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Erschienen in:
01.04.2016 | General Gynecology
Treatment failure following excision therapy of CIN: the impact of direct colposcopic vision during procedure
Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2016
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Purpose
To assess whether the use of direct colposcopic vision during excision therapy of cervical intraepithelial neoplasia (CIN) has an impact on the risk of treatment failure.
Methods
Data from 285 patients who had had excision therapy with proven CIN at specimen histological analysis were reviewed. Primary endpoint was the occurrence of post-treatment failure defined by the histological diagnosis of CIN 2–3 during follow-up. Data were analysed according to the use of colposcopy at the time of initial therapy of CIN.
Results
The use of direct colposcopic vision (DCV) resulted in a significant reduction in the mean height (p = 0.008) and diameter (p < 0.001) of the excised specimen. Patients’ median follow-up was 28.4 (±1.3) months. A total of 43 (15.2 %) patients were diagnosed with treatment failure. Compared to excisions performed without any use of colposcopy, DCV was not found to have any significant impact on the risk of treatment failure (HR: 0.58; 95 % CI 0.16–2.13, p = 0.412), neither when compared to excisions performed immediately after colposcopy (HR: 0.91; 95 % CI 0.47–1.79; p = 0.794). The only factors found to have a significant impact on the risk of treatment failure was the identification of clear margins (HR: 0.36; 95 %CI 0.19–0.69; p = 0.002) and the diameter of the surgical specimen (HR: 0.94; 95 %CI 0.89–0.99; p = 0.040).
Conclusions
Although the use of DCV during excision therapy of CIN was associated with a significant reduction in the dimensions of the excised cervical specimen, it did not result in a significant change in the risk of treatment failure.