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Respiratory Research

Ausgabe 1/2023

Inhalt (320 Artikel)

Open Access COVID-19 Correspondence

Use of almitrine in spontaneously breathing patients with COVID-19 treated with high-flow nasal cannula oxygen therapy and with persistent hypoxemia

Clément Saccheri, Lucas Morand, Marie Juston, Denis Doyen, Hervé Hyvernat, Romain Lombardi, Raphaël Devanlay, Émilie Panicucci, Jean Dellamonica, Mathieu Jozwiak

Open Access Correspondence

In ‘real world’ patients with COPD, exacerbation history, and not blood eosinophils, is the most reliable predictor of future exacerbations

Heinrich Worth, Roland Buhl, Carl-Peter Criée, Peter Kardos, Eva Gückel, Claus F. Vogelmeier

Open Access Research

Effects of mesenchymal stem cell-derived nanovesicles in experimental allergic airway inflammation

Elga Bandeira, Su Chul Jang, Cecilia Lässer, Kristina Johansson, Madeleine Rådinger, Kyong-Su Park

Open Access Correction

Correction to: Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram construction

Yuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu, Wei Hong, Mei Jiang, Kai Yang, Wenju Lu, Yiping Luo, Jun Zhang, Zhe Cheng, Chunli Liu, Jian Wang

Open Access Research

Eating habit of adding salt to foods and incident sleep apnea: a prospective cohort study

Tingting Li, Lin Song, Guang Li, Fengping Li, Xiaoge Wang, Liangkai Chen, Shuang Rong, Li Zhang

Open Access Research

Expert consensus on the management of systemic sclerosis-associated interstitial lung disease

Franck F. Rahaghi, Vivien M. Hsu, Robert J. Kaner, Maureen D. Mayes, Ivan O. Rosas, Rajan Saggar, Virginia D. Steen, Mary E. Strek, Elana J. Bernstein, Nitin Bhatt, Flavia V. Castelino, Lorinda Chung, Robyn T. Domsic, Kevin R. Flaherty, Nishant Gupta, Bashar Kahaleh, Fernando J. Martinez, Lee E. Morrow, Teng Moua, Nina Patel, Oksana A. Shlobin, Brian D. Southern, Elizabeth R. Volkmann, Dinesh Khanna

Open Access Research

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts

Zili Zhou, Shixiu Liang, Zicong Zhou, Jieyi Liu, Jinming Zhang, Xiaojing Meng, Fei Zou, Haijin Zhao, Changhui Yu, Shaoxi Cai

Open Access Research

The main e-cigarette component vegetable glycerin enhances neutrophil migration and fibrosis in endotoxin-induced lung injury via p38 MAPK activation

Vincent Yi-Fong Su, Wei-Chih Chen, Wen-Kuang Yu, Huai-Hsuan Wu, Hao Chen, Kuang-Yao Yang

Open Access COVID-19 Research

Comparison of clinician diagnosis of COVID-19 with real time polymerase chain reaction in an adult-representative population in Sweden

Eman Quraishi, Chiamaka Jibuaku, Daniil Lisik, Göran Wennergren, Jan Lötvall, Fredrik Nyberg, Linda Ekerljung, Madeleine Rådinger, Hannu Kankaanranta, Bright I. Nwaru

Open Access Research

Gut microbiota composition can reflect immune responses of latent tuberculosis infection in patients with poorly controlled diabetes

Hung-Ling Huang, Yong-Chun Luo, Po-Liang Lu, Cheng-Hsieh Huang, Kun-Der Lin, Meng-Rui Lee, Meng-Hsuan Cheng, Yao-Tsung Yeh, Cheng-Yuan Kao, Jann-Yuan Wang, Jinn-Moon Yang, Inn-Wen Chong

Open Access COVID-19 Research

Impaired cell–cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development

Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye, Qi Sun

Open Access Research

Pulmonary sequestration in adult patients: a single-center retrospective study

Siying Ren, Lulu Yang, Ying Xiao, Zhongyi Tong, Li Wang, Yan Hu

Open Access Research

Validation of the CaReQoL asthma: a patient reported outcome measure for monitoring the perceived effects of pulmonary rehabilitation in adult patients with severe refractory asthma

Linda Springvloet, Mattanja Triemstra, Bart Knottnerus, Marlon Rolink, Harry Heijerman, Dolf de Boer

Open Access Comment

Recognising the importance of chronic lung disease: a consensus statement from the Global Alliance for Chronic Diseases (Lung Diseases group)

Gillian Sandra Gould, John R. Hurst, Antigona Trofor, Jennifer A. Alison, Gregory Fox, Muralidhar M. Kulkarni, Craig E. Wheelock, Marilyn Clarke, Ratika Kumar

Open Access Research

Optimizing molecular testing of lung cancer needle biopsy specimens: potential solutions from an interdisciplinary qualitative study

Florian J. Fintelmann, Nikki A. Martin, Ismail Tahir, Elissa M. Quinn, Timothy C. Allen, Lija Joseph, Boris Nikolic, Christopher Lee

Open Access Research

Tolerability, safety and survival in patients with severe pulmonary arterial hypertension treated with intravenous epoprostenol (Veletri®): a prospective, 6-months, open label, observational, non-interventional study

Julia Degering, Benjamin Egenlauf, Satenik Harutyunova, Nicola Benjamin, Amina Salkić, Panagiota Xanthouli, Christina A. Eichstaedt, Rebekka Seeger, Olivier Sitbon, Ekkehard Grünig

Open Access Comment

Functional respiratory impairment and related factors in patients with interstitial pneumonia with autoimmune features (IPAF): Multicenter study from NEREA registry

Maria Asuncion Nieto, Olga Sanchez-Pernaute, Cristina Vadillo, Maria Jesus Rodriguez-Nieto, Fredeswinda Romero-Bueno, Belen López-Muñiz, Laura Cebrian, Maria Teresa Rio-Ramirez, Rosalia Laporta, Gema Bonilla, Tatiana Cobo, Leticia Leon, Lydia Abasolo, Lydia Abasolo, Maria Asuncion Nieto, Cristina Vadillo, Irene Martín Lores, Ana Bustos Garcia de Castro, Fredeswinda Romero-Bueno, Maria Jesus Rodriguez-Nieto, Olga Sanchez Pernaute, Carmelo Palacios, Luis Gomez Carrera, Gema Bonilla, Gemma Mora Ortega, Tatiana Cobo, Belén López-Muñiz, Laura Cebrián, Hilda Godoy, Rosalia Laporta, Irene Llorente Cubas, Claudia Valenzuela, Rosario Garcia de Vicuña, Ana Jauregui, Juan Rigual, Jesús Loarce Martos, Jose Luis Morell Hita

Open Access Research

Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

Kenneth Verstraete, Nilakash Das, Iwein Gyselinck, Marko Topalovic, Thierry Troosters, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Robert Jensen, Maarten De Vos, Wim Janssens

Open Access Research

Blocking RAGE expression after injury reduces inflammation in mouse model of acute lung injury

Lynne L. Johnson, Yared Tekabe, Tina Zelonina, Xinran Ma, Geping Zhang, Monica Goldklang, Jeanine D’Armiento

Open Access Research

Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls

Dennis Kruk, Anna C. Y. Yeung, Alen Faiz, Nick H. T. ten Hacken, Wim Timens, Toin H. van Kuppevelt, Willeke Daamen, Danique Hof, Martin C. Harmsen, Mauricio Rojas, Irene H. Heijink

Open Access Research

Detection of early-stage lung cancer in sputum using automated flow cytometry and machine learning

Madeleine E. Lemieux, Xavier T. Reveles, Jennifer Rebeles, Lydia H. Bederka, Patricia R. Araujo, Jamila R. Sanchez, Marcia Grayson, Shao-Chiang Lai, Louis R. DePalo, Sheila A. Habib, David G. Hill, Kathleen Lopez, Lara Patriquin, Robert Sussman, Roby P. Joyce, Vivienne I. Rebel

Open Access Research

RAGE inhibition alleviates lipopolysaccharides-induced lung injury via directly suppressing autophagic apoptosis of type II alveolar epithelial cells

Xi Xiong, Jiaying Dou, Jingyi Shi, Yuqian Ren, Chunxia Wang, Yucai Zhang, Yun Cui

Open Access Research

Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury

Xinrui Rao, Dong Zhou, Huilin Deng, Yunshang Chen, Jian Wang, Xiaoshu Zhou, Xiaohua Jie, Yingzhuo Xu, Zilong Wu, Geng Wang, Xiaorong Dong, Sheng Zhang, Rui Meng, Chuangyan Wu, Shijie Xing, Kai Fan, Gang Wu, Rui Zhou

Open Access Research

Nasal TSLP and periostin in infants with severe bronchiolitis and risk of asthma at 4 years of age

Maria Luz Garcia-Garcia, Beatriz Sastre, Maria Arroyas, Maite Beato, Patricia Alonso, José Manuel Rodrigo-Muñoz, Victoria Del Pozo, Inmaculada Casas, Cristina Calvo

Open Access Correction

Correction: ColdZyme® protects airway epithelia from infection with BA.4/5

Viktoria Zaderer, Stefanie Dichtl, Rosa Bellmann-Weiler, Cornelia Lass-Flörl, Wilfried Posch, Doris Wilflingseder

Open Access Research

Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer

Yu Yao, Huaping Yang, Bo Zhu, Song Wang, Jiaohui Pang, Xiaoying Wu, Yang Xu, Junli Zhang, Jinfeng Zhang, Qiuxiang Ou, Hui Tian, Zheng Zhao

Open Access Original Paper

Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota

Sara Melo-Dias, Miguel Cabral, Andreia Furtado, Sara Souto-Miranda, Maria Aurora Mendes, João Cravo, Catarina Rodrigues Almeida, Alda Marques, Ana Sousa

Open Access Research

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis

Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor, Russell P. Tracy, Tuuli Lappalainen, R. Graham Barr, Frank Sciurba, Craig P. Hersh, Panayiotis V. Benos

Open Access Correction

Correction: Subtyping preserved ratio impaired spirometry (PRISm) by using quantitative HRCT imaging characteristics

Jinjuan Lu, Haiyan Ge, Lin Qi, Shaojie Zhang, Yuling Yang, Xuemei Huang, Ming Li

Open Access Research

Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma

Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro, Chantal Donovan

Open Access Research

SLC38A6 expression in macrophages exacerbates pulmonary inflammation

Yizhao Peng, Weichao Chen, Fumeng Huang, Manman Geng, Xiaowei Li, Fujun Zhang, Wenhua Zhu, Liesu Meng, Rikard Holmdahl, Jing Xu, Shemin Lu

Open Access Research

The impact of diagnostic delay on survival in alpha-1-antitrypsin deficiency: results from the Austrian Alpha-1 Lung Registry

Tobias Meischl, Karin Schmid-Scherzer, Florian Vafai-Tabrizi, Gert Wurzinger, Eva Traunmüller-Wurm, Kristina Kutics, Markus Rauter, Fikreta Grabcanovic-Musija, Simona Müller, Norbert Kaufmann, Judith Löffler-Ragg, Arschang Valipour, Georg-Christian Funk

Open Access Review

Risk factors for herpes zoster: should people with asthma or COPD be vaccinated?

