
Zurück zum Zitat Strand V, Cohen S, Schiff M et al (1999) Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med 159:2542–2550PubMedCrossRef Strand V, Cohen S, Schiff M et al (1999) Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med 159:2542–2550PubMedCrossRef
48.
Zurück zum Zitat Strunk J, Lange U, Müller-Ladner U (2005) Rheumatoid arthritis. Dtsch Med Wochenschr 130:1761–1768PubMedCrossRef Strunk J, Lange U, Müller-Ladner U (2005) Rheumatoid arthritis. Dtsch Med Wochenschr 130:1761–1768PubMedCrossRef
49.
Zurück zum Zitat Symmons D, Turner G, Webb R et al (2002) The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology 41:793–800PubMedCrossRef Symmons D, Turner G, Webb R et al (2002) The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology 41:793–800PubMedCrossRef
50.
Zurück zum Zitat Symmons DPM (2002) Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome. Best Pract Res Clin Rheumatol 16:707–722PubMedCrossRef Symmons DPM (2002) Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome. Best Pract Res Clin Rheumatol 16:707–722PubMedCrossRef
51.
Zurück zum Zitat Symmons DPM, Barrett EM, Bankhead CR et al (1994) The incidence of rheumatoid arthritis in the United Kingdom: Results from the Norfolk Arthritis Register. Rheumatology 33:735–739CrossRef Symmons DPM, Barrett EM, Bankhead CR et al (1994) The incidence of rheumatoid arthritis in the United Kingdom: Results from the Norfolk Arthritis Register. Rheumatology 33:735–739CrossRef
52.
Zurück zum Zitat van Boekel MAM, Vossenaar ER,van den Hoogen FHJ, van Venrooij WJ (2002) Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 4:87–93 van Boekel MAM, Vossenaar ER,van den Hoogen FHJ, van Venrooij WJ (2002) Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 4:87–93
53.
Zurück zum Zitat van de Putte LB, Atkins C, Malaise M et al (2004) Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed. Ann Rheum Dis 63:508–516CrossRef van de Putte LB, Atkins C, Malaise M et al (2004) Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed. Ann Rheum Dis 63:508–516CrossRef
54.
Zurück zum Zitat van de Putte LB, Rau R, Breedveld FC et al (2003) Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study. Ann Rheum Dis 62:1168–1177CrossRef van de Putte LB, Rau R, Breedveld FC et al (2003) Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study. Ann Rheum Dis 62:1168–1177CrossRef
55.
Zurück zum Zitat van der Heijde D, Landewé R, Klareskog L et al (2005) Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study. Arthritis Rheum 52:49–60CrossRef van der Heijde D, Landewé R, Klareskog L et al (2005) Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study. Arthritis Rheum 52:49–60CrossRef
56.
Zurück zum Zitat van der Heijde DM (1996) Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillieres Clin Rheumatol 10:435–453CrossRef van der Heijde DM (1996) Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillieres Clin Rheumatol 10:435–453CrossRef
57.
Zurück zum Zitat van Gestel AM, Laan RF, Haagsma CJ et al (1995) Oral steroids as bridge therapy in rheumatoid arthritis patients starting with parenteral gold. A randomized double-blind placebo-controlled trial. Br J Rheumatol 34:347–351CrossRef van Gestel AM, Laan RF, Haagsma CJ et al (1995) Oral steroids as bridge therapy in rheumatoid arthritis patients starting with parenteral gold. A randomized double-blind placebo-controlled trial. Br J Rheumatol 34:347–351CrossRef
58.
Zurück zum Zitat Wakefield RJ, Gibbon WW, Conaghan PG et al (2000) The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum 43:2762–2770PubMedCrossRef Wakefield RJ, Gibbon WW, Conaghan PG et al (2000) The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum 43:2762–2770PubMedCrossRef
59.
Zurück zum Zitat Weinblatt M, Combe B, Covucci A et al (2006) Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study. Arthritis Rheum 54:2807–2816PubMedCrossRef Weinblatt M, Combe B, Covucci A et al (2006) Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study. Arthritis Rheum 54:2807–2816PubMedCrossRef
60.
Zurück zum Zitat Wollenhaupt J, Krüger K (2010) Nicht-TNF-Biologika in der Therapiestrategie bei rheumatoider Arthritis. Z Rheumatol 69:618–625PubMedCrossRef Wollenhaupt J, Krüger K (2010) Nicht-TNF-Biologika in der Therapiestrategie bei rheumatoider Arthritis. Z Rheumatol 69:618–625PubMedCrossRef
61.
Zurück zum Zitat Zidi I, Bouaziz A, Mnif W et al (2010) Golimumab therapy of rheumatoid arthritis: an overview. Scand J Immunol 72:75–85PubMedCrossRef Zidi I, Bouaziz A, Mnif W et al (2010) Golimumab therapy of rheumatoid arthritis: an overview. Scand J Immunol 72:75–85PubMedCrossRef
62.
Zurück zum Zitat Zintzaras E, Voulgarelis M, Moutsopoulos HM (2005) The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med 165:2337–2344PubMedCrossRef Zintzaras E, Voulgarelis M, Moutsopoulos HM (2005) The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med 165:2337–2344PubMedCrossRef
Metadaten
Titel
Therapiestrategien bei rheumatoider Arthritis
verfasst von
Dr. H. Bastian
E. Feist
G.-R. Burmester
Publikationsdatum
01.06.2011
Verlag
Springer-Verlag
Erschienen in
Die Innere Medizin / Ausgabe 6/2011
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-010-2765-4

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Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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