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Erschienen in: Comparative Clinical Pathology 6/2019

13.06.2019 | Original Article

Toxicological evaluation of aqueous extract of different varieties of guava (Psidium guajava Linn) leaves

verfasst von: Leye Jonathan Babatola, Ganiyu Oboh, Adedayo Oluwaseun Ademiluyi

Erschienen in: Comparative Clinical Pathology | Ausgabe 6/2019

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Abstract

Guava (Psidium guajava Linn) is a common fruit tree in Nigeria with different species; the leaves, fruits, and the bark are often used in folklore for different medicinal purposes. However, there is a dearth of information on safety assessment of the leaves extract of guava from different species. These studies conducted toxicological evaluation of white, red, and pink guava leaves extract in rats for 14 days. Oral administration of 50, 500, and 5000 mg/kg BWT was carried out; they were observed for toxicity signs hourly for the first 6 h after administration, and every day of the experimental period. Clinical indicators, body weight differences, mortality, and biochemical parameters were examined during the experimental period. There were no deaths, a slight body weight increase was observed in the rats, and no clinical sign was noticed throughout the period of the experiment. There were no significant changes in the rat tissue malondialdehyde (MDA) levels, and the serum liver indicator enzymes (aspartate aminotransferase (AST), alkaline phosphate (ALP), and alanine aminotransferase (ALT), bilirubin) and serum renal marker enzymes (creatinine, urea, uric acid, and blood urea nitrogen (BUN)) of rats administered when compared with the control. This entail that the NOAEL (no observed adverse effect level) estimate of white, red, and pink guava leaves extract is 50–5000 mg/kg.
Literatur
Zurück zum Zitat Acute Oral Toxicity (OECD Test Guideline 425) Statistical Programme Version 1.0, 2001 Acute Oral Toxicity (OECD Test Guideline 425) Statistical Programme Version 1.0, 2001
Zurück zum Zitat Akinmoladun A.C., Obuotor E.M., Farombi E.O. (2010). Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants. J Med Food 13 (2): 444–451 Akinmoladun A.C., Obuotor E.M., Farombi E.O. (2010). Evaluation of antioxidant and free radical scavenging capacities of some Nigerian indigenous medicinal plants. J Med Food 13 (2): 444–451
Zurück zum Zitat Arima H, Danno G (2002) Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem 66(8):1727–1730CrossRef Arima H, Danno G (2002) Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem 66(8):1727–1730CrossRef
Zurück zum Zitat Ayub MY, Norazmir MN, Mamot S, Jeeven K, Hadijah H (2010) Antihypertensive effect of pink guava (Psidium guajava) puree on spontaneous hypertensive rats. Int Food Res J 17:89–96 Ayub MY, Norazmir MN, Mamot S, Jeeven K, Hadijah H (2010) Antihypertensive effect of pink guava (Psidium guajava) puree on spontaneous hypertensive rats. Int Food Res J 17:89–96
Zurück zum Zitat Bnouham M, Merhfour FZ, Elachoui M, Legssyer A, Mekhfi H, Lamnaouer D, Ziyyat A (2006) Toxic effects of some medicinal plants used in Moroccan traditional medicine. Moroccan J. Biol 2(3):21–30 Bnouham M, Merhfour FZ, Elachoui M, Legssyer A, Mekhfi H, Lamnaouer D, Ziyyat A (2006) Toxic effects of some medicinal plants used in Moroccan traditional medicine. Moroccan J. Biol 2(3):21–30
Zurück zum Zitat Crosby DG, Crosby DF (1998) Environmental toxicology and chemistry. Oxford University Press, New York Crosby DG, Crosby DF (1998) Environmental toxicology and chemistry. Oxford University Press, New York
Zurück zum Zitat Erdem A, Gondogan NU, Usubütün A, Kilinç K, Erdem SR, Kara A, Bozkurt A (2000) The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant 15(8):1175–1182CrossRef Erdem A, Gondogan NU, Usubütün A, Kilinç K, Erdem SR, Kara A, Bozkurt A (2000) The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant 15(8):1175–1182CrossRef