Ekaterina Safonova, Barbara P. Yawn, Tobias Welte, Chengbin Wang

Open Access Research

Genetic association and causal inference between lung function and venous thromboembolism

Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang, Youxin Wang

Open Access Research

BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease

Yifei Duan, Siyi Zhou, Jianmiao Wang

Open Access Research

X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study

Lystra P. Hayden, Brian D. Hobbs, Robert Busch, Michael H. Cho, Ming Liu, Camila M. Lopes-Ramos, David A. Lomas, Per Bakke, Amund Gulsvik, Edwin K. Silverman, James D. Crapo, Terri H. Beaty, Nan M. Laird, Christoph Lange, Dawn L. DeMeo

Open Access Research

Vascular and pulmonary effects of ibuprofen on neonatal lung development

Xueyu Chen, Dongshan Han, Xuan Wang, Xuemei Huang, Zilu Huang, Yijun Liu, Junyan Zhong, Frans J. Walther, Chuanzhong Yang, Gerry T. M. Wagenaar

Open Access Research

Lung Inflammation in alpha-1-antitrypsin deficient individuals with normal lung function

Nurdan Kokturk, Nazli Khodayari, Jorge Lascano, E. Leonard Riley, Mark L. Brantly

Open Access Research

Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2

Ana N. Gonçalves, Rute S. Moura, Jorge Correia-Pinto, Cristina Nogueira-Silva

Open Access Review

Aspiration prevention surgeries: a review

Rumi Ueha, Redentor B. Magdayao, Misaki Koyama, Taku Sato, Takao Goto, Tatsuya Yamasoba

Open Access Research

Longitudinal association between adiposity changes and lung function deterioration

Youngmok Park, Jiyoung Kim, Young Sam Kim, Ah Young Leem, Jinyeon Jo, Kyungsoo Chung, Moo Suk Park, Sungho Won, Ji Ye Jung

Open Access Research

PEEP application during mechanical ventilation contributes to fibrosis in the diaphragm

Xiaoli Qian, Ye Jiang, Jianwei Jia, Weimin Shen, Yuejia Ding, Yuhan He, Peifeng Xu, Qing Pan, Ying Xu, Huiqing Ge

Open Access Research

Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers

Shotaro Yamano, Tomoki Takeda, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, Yoichiro Kobashi, Kenzo Okamoto, Takumi Kishimoto, Yumi Umeda

Open Access COVID-19 Research

Evolution and long‑term respiratory sequelae after severe COVID-19 pneumonia: nitric oxide diffusion measurement value

Marta Núñez-Fernández, Cristina Ramos-Hernández, Francisco García-Río, Alexandre Pérez-González, Amara Tilve-Gómez, Paula Rodríguez-Fernández, Andrés Nodar-Germiñas, Alberto Fernández-García, Alberto Ruano-Raviña, Alberto Fernández-Villar

Open Access Research

Interstitial lung abnormalities in a large clinical lung cancer screening cohort: association with mortality and ILD diagnosis

Avignat S. Patel, Ezra Miller, Shawn M. Regis, Gary M. Hunninghake, Lori Lyn Price, Melissa Gawlik, Andrea B. McKee, Kimberly M. Rieger-Christ, Victor Pinto-Plata, Timothy N. Liesching, Christoph Wald, Jeffrey Hashim, Brady J. McKee, Lee Gazourian

Open Access Research

Decreased ubiquitin modifying enzyme A20 associated with hyper-responsiveness to ovalbumin challenge following intrauterine growth restriction

Xuefeng Xu, Fei Zheng, Shanshan Xu, Minfei Hu, Chengcheng Hang, Lingke Liu, Chencong Shen, Weizhong Gu, Lizhong Du

Open Access Research

Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux

Open Access Research

A novel, accurate, and non-invasive liquid biopsy test to measure cellular immune responses as a tool to diagnose early-stage lung cancer: a clinical trials study

Shafrira Shai, Fernando Patolsky, Hagai Drori, Eyal J. Scheinman, Eyal Davidovits, Giora Davidovits, Shoval Tirman, Nadir Arber, Amit Katz, Yochai Adir

Open Access COVID-19 Original Paper

Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong

Wang Chun Kwok, Terence Chi Chun Tam, David Chi Leung Lam, Jackson Ka Chun Leung, King Pui Florence Chan, Shung Kay Samuel Chan, Ka Yan Chiang, Mary Sau Man Ip, James Chung Man Ho

Open Access Review

A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

Hanie Abolfathi, Mohadeseh Arabi, Mojgan Sheikhpour

Open Access Research

Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice

Xixi Lin, Like Wang, Xiaojie Lu, Yuanyuan Zhang, Rongying Zheng, Ruijie Chen, Weixi Zhang

Open Access Correction

Correction: Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry

Marc Miravitlles, Alice M. Turner, María Torres-Duran, Hanan Tanash, Carlota Rodríguez-García, José Luis López-Campos, Jan Chlumsky, Catarina Guimaraes, Juan Luis Rodríguez-Hermosa, Angelo Corsico, Cristina Martinez-González, José María Hernández-Pérez, Ana Bustamante, David G. Parr, Francisco Casas-Maldonado, Ana Hecimovic, Wim Janssens, Beatriz Lara, Miriam Barrecheguren, Cruz González, Jan Stolk, Cristina Esquinas, Christian F. Clarenbach

Open Access COVID-19 Research

Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial

Helene A. Haeberle, Stefanie Calov, Peter Martus, Lina Maria Serna-Higuita, Michael Koeppen, Almuth Goll, Alice Bernard, Alexander Zarbock, Melanie Meersch, Raphael Weiss, Martin Mehrländer, Gernot Marx, Christian Putensen, Tamam Bakchoul, Harry Magunia, Bernhard Nieswandt, Valbona Mirakaj, Peter Rosenberger

Open Access COVID-19 Research

Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative

Muhammad H. Gul, Zin Mar Htun, Vinicio de Jesus Perez, Muhammad Suleman, Samiullah Arshad, Muhammad Imran, Mahender Vyasabattu, Jeremy P. Wood, Michael Anstead, Peter E. Morris

Open Access COVID-19 Research

Comparison of systemic inflammatory profiles in COVID-19 and community-acquired pneumonia patients: a prospective cohort study

Elsa D. Ibáñez-Prada, Matthew Fish, Yuli V. Fuentes, Ingrid G. Bustos, Cristian C. Serrano-Mayorga, Julian Lozada, Jennifer Rynne, Aislinn Jennings, Ana M. Crispin, Ana Maria Santos, John Londoño, Manu Shankar-Hari, Luis Felipe Reyes

Open Access Correction

Correction: Reference values of impulse oscillometry (IOS) for healthy Chinese children aged 4–17 years

Jinhong Wu, Hao Zhang, Yongsheng Shi, Jinrong Wang, Yuling Han, Qiaoling Zhang, Ning Wang, Sha Liu, Yuehua Zhang, Huifen Zi, Fei Wang, Aihong Liu, Yuxin Song, ChunMei Jia, Yong Feng, Quanhua Liu, liya Wan, Minghong Ji, Zhen Long, Jianfeng Huang, Li Liu, Yun Sun, Suping Tang, Xiaoyan Dong, Xiaojian Zhou, Wenhui Jiang, Li Shen, Haohua Jiang

Open Access COVID-19 Research

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

Laura M. Palma Medina, Haris Babačić, Majda Dzidic, Åsa Parke, Marina Garcia, Kimia T. Maleki, Christian Unge, Magda Lourda, Egle Kvedaraite, Puran Chen, Jagadeeswara Rao Muvva, Martin Cornillet, Johanna Emgård, Kirsten Moll, Jakob Michaëlsson, Malin Flodström-Tullberg, Susanna Brighenti, Marcus Buggert, Jenny Mjösberg, Karl-Johan Malmberg, Johan K. Sandberg, Sara Gredmark-Russ, Olav Rooyackers, Mattias Svensson, Benedict J. Chambers, Lars I. Eriksson, Maria Pernemalm, Niklas K. Björkström, Soo Aleman, Hans-Gustaf Ljunggren, Jonas Klingström, Kristoffer Strålin, Anna Norrby-Teglund

Open Access Research

Benchmarking omics-based prediction of asthma development in children

Xu-Wen Wang, Tong Wang, Darius P. Schaub, Can Chen, Zheng Sun, Shanlin Ke, Julian Hecker, Anna Maaser-Hecker, Oana A. Zeleznik, Roman Zeleznik, Augusto A. Litonjua, Dawn L. DeMeo, Jessica Lasky-Su, Edwin K. Silverman, Yang-Yu Liu, Scott T. Weiss

Open Access Correspondence

Exhaled biomarkers in adults with non-productive cough

Össur Ingi Emilsson, Spela Kokelj, Jörgen Östling, Anna-Carin Olin

Open Access COVID-19 Research

Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

Flavio P. Veras, Giovanni F. Gomes, Bruna M. S. Silva, Diego B. Caetité, Cicero J. L. R. Almeida, Camila Meirelles S. Silva, Ayda H. Schneider, Emily S. Corneo, Caio S. Bonilha, Sabrina S. Batah, Ronaldo Martins, Eurico Arruda, Alexandre T. Fabro, José C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha

Open Access Research

IL-27 induces autophagy through regulation of the DNMT1/lncRNA MEG3/ERK/p38 axis to reduce pulmonary fibrosis

Li Ting, Yingying Feng, Ying Zhou, Zhongkai Tong, Zhaoxing Dong

Open Access Research

Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Sun Mi Choi, Yosep Mo, Ji-Young Bang, Young Gyun Ko, Yoon Hae Ahn, Hye Young Kim, Jaemoon Koh, Jae-Joon Yim, Hye-Ryun Kang

Open Access Research

Azithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathway

Yun Song, Wenhuan Fu, Youzhi Zhang, Doudou Huang, Jian Wu, Shuangmei Tong, Mingkang Zhong, Huifang Cao, Bin Wang

Open Access Research

Effectiveness and economic impact of Dupilumab in asthma: a population-based cohort study

Paola Faverio, Raffaella Ronco, Matteo Monzio Compagnoni, Matteo Franchi, Giovanni Franco, Giulia Bonaiti, Martina Bonifazi, Federico Mei, Fabrizio Luppi, Alberto Pesci, Giovanni Corrao

