nach oben

European Child & Adolescent Psychiatry

Erschienen in:

24.06.2020 | Review

Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis

verfasst von: Adriana Pastore, Giovanni de Girolamo, Silvio Tafuri, Aldo Tomasicchio, Francesco Margari

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Evidence of the association between traumatic experiences and psychosis are uncertain with respect to temporal order, clinical outcomes and the role of the age and genetic liability. The aim of the present meta-analysis was to explore the temporal relationship between the development of psychosis and traumatic exposure using prospective studies and to examine the role of moderation factors on overall effect sizes. Studies were identified by searching Embase-Ovid, PsycINFO (EBSCO), Pubmed, Scopus, Web of Science databases, and yielded an initial total of 9016 papers, leaving finally 23 after the screening process. Three sets of meta-analyses estimated the risk of developing psychotic experiences or full clinical psychosis by having experienced maltreatment by an adult or bullying by peers or parental death, using the random-effects model. Bullying by peers (OR = 2.28 [1.64, 4.34]), maltreatment by an adult (OR = 2.20 [1.72, 2.81]) and parental death (OR = 1.24 [1.06, 1.44]) all increased the risk of psychosis. Moderator analysis showed that negative effects of bullying were detected especially in those with genetic liability for psychosis and exposure to multiple trauma types; studies with higher prevalence of males showed a stronger risk for those exposed to parental death. No significant meta-regression was found between the risk of developing a full clinical psychosis or a psychotic experience. Lack of studies hampered the results about the age of trauma occurrence. The cumulative effect of being bullied from peers and experiencing other adversities during childhood and/or adolescence, together with genetic liability for psychosis, appears to confer the highest risk for developing psychotic symptoms later in life.

van Dam DS, van der Ven E, Velthorst E, Selten JP, Morgan C, de Haan L (2012) Childhood bullying and the association with psychosis in non-clinical and clinical samples: a review and meta-analysis. Psychol Med 42:2463–2474PubMed

Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, Read J, van Os J, Bentall RP (2012) Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 38:661–671PubMedPubMedCentral

Abajobir AA, Kisely S, Scott JG, Williams G, Clavarino A, Strathearn L, Najman JM (2017) Childhood maltreatment and young adulthood hallucinations, delusional experiences, and psychosis: a longitudinal study. Schizophr Bull 43:1045–1055PubMedPubMedCentral

Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A (2011) Childhood trauma and children’s emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. Am J Psychiatry 168:65–72PubMed

De Loore E, Drukker M, Gunther N, Feron F, Deboutte D, Sabbe B, Mengelers R, van Os J, Myin-Germeys I (2007) Childhood negative experiences and subclinical psychosis in adolescence: a longitudinal general population study. Early Interv Psychiatry 1:201–207

Andersen SL, Tomada A, Vincow ES, Valente E, Polcari A, Teicher MH (2008) Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J Neuropsychiatry Clin Neurosci 20:292–301PubMedPubMedCentral

Read J, van Os J, Morrison AP, Ross CA (2005) Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 112:330–350PubMed

Green JG, McLaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2010) Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 67:113–123PubMedPubMedCentral

Husted JA, Ahmed R, Chow EWC, Brzustowicz LM, Bassett AS (2010) Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene. Schizophr Res 121:187–192PubMedPubMedCentral

10.

Habets P, Marcelis M, Gronenschild E, Drukker M, van Os J, Group (2011) Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia. Biol Psychiatry 69:487–494

11.

Schreier A, Wolke D, Thomas K, Horwood J, Hollis C, Gunnell D, Lewis G, Thompson A, Zammit S, Duffy L, Salvi G, Harrison G (2009) Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Arch Gen Psychiatry 66:527–536PubMed

12.

Lardinois M, Lataster T, Mengelers R, Van Os J, Myin-Germeys I (2011) Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatr Scand 123:28–35PubMed

13.

Janssen I, Krabbendam L, Bak M, Hanssen M, Vollebergh W, de Graaf R, van Os J (2004) Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 109:38–45PubMed

14.

Shevlin M, Houston JE, Dorahy MJ, Adamson G (2008) Cumulative traumas and psychosis: an analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey. Schizophr Bull 34:193–199PubMed

15.

Pfeifer S, Krabbendam L, Myin-Germeys I, Derom C, Wichers M, Jacobs N, Thiery EW, van Os J (2010) A cognitive intermediate phenotype study confirming possible gene-early adversity interaction in psychosis outcome: a general population twin study. Psychosis 2:1–11

16.

Wahlberg KE, Lynne LC, Oja H, Keskitalo P, Pykalainen L, Lahti I, Moring J, Naarala M, Sorri A, Seitamaa M, Laksy K, Kolassa J, Tienari P (1997) Gene-environment interaction in vulnerability to schizophrenia: findings from the Finnish adoptive family study of schizophrenia. Am J Psychiatry 154:355–362PubMed

17.

Wicks S, Hjern A, Dalman C (2010) Social risk or genetic liability for psychosis? A study of children born in sweden and reared by adoptive parents. Am J Psychiatry 167:1240–1246PubMed

18.

