Acknowledgements
This study is part of the GEN-COVID Multicenter study,
https://sites.google.com/dbm.unisi.it/gen-covid, the Italian multicenter study aimed at identifying the COVID-19 host genetic bases. Specimens were provided by the COVID-19 Biobank of Siena, which is part of the Genetic Biobank of Siena, member of BBMRI-IT, Telethon Network of Genetic Biobanks (project no. GTB18001), EuroBioBank, and RD-Connect. All authors of this paper are members of the European Reference Network on rare respiratory diseases (ERN-LUNG). We thank the CINECA consortium for providing computational resources, and the Network for Italian Genomes (NIG;
http://www.nig.cineca.it) for its support.
Francesca Mari1,2,3, Sergio Daga1,2, Ilaria Meloni1,2, Mirella Bruttini1,2,3, Susanna Croci1,2, Mirjam Lista1,2, Debora Maffeo1,2, Elena Pasquinelli1,2, Viola Bianca Serio1,2, Enrica Antolini1,2, Simona Letizia Basso1,2, Samantha Minetto1,2, Rossella Tita3, Maria Antonietta Mencarelli3, Caterina Lo Rizzo3, Anna Maria Pinto3, Francesca Ariani1,2,3, Francesca Montagnani2,4, Mario Tumbarello2,4, Ilaria Rancan2,4, Massimiliano Fabbiani4, Paolo Cameli5, David Bennett5, Federico Anedda6, Simona Marcantonio6, Sabino Scolletta6, Federico Franchi6, Maria Antonietta Mazzei7, Susanna Guerrini7, Edoardo Conticini8, Luca Cantarini8, Bruno Frediani8, Danilo Tacconi9, Chiara Spertilli Raffaelli9, Arianna Emiliozzi9, Marco Feri10, Alice Donati10, Raffaele Scala11, Luca Guidelli11, Genni Spargi12, Marta Corridi12, Cesira Nencioni13, Leonardo Croci13, Gian Piero Caldarelli14, Davide Romani15, Paolo Piacentini15, Maria Bandini15, Elena Desanctis15, Silvia Cappelli15, Anna Canaccini16, Agnese Verzuri16, Valentina Anemoli16, Manola Pisani16, Agostino Ognibene17, Maria Lorubbio17, Alessandro Pancrazzi17, Massimo Vaghi18, Antonella D'Arminio Monforte19, Federica Gaia Miraglia19, Mario U. Mondelli20,21, Stefania Mantovani20, Raffaele Bruno20,22, Marco Vecchia20, Marcello Maffezzoni22, Enrico Martinelli23, Massimo Girardis24, Stefano Busani24, Sophie Venturelli24, Andrea Cossarizza25, Andrea Antinori26, Alessandra Vergori26, Stefano Rusconi27,28, Matteo Siano28, Arianna Gabrieli28, Agostino Riva27,28, Daniela Francisci29, Elisabetta Schiaroli29, Carlo Pallotto29, Saverio Giuseppe Parisi30, Monica Basso30, Sandro Panese31, Stefano Baratti31, Pier Giorgio Scotton32, Francesca Andretta32, Mario Giobbia32, Renzo Scaggiante33, Francesca Gatti33, Francesco Castelli34, Eugenia Quiros-Roldan34, Melania Degli Antoni34, Isabella Zanella35,36, Matteo della Monica37, Carmelo Piscopo37, Mario Capasso38,39, Roberta Russo38,39, Immacolata Andolfo38,39, Achille Iolascon38,39, Giuseppe Fiorentino40, Massimo Carella41, Marco Castori41, Giuseppe Merla38,42, Gabriella Maria Squeo42, Filippo Aucella43, Pamela Raggi44, Rita Perna44, Matteo Bassetti45,46, Antonio Di Biagio45,46, Maurizio Sanguinetti47,48, Luca Masucci47,48, Alessandra Guarnaccia47, Serafina Valente49, Alex Di Florio49, Marco Mandalà50, Alessia Giorli50, Lorenzo Salerni50, Patrizia Zucchi51, Pierpaolo Parravicini51, Elisabetta Menatti52, Tullio Trotta53, Ferdinando Giannattasio53, Gabriella Coiro53, Fabio Lena54, Gianluca Lacerenza54, Cristina Mussini55, Luisa