Open Access Research

Weight loss and outcomes in subjects with progressive pulmonary fibrosis: data from the INBUILD trial

Michael Kreuter, Elisabeth Bendstrup, Stéphane Jouneau, Toby M. Maher, Yoshikazu Inoue, Corinna Miede, Dirk Lievens, Bruno Crestani

Open Access Correspondence

Childhood asthma diagnoses declined during the COVID-19 pandemic in the United States

Daniel B. Horton, Amanda L. Neikirk, Yiling Yang, Cecilia Huang, Reynold A. Panettieri Jr, Stephen Crystal, Brian L. Strom, Lauren E. Parlett

Open Access Research

Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

Zili Zhang, Jian Wang, Yuanyuan Li, Fei Liu, Lingdan Chen, Shunping He, Fanjie Lin, Xinguang Wei, Yaowei Fang, Qiongqiong Li, Juntuo Zhou, Wenju Lu

Open Access Research

National, subnational and risk attributed burden of chronic respiratory diseases in Iran from 1990 to 2019

Mahsa Heidari-Foroozan, Alisam Aryan, Zahra Esfahani, Mohammad Amin Shahrbaf, Sahar Saeedi Moghaddam, Mohammad Keykhaei, Erfan Ghasemi, Mohammad-Mahdi Rashidi, Nazila Rezaei, Seyyed-Hadi Ghamari, Mohsen Abbasi-Kangevari, Sahar Mohammadi Fateh, Yousef Farzi, Negar Rezaei, Bagher Larijani

Open Access Review

The emerging role of the piRNA/PIWI complex in respiratory tract diseases

Yizhu Yao, Yaozhe Li, Xiayan Zhu, Chengguang Zhao, Lehe Yang, Xiaoying Huang, Liangxing Wang

Open Access Research

Surface electromyography to quantify neuro-respiratory drive and neuro-mechanical coupling in mechanically ventilated children

Alette A. Koopman, Jefta van Dijk, Eline Oppersma, Robert G. T. Blokpoel, Martin C. J. Kneyber

Open Access Research

Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling

Lihuang Su, Xiuchun Li, Xulong Mao, Tingting Xu, Yiying Zhang, Shini Li, Xiayan Zhu, Liangxing Wang, Dan Yao, Jian Wang, Xiaoying Huang

Open Access Research

An artificial intelligence approach for predicting death or organ failure after hospitalization for COVID-19: development of a novel risk prediction tool and comparisons with ISARIC-4C, CURB-65, qSOFA, and MEWS scoring systems

Stephen Wai Hang Kwok, Guanjin Wang, Ferdous Sohel, Kianoush B. Kashani, Ye Zhu, Zhen Wang, Eduardo Antpack, Kanika Khandelwal, Sandeep R. Pagali, Sanjeev Nanda, Ahmed D. Abdalrhim, Umesh M. Sharma, Sumit Bhagra, Sagar Dugani, Paul Y. Takahashi, Mohammad H. Murad, Mohammed Yousufuddin

Open Access Research

Time-resolved transcriptomic profiling of the developing rabbit’s lungs: impact of premature birth and implications for modelling bronchopulmonary dysplasia

Matteo Storti, Maria Laura Faietti, Xabier Murgia, Chiara Catozzi, Ilaria Minato, Danilo Tatoni, Simona Cantarella, Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Matteo Zoboli, Mar Vilanova, Ester Sánchez-Jiménez, Marina Gay, Marta Vilaseca, Gino Villetti, Barbara Pioselli, Fabrizio Salomone, Simone Ottonello, Barbara Montanini, Francesca Ricci

Open Access Research

Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

Zhuhua Wu, Li Zhu, Xinran Nie, Yingli Liu, Xiaoju Zhang, Yong Qi

Open Access Research

Dietary patterns, lung function and asthma in childhood: a longitudinal study

Mohammad Talaei, Pauline M. Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergström, Seif O. Shaheen

Open Access Research

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets

Ana M. Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund

Open Access Research

Pseudomonas aeruginosa isolation is an important predictor for recurrent hemoptysis after bronchial artery embolization in patients with idiopathic bronchiectasis: a multicenter cohort study

Le-Le Wang, Hai-Wen Lu, Ling-Ling Li, Yong-Hua Gao, Yu-Hua Xu, Hong-Xiao Li, Yun-Zhu Xi, Fu-Sheng Jiang, Xue-Feng Ling, Wei Wei, Fa-Jiu Li, Bei Mao, Sen Jiang, Jin-Fu Xu

Open Access Research

Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression

Yong Jun Choi, Heejae Han, Jae-Hyun Lee, Jaeuk Lee, Chi Young Kim, Min Kwang Byun, Jae Hwa Cho, Hye Jung Park

Open Access Research

Enhanced immune complex formation in the lungs of patients with dermatomyositis

Yoshiaki Zaizen, Masaki Okamoto, Koichi Azuma, Junya Fukuoka, Hironao Hozumi, Noriho Sakamoto, Takafumi Suda, Hiroshi Mukae, Tomoaki Hoshino

Open Access Correspondence

No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients

Quentin Philippot, Paul Bastard, Anne Puel, Jean-Laurent Casanova, Aurélie Cobat, Cédric Laouénan, Coralie Tardivon, Bruno Crestani, Raphael Borie

Open Access Correspondence

GlyPerA™ effectively shields airway epithelia from SARS-CoV-2 infection and inflammatory events

Viktoria Zaderer, Stefanie Dichtl, Wilfried Posch, Ivane Abiatari, Günther K. Bonn, Thomas Jakschitz, Lukas A. Huber, Teymuras V. Kurzchalia, Doris Wilflingseder

Open Access Research

The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

Katherine E. Stephenson, Joanne Porte, Aoife Kelly, William A. Wallace, Catherine E. Huntington, Catherine L. Overed-Sayer, E. Suzanne Cohen, R. Gisli Jenkins, Alison E. John

Open Access Research

Group 3 innate lymphoid cells secret neutrophil chemoattractants and are insensitive to glucocorticoid via aberrant GR phosphorylation

Li Xiu He, Ling Yang, Ting Liu, Yi Na Li, Ting Xuan Huang, Lan Lan Zhang, Jian Luo, Chun Tao Liu

Open Access Research

Intense solar activity reduces urinary 6-sulfatoxymelatonin in patients with COPD

Carolina L. Zilli Vieira, Petros Koutrakis, Man Liu, Daniel J. Gottlieb, Eric Garshick

Open Access Correspondence

Insomnia in chronic obstructive pulmonary disease and associations with healthcare utilization and costs

Faith S. Luyster, Monique Y. Boudreaux-Kelly, Jessica M. Bon

Open Access Correction

Correction to: Variability in low-flow oxygen delivery by nasal cannula evaluated in neonatal and infant airway replicas

Mozhgan Sabz, Scott Tavernini, Kineshta Pillay, Cole Christianson, Michelle Noga, Warren H. Finlay, Hossein Rouhani, Andrew R. Martin

Open Access Review

Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease

Matthew Preteroti, Emily T. Wilson, David H. Eidelman, Carolyn J. Baglole

Open Access Research

Use of a pulmosphere model to evaluate drug antifibrotic responses in interstitial lung diseases

Kevin G. Dsouza, Ranu Surolia, Tejaswini Kulkarni, Fu Jun Li, Pooja Singh, Huaxiu Zeng, Crystal Stephens, Abhishek Kumar, Zheng Wang, Veena B. Antony

Open Access Research

The prognostic value of gastroesophageal reflux disorder in interstitial lung disease related hospitalizations

Shehabaldin Alqalyoobi, Bertis Brit Little, Justin M. Oldham, Ogugua Ndili Obi

Open Access Research

The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease

Ling Lin, Qing Song, Jiaxi Duan, Cong Liu, Wei Cheng, Aiyuan Zhou, Yating Peng, Zijing Zhou, Yuqin Zeng, Yan Chen, Shan Cai, Ping Chen

Open Access Research

Morphologically intact airways in lung fibrosis have an abnormal proteome

Jeremy A. Herrera, Lewis A. Dingle, M. Angeles Monetero, Rajamiyer V. Venkateswaran, John F. Blaikley, Felice Granato, Stella Pearson, Craig Lawless, David J. Thornton

Open Access Research

Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p–HMGB1 axis

Mingming Jin, Yan Wang, Dawei Zhou, Wanchao Liu, Ruodong Han, Yongbin Chi

Open Access Research

Biomarkers of cellular senescence in idiopathic pulmonary fibrosis

Zaira Aversa, Elizabeth J. Atkinson, Eva M. Carmona, Thomas A. White, Amanda A. Heeren, Sarah K. Jachim, Xu Zhang, Steven R. Cummings, Sergio E. Chiarella, Andrew H. Limper, Nathan K. LeBrasseur

Open Access Research

Pulmonary rehabilitation after severe exacerbation of COPD: a nationwide population study

Marina Guecamburu, Anaëlle Coquelin, Amandine Rapin, Nelly Le Guen, Agnès Solomiac, Pauline Henrot, Marie Erbault, Sandrine Morin, Maéva Zysman

Open Access Research

IRAK-M has effects in regulation of lung epithelial inflammation

Jia Li, Zhoude Zheng, Yi Liu, Hongbing Zhang, Youming Zhang, Jinming Gao

Open Access Correspondence

Co-profiling reveals distinct patterns of genomic chromatin accessibility and gene expression in pulmonary hypertension caused by chronic hypoxia

Dongdong Yu, Ting Zhang, Guangyuan Zhou, Zeang Wu, Rui Xiao, Han Zhang, Bingxun Liu, Xiangpan Li, Matthieu Ruiz, Jocelyn Dupuis, Liping Zhu, Qinghua Hu

