Erschienen in:
13.07.2020 | Correspondence
Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex
verfasst von:
Gabor G. Kovacs, John L. Robinson, Daniel P. Perl, Virginia M.-Y. Lee, John Q. Trojanowski
Erschienen in:
Acta Neuropathologica
|
Ausgabe 4/2020
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Excerpt
Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a progressive neurodegenerative disorder characterized by diverse neuronal and glial tau pathologies [
6]. With the aim to evaluate aging-related tau astrogliopathy (ARTAG) we examined the collection at the CNDR, University of Pennsylvania, consisting of blocks of the frontal parietal, temporal, and occipital cortices in 33, the hippocampus in 13, and the spinal cord samples in 30 additional cases. Formalin fixed, paraffin-embedded tissue blocks were evaluated using anti-tau antibodies PHF-1 (Ser396/Ser404, 1:2000; Gift of Peter Davies) and AT8 (phospho-epitope Ser202/Thr205; Pierce Biotechnology, Rockford, IL, USA). …