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Journal of Cardiovascular Translational Research

Erschienen in:

03.10.2022 | Review

tRNA-Derived Small RNAs: Novel Insights into the Pathogenesis and Treatment of Cardiovascular Diseases

verfasst von: Shuxin Wang, Zhengyang Luo, Ludong Yuan, Xiaofang Lin, Yuting Tang, Leijing Yin, Pengfei Liang, Bimei Jiang

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 2/2023

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Abstract

tRNA-derived small RNAs (tsRNAs) are non-coding RNAs with diverse functions in various diseases. Although research on tsRNAs has focused on their roles in cancer, such as gene expression regulation to influence cancer progression and realize clinical effects, a growing number of studies are investigating the association of tsRNAs with cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction, and pulmonary hypertension. tsRNA expression varies across these diseases and could be regulated by epigenetics, tsRNA structure, and tRNA-binding proteins. tsRNAs play key roles in CVD progression, including the regulation of protein synthesis, and the different mechanisms underlying these functional roles of tsRNAs have been elucidated. Furthermore, tsRNAs are potential diagnostic biomarkers and therapeutic targets in CVDs. In this review, we summarize the biogenesis, classification, and regulation of tsRNAs and their potential application for CVD diagnosis and therapy. We also highlight the current challenges and provide perspectives for further investigation.

Graphical abstract

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Titel: tRNA-Derived Small RNAs: Novel Insights into the Pathogenesis and Treatment of Cardiovascular Diseases
verfasst von: Shuxin Wang
Zhengyang Luo
Ludong Yuan
Xiaofang Lin
Yuting Tang
Leijing Yin
Pengfei Liang
Bimei Jiang
Publikationsdatum: 03.10.2022
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 2/2023
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-022-10322-0

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tRNA-Derived Small RNAs: Novel Insights into the Pathogenesis and Treatment of Cardiovascular Diseases

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