Open Access Research

Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways

Crystal A. Mariano, Samaneh Sattari, Gustavo O. Ramirez, Mona Eskandari

Open Access Research

Chronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD

Erin L. Tomaszewski, Mark J. Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K. Reddel, Claus F. Vogelmeier, Hana Müllerová, Paul W. Jones, Ricardo del Olmo, Gary Anderson, Helen Reddel, Marcelo Rabahi, Andrew McIvor, Mohsen Sadatsafavi, Ulla Weinreich, Pierre-Régis Burgel, Gilles Devouassoux, Alberto Papi, Hiromasa Inoue, Adrian Rendon, Maarten van den Berge, Richard Beasley, Alvar Agustí García-Navarro, Rosa Faner, José Olaguibel Rivera, Christer Janson, Magdalena Bilińska-Izydorczyk, Malin Fagerås, Titti Fihn-Wikander, Stefan Franzén, Christina Keen, Kristoffer Ostridge, James Chalmers, Timothy Harrison, Ian Pavord, David Price, Adnan Azim, Laura Belton, Francois-Xavier Blé, Clement Erhard, Kerry Gairy, Rod Hughes, Glenda Lassi, Hana Müllerová, Eleni Rapsomaniki, Ian Christopher Scott, Bradley Chipps, Barry Make, Stephanie Christenson, Erin Tomaszewski, Ricardo del Olmo, Gabriel Benhabib, Xavier Bocca Ruiz, Raul Eduardo Lisanti, Gustavo Marino, Walter Mattarucco, Juan Nogueira, Maria Parody, Pablo Pascale, Pablo Rodriguez, Damian Silva, Graciela Svetliza, Carlos F. Victorio, Roxana Willigs Rolon, Anahi Yañez, Helen Reddel, Stuart Baines, Simon Bowler, Peter Bremner, Sheetal Bull, Patrick Carroll, Mariam Chaalan, Claude Farah, Gary Hammerschlag, Kerry Hancock, Zinta Harrington, Gregory Katsoulotos, Joshua Kim, David Langton, Donald Lee, Matthew Peters, Lakshman Prassad, Dimitar Sajkov, Francis Santiago, Frederick Graham Simpson, Sze Tai, Paul Thomas, Peter Wark, Marcelo Rabahi, José Eduardo Delfini Cançado, Thúlio Cunha, Marina Lima, Alexandre Pinto Cardoso, J. Mark FitzGerald, Andrew McIvor, Syed Anees, John Bertley, Alan Bell, Amarjit Cheema, Guy Chouinard, Michael Csanadi, Anil Dhar, Ripple Dhillon, David Kanawaty, Allan Kelly, William Killorn, Daniel Landry, Robert Luton, Piushkumar Mandhane, Bonavuth Pek, Robert Petrella, Daniel Stollery, Chen Wang, Meihua Chen, Yan Chen, Wei Gu, Kim Ming Christopher Hui, Manxiang Li, Shiyue Li, Ma Lijun, Guangyue Qin, Weidong Song, Wei Tan, Yijun Tang, Tan Wang, Fuqiang Wen, Feng Wu, PingChao Xiang, Zuke Xiao, Shengdao Xiong, Jinghua Yang, Jingping Yang, Caiqing Zhang, Min Zhang, Ping Zhang, Wei Zhang, Xiaohe Zheng, Dan Zhu, Carlos Matiz Bueno, Fabio Bolivar Grimaldos, Alejandra Cañas Arboleda, Dora Molina de Salazar, Ulla Weinreich, Elisabeth Bendstrup, Ole Hilberg, Carsten Kjellerup, Pierre-Régis Burgel, Gilles Devouassoux, Chantal Raherison, Philippe Bonniaud, Olivier Brun, Christos Chouaid, Francis Couturaud, Jacques de Blic, Didier Debieuvre, Dominique Delsart, Axelle Demaegdt, Pascal Demoly, Antoine Deschildre, Carole Egron, Lionel Falchero, François Goupil, Romain Kessler, Pascal Le Roux, Pascal Mabire, Guillaume Mahay, Stéphanie Martinez, Boris Melloni, Laurent Moreau, Emilie Riviere, Pauline Roux-Claudé, Michel Soulier, Guillaume Vignal, Azzedine Yaici, Robert Bals, Sven Philip Aries, Ekkehard Beck, Andreas Deimling, Jan Feimer, Vera Grimm-Sachs, Gesine Growth, Felix Herth, Gerhard Hoheisel, Frank Kanniess, Thomas Lienert, Silke Mronga, Jörg Reinhardt, Christian Schlenska, Christoph Stolpe, Ishak Teber, Hartmut Timmermann, Thomas Ulrich, Peter Velling, Sabina Wehgartner-Winkler, Juergen Welling, Ernst-Joachim Winkelmann, Alberto Papi, Carlo Barbetta, Fulvio Braido, Vittorio Cardaci, Enrico Maria Clini, Maria Teresa Costantino, Giuseppina Cuttitta, Mario di Gioacchino, Alessandro Fois, Maria Pia Foschino-Barbaro, Enrico Gammeri, Riccardo Inchingolo, Federico Lavorini, Antonio Molino, Eleonora Nucera, Vincenzo Patella, Alberto Pesci, Fabio Ricciardolo, Paola Rogliani, Riccardo Sarzani, Carlo Vancheri, Rigoletta Vincenti, Hiromasa Inoue, Takeo Endo, Masaki Fujita, Yu Hara, Takahiko Horiguchi, Keita Hosoi, Yumiko Ide, Minehiko Inomata, Koji Inoue, Sumito Inoue, Motokazu Kato, Masayuki Kawasaki, Tomotaka Kawayama, Toshiyuki Kita, Kanako Kobayashi, Hiroshi Koto, Koichi Nishi, Junpei Saito, Yasuo Shimizu, Toshihiro Shirai, Naruhiko Sugihara, Ken-ichi Takahashi, Hiroyuki Tashimo, Keisuke Tomii, Takashi Yamada, Masaru Yanai, Adrian Rendon, Ruth Cerino Javier, Alfredo Domínguez Peregrina, Marco Fernández Corzo, Efraín Montano Gonzalez, Alejandra Ramírez-Venegas, Maarten van den Berge, Willem Boersma, R. S. Djamin, Michiel Eijsvogel, Frits Franssen, Martijn Goosens, Lidwien Graat-Verboom, Johannes in’t Veen, Rob Janssen, Kim Kuppens, Mario van de Ven, Per Bakke, Ole Petter Brunstad, Gunnar Einvik, Kristian Jong Høines, Alamdar Khusrawi, Torbjorn Oien, Ho Joo Yoon, Yoon-Seok Chang, Young Joo Cho, Yong Il Hwang, Woo Jin Kim, Young-Il Koh, Byung-Jae Lee, Kwan-Ho Lee, Sang-Pyo Lee, Yong Chul Lee, Seong Yong Lim, Kyung Hun Min, Yeon-Mok Oh, Choon-Sik Park, Hae-Sim Park, Heung-Woo Park, Chin Kook Rhee, Hyoung-Kyu Yoon, Alvar Agustí García-Navarro, José Olaguibel Rivera, Rubén Andújar, Laura Anoro, María Buendía García, Paloma Campo Mozo, Sergio Campos, Francisco Casas Maldonado, Manuel Castilla Martínez, Carolina Cisneros Serrano, Lorena Comeche Casanova, Dolores Corbacho, Felix Del Campo Matías, Jose Echave-Sustaeta, Gloria Francisco Corral, Pedro Gamboa Setién, Marta García Clemente, Ignacio García Núñez, Jose García Robaina, Mercedes García Salmones, Jose Maria Marín Trigo, Marta Nuñez Fernandez, Sara Nuñez Palomo, Luis Pérez de Llano, Ana Pueyo Bastida, Ana Rañó, José Rodríguez González-Moro, Albert Roger Reig, José Velasco Garrido, Christer Janson, Dan Curiac, Cornelia Lif-Tiberg, Anders Luts, Lennart Råhlen, Stefan Rustscheff, Timothy Harrison, Frances Adams, Drew Bradman, Emma Broughton, John Cosgrove, Patrick Flood-Page, Elizabeth Fuller, David Hartley, Keith Hattotuwa, Gareth Jones, Keir Lewis, Lorcan McGarvey, Alyn Morice, Preeti Pandya, Manish Patel, Kay Roy, Ramamurthy Sathyamurthy, Swaminathan Thiagarajan, Alice Turner, Jorgen Vestbo, Wisia Wedzicha, Tom Wilkinson, Pete Wilson, Bradley Chipps, Lo’Ay Al-Asadi, James Anholm, Francis Averill, Sandeep Bansal, Alan Baptist, Colin Campbell, Michael A. Campos, Gretchen Crook, Samuel DeLeon, Alain Eid, Ellen Epstein, Stephen Fritz, Hoadley Harris, Mitzie Hewitt, Fernando Holguin, Golda Hudes, Richard Jackson, Alan Kaufman, David Kaufman, Ari Klapholz, Harshavardhan Krishna, Daria Lee, Robert Lin, Diego Maselli-Caceres, Vinay Mehta, James N. Moy, Ugo Nwokoro, Purvi Parikh, Sudhir Parikh, Frank Perrino, James Ruhlmann, Catherine Sassoon, Russell A. Settipane, Daniel Sousa, Peruvemba Sriram, Richard Wachs

Open Access Correction

Correction: Early corticosteroid dose tapering in patients with acute exacerbation of idiopathic pulmonary fibrosis

Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa, Yosuke Yamamoto

Open Access Research

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial

Christian Friedrich, Klaus Francke, Surinder S. Birring, Jan Willem K. van den Berg, Paul A. Marsden, Lorcan McGarvey, Alice M. Turner, Pascal Wielders, Isabella Gashaw, Stefan Klein, Alyn H. Morice

Open Access Research

Mitochondrial creatine kinase 1 regulates the cell cycle in non-small cell lung cancer via activation of cyclin-dependent kinase 4

Mengjie Yang, Xuecen Wang, Zhihua Ye, Tingyu Liu, Yuan Meng, Youfa Duan, Xuexia Yuan, Xin Yue, Wenbin Deng, Ran-yi Liu

Open Access Review

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis

Julien Guiot, Monique Henket, Claire Remacle, Maureen Cambier, Ingrid Struman, Marie Winandy, Catherine Moermans, Edouard Louis, Michel Malaise, Clio Ribbens, Renaud Louis, Makon-Sébastien Njock

Open Access Research

Pan-cancer landscape of CENPO and its underlying mechanism in LUAD

Tongdong Shi, Zaoxiu Hu, Li Tian, Yanlong Yang

Open Access Correction

Correction to: Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation

Peng Liu, Kang Miao, Lei Zhang, Yong Mou, Yongjian Xu, Weining Xiong, Jun Yu, Yi Wang

Open Access Research

Previous pulmonary infection impacts thoracoscopic procedure outcomes in patients with congenital lung malformations: a retrospective cohort study

Dengke Luo, Kaisheng Cheng, Miao Yuan, Chang Xu, Taozhen He, Ru Jia, Shiyi Dai, Chenyu Liu

Open Access Research

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis

Minxue Jia, Lorena Rosas, Maria G. Kapetanaki, Tracy Tabib, John Sebrat, Tamara Cruz, Anna Bondonese, Ana L. Mora, Robert Lafyatis, Mauricio Rojas, Panayiotis V. Benos

Open Access Research

Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway

Wei Zhou, Yapeng Hou, Tong Yu, Tingyu Wang, Yan Ding, Hongguang Nie

Open Access Research

Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials

Wenjia Chen, Helen K. Reddel, J Mark FitzGerald, Richard Beasley, Christer Janson, Mohsen Sadatsafavi

