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Erschienen in: Neurological Sciences 8/2020

01.05.2020 | Brief Communication

Treating dissociative post-traumatic stress disorder presenting as a functional movement disorder with transcranial magnetic stimulation targeting the cingulate gyrus

verfasst von: Robin Blades, Sheldon Jordan, Sergio Becerra, Branon Eusebio, Mark Heatwole, Jessica Iovine, Kennedy Mahdavi, Michael Mamoun, Natalie Nicodemus, Hannah Packham, Norman Spivak, Taylor Kuhn

Erschienen in: Neurological Sciences | Ausgabe 8/2020

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Abstract

A 29-year-old woman presented with head and neck dystonia, as well as functional seizures. The patient was an active military service member with a history of combat-related trauma. Resting blood oxygen level dependent (BOLD) functional MRI (fMRI) scans of the brain demonstrated an increased anterior cingulate component of the salience network and hyper-connectivity between the insula and cingulate. Following neurological and psychiatric evaluation, she was diagnosed with dissociative post-traumatic stress disorder, partially presenting as a functional movement disorder. Inhibitory repetitive transcranial magnetic stimulation (rTMS) was prescribed with the anterior cingulate as the primary target, and supplementary motor and premotor cortices as secondary targets. The treatment was intended to suppress tremors both directly and indirectly. Thirty-six sessions later, her symptoms were in remission, and she returned to active duty. This case demonstrates the potential efficacy of fMRI-guided rTMS in the treatment of dissociative PTSD.
Literatur
1.
Zurück zum Zitat Asanuma K, Carbon-Correll M, Eidelberg D (2005) Neuroimaging in human dystonia. J Med Investig 52:272–279CrossRef Asanuma K, Carbon-Correll M, Eidelberg D (2005) Neuroimaging in human dystonia. J Med Investig 52:272–279CrossRef
2.
Zurück zum Zitat Baker D, Risbrough V Behavioral neurobiology of PTSD, Curr Top Behav Neurosci. 38:229–248 Baker D, Risbrough V Behavioral neurobiology of PTSD, Curr Top Behav Neurosci. 38:229–248
3.
Zurück zum Zitat Boyd J, Protopopescu A, O’Connor C, Neufeld R, Jetly R, Hood H, Lanius R, McKinnon MC (2018) Dissociative symptoms mediate relation between PTSD symptoms and functional impairment in a sample of military members, veterans, and first responders with PTSD. Eur J Psychotraumatol 9(1):1463794PubMedPubMedCentralCrossRef Boyd J, Protopopescu A, O’Connor C, Neufeld R, Jetly R, Hood H, Lanius R, McKinnon MC (2018) Dissociative symptoms mediate relation between PTSD symptoms and functional impairment in a sample of military members, veterans, and first responders with PTSD. Eur J Psychotraumatol 9(1):1463794PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Brand B, Myrick A, Sar V, Lanius R (2011) Chapter section 106 psychogenic movement disorders and other conversion disorders trauma and dissociation: clinical manifestations, diagnosis, epidemiology, pathogenesis and treatment. Cambridge University Press Brand B, Myrick A, Sar V, Lanius R (2011) Chapter section 106 psychogenic movement disorders and other conversion disorders trauma and dissociation: clinical manifestations, diagnosis, epidemiology, pathogenesis and treatment. Cambridge University Press
5.
Zurück zum Zitat Cloitre M, Petkova E, Wang J, Lu F (2012) An examination of the influence of a sequential treatment on the course and impact of dissociation among women with PTSD related to childhood abuse. Depress Anxiety 29(8):709–717PubMedCrossRef Cloitre M, Petkova E, Wang J, Lu F (2012) An examination of the influence of a sequential treatment on the course and impact of dissociation among women with PTSD related to childhood abuse. Depress Anxiety 29(8):709–717PubMedCrossRef
6.
