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12.08.2019 | Original Article

Two-hour postload plasma glucose and pigment epithelium-derived factor levels are markers of coronary artery inflammation in type 2 diabetic patients

verfasst von: Nobuhiro Tahara, MD, PhD, Yoshikazu Nitta, MD, PhD, Munehisa Bekki, MD, Atsuko Tahara, MD, Shoko Maeda-Ogata, MD, Yoichi Sugiyama, MD, Akihiro Honda, MD, PhD, Sachiyo Igata, PhD, Tomohisa Nakamura, MD, Jiahui Sun, MD, Seiji Kurata, MD, PhD, Kiminori Fujimoto, MD, PhD, Toshi Abe, MD, PhD, Takanori Matsui, PhD, Sho-ichi Yamagishi, MD, PhD, Yoshihiro Fukumoto, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 4/2020

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Abstract

Background

We have previously found that pioglitazone attenuates inflammation in the left main trunk of coronary artery (LMT), evaluated as target-to-background ratio (TBR) by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in patients with impaired glucose tolerance or type 2 diabetes.

Objectives

We assessed which clinical variables could predict the change in TBR in the LMT after 4-month add-on therapy with oral hypoglycemic agents (OHAs).

Methods

A total of 38 type 2 diabetic patients with carotid atherosclerosis who had already received OHAs except for pioglitazone was enrolled. At baseline and 4 months after add-on therapy with pioglitazone or glimepiride, all patients underwent 75 g oral glucose tolerance test, blood chemistry analysis, and FDG-PET/CT.

Results

Fasting plasma glucose, 30-, 60-, 90-, 120-minutes postload plasma glucose, HbA1c, and LMT-TBR values were significantly decreased by add-on therapy, whereas high-density lipoprotein-cholesterol and adiponectin levels were increased. Increased serum levels of pigment epithelium-derived factor (PEDF), a marker of insulin resistance and non-use of aspirin at baseline could predict the favorable response of LMT-TBR to add-on therapy. Moreover, Δ120-minutes postload plasma glucose and ΔPEDF were independent correlates of ΔLMT-TBR.

Conclusions

Our present study suggests that 120-minutes postload plasma glucose and PEDF values may be markers and potential therapeutic targets of coronary artery inflammation in type 2 diabetic patients.

Clinical Trial Registration

URL: http://clinicaltrials.gov. Unique identifier: NCT00722631.

Graphic Abstract

New markers for diabetes and CAD is on the horizon! Two-hour postload plasma glucose and pigment epithelium derived factor are markers of coronary artery inflammation in type 2 diabetic patients.

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Titel: Two-hour postload plasma glucose and pigment epithelium-derived factor levels are markers of coronary artery inflammation in type 2 diabetic patients
verfasst von: Nobuhiro Tahara, MD, PhD
Yoshikazu Nitta, MD, PhD
Munehisa Bekki, MD
Atsuko Tahara, MD
Shoko Maeda-Ogata, MD
Yoichi Sugiyama, MD
Akihiro Honda, MD, PhD
Sachiyo Igata, PhD
Tomohisa Nakamura, MD
Jiahui Sun, MD
Seiji Kurata, MD, PhD
Kiminori Fujimoto, MD, PhD
Toshi Abe, MD, PhD
Takanori Matsui, PhD
Sho-ichi Yamagishi, MD, PhD
Yoshihiro Fukumoto, MD, PhD
Publikationsdatum: 12.08.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 4/2020
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-019-01842-5

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Two-hour postload plasma glucose and pigment epithelium-derived factor levels are markers of coronary artery inflammation in type 2 diabetic patients