Bechdolf A, Thompson A, Nelson B, Cotton S, Simmons MB, Amminger GP, Leicester S, Francey SM, McNab C, Krstev H, Sidis A, McGorry PD, Yung AR (2010) Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group. Acta Psychiatr Scand 121:377–384PubMed

19.

Wigman JT, van Winkel R, Ormel J, Verhulst FC, van Os J, Vollebergh WA (2012) Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta Psychiatr Scand 126:266–273PubMed

20.

Roberts BW, DelVecchio WF (2000) The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies. Psychol Bull 26:3–25

21.

Benedict RHB, Zgaljardic DJ (1998) Practice effects during repeated administrations of memory tests with and without alternate forms. J Clin Exp Neuropsyc. 20:339–352

22.

Fergusson M (1999) Childhood sexual abuse. An evidence based perspective. Sage Publications Inc, Thousand Oaks

23.

Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S (2009) Burden and consequences of child maltreatment in high-income countries. Lancet 373:68–81PubMed

24.

Bendall S, Jackson HJ, Hulbert CA, McGorry PD (2008) Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophr Bull 34:568–579PubMed

25.

Alvarez-Jimenez M, Gleeson JF, Henry LP, Harrigan SM, Harris MG, Amminger GP, Killackey E, Yung AR, Herrman H, Jackson HJ, McGorry PD (2011) Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosis. Schizophr Res 125:236–246PubMed

26.

Edwards VJ, Holden GW, Felitti VJ, Anda RF (2003) Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study. Am J Psychiatry 160:1453–1460PubMed

27.

Lau AS, Leeb RT, English D, Graham JC, Briggs EC, Brody KE, Marshall JM (2005) What’s in a name? A com- parison of methods for classifying predominant type of mal-treatment. Child Abuse Negl 29:533–551PubMed

28.

Wolke D, Lereya ST, Fisher HL, Lewis G, Zammit S (2014) Bullying in elementary school and psychotic experiences at 18 years: a longitudinal, population-based cohort study. Psychol Med 44:2199–2211PubMed

29.

Galletly C, Van Hooff M, McFarlane A (2011) Psychotic symptoms in young adults exposed to childhood trauma—a 20 year follow-up study. Schizophr Res 127:76–82PubMed

30.

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151(4):264–269

31.

Hedges LV, Vevea JL (1998) Fixed- and random-effects models in meta-analysis. Psychol Methods 3:486–504

32.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560PubMedPubMedCentral

33.

Wells GA, Shea B, O’Connell D (2019) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. Ottawa Hospital Research Institute, Ottawa. (http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp) Accessed 14 Jun 2019

34.

Crocetti (2016) Systematic reviews with meta-analysis: why, when, and how? Emerg Adulthood 4:3–18

35.

Rothstein (2005) Publication bias in meta-analysis: prevention, assessment and adjustments. Wiley, Chichester

36.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedPubMedCentral

37.

Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101PubMed

38.

Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463PubMed

39.

Cutajar MC, Mullen PE, Ogloff JR, Thomas SD, Wells DL, Spataro J (2010) Psychopathology in a large cohort of sexually abused children followed up to 43 years. Child Abuse Negl 34:813–822PubMed

40.

Elklit A, Shevlin M (2011) Female sexual victimization predicts psychosis: a case-control study based on the Danish Registry System. Schizophr Bull 37:1305–1310PubMed

41.

Kelleher I, Keeley H, Corcoran P, Ramsay H, Wasserman C, Carli V, Sarchiapone M, Hoven C, Wasserman D, Cannon M (2013) Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry 170:734–741PubMed

42.

Lataster J, Myin-Germeys I, Lieb R, Wittchen HU, van Os J (2012) Adversity and psychosis: a 10-year prospective study investigating synergism between early and recent adversity in psychosis. Acta Psychiatr Scand 125:388–399PubMed

43.

Spauwen J, Krabbendam L, Lieb R, Wittchen HU, van Os J (2006) Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. Br J Psychiatry 188:527–533PubMed

44.

Fisher HL, Schreier A, Zammit S, Maughan B, Munafo MR, Lewis G, Wolke D (2013) Pathways between childhood victimization and psychosis-like symptoms in the ALSPAC birth cohort. Schizophr Bull 39:1045–1055PubMed

45.

van der Ven E, Dalman C, Wicks S, Allebeck P, Magnusson C, van Os J, Selten JP (2015) Testing Odegaard’s selective migration hypothesis: a longitudinal cohort study of risk factors for non-affective psychotic disorders among prospective emigrants. Psychol Med 45:727–734PubMed

46.

van Nierop M, Janssens M, OoPI Genetic Risk, Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer CJ, Myin-Germeys I, van Os J, Wiersma D (2013) Evidence that transition from health to psychotic disorder can be traced to semi-ubiquitous environmental effects operating against background genetic risk. PLoS One 8:e76690PubMedPubMedCentral

47.