Zurück zum Zitat Daniels JK, Frewen P, Theberge J, Lanius RA (2016) Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder. Acta Psychiatr Scand 133(3):232–240PubMedCrossRef Daniels JK, Frewen P, Theberge J, Lanius RA (2016) Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder. Acta Psychiatr Scand 133(3):232–240PubMedCrossRef
7.
Zurück zum Zitat Deiber MP, Honda M, Ibañez V, Sadato N, Hallett M (1999) Mesial motor areas in self-initiated versus externally triggered movements examined with FMRI: effect of movement type and rate. J Neurophysiol 81(6):3065–3077PubMedCrossRef Deiber MP, Honda M, Ibañez V, Sadato N, Hallett M (1999) Mesial motor areas in self-initiated versus externally triggered movements examined with FMRI: effect of movement type and rate. J Neurophysiol 81(6):3065–3077PubMedCrossRef
8.
Zurück zum Zitat Enders L, Spector JT, Altenmuller E, Schmidt A, Klein C, Jabush HC (2011) Musicians dystonia and comorbid anxiety: two sides of one coin? Mov Disord 26(3):539–542PubMedCrossRef Enders L, Spector JT, Altenmuller E, Schmidt A, Klein C, Jabush HC (2011) Musicians dystonia and comorbid anxiety: two sides of one coin? Mov Disord 26(3):539–542PubMedCrossRef
9.
Zurück zum Zitat Hamada M, Ugawa Y, Tsuji S (2008) High-frequency rTMS over the supplementary motor area for treatment of Parkinson’s disease. Mov Disord 23(11):1524–1531PubMedCrossRef Hamada M, Ugawa Y, Tsuji S (2008) High-frequency rTMS over the supplementary motor area for treatment of Parkinson’s disease. Mov Disord 23(11):1524–1531PubMedCrossRef
10.
Zurück zum Zitat Hamner MB, Lorberbaum JP, George MS (1999) Potential role of the anterior cingulate cortex in PTSD: review and hypothesis. Depress Anxiety 9(1):1–14PubMedCrossRef Hamner MB, Lorberbaum JP, George MS (1999) Potential role of the anterior cingulate cortex in PTSD: review and hypothesis. Depress Anxiety 9(1):1–14PubMedCrossRef
12.
Zurück zum Zitat Harricharan S, Nicholson AA, Densmore M, Théberge J, McKinnon MC, Neufeld RW, Lanius RA (2017) Sensory overload and imbalance: resting-state vestibular connectivity in PTSD and its dissociative subtype. Neuropsychologia 106:169–178PubMedCrossRef Harricharan S, Nicholson AA, Densmore M, Théberge J, McKinnon MC, Neufeld RW, Lanius RA (2017) Sensory overload and imbalance: resting-state vestibular connectivity in PTSD and its dissociative subtype. Neuropsychologia 106:169–178PubMedCrossRef
13.
Zurück zum Zitat Huijstee J, Vermetten E (2017) The dissociative subtype of post-traumatic stress disorder: research update on clinical and neurobiological features. In: Vermetten E Huijstee J, Vermetten E (2017) The dissociative subtype of post-traumatic stress disorder: research update on clinical and neurobiological features. In: Vermetten E
14.
Zurück zum Zitat Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM (2012) FSL. NeuroImage 62(2):782–790PubMedCrossRef Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM (2012) FSL. NeuroImage 62(2):782–790PubMedCrossRef
15.
Zurück zum Zitat Kozel FA, Motes MA, Didehbani N, DeLaRosa B, Bass C, Schraufnagel CD, Jones P, Morgan CR, Spence JS, Kraut MA, Hart J Jr (2018) Repetitive TMS to augment cognitive processing therapy in combat veterans of recent conflicts with PTSD: a randomized clinical trial. J Affect Disord 229:506–514PubMedCrossRef Kozel FA, Motes MA, Didehbani N, DeLaRosa B, Bass C, Schraufnagel CD, Jones P, Morgan CR, Spence JS, Kraut MA, Hart J Jr (2018) Repetitive TMS to augment cognitive processing therapy in combat veterans of recent conflicts with PTSD: a randomized clinical trial. J Affect Disord 229:506–514PubMedCrossRef
16.
Zurück zum Zitat Lanius RA, Williamson PC, Boksman K, Densmore M, Gupta M, Neufeld RW et al (2002) Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatry 52(4):305–311PubMedCrossRef Lanius RA, Williamson PC, Boksman K, Densmore M, Gupta M, Neufeld RW et al (2002) Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatry 52(4):305–311PubMedCrossRef
17.