Open Access Research

The effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach

Eduardo Genofre, Donna Carstens, Wilfried DeBacker, Patrick Muchmore, Reynold A. Panettieri Jr, Kirsty Rhodes, Vivian H. Shih, Frank Trudo

Open Access Research

H3K4me3-related lncRNAs signature and comprehensive analysis of H3K4me3 regulating tumor immunity in lung adenocarcinoma

Tao Fan, Mingchuang Zhu, Shan Muhammad, Chu Xiao, Shuofeng Li, He Tian, Yu Liu, Liyan Xue, Bo Zheng, Chunxiang Li, Jie He

Open Access Correction

Correction: Aspiration prevention surgeries: a review

Rumi Ueha, Redentor B. Magdayao, Misaki Koyama, Taku Sato, Takao Goto, Tatsuya Yamasoba

Open Access Research

Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling

Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung

Open Access Research

IL-6 and cfDNA monitoring throughout COVID-19 hospitalization are accurate markers of its outcomes

Salvador Bello, Ana Belén Lasierra, Lucía López-Vergara, Cristina de Diego, Laura Torralba, Pablo Ruiz de Gopegui, Raquel Lahoz, Claudia Abadía, Javier Godino, Alberto Cebollada, Beatriz Jimeno, Carlota Bello, Antonio Tejada, Antoni Torres

Open Access Research

A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy

Martina Buccardi, Erica Ferrini, Francesca Pennati, Elena Vincenzi, Roberta Eufrasia Ledda, Andrea Grandi, Davide Buseghin, Gino Villetti, Nicola Sverzellati, Andrea Aliverti, Franco Fabio Stellari

Open Access Research

Integrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation

Zheng Tan, Fengxia Li, Qiang Chen, Hongyu Chen, Ziru Xue, Jian Zhang, Yue Gao, Liang Liang, Ting Huang, Shouhua Zhang, Jianhua Li, Qiang Shu, Lan Yu

Open Access Research

Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS

Mitsuaki Nishikimi, Shinichiro Ohshimo, Wataru Fukumoto, Tatsuhiko Anzai, Kazuo Awai, Takayuki Ogura, Toshikazu Abe, Mamoru Masuda, Kenji Fujizuka, Mitsunobu Nakamura, Michihito Kyo, Kunihiko Takahashi, Nobuaki Shime

Open Access Research

Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung cancer patients

Wenxue Wang, Xiao Liang, Hui Kong, Yun Yang, Yilan Xia, Qiongjiao Wang, Andong Xia, Jiawei Geng

Open Access Correspondence

Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium

Simon D. Pouwels, Maarten van den Berge, Gwenda F. Vasse, Wim Timens, Corry-Anke Brandsma, Hananeh Aliee, Pieter S. Hiemstra, Victor Guryev, Alen Faiz

Open Access Research

Respiratory microbiota and radiomics features in the stable COPD patients

Rong Wang, Chunrong Huang, Wenjie Yang, Cui Wang, Ping Wang, Leixin Guo, Jin Cao, Lin Huang, Hejie Song, Chenhong Zhang, Yunhui Zhang, Guochao Shi

Open Access Research

Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis

Ji-Min Li, Wen-Hsin Chang, Linhui Li, David C. Yang, Ssu-Wei Hsu, Nicholas J. Kenyon, Ching-Hsien Chen

Open Access Research

Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

David Cipolla, Jimin Zhang, Brice Korkmaz, James D. Chalmers, Jessica Basso, Daniel Lasala, Carlos Fernandez, Ariel Teper, Kevin C. Mange, Walter R. Perkins, Eugene J. Sullivan

Open Access Research

Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers

Mario F. Perez, Marina Yurieva, Spandana Poddutoori, Eric M. Mortensen, Laura E. Crotty Alexander, Adam Williams

Open Access Research

Long-term effectiveness of benralizumab in severe eosinophilic asthma patients treated for 96-weeks: data from the ANANKE study

Alessandra Vultaggio, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Stefano Centanni, Maria D’Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Marco Benci, Silvia Boarino, Jan Walter Schroeder

Open Access Research

Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome

Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee

Open Access Research

The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study

Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Cristina Barbara, A. Sonia Buist, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Gregory E. Erhabor, Frits M. E. Franssen, Mohammed Al Ghobain, Thorarinn Gislason, Christer Janson, Ali Kocabaş, David Mannino, Guy Marks, Kevin Mortimer, Asaad Ahmed Nafees, Daniel Obaseki, Stefanni Nonna M. Paraguas, Li Cher Loh, Abdul Rashid, Sundeep Salvi, Terence Seemungal, Michael Studnicka, Wan C. Tan, Emiel F. M. Wouters, Hazim Abozid, Alexander Mueller, Peter Burney, Andre F. S. Amaral

Open Access Research

Multi-omic assessment shows dysregulation of pulmonary and systemic immunity to e-cigarette exposure

David P. Scieszka, Devon Garland, Russell Hunter, Guy Herbert, Selita Lucas, Yan Jin, Haiwei Gu, Matthew J. Campen, Judy L. Cannon

Open Access Research

Ambient fine particulate matter and allergic symptoms in the middle-aged and elderly population: results from the PIFCOPD study

Shanshan Wei, Jiping Liao, Tao Xue, Kunyao Yu, Xiuhua Fu, Ruiying Wang, Xiaomin Dang, Cheng Zhang, Hua Qiao, Shujuan Jiang, Jianhong Xiao, Lixia Dong, Jinzhi Yin, Xixin Yan, Weihua Jia, Guifang Zhang, Rui Chen, Bo Zhou, Beibei Song, Jing Li, Mengyu Yin, Lina Zhang, Liping Xie, Shaochen Dong, Jian Sun, Peng Gao, Bifang Miao, Wei Li, Lan He, Qian Ning, Limin Zhao, Hengyi Liu, Han Cao, Guangfa Wang

Open Access Research

Plasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer

Wenjing Chang, Jichao Zhu, Dianyu Yang, Anquan Shang, Zujun Sun, Wenqiang Quan, Dong Li

Open Access Research

Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression

Peifeng Ruan, Jamie L Todd, Hongyu Zhao, Yi Liu, Richard Vinisko, Julia F. Soellner, Ramona Schmid, Robert J. Kaner, Tracy R. Luckhardt, Megan L. Neely, Imre Noth, Mary Porteous, Rishi Raj, Zeenat Safdar, Mary E Strek, Christian Hesslinger, Scott M. Palmer, Thomas B. Leonard, Margaret L. Salisbury

Open Access Research

An ICD-Associated DAMP Gene signature predicts survival and immunotherapy response of patients with lung adenocarcinoma

Yuxin Wu, Kexin Li, Shuang Liang, Xiaoying Lou, Yiling Li, Danfei Xu, Yue Wu, Yuan Wang, Wei Cui

Open Access Correspondence

The effect of CPAP on the upper airway and ventilatory flow in patients with obstructive sleep apnea

Eli Van de Perck, Elahe Kazemeini, Karlien Van den Bossche, Marc Willemen, Johan Verbraecken, Olivier M Vanderveken, Sara Op de Beeck

Open Access Correspondence

Dysbiosis of the intestinal fungal microbiota increases lung resident group 2 innate lymphoid cells and is associated with enhanced asthma severity in mice and humans

Amjad N. Kanj, Theodore J. Kottom, Kyle J. Schaefbauer, Malay Choudhury, Andrew H. Limper, Joseph H. Skalski

Open Access Research

Integrin α10β1-selected mesenchymal stem cells reduced hypercoagulopathy in a porcine model of acute respiratory distress syndrome

Dag Edström, Anna Niroomand, Martin Stenlo, Kristina Uvebrant, Deniz A. Bölükbas, Gabriel Hirdman, Ellen Broberg, Hooi Ching Lim, Snejana Hyllén, Evy Lundgren-Åkerlund, Leif Pierre, Franziska Olm, Sandra Lindstedt

Open Access Research

Ventilator-associated pneumonia in neurocritically ill patients: insights from the ENIO international prospective observational study

Denise Battaglini, Luca Parodi, Raphael Cinotti, Karim Asehnoune, Fabio Silvio Taccone, Giovanni Orengo, Gianluigi Zona, Antonio Uccelli, Giulio Ferro, Michela Robba, Paolo Pelosi, Chiara Robba

Open Access Research

Economic impact of a more extensive use of FENO testing on the Italian population with asthma

Carla Rognoni, Carlo Milano, Enrico Heffler, Matteo Bonini, Luisa Brussino, Giovanna Elisiana Carpagnano, Fabio Luigi Massimo Ricciardolo, Francesco Costa, Patrizio Armeni

Open Access Research

A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis

Takeshi Imakura, Seidai Sato, Kazuya Koyama, Hirohisa Ogawa, Takahiro Niimura, Kojin Murakami, Yuya Yamashita, Keiko Haji, Nobuhito Naito, Kozo Kagawa, Hiroshi Kawano, Yoshito Zamami, Keisuke Ishizawa, Yasuhiko Nishioka

Open Access Research

HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo

Qianqian Zhang, Yuqian Chen, Qingting Wang, Yan Wang, Wei Feng, Limin Chai, Jin Liu, Danyang Li, Huan Chen, Yuanjie Qiu, Nirui Shen, Xiangyu Shi, Xinming Xie, Manxiang Li

Open Access Research

Machine diagnosis of chronic obstructive pulmonary disease using a novel fast-response capnometer

Leeran Talker, Daniel Neville, Laura Wiffen, Ahmed B. Selim, Matthew Haines, Julian C. Carter, Henry Broomfield, Rui Hen Lim, Gabriel Lambert, Jonathon Winter, Andrew Gribbin, Milan Chauhan, Ruth De Vos, Paul Kalra, Selina Begum, Barbara Robinson, Bernadette Mundy, Heather Rutter, Karen Madronal, Scott T. Weiss, Gail Hayward, Thomas Brown, Anoop Chauhan, Ameera X. Patel

Open Access Research

The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study

Anaïs Roeser, Lucile Sese, Guillaume Chassagnon, Benjamin Chaigne, Bertrand Dunogue, Stéphane Tran Ba, Salma Jebri, Pierre-Yves Brillet, Marie Pierre Revel, Frédérique Aubourg, Robin Dhote, Frédéric Caux, Isabella Annesi-Maesano, Luc Mouthon, Hilario Nunes, Yurdagül Uzunhan

Open Access Correspondence

Comprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort study

Fiorella Calabrese, Francesca Lunardi, Elisa Baldasso, Federica Pezzuto, Asuman Kilitci, Gheorghe-Emilian Olteanu, Claudia Del Vecchio, Francesco Fortarezza, Annalisa Boscolo, Marco Schiavon, Luca Vedovelli, Annamaria Cattelan, Dario Gregori, Federico Rea, Paolo Navalesi

