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Seminars in Immunopathology

Erschienen in:

02.10.2017 | Review

Transfer of maternal immunity and programming of the newborn immune system

verfasst von: Madeleine F. Jennewein, Bahaa Abu-Raya, Yiwei Jiang, Galit Alter, Arnaud Marchant

Erschienen in: Seminars in Immunopathology | Ausgabe 6/2017

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Abstract

As placental mammals, the pregnant women and the fetus have intense and prolonged interactions during gestation. There is increasing evidence that multiple molecular as well as cellular components originating in pregnant women are transferred to the fetus. The transfer of maternal antibodies has long been recognized as a central component of newborn immunity against pathogens. More recent studies indicate that inflammatory mediators, micronutrients, microbial products and maternal cells are transferred in utero and influence the fetal immune system. Together, these multiple signals are likely to form a complex network of interactions that program the neonatal immune system and tune its homeostatic regulation. Maternal disorders, in particular infectious diseases, modify these signals and may thereby alter immunity in early life. Understanding maternal programming of the newborn immune system could provide a basis for interventions promoting child health.

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Titel: Transfer of maternal immunity and programming of the newborn immune system
verfasst von: Madeleine F. Jennewein
Bahaa Abu-Raya
Yiwei Jiang
Galit Alter
Arnaud Marchant
Publikationsdatum: 02.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 6/2017
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-017-0653-x

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