Zurück zum Zitat Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D (2010) Emotion dysregulation in PTSD: neurobiological and clinical evidence for a dissociative subtype. Am J Psychiatry 167(6):640–647PubMedPubMedCentralCrossRef Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D (2010) Emotion dysregulation in PTSD: neurobiological and clinical evidence for a dissociative subtype. Am J Psychiatry 167(6):640–647PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Laycox LH, Foa EB, Morral AR (1998) Influence of emotional engagement and habituation on exposure therapy for PTSD. J Consult Clin Psychol 66(1):185–192CrossRef Laycox LH, Foa EB, Morral AR (1998) Influence of emotional engagement and habituation on exposure therapy for PTSD. J Consult Clin Psychol 66(1):185–192CrossRef
19.
Zurück zum Zitat Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM (1999) Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry 45(7):817–826PubMedCrossRef Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM (1999) Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry 45(7):817–826PubMedCrossRef
21.
22.
Zurück zum Zitat Nicholson AA, Densmore M, Frewen PA, Theberge J, Neufeld RW, McKinnonc MC, Lanius RA (2015) The dissociative subtype of posttraumatic stress disorder: unique resting-state functional connectivity of basolateral and centromedial amygdala complexes. Neuropsychopharmacology 40(10):2317–2326PubMedPubMedCentralCrossRef Nicholson AA, Densmore M, Frewen PA, Theberge J, Neufeld RW, McKinnonc MC, Lanius RA (2015) The dissociative subtype of posttraumatic stress disorder: unique resting-state functional connectivity of basolateral and centromedial amygdala complexes. Neuropsychopharmacology 40(10):2317–2326PubMedPubMedCentralCrossRef
23.
Zurück zum Zitat Nicholson AA, Friston KJ, Zieidman P, Harricharan S, McKinnon MC, Densmore M et al (2017) Dynamic causal modeling in PTSD and its dissociative subtype: bottom-up versus top-down processing within fear and emotion regulation circuitry. Hum Brain Mapp 38(11):5551–5561PubMedPubMedCentralCrossRef Nicholson AA, Friston KJ, Zieidman P, Harricharan S, McKinnon MC, Densmore M et al (2017) Dynamic causal modeling in PTSD and its dissociative subtype: bottom-up versus top-down processing within fear and emotion regulation circuitry. Hum Brain Mapp 38(11):5551–5561PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Novakovic V, Sher L, Kyle AB, Mindes J, Golier JA, Yehuda R (2011) Brain stimulation in posttraumatic stress disorder. Eur J Psychotraumatol 2(1):5609CrossRef Novakovic V, Sher L, Kyle AB, Mindes J, Golier JA, Yehuda R (2011) Brain stimulation in posttraumatic stress disorder. Eur J Psychotraumatol 2(1):5609CrossRef
25.
Zurück zum Zitat Osuch EA, Benson BE, Luckenbaugh DA, Geraci M, Post RM, McCann U (2009) Repetitive TMS combined with exposure therapy for PTSD: a preliminary study. J Anxiety Disord 23(1):54–59PubMedCrossRef Osuch EA, Benson BE, Luckenbaugh DA, Geraci M, Post RM, McCann U (2009) Repetitive TMS combined with exposure therapy for PTSD: a preliminary study. J Anxiety Disord 23(1):54–59PubMedCrossRef
26.
Zurück zum Zitat Özdemir B, Celik C, Oznur T (2015) Assessment of dissociation among combat-exposed soldiers with and without posttraumatic stress disorder. Eur J Psychotraumatol 6:26657PubMedCrossRef Özdemir B, Celik C, Oznur T (2015) Assessment of dissociation among combat-exposed soldiers with and without posttraumatic stress disorder. Eur J Psychotraumatol 6:26657PubMedCrossRef
27.
Zurück zum Zitat Pruim RHR, Mennes M, Buitelaar JK, Beckmann CF (2015) Evaluation of ICA-AROMA and alternative strategies for motion artifact removal in resting state fMRI. NeuroImage 112:278–287PubMedCrossRef Pruim RHR, Mennes M, Buitelaar JK, Beckmann CF (2015) Evaluation of ICA-AROMA and alternative strategies for motion artifact removal in resting state fMRI. NeuroImage 112:278–287PubMedCrossRef
28.