Open Access Research

Collaborative cross strain CC011/UncJ as a novel mouse model of T2-high, severe asthma

Lauren J. Donoghue, Kathryn M. McFadden, Daniel Vargas, Gregory J. Smith, Robert M. Immormino, Timothy P. Moran, Samir N. P. Kelada

Open Access Research

Ferroptosis-related signature and immune infiltration characterization in acute lung injury/acute respiratory distress syndrome

Aijia Ma, Zhongxue Feng, Yang Li, Qin Wu, Huaiyu Xiong, Meiling Dong, Jiangli Cheng, Zhenling Wang, Jing Yang, Yan Kang

Open Access Research

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Miguel A. Hernandez-Lara, Santosh Kumar Yadav, Stanley Conaway Jr., Sushrut D. Shah, Raymond B. Penn, Deepak A. Deshpande

Open Access Research

Regulation of whole-transcriptome sequencing expression in COPD after personalized precise exercise training: a pilot study

Panpan Liu, Meilan Zhang, Hongchang Gao, Shaojun Han, Jinming Liu, Xingguo Sun, Lei Zhao

Open Access Research

The intermediate filament protein nestin serves as a molecular hub for smooth muscle cytoskeletal signaling

Yinna Wang, Guoning Liao, Yidi Wu, Ruping Wang, Dale D. Tang

Open Access Research

Ultra-rare RTEL1 gene variants associate with acute severity of COVID-19 and evolution to pulmonary fibrosis as a specific long COVID disorder

Laura Bergantini, Margherita Baldassarri, Miriana d’Alessandro, Giulia Brunelli, Gaia Fabbri, Kristina Zguro, Andrea Degl’Innocenti, Francesca Mari, Sergio Daga, Ilaria Meloni, Mirella Bruttini, Susanna Croci, Mirjam Lista, Debora Maffeo, Elena Pasquinelli, Viola Bianca Serio, Enrica Antolini, Simona Letizia Basso, Samantha Minetto, Rossella Tita, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Arianna Emiliozzi, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Maria Lorubbio, Alessandro Pancrazzi, Massimo Vaghi, Antonella D.’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Stefania Mantovani, Raffaele Bruno, Marco Vecchia, Marcello Maffezzoni, Enrico Martinelli, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Carlo Pallotto, Saverio Giuseppe Parisi, Monica Basso, Sandro Panese, Stefano Baratti, Pier Giorgio Scotton, Francesca Andretta, Mario Giobbia, Renzo Scaggiante, Francesca Gatti, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Isabella Zanella, Matteo della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Giuseppe Merla, Gabriella Maria Squeo, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Alex Di Florio, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Elisabetta Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Gianluca Lacerenza, Cristina Mussini, Luisa Tavecchia, Lia Crotti, Gianfranco Parati, Roberto Menè, Maurizio Sanarico, Marco Gori, Francesco Raimondi, Alessandra Stella, Filippo Biscarini, Tiziana Bachetti, Maria Teresa La Rovere, Maurizio Bussotti, Serena Ludovisi, Katia Capitani, Simona Dei, Sabrina Ravaglia, Annarita Giliberti, Giulia Gori, Rosangela Artuso, Elena Andreucci, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Bianchi, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Giulia Micheli, Marco Falcone, Donato Urso, Giusy Tiseo, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, Antonella Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Alessio Bellucci, Marta Colaneri, Patrizia Casprini, Cristoforo Pomara, Massimiliano Esposito, Roberto Leoncini, Michele Cirianni, Lucrezia Galasso, Marco Antonio Bellini, Chiara Gabbi, Nicola Picchiotti, Simone Furini, Chiara Fallerini, Elena Bargagli, Alessandra Renieri

Open Access Research

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

David de Gonzalo-Calvo, Marta Molinero, Iván D. Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C. García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Anna Moncusí-Moix, Ángel Estella, Luis Tamayo Lomas, Amalia Martínez de la Gándara, Lorenzo Socias, Yhivian Peñasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martínez Varela, María Cruz Martin Delgado, Pablo Vidal-Cortés, Juan López Messa, Felipe Pérez-García, Jesús Caballero, José M. Añón, Ana Loza-Vázquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemí Jorge García, Carmen Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Antoni Torres, Ferran Barbé

Open Access Research

Chronic allergic asthma induces T-cell exhaustion and impairs virus clearance in mice

So Yeon Ahn, Jueun Lee, Dong-Ha Lee, Thi Len Ho, Chau Thuy Tien Le, Eun-Ju Ko

Open Access Research

Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype

Kristi J. Warren, Emily M. Beck, Sean J. Callahan, My N. Helms, Elizabeth Middleton, Sean Maddock, Jason R. Carr, Dixie Harris, Denitza P. Blagev, Michael J. Lanspa, Samuel M. Brown, Robert Paine III

Open Access Correspondence

Early detection and stratification of lung cancer aided by a cost-effective assay targeting circulating tumor DNA (ctDNA) methylation

Zhoufeng Wang, Kehui Xie, Guonian Zhu, Chengcheng Ma, Cheng Cheng, Yangqian Li, Xue Xiao, Chengpin Li, Jun Tang, Hui Wang, Zhixi Su, Dan Liu, Wengeng Zhang, Yan Huang, Huairong Tang, Rui Liu, Weimin Li

Open Access Research

Heterogeneity of weight gain after initiation of Elexacaftor/Tezacaftor/Ivacaftor in people with cystic fibrosis

Andrea Gramegna, Fabio Majo, Gianfranco Alicandro, Gloria Leonardi, Luca Cristiani, Francesco Amati, Martina Contarini, Stefano Aliberti, Alessandro Giovanni Fiocchi, Francesco Blasi

Open Access Correspondence

Plasma matrix metalloproteinase-3 predicts mortality in acute respiratory distress syndrome: a biomarker analysis of a randomized controlled trial

Timothy W. Jones, Sultan Almuntashiri, Aaron Chase, Abdullah Alhumaid, Payaningal R. Somanath, Andrea Sikora, Duo Zhang

Open Access Research

NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis

Annemarie Aue, Nils Englert, Leon Harrer, Fabian Schwiering, Annika Gaab, Peter König, Ralf Adams, Achim Schmidtko, Andreas Friebe, Dieter Groneberg

Open Access Research

Reconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort

Lei-Lei Wu, Li-Hong Qiu, Xiaolu Chen, Wan-Jun Yu, Chong-Wu Li, Jia-Yi Qian, Shen-Hua Liang, Peng Lin, Hao Long, Lan-Jun Zhang, Zhi-Xin Li, Kun Li, Feng Jiang, Guo-Wei Ma, Dong Xie

Open Access Research

Global, regional, and national burden of asthma and its attributable risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

Zhufeng Wang, Yun Li, Yi Gao, Yu Fu, Junfeng Lin, Xuedong Lei, Jinping Zheng, Mei Jiang

Open Access Correspondence

Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing

Zhili Wang, Yu He, Qinyuan Li, Yan Zhao, Guangli Zhang, Zhengxiu Luo

Open Access Research

Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial

Visasiri Tantrakul, Atiporn Ingsathit, Somprasong Liamsombut, Sasivimol Rattanasiri, Prapun Kittivoravitkul, Nutthaphon Imsom-Somboon, Siwaporn Lertpongpiroon, Surasak Jantarasaengaram, Werapath Somchit, Worakot Suwansathit, Janejira Pengjam, Sukanya Siriyotha, Panyu Panburana, Christian Guilleminault, Aroonwan Preutthipan, John Attia, Ammarin Thakkinstian

Open Access Research

Fibrin degradation products and survival in patients with chronic obstructive pulmonary disease: a protocolized prospective observational study

Peter Kamstrup, Pradeesh Sivapalan, Christian Rønn, Ema Rastoder, Daniel Modin, Anna Kjaer Kristensen, Elisabeth Bendstrup, Rikke Sørensen, Tor Biering-Sørensen, Charlotte Suppli Ulrik, Jørgen Vestbo, Jens-Ulrik Jensen

Open Access Research

Burden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort

Kjell Erik Julius Håkansson, Silvia Cabrera Guerrero, Vibeke Backer, Charlotte Suppli Ulrik, Deepa Rastogi

Open Access Research

Decreased level of serum NT-proCNP associates with disease severity in COVID-19

Istvan Bojti, Anne-Sophie Przewosnik, Hendrik Luxenburger, Maike Hofmann, Christoph Neumann-Haefelin, Jennifer S. Esser, Patrick M. Siegel, Alexander Maier, Sarolta Bojtine Kovacs, Laszlo Kardos, Zoltan Csanádi, Marina Rieder, Daniel Duerschmied, Achim Lother, Christoph Bode, Gabor Tamas Szabó, Daniel Czuriga

Open Access Research

Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections

Shumin Liao, Yanhong Huang, Jinxiu Zhang, Qinglan Xiong, Mengshi Chi, Liang Yang, Junhang Zhang, Liang Li, Yunping Fan

Open Access Research

Deciphering a cell death-associated signature for predicting prognosis and response to immunotherapy in lung squamous cell carcinoma

Guangxian Mao, Dongyong Yang, Bin Liu, Yu Zhang, Sijia Ma, Shang Dai, Guoqiang Wang, Wenxiang Tang, Huafei Lu, Shangli Cai, Jialiang Zhu, Huaping Yang

Open Access Research

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure

Li Gao, Nicholas Rafaels, Tanda M. Dudenkov, Mahendra Damarla, Rachel Damico, James P. Maloney, Marc Moss, Greg S. Martin, Jonathan Sevransky, Carl Shanholtz, Dan L. Herr, Joe G.N. Garcia, Tamara Hernandez-Beeftink, Jesús Villar, Carlos Flores, Terri H. Beaty, Roy Brower, Paul M. Hassoun, Kathleen C. Barnes

Open Access Research

Therapeutic properties of Helicobacter pylori-derived vacuolating cytotoxin A in an animal model of chronic allergic airway disease

Jonas Raspe, Mona S. Schmitz, Kimberly Barbet, Georgia C. Caso, Timothy L. Cover, Anne Müller, Christian Taube, Sebastian Reuter

Open Access Research

Enhancing the interferon-γ release assay through omission of nil and mitogen values

Yun Jung Jung, Ji Eun Park, Ji Won Park, Keu Sung Lee, Wou Young Chung, Joo Hun Park, Seung Soo Sheen, Seulgi You, Joo Sung Sun, Kyung Joo Park, Youn Jung Kim, Kwang Joo Park

Open Access Correspondence

High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils

Yael Strulovici-Barel, Robert J. Kaner, Ronald G. Crystal

Open Access Correction

Correction to: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p–HMGB1 axis

Mingming Jin, Yan Wang, Dawei Zhou, Wanchao Liu, Ruodong Han, Yongbin Chi

Open Access Research

Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng, Liang Dong

Open Access Comment

Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population

Rajesh Shigdel, Ane Johannessen, Huang Lin, Shyamal Peddada, Francisco Gómez Real, Tamar Ringel-Kulka, Cecilie Svanes, Randi Jacobsen Bertelsen