Zurück zum Zitat Gorinstein S, Zemser M, Haruenkit R, Chuthakorn R, Grauer F, Martin-Belloso O, Trakhtenberg S (1999) Comparative content of total polyphenols and dietary fiber in tropical fruits and persimmon. J Nutr Biochem 10(6):367–371CrossRef Gorinstein S, Zemser M, Haruenkit R, Chuthakorn R, Grauer F, Martin-Belloso O, Trakhtenberg S (1999) Comparative content of total polyphenols and dietary fiber in tropical fruits and persimmon. J Nutr Biochem 10(6):367–371CrossRef
Zurück zum Zitat Gupta Bhardwaj S, Deepika SGL, Bihani SD (2012) Study of acute, sub acute and chronic toxicity test. IJARPB 2(2):103–129 Gupta Bhardwaj S, Deepika SGL, Bihani SD (2012) Study of acute, sub acute and chronic toxicity test. IJARPB 2(2):103–129
Zurück zum Zitat Jaiarj P, Khoohaswan P, Wongkrajang Y, Peungvicha P, Suriyawong P, Saraya ML et al (1999) Anticough and antimicrobial activities of Psidium guajava Linn. Leaf extract. J Ethnopharmacol 67:203–212CrossRef Jaiarj P, Khoohaswan P, Wongkrajang Y, Peungvicha P, Suriyawong P, Saraya ML et al (1999) Anticough and antimicrobial activities of Psidium guajava Linn. Leaf extract. J Ethnopharmacol 67:203–212CrossRef
Zurück zum Zitat Lin J, Puckree T, Mvelase TP (2002) Anti-diarrheal evaluation of some medicinal plants used by Zulu traditional healers. J Ethnopharmacol 79(1):53–56CrossRef Lin J, Puckree T, Mvelase TP (2002) Anti-diarrheal evaluation of some medicinal plants used by Zulu traditional healers. J Ethnopharmacol 79(1):53–56CrossRef
Zurück zum Zitat Manikandan R, Vijaya Anand A (2016) Evaluation of antioxidant activity of Pisidum guajava Linn. in streptozotocin-induced diabetic rats. Free Rad Antiox 6(1):72–76CrossRef Manikandan R, Vijaya Anand A (2016) Evaluation of antioxidant activity of Pisidum guajava Linn. in streptozotocin-induced diabetic rats. Free Rad Antiox 6(1):72–76CrossRef
Zurück zum Zitat Metwally AM, Omar AA, Ghazy NM, Harraz FM, El Sohafy SM (2011) Monograph of Psidium guajava l. leaves. Pharm J 3(21):88–104 Metwally AM, Omar AA, Ghazy NM, Harraz FM, El Sohafy SM (2011) Monograph of Psidium guajava l. leaves. Pharm J 3(21):88–104
Zurück zum Zitat Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, AlMazroa MA, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Abdulhak AB, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng ATA, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, Leo DD, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Memish ZA, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KMV, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA III, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, de Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Silberberg D, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJC, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SRM, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AKM, Zheng ZJ, Zonies D, Lopez AD (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2197–2223CrossRef Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, AlMazroa MA, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Abdulhak AB, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng ATA, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, Leo DD, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Memish ZA, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KMV, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA III, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, de Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Silberberg D, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJC, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SRM, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AKM, Zheng ZJ, Zonies D, Lopez AD (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2197–2223CrossRef
Zurück zum Zitat Oboh G, Babatola LJ, Ademiluyi AO (2014) Antioxidant properties of phenolic extracts of African mistletoe (Loranthus begwensis L.) from Kolanut and breadfruit trees. J Food Sci Qual Manag 32:6–11 Oboh G, Babatola LJ, Ademiluyi AO (2014) Antioxidant properties of phenolic extracts of African mistletoe (Loranthus begwensis L.) from Kolanut and breadfruit trees. J Food Sci Qual Manag 32:6–11
Zurück zum Zitat Ojewole JA (2005) Hypoglycemic and hypotensive effects of Psidium guajava L, (Myrtaceae) leaf aqueous extracts. Methods Find Exp Clin Pharmacol 27:689–695CrossRef Ojewole JA (2005) Hypoglycemic and hypotensive effects of Psidium guajava L, (Myrtaceae) leaf aqueous extracts. Methods Find Exp Clin Pharmacol 27:689–695CrossRef