Zurück zum Zitat Rabellino D, Densmore M, Harricharan S, Jean T, McKinnon MC, Lanius RA (2018a) Resting-state functional connectivity of the bed nucleus of the stria terminalis in post-traumatic stress disorder and its dissociative subtype. Hum Brain Mapp 39(3):1367–1379PubMedCrossRef Rabellino D, Densmore M, Harricharan S, Jean T, McKinnon MC, Lanius RA (2018a) Resting-state functional connectivity of the bed nucleus of the stria terminalis in post-traumatic stress disorder and its dissociative subtype. Hum Brain Mapp 39(3):1367–1379PubMedCrossRef
29.
Zurück zum Zitat Rabellino D, Densmore M, Théberge J, McKinnon MC, Lanius RA (2018b) The cerebellum after trauma: resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype. Hum Brain Mapp 39(8):3354–3374PubMedPubMedCentralCrossRef Rabellino D, Densmore M, Théberge J, McKinnon MC, Lanius RA (2018b) The cerebellum after trauma: resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype. Hum Brain Mapp 39(8):3354–3374PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Ramsawh HJ, Fullerton CS, Mash HB, Ng TH, Kessler RC, Stein MB, Ursano RJ (2014) Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the U.S. Army. J Affect Disord 161:116–122PubMedCrossRef Ramsawh HJ, Fullerton CS, Mash HB, Ng TH, Kessler RC, Stein MB, Ursano RJ (2014) Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the U.S. Army. J Affect Disord 161:116–122PubMedCrossRef
31.
Zurück zum Zitat Schiavone FL, Frewen P, McKinnon M, Lanius RA (2018) The dissociative subtype of PTSD: an update of the literature. PTSD Research Quarterly: National Center for PTSD 29(3) Schiavone FL, Frewen P, McKinnon M, Lanius RA (2018) The dissociative subtype of PTSD: an update of the literature. PTSD Research Quarterly: National Center for PTSD 29(3)
32.
Zurück zum Zitat Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23:208–219CrossRef Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23:208–219CrossRef
33.
Zurück zum Zitat Spottswood M, Davydow DS, Huang H (2017) The prevalence of posttraumatic stress disorder in primary care: a systematic review. Harv Rev Psychiatry 25(4):159–169PubMedPubMedCentral Spottswood M, Davydow DS, Huang H (2017) The prevalence of posttraumatic stress disorder in primary care: a systematic review. Harv Rev Psychiatry 25(4):159–169PubMedPubMedCentral
34.
Zurück zum Zitat Wolf EJ, Lunney CA, Miller MW, Resick PA, Friedman MJ, Schnurr PP (2012) The dissociative subtype of PTSD: a replication and extension. Depress Anxiety 29(8):679–688PubMedCrossRef Wolf EJ, Lunney CA, Miller MW, Resick PA, Friedman MJ, Schnurr PP (2012) The dissociative subtype of PTSD: a replication and extension. Depress Anxiety 29(8):679–688PubMedCrossRef
35.
Zurück zum Zitat Woodward SH, Kaloupek DG, Streeter CC, Martinez C, Schaer M, Eliez S (2006) Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 59(7):582–587PubMedCrossRef Woodward SH, Kaloupek DG, Streeter CC, Martinez C, Schaer M, Eliez S (2006) Decreased anterior cingulate volume in combat-related PTSD. Biol Psychiatry 59(7):582–587PubMedCrossRef
36.
Zurück zum Zitat Woolrich MW, Jbabdi S, Patenaude B, Chapell M, Makni S, Behrens T et al (2009) Bayesian analysis of neuroimaging data in FSL. NeuroImage 45:173–186CrossRef Woolrich MW, Jbabdi S, Patenaude B, Chapell M, Makni S, Behrens T et al (2009) Bayesian analysis of neuroimaging data in FSL. NeuroImage 45:173–186CrossRef
Metadaten
Titel
Treating dissociative post-traumatic stress disorder presenting as a functional movement disorder with transcranial magnetic stimulation targeting the cingulate gyrus
verfasst von
Robin Blades
Sheldon Jordan
Sergio Becerra
Branon Eusebio
Mark Heatwole
Jessica Iovine
Kennedy Mahdavi
Michael Mamoun
Natalie Nicodemus
Hannah Packham
Norman Spivak
Taylor Kuhn
Publikationsdatum
01.05.2020
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 8/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04433-2

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