Open Access Research

LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland, Anthony Bosco

Open Access Research

AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells

Eugene Becker Jr., Maroof Husain, Nathaniel Bone, Samuel Smith, Peter Morris, Jaroslaw W. Zmijewski

Open Access Research

Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling

Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig, György Haskó

Open Access Review

Protective effects of inhaled antioxidants against air pollution-induced pathological responses

Kevin D. Schichlein, Gregory J. Smith, Ilona Jaspers

Open Access Correspondence

Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats

Mihaela Teodorescu, Ruolin Song, Jacqueline A. Brinkman, Ronald L. Sorkness

Open Access Research

Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study

Arianne K. Baldomero, David M. MacDonald, Adam Kaplan, Eric Lock, Michael H. Cho, Russell Bowler, Lucas Gillenwater, Ken M. Kunisaki, Chris H. Wendt

Open Access Research

Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom, Sailesh Kotecha

Open Access Research

Metformin attenuates chronic lung allograft dysfunction: evidence in rat models

Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu, Lunxu Liu

Open Access Research

Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1

Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort, Ian M. Adcock

Open Access Review

Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD

Mario Cazzola, Clive P. Page, Jadwiga A. Wedzicha, Bartolome R. Celli, Antonio Anzueto, Maria Gabriella Matera

Open Access Research

Validation of clinical-radiological scores for prognosis of mortality in acute pulmonary embolism

Alexey Surov, Maximilian Thormann, Caroline Bär, Andreas Wienke, Jan Borggrefe

Open Access Research

Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19

Emma J. Kooistra, Kilian Dahm, Antonius E. van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L. Smeets, Sjef van der Velde, Maarten J. W. van den Berg, Johannes G. van der Hoeven, Anna C. Aschenbrenner, Joachim L. Schultze, Thomas Ulas, Matthijs Kox, Peter Pickkers

Open Access Research

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage-Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko, Efrat Eliyahu

Open Access Research

CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity

Elizabeth L. Kramer, Kristin M. Hudock, Cynthia R. Davidson, John P. Clancy

Open Access Research

The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6–11 with cystic fibrosis in a real-world setting

Paul McNally, Barry Linnane, Michael Williamson, Basil Elnazir, Christopher Short, Clare Saunders, Laura Kirwan, Rea David, Mariette P. C. Kemner-Van de Corput, Harm A.W.M. Tiddens, Jane C Davies, Des W Cox

Open Access Retraction Note

Retraction Note: Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production

Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie, Yicheng Xie

Open Access Research

Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD

Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura, Satoshi Konno

Open Access Research

Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model

Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu, Wenju Lu, Tengteng Zhao, Jian Wang, Yuqin Chen

Open Access Correspondence

Race-specific spirometry equations may overestimate asthma control in Black children and adolescents

Allison J. Burbank, Claire E. Atkinson, Andre E. Espaillat, Stephen A. Schworer, Katherine Mills, Jennifer Rooney, Ceila E. Loughlin, Wanda Phipatanakul, Michelle L. Hernandez

Open Access Research

Polo-like kinase 1 promotes pulmonary hypertension

Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang, Chen Wang, Yan Meng, Xinling Du, Hongbing Zhang

Open Access Research

Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models

Alane Blythe C. Dy, Jason Girkin, Antonella Marrocco, Adam Collison, Chimwemwe Mwase, Michael J. O’Sullivan, Thien-Khoi N. Phung, Joerg Mattes, Cynthia Koziol-White, James E. Gern, Yury A. Bochkov, Nathan W. Bartlett, Jin-Ah Park

Open Access Research

Accumulation of oxysterols in the erythrocytes of COVID-19 patients as a biomarker for case severity

Alaa Khedr, Maan T. Khayat, Ahdab N. Khayyat, Hany Z. Asfour, Rahmah A. Alsilmi, Ahmed K. Kammoun

Open Access Research

Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways

Ying Wang, Dennis K. Ninaber, Alen Faiz, Abraham C. van der Linden, Annemarie van Schadewijk, René Lutter, Pieter S. Hiemstra, Anne M. van der Does, Abilash Ravi

Open Access Research

Clinical practice of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease

Judith Elshof, Judith M. Vonk, Anouschka van der Pouw, Cella van Dijk, Petra Vos, Huib A.M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman

Open Access Research

Lung function trajectories in patients with idiopathic pulmonary fibrosis

Megan L Neely, Anne S Hellkamp, Shaun Bender, Jamie L Todd, Timothy Liesching, Tracy R Luckhardt, Justin M Oldham, Rishi Raj, Eric S White, Scott M Palmer

Open Access Correction

Correction to: Impact of Haemophilus influenzae type b combination vaccination on asthma symptoms and pneumonia in 5-year-old children in rural Bangladesh: a longitudinal study and comparison with a previous cross-sectional study

Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata, Md Alfazal Khan

Open Access Research

Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro

Laura Cucinotta, Deborah Mannino, Giovanna Casili, Alberto Repici, Lelio Crupi, Irene Paterniti, Emanuela Esposito, Michela Campolo

Open Access Research

IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte

Xiujuan Yao, Qinglin Chen, Xiangdong Wang, Xiaofang Liu, Luo Zhang

Open Access Research

A comparative study of in vitro air–liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution

Rachel A. Prescott, Alec P. Pankow, Maren de Vries, Keaton M. Crosse, Roosheel S. Patel, Mark Alu, Cynthia Loomis, Victor Torres, Sergei Koralov, Ellie Ivanova, Meike Dittmann, Brad R. Rosenberg

Open Access Research

Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway

Xiaofan Lai, Yingying Lin, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang, Wenqi Huang

Open Access Research

Quantifying ventilation by X-ray velocimetry in healthy adults

Trishul Siddharthan, Kyle Grealis, Jason P. Kirkness, Tamás Ötvös, Darko Stefanovski, Alex Tombleson, Molly Dalzell, Ernesto Gonzalez, Kinjal Bhatt Nakrani, David Wenger, Michael G. Lester, Bradley W. Richmond, Andreas Fouras, Naresh M. Punjabi

Open Access Research

Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation

Jin Liu, Yuqian Chen, Huan Chen, Yan Wang, Danyang Li, Qianqian Zhang, Limin Chai, Yuanjie Qiu, Jia Zhang, Nirui Shen, Qingting Wang, Jian Wang, Manxiang Li

Open Access Research

L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients

Stefania Lo Cicero, Germana Castelli, Giovanna Blaconà, Sabina Maria Bruno, Giovanni Sette, Riccardo Pigliucci, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Francesca Spadaro, Ruggero De Maria, Mauro Biffoni, Giuseppe Cimino, Felice Amato, Marco Lucarelli, Adriana Eramo

Open Access Research

SACE and IL-2R as serum biomarkers for evaluation of multi-organ involvement and prognosis of sarcoidosis

Ying Zhou, Xianqiu Chen, Mengmeng Zhao, Elyse E. Lower, Robert P. Baughman

Open Access Research

A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study

Jingge Qu, Mengtao Li, Xiao Zhang, Miaojia Zhang, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Junyan Qian, Can Huang, Jiuliang Zhao, Qian Wang, Yongtai Liu, Zhuang Tian, Yanhong Wang, Wei Wei, Xiaofeng Zeng

Open Access Research

Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study

Surajit Dey, Wenying Lu, Greg Haug, Collin Chia, Josie Larby, Heinrich C. Weber, Archana Vijay Gaikwad, Prem Bhattarai, Affan Mahmood Shahzad, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

Open Access Research

TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation

Mingting Wu, Zhenyan Wang, Xiaoqian Shi, Danni Zan, Hong Chen, Shuqiao Yang, Fangping Ding, Liu Yang, Pingping Tan, Runlin Z. Ma, Jing Wang, Lishuang Ma, Yingmin Ma, Jiawei Jin

Open Access Research

Predictors of the response to phosphodiesterase-5 inhibitors in pulmonary arterial hypertension: an analysis of the Spanish registry

Agustin R. Garcia, Isabel Blanco, Lluis Ramon, Jesús Pérez-Sagredo, Francisco J. Guerra-Ramos, Clara Martín-Ontiyuelo, Olga Tura-Ceide, Francisco Pastor-Pérez, Pilar Escribano-Subías, Joan A. Barberà

Open Access Research

Incident low muscle mass is associated with greater lung disease and lower circulating leptin in a tobacco-exposed longitudinal cohort

Richard H. Zou, S. Mehdi Nouraie, Chad Karoleski, Yingze Zhang, Frank C. Sciurba, Daniel E. Forman, Jessica Bon

Open Access Correspondence

Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease

Meropi Karakioulaki, Caroline Maria Berkemeier, Ingmar Heijnen, Leticia Grize, Eleni Papakonstantinou, Antonis Goulas, Michael Tamm, Daiana Stolz

Open Access Research

Modeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging

Omar Usmani, Grace Li, Jan De Backer, Hosein Sadafi, Libo Wu, Jonathan Marshall

Open Access Research

CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s

Jianhui Sun, Huacai Zhang, Di Liu, Wenyi Liu, Juan Du, Dalin Wen, Luoxi Li, Anqiang Zhang, Jianxin Jiang, Ling Zeng

Open Access Correction

Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients

Stefania Lo Cicero, Germana Castelli, Giovanna Blaconà, Sabina Maria Bruno, Giovanni Sette, Riccardo Pigliucci, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Francesca Spadaro, Ruggero De Maria, Mauro Biffoni, Giuseppe Cimino, Felice Amato, Marco Lucarelli, Adriana Eramo

Open Access Research

Benefit of prompt initiation of single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) in patients with COPD in England following an exacerbation: a retrospective cohort study

Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey, David M. G. Halpin

Open Access Research

Early vvECMO implantation may be associated with lower mortality in ARDS

Peter Rosenberger, Lisa Korell, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Linyan Tang, Andreas Körner, Peter Martus, Michael Koeppen

Open Access Review

Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy

Kunlu Shen, Mengyuan Zhang, Ruiheng Zhao, Yun Li, Chunxiao Li, Xin Hou, Bingqing Sun, Bowen Liu, Min Xiang, Jiangtao Lin

Open Access Research

Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients

Christian Rønn, Peter Kamstrup, Josefin Eklöf, Louise Lindhardt Toennesen, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Ram Benny Dessau, Jon Torgny Wilcke, Pradeesh Sivapalan, Charlotte Suppli Ulrik, Jens-Ulrik Stæhr Jensen

Open Access Correspondence

A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients

Arnaud Prigent, Clément Blanloeil, Anne-Laure Serandour, Franck Barlet, Frédéric Gagnadoux, Dany Jaffuel

Open Access Research

Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: ORBE II study

Alicia Padilla-Galo, Isabel Moya Carmona, Pilar Ausín, Luis Carazo Fernández, Ismael García-Moguel, José Luis Velasco-Garrido, Rubén Andújar-Espinosa, Francisco Casas-Maldonado, Eva Martínez-Moragón, Carlos Martínez Rivera, Elisabet Vera Solsona, Fernando Sánchez-Toril López, Andrea Trisán Alonso, Marina Blanco Aparicio, Marcela Valverde-Monge, Borja Valencia Azcona, Marta Palop Cervera, Javier Nuevo, Jesús Sánchez Tena, Gustavo Resler, Elisa Luzón, Alberto Levy Naon

Open Access Research

Lung immune signatures define two groups of end-stage IPF patients

Tamara Cruz, Núria Mendoza, Sandra Casas-Recasens, Guillaume Noell, Fernanda Hernandez-Gonzalez, Alejandro Frino-Garcia, Xavi Alsina-Restoy, María Molina, Mauricio Rojas, Alvar Agustí, Jacobo Sellares, Rosa Faner

Open Access Research

Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells

Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu, Shi-Yue Li

Open Access Review

Rhinovirus induces airway remodeling: what are the physiological consequences?

Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr., Cynthia J. Koziol-White

Open Access Research

KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis

Maria Hollmén, Atte Laaka, Juulia J. Partanen, Jukka Koskela, Eva Sutinen, Riitta Kaarteenaho, Mari Ainola, Marjukka Myllärniemi

Open Access Research

Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan

Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda, Yukari Kato, Norihiro Harada, Shoji Suzuki, Shuichi Yoshida, Hiroki Tateno, Yoshitake Yamada, Masahiro Jinzaki, Toyohiro Hirai, Yukinori Okada, Ryuji Koike, Makoto Ishii, Naoki Hasegawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga

Open Access Review

3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function

Sakshi Phogat, Fama Thiam, Safiya Al Yazeedi, Filsan Ahmed Abokor, Emmanuel Twumasi Osei

Open Access Research

Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples

Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants, Silvia Rossi Paccani

Open Access Research

The effect of inhaled extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide on distal and central airway indices, assessed using Functional Respiratory Imaging in COPD (DARWiIN)

Gwen S. Skloot, Alessandro Guasconi, Benjamin R. Lavon, George Georges, Wilfried De Backer, Dmitry Galkin, Mauro Cortellini, Ilaria Panni, Jason H. T. Bates

Open Access Correspondence

Bronchial epithelial gene expression and interstitial lung abnormalities

Aravind A. Menon, Minyi Lee, Xu Ke, Rachel K. Putman, Takuya Hino, Jonathan A. Rose, Fenghai Duan, Samuel Y. Ash, Michael H. Cho, George T. O’Connor, Josée Dupuis, Hiroto Hatabu, Marc E. Lenburg, Ehab S. Billatos, Gary M. Hunninghake, Avi Spira, Elizabeth Moses, Jennifer Beane, Josh Campbell, Jack Cunningham, Gang Liu, Hanqiao Liu, Sherry Zhang, Jiarui Zhang, Xingyi Shi, Carter Merenstein, Yue Zhao, Denise Aberle, Mitchell Schnall, Charles Apgar, Irene Mahon, Lindsey Dymond, Joe Bauza, Sarah Gevo, Constantine Gastonis, Helga Marquez, David Elashoff, Ignacio Wistuba, Humam Kadara, Junya Fujimoto, Clifton Dalgard, Matthew Wilkerson, Denise Aberle, George Washko, Charles M. Kinsey, Denise Fine, Ron Goldstein, Kathleen LaCerda, John Battaile, Mitchell Kroll, Bob Keith, Mary Jackson, Steve Dubinett, Gina Lee, Babak Aryanfar, Rafael Corona, Anil Vachani, Sam Soloman, Charles Atwood, Gregory Owens, Hanna Edvardsson, Pierre Massion, Trey Helton, Mary Reid, Chris Kuzniewski, Jacob Carmichael, Holly LaPerriere, J. ScottParrish, Lindsey White, Anna Kaur, Robert Browning Jr., Maggie Nelissery, Folashade Akanni, Luis Rojas

Open Access Research

Effectiveness of the booster dose of inactivated COVID-19 vaccine against Omicron BA.5 infection: a matched cohort study of adult close contacts

Ting Zeng, Yaoqin Lu, Yanji Zhao, Zihao Guo, Shengzhi Sun, Zhidong Teng, Maozai Tian, Jun Wang, Shulin Li, Xucheng Fan, Weiming Wang, Yongli Cai, Gengze Liao, Xiao Liang, Daihai He, Kai Wang, Shi Zhao

Open Access Research

Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats

Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu, Shih-En Tang

Open Access Research

Microbial signatures in amniotic fluid at preterm birth and association with bronchopulmonary dysplasia

Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Kublik, Michael Schloter, Harald Ehrhardt

Open Access Research

Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort

Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou, Elio Riboli

Open Access Review

Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?

Yuto Yasuda, Lu Wang, Pasquale Chitano, Chun Y. Seow

Open Access Correspondence

Walking the path of treatable traits in interstitial lung diseases

Francesco Amati, Paolo Spagnolo, Christopher J. Ryerson, Justin M. Oldham, Andrea Gramegna, Anna Stainer, Marco Mantero, Nicola Sverzellati, Donato Lacedonia, Luca Richeldi, Francesco Blasi, Stefano Aliberti

Open Access Research

Circular RNA P4HB promotes glycolysis and tumor progression by binding with PKM2 in lung adenocarcinoma

Haoran Li, Haifa Guo, Qi Huang, Shaodong Wang, Xiao Li, Mantang Qiu

Open Access Research

Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis

Philomène Lavis, Julien Pingitore, Gilles Doumont, Ani Garabet, Gaetan Van Simaeys, Simon Lacroix, Nicolas Passon, Christophe Van Heymbeek, Coraline De Maeseneire, Justine Allard, Amandine Collin, François Huaux, Christine Decaestecker, Isabelle Salmon, Serge Goldman, Alessandra Kupper Cardozo, Benjamin Bondue

Open Access Research

MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway

Lu Liu, Ling Zhou, Lingling Wang, Zhenyu Mao, Pengdou Zheng, Fengqin Zhang, Huojun Zhang, Huiguo Liu

Open Access Review

The development of amivantamab for the treatment of non-small cell lung cancer

Danielle Brazel, Misako Nagasaka

Open Access Research

Mechanical thrombectomy in intermediate- and high-risk acute pulmonary embolism: hemodynamic outcomes at three months

Lucas Lauder, Patricia Pérez Navarro, Felix Götzinger, Sebastian Ewen, Hussam Al Ghorani, Bernhard Haring, Philipp M. Lepper, Saarraaken Kulenthiran, Michael Böhm, Andreas Link, Bruno Scheller, Felix Mahfoud

Open Access Study Protocol

Ultrasound evaluation of diaphragmatic function in patients with idiopathic pulmonary fibrosis: a retrospective observational study

Jules Milesi, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard

Open Access Research

Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma

Chenli Chang, Gongqi Chen, Wenliang Wu, Dian Chen, Shengchong Chen, Jiali Gao, Yuchen Feng, Guohua Zhen

Open Access Research

Do alternative tobacco products induce less adverse respiratory risk than cigarettes?

Tariq A. Bhat, Suresh G. Kalathil, Noel Leigh, Alan Hutson, Maciej L. Goniewicz, Yasmin M. Thanavala

Open Access Research

Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways

Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva Verjans

Open Access Research

Differential airway resistome and its correlations with clinical characteristics in Haemophilus- or Pseudomonas-predominant microbial subtypes of bronchiectasis

Xin-zhu Yi, Jun-hao Yang, Yan Huang, Xiao-rong Han, Hui-min Li, Lai-jian Cen, Zhen-hong Lin, Cui-xia Pan, Zhang Wang, Wei-jie Guan

Open Access Research

Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers

Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L. Curtis, Jennifer M. Wang, Rubén San José Estépar, Ivan O. Rosas, Jared R. Mayers, Brian D. Hobbs, Craig P. Hersh, Samuel Y. Ash, MeiLan K. Han, Russell P. Bowler, Kathleen A. Stringer, George R. Washko, Wassim W. Labaki

Open Access Correction

Correction to: Cigarette smoke exposed airway epithelial cells-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E Lascano, Xiao Qiang, Jesse R West, L Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly

Open Access Research

Human airway tuft cells influence the mucociliary clearance through cholinergic signalling

Monika I. Hollenhorst, Thomas Husnik, Malin Zylka, Nele Duda, Veit Flockerzi, Thomas Tschernig, Stephan Maxeiner, Gabriela Krasteva-Christ

Open Access Research

Trend and heterogeneity in forced vital capacity among Chinese students during 1985–2019: results from Chinese National Survey on Students’ Constitution and Health

Siying Zhang, Lihong Wu, Yumei Zhong, Meirou Shao, Zhiyi Wei, Wenfeng Dong, Aiping Zhu, Fang-biao Tao, Xiulong Wu

Open Access Research

Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice

Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y. W. Lam, Wupeng Liao, Yuansheng Yang, W. S. Fred Wong, Ruowen Ge

Open Access Research

[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload

Xiaohui Zeng, Ruiyue Zhao, Zhixiong Wu, Zhuoji Ma, Chunxian Cen, Shanshan Gao, Wanxian Hong, Yanrong Yao, Kexin Wen, Shangwei Ding, Jian Wang, Wenju Lu, Xinlu Wang, Tao Wang

Open Access Research

Differentiating interstitial lung diseases from other respiratory diseases using electronic nose technology

Iris G. van der Sar, Marlies S. Wijsenbeek, Gert-Jan Braunstahl, Jason O. Loekabino, Anne-Marie C. Dingemans, Johannes C. C. M. In ‘t Veen, Catharina C. Moor

Open Access Research

Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer

Niayesh Razi, Weizhong Li, Maxinne A. Ignacio, Jeffrey M. Loube, Eva L. Agostino, Xiaoping Zhu, Margaret A. Scull, Jeffrey J. DeStefano

Open Access Research

Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension

Valentine Mismetti, Xavier Delavenne, David Montani, Souad Bezzeghoud, Olivier Delezay, Sophie Hodin, David Launay, Sylvain Marchand-Adam, Hilario Nunes, Edouard Ollier, Martine Reynaud-Gaubert, Jean Pastre, Julie Traclet, Sébastien Quetant, Sabrina Zeghmar, Laurent Bertoletti, Vincent Cottin

Open Access Correspondence

Impact of psychiatric disorders on