Zurück zum Zitat Patrick-Iwuanyanwu Kingsley C, Onyeike EN, Wegwu MO (2010) Hepatoprotective effects of methanolic extract and fractions of African mistletoe tapinanthus bangwensis (engl. & k. krause) from Nigeria. EXCLI J 9:187–194 ISSN 1611-2156PubMedPubMedCentral Patrick-Iwuanyanwu Kingsley C, Onyeike EN, Wegwu MO (2010) Hepatoprotective effects of methanolic extract and fractions of African mistletoe tapinanthus bangwensis (engl. & k. krause) from Nigeria. EXCLI J 9:187–194 ISSN 1611-2156PubMedPubMedCentral
Zurück zum Zitat Philips BU, Health CJ, Ossowska Z, Bussey TJ, Saksida LM (2017) Optimisation of cognitive performance in rodent operant (touchscreen) testing: evaluation and effects of reinforce strength. Learn Behav 45(3):252–262CrossRef Philips BU, Health CJ, Ossowska Z, Bussey TJ, Saksida LM (2017) Optimisation of cognitive performance in rodent operant (touchscreen) testing: evaluation and effects of reinforce strength. Learn Behav 45(3):252–262CrossRef
Zurück zum Zitat Ross IA (1999) Medicinal plants of the world: chemical constituents, traditional and modern medicinal uses. Humana press, New Jersey Ross IA (1999) Medicinal plants of the world: chemical constituents, traditional and modern medicinal uses. Humana press, New Jersey
Zurück zum Zitat Public Health Service (1996) Public Health Service policy on Humane care and use of laboratory animals. U.S. Department of Health and Human Services, Washington, D.C., p 16 Public Health Service (1996) Public Health Service policy on Humane care and use of laboratory animals. U.S. Department of Health and Human Services, Washington, D.C., p 16
Zurück zum Zitat Roy CK, Das AK (2010) Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. Pak J Pharm Sci 23(1):15–20PubMed Roy CK, Das AK (2010) Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity. Pak J Pharm Sci 23(1):15–20PubMed
Zurück zum Zitat Roy CK, Kamath JV, Asad M (2006) Hepatoprotective activity of Psidium guajava L leaf extract. Indian J Exp Biol 44:305–311PubMed Roy CK, Kamath JV, Asad M (2006) Hepatoprotective activity of Psidium guajava L leaf extract. Indian J Exp Biol 44:305–311PubMed
Zurück zum Zitat Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T (2004) Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous non-insulin-dependant diabetes mellitus (NIDDM) rats. J Health Sci 50(6):674–678CrossRef Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T (2004) Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous non-insulin-dependant diabetes mellitus (NIDDM) rats. J Health Sci 50(6):674–678CrossRef
Zurück zum Zitat Tédong L, Dzeufiet PDD, Dimo T, Asongalem EA, Sokeng SN, Flejou JF, Callard P, Kamtchouing P (2007) Acute and subchronic toxicity of Anacardium occidentale Linn (Anacardiaceae) leaves hexane extract in mice. Afr J Traditional Altern Med 4(2):140–147 Tédong L, Dzeufiet PDD, Dimo T, Asongalem EA, Sokeng SN, Flejou JF, Callard P, Kamtchouing P (2007) Acute and subchronic toxicity of Anacardium occidentale Linn (Anacardiaceae) leaves hexane extract in mice. Afr J Traditional Altern Med 4(2):140–147
Zurück zum Zitat Vijaya A, Manikandan VK, Kumar S, Pushpa AH (2016) Phytopharmacological overview of Psidium guajava Linn. Pharm J 8(4):314–320 Vijaya A, Manikandan VK, Kumar S, Pushpa AH (2016) Phytopharmacological overview of Psidium guajava Linn. Pharm J 8(4):314–320
Zurück zum Zitat Ware, G.W., (2001). Ed., Reviews of environmental contamination and toxicology, Springer-Verlag, Heidelberg Ware, G.W., (2001). Ed., Reviews of environmental contamination and toxicology, Springer-Verlag, Heidelberg
Metadaten
Titel
Toxicological evaluation of aqueous extract of different varieties of guava (Psidium guajava Linn) leaves
verfasst von
Leye Jonathan Babatola
Ganiyu Oboh
Adedayo Oluwaseun Ademiluyi
Publikationsdatum
13.06.2019
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 6/2019
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-019-03002-0

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