Tavecchia56, Lia Crotti57,58,59,60,61, Gianfranco Parati57,58, Roberto Menè57,58, Maurizio Sanarico62, Marco Gori63,64, Francesco Raimondi65, Alessandra Stella65, Filippo Biscarini66, Tiziana Bachetti67, Maria Teresa La Rovere68, Maurizio Bussotti69, Serena Ludovisi70, Katia Capitani71, Simona Dei72, Sabrina Ravaglia73, Annarita Giliberti74, Giulia Gori74, Rosangela Artuso74, Elena Andreucci74, Angelica Pagliazzi74, Erika Fiorentini74, Antonio Perrella75, Francesco Bianchi2,75, Paola Bergomi76, Emanuele Catena76, Riccardo Colombo76, Sauro Luchi77, Giovanna Morelli77, Paola Petrocelli77, Sarah Iacopini77, Sara Modica77, Silvia Baroni78, Giulia Micheli79, Marco Falcone80, Donato Urso80, Giusy Tiseo80, Tommaso Matucci80, Davide Grassi81, Claudio Ferri81, Franco Marinangeli82, Francesco Brancati83,84, Antonella Vincenti85, Valentina Borgo85, Stefania Lombardi85, Mirco Lenzi85, Massimo Antonio Di Pietro86, Francesca Vichi86, Benedetta Romanin86, Letizia Attala86, Cecilia Costa86, Andrea Gabbuti86, Alessio Bellucci86, Marta Colaneri22, Patrizia Casprini87, Cristoforo Pomara88, Massimiliano Esposito88, Roberto Leoncini89, Michele Cirianni89, Lucrezia Galasso89, Marco Antonio Bellini90, Chiara Gabbi91, Nicola Picchiotti63, Simone Furini2,92
1 Medical Genetics, University of Siena, Siena, 53100, Italy
2 Med Biotech Hub and Competence Center,
Department of Medical Biotechnologies, University of Siena, Siena, 53100, Italy
3 Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, 53100, Italy
4 Department of Medical Sciences, Infectious and Tropical Diseases Unit, Azienda Ospedaliera Universitaria Senese, Siena, 53100, Italy
5 Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena, Siena, 53100, Italy
6 Dept of Emergency and Urgency, Medicine, Surgery and Neurosciences, Unit of Intensive Care Medicine, Siena University Hospital, Siena, 53100, Italy
7 Department of Medical, Surgical and Neuro Sciences and Radiological Sciences, Unit of Diagnostic Imaging, University of Siena, 53100, Italy
8 Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Siena 53100, Italy
9 Department of Specialized and Internal Medicine, Infectious Diseases Unit, San Donato Hospital Arezzo 52100, Italy
10 Department of Emergency,
Anesthesia Unit, San Donato Hospital, Arezzo, Italy
11 Department of Specialized and Internal Medicine, Pneumology Unit and UTIP, San Donato Hospital, Arezzo, 52100, Italy
12 Department of Emergency, Anesthesia Unit, Misericordia Hospital, Grosseto, 58100 Italy
13 Department of Specialized and Internal Medicine, Infectious Diseases Unit, Misericordia Hospital, Grosseto, 58100 Italy
14 Clinical Chemical Analysis Laboratory, Misericordia Hospital, Grosseto, 58100, Italy
15 Dipartimento di Prevenzione, Azienda USL Toscana Sud Est, 53100 Italy
16 Dipartimento Tecnico-Scientifico Territoriale, Azienda USL Toscana Sud Est, 53100, Italy
17 UOC Laboratorio Analisi Chimico Cliniche, Arezzo, 52100, Italy
18 Chirurgia Vascolare, Ospedale Maggiore di Crema, 26013 Italy
19 Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan, Milan, 20142, Italy
20 Division of Clinical Immunology—Infectious Diseases, Department of Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy
21 Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Italy
22 University of Pavia, Pavia, 27100 Italy
23 Department of Respiratory Diseases, Azienda Ospedaliera di Cremona, Cremona, 26100, Italy
24 Department of Anesthesia and Intensive Care, University of Modena and Reggio Emilia, Modena, 41121, Italy
25 Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, 41121, Italy
26 HIV/AIDS Department, National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani, Rome, 00161, Italy
27 III Infectious Diseases Unit, ASST-FBF-Sacco, Milan, 20146, Italy
28 Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Milan, 20146, Italy
29 Infectious Diseases Clinic, “Santa Maria della Misericordia” Hospital, University of Perugia, Perugia, 06100, Italy
30 Department of Molecular Medicine, University of Padova, Italy
31 Clinical Infectious Diseases, Mestre Hospital, Venezia, Italy.
32 Department of Infectious Diseases, Treviso Hospital, Local Health Unit 2 Marca Trevigiana, Treviso, Italy
33 Infectious Diseases Clinic, ULSS1, Belluno, Italy
34 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
35 Department of Molecular and Translational Medicine, University of Brescia, Italy;
36 Clinical Chemistry Laboratory, Cytogenetics and Molecular Genetics Section, Diagnostic Department, ASST Spedali Civili di Brescia, Italy
37 Medical Genetics and Laboratory of Medical Genetics Unit, A.O.R.N. "Antonio Cardarelli", Naples, Italy
38 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy
39 CEINGE Biotecnologie Avanzate, Naples, Italy
40 Unit of Respiratory Physiopathology, AORN dei Colli, Monaldi Hospital, Naples, Italy
41 Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
42 Laboratory of Regulatory and Functional Genomics, Fondazione IRCCS Casa Sollievo della Sofferenza, Foggia, Italia
43 Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
44 Clinical Trial Office, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
45 Department of Health Sciences, University of Genova, Genova, Italy
46 Infectious Diseases Clinic, Policlinico San Martino Hospital, IRCCS for Cancer Research Genova, Italy
47 Microbiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of Medicine, Rome, Italy
48 Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
49 Department of Cardiovascular Diseases, University of Siena, Siena, Italy
50 Otolaryngology Unit, University of Siena, Italy
51 Department of Internal Medicine, ASST Valtellina e Alto Lario, Sondrio, Italy
52 Study Coordinator Oncologia Medica e Ufficio Flussi Sondrio, Italy
53 First Aid Department, Luigi Curto Hospital, Polla, Salerno, Italy
54 Department of Pharmaceutical Medicine, Misericordia Hospital, Grosseto, Italy.
55 Infectious Diseases Clinics, University of Modena and Reggio Emilia, Modena, Italy
56 U.O.C. Medicina, ASST Nord Milano, Ospedale Bassini, Cinisello Balsamo (MI), Italy
57 Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy
58 Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
59 Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Milan, Italy
60 Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics, Milan, Italy
61 Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart
62 Independent Data Scientist, Milan, Italy
63 University of Siena, DIISM-SAILAB, Siena, Italy
64 Maasai, I3S CNRS, Université Côte d'Azur, France
65 Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy
66 CNR-Consiglio Nazionale delle Ricerche, Istituto di Biologia e Biotecnologia Agraria (IBBA), Milano, Italy
67 Direzione Scientifica, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy
68 Istituti Clinici Scientifici Maugeri IRCCS, Department of Cardiology, Institute of Montescano, Pavia, Italy
69 Istituti Clinici Scientifici Maugeri IRCCS, Department of Cardiology, Institute of Milan, Italy
70 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
71 Core Research Laboratory, ISPRO, Florence, Italy
72 Health Management, Azienda USL Toscana Sud Est, Tuscany, Italy
73 IRCCS C. Mondino Foundation, Pavia, Italy
74 Medical Genetics Unit, Meyer Children's University Hospital, Firenze, Italy
75 Department of Medicine, Pneumology Unit, Misericordia Hospital, Grosseto, Italy.
76 Department of Anesthesia and Intensive Care Unit, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Polo Universitario, University of Milan, Milan, Italy
77 Infectious Disease Unit, Hospital of Lucca, Italy
78 Department of Diagnostic and Laboratory Medicine, Institute of Biochemistry and Clinical Biochemistry, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
79 Clinic of Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
80 Department of Clinical and Experimental Medicine, Infectious Diseases Unit, University of Pisa, Pisa, Italy
81 Department of Clinical Medicine, Public Health, Life and Environment Sciences, University of L'Aquila, Italy
82 Anesthesiology and Intensive Care, University of L'Aquila, L'Aquila, Italy
83 Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L’Aquila, Italy
84 Human Functional Genomics Laboratory, IRCCS San Raffaele Roma, 00167, Rome, Italy
85 Infectious Disease Unit, Hospital of Massa, Italy
86 Infectious Diseases Unit, Santa Maria Annunziata Hospital, USL Centro, Florence, Italy
87 Laboratory of Clinical Pathology and Immunoallergy, Florence-Prato, Italy
88 Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy
89 Laboratorio Patologia Clinica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy
90 Ambulatory Chronic Polipathology of Siena, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy
91 Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
92 Bioinformatics, University of Bologna, Italy