Konings M, Stefanis N, Kuepper R, de Graaf R, ten Have M, van Os J, Bakoula C, Henquet C (2012) Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychol Med 42:149–159PubMed

48.

Kramer IM, Simons CJ, Myin-Germeys I, Jacobs N, Derom C, Thiery E, van Os J, Wichers M (2012) Evidence that genes for depression impact on the pathway from trauma to psychotic-like symptoms by occasioning emotional dysregulation. Psychol Med 42:283–294PubMed

49.

Kuepper R, van Os J, Lieb R, Wittchen HU, Henquet C (2011) Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study. Psychol Med 41:2121–2129PubMed

50.

Lee WE, Kwok CH, Hunter EC, Richards M, David AS (2012) Prevalence and childhood antecedents of depersonalization syndrome in a UK birth cohort. Soc Psychiatry Psychiatr Epidemiol 47:253–261PubMed

51.

Makikyro T, Sauvola A, Moring J, Veijola J, Nieminen P, Jarvelin MR, Isohanni M (1998) Hospital-treated psychiatric disorders in adults with a single-parent and two-parent family background: a 28-year follow-up of the 1966 Northern Finland Birth Cohort. Fam Process 37:335–344PubMed

52.

Laursen TM, Munk-Olsen T, Nordentoft M, Bo Mortensen P (2007) A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a danish population-based cohort. J Clin Psychiatry 68:1673–1681PubMed

53.

Boden JM, van Stockum S, Horwood LJ, Fergusson DM (2016) Bullying victimization in adolescence and psychotic symptomatology in adulthood: evidence from a 35-year study. Psychol Med 46:1311–1320PubMed

54.

Catone G, Marwaha S, Kuipers E, Lennox B, Freeman D, Bebbington P, Broome M (2015) Bullying victimisation and risk of psychotic phenomena: analyses of British national survey data. Lancet Psychiatry 2:618–624PubMed

55.

Shakoor S, McGuire P, Cardno A, Freeman D, Plomin R, Ronald A (2015) A shared genetic propensity underlies experiences of bullying victimization in late childhood and self-rated paranoid thinking in adolescence. Schizophr Bull 41:754–763PubMed

56.

Croft J, Heron J, Teufel C, Cannon M, Wolke D, Thompson A, Houtepen L, Zammit S (2018) Association of trauma type, age of exposure, and frequency in childhood and adolescence with psychotic experiences in early adulthood. JAMA Psychiatry 76:79–86PubMedCentral

57.

McGrath JJ, McLaughlin KA, Saha S (2017) The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries. Psychol Med 47(7):1230–1245PubMedPubMedCentral

58.

Crush E, Arseneault L, Jaffee SR, Danese A, Fisher HL (2018) Protective factors for psychotic symptoms among poly-victimized children. Schizophr Bul 44(3):691–700

59.

Zubin J, Spring B (1977) Vulnerability–a new view of schizophrenia. J Abnorm Psychol 86:103–126PubMed

60.

Lim C, Chong SA, Keefe R (2009) Psychosocial factors in the neurobiology of schizophrenia: a selective review. Ann Acad Med Singapore 38:402–406PubMed

61.

Spataro J, Mullen PE, Burgess PM, Wells DL, Moss SA (2004) Impact of child sexual abuse on mental health: prospective study in males and females. Br J Psychiatry 184:416–421PubMed

62.

Kendler KS, Kessler RC, Walters EE, Maclean C, Neale MC, Heath AC, Eaves LJ (1995) Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry 152:833–842PubMed

63.

Kendler KS, KarkowskiShuman L (1997) Stressful life events and genetic liability to major depression: genetic control of exposure to the environment. Psychol Med 27:539–547PubMed

64.

Wohlwill JF (1973) The study of behavioral development. Academic, New York

65.

Dantchev Slava, Zammit Stanley, Wolke Dieter (2018) Sibling bullying in middle childhood and psychotic disorder at 18 years : a prospective cohort study. Psychol Med 48:2321–2328PubMed

Titel: Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis
verfasst von: Adriana Pastore
Giovanni de Girolamo
Silvio Tafuri
Aldo Tomasicchio
Francesco Margari
Publikationsdatum: 24.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 2/2022
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-020-01574-9

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Traumatic experiences in childhood and adolescence: a meta-analysis of prospective studies assessing risk for psychosis

Abstract

Neu im Fachgebiet Psychiatrie

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Update Psychiatrie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

Sexual preference for prepubescent children is associated with enhanced processing of child faces in juveniles

Testing the evolutionary advantage theory of attention-deficit/hyperactivity disorder traits

Internet-based guided self-help comprehensive behavioral intervention for tics (ICBIT) for youth with tic disorders: a feasibility and effectiveness study with 6 month-follow-up

Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study

Medical disorders in a Danish cohort of children with attention-deficit hyperactivity disorder

Twelve-month service use, suicidality and mental health problems of European adolescents after a school-based screening for current suicidality

Neu im Fachgebiet Psychiatrie

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Demenzkranke durch Antipsychotika vielfach gefährdet

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

Update Psychiatrie