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Erschienen in:
22.02.2023 | Images
TRBC1 enables identification of an otherwise immunophenotypically silent case of angioimmunoblastic T-cell lymphoma
Erschienen in: Journal of Hematopathology | Ausgabe 1/2023
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An 85-year-old woman presented with a month-long history of night sweats, chills, and appetite loss. Imaging showed diffuse lymphadenopathy above and below the diaphragm with splenomegaly. Histological and immunohistochemical evaluation revealed angioimmunoblastic T cell lymphoma (AITL; nodal T-follicular helper cell lymphoma, angioimmunoblastic-type per 5th edition WHO) with an associated EBV-positive B cell lymphoma (Fig. 1). Next-generation sequencing demonstrated positive rearrangements in TCR-γ, TCR-β, IGH, and IGK and pathogenic mutations in RHOA G17V and TET2 Q1903.
Fig. 1
A, B Histological sections show complete effacement of the lymph node architecture by a diffuse infiltrate of mostly small lymphocytes with admixed eosinophils and histiocytes. Paracortical areas show increased vascularity with an arborizing pattern. Hematoxylin and eosin; ×100 magnification; B hematoxylin and eosin; × 400 magnification. C Flow cytometry shows no loss of CD3 on the CD4+ T cell population and no expression of CD10 on the CD5+ T cell population. D Flow cytometry shows no loss of CD2, CD5, or CD7 on CD4+ T cells. TRBC1 expression on the CD4 T cell population is mostly negative (aberrant/clonal) while heterogeneous (normal) on the CD8 population
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