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06.01.2020 | Original Article

Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial

verfasst von: Mabelle Freitas Monteiro, Henrique Tonelli, Aurélio Amorim Reis, Marcio Zaffalon Casati, Karina Gonzales Silvério, Francisco Humberto Nociti Junior, Enilson Antônio Sallum, Renato Corrêa Viana Casarin

Erschienen in: Clinical Oral Investigations | Ausgabe 4/2020

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Abstract

Objectives

Studies have demonstrated that children from aggressive periodontitis (AgP) parents presented precocious alterations in their periodontal condition, and the use of chemical agents in association to plaque control could be useful to control these alterations. This study aimed to evaluate the effect of Triclosan toothpaste to modulate the clinical and subgingival condition in children from AgP parents.

Methods

Fifteen children from AgP parents and 15 from periodontally healthy parents were included in this crossover placebo study. Children were randomly allocated into triclosan or placebo therapy, using selected toothpaste for 45 days. After 15 days of wash-out, groups were crossed, changing the used toothpaste. Clinical examination and saliva, crevicular gingival fluid (GCF), and subgingival biofilm collection were performed at baseline and 45 days of each phase. GCF cytokines’ levels were analyzed by Luminex/MAGpix platform and subgingival and salivary periodontal pathogens’ levels by qPCR.

Results

At baseline, AgP group presented higher plaque index (PI), gingival index (GI), and bleeding on probing (BoP), higher Aggregatibacter actinomycetemcomitans (Aa) abundance in saliva and subgingival biofilm, and lower levels of INF-ɣ, IL-4, and IL-17 in GCF. Placebo therapy only reduced PI in both groups. Triclosan toothpaste reduced PI and GI in both groups. Triclosan promoted reduction of BoP and probing depth (PD), Aa salivary, and IL-1β levels in AgP group. In health group, triclosan reduced INF-ɣ and IL-4 concentration.

Conclusion

Triclosan toothpaste demonstrated to be more effective than placebo toothpaste to control the periodontal condition in children from AgP parents, by reducing the BoP, PD, salivary Aa, and IL-1β.

Clinical relevance

Triclosan toothpaste can improve oral conditions in higher-risk population for AgP.

Trial registration

This study was registered at ClinicalTrials.gov with the identifier NCT03642353.

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Titel: Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial
verfasst von: Mabelle Freitas Monteiro
Henrique Tonelli
Aurélio Amorim Reis
Marcio Zaffalon Casati
Karina Gonzales Silvério
Francisco Humberto Nociti Junior
Enilson Antônio Sallum
Renato Corrêa Viana Casarin
Publikationsdatum: 06.01.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 4/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-03121-6

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Triclosan toothpaste as an adjunct therapy to plaque control in children from periodontitis families: a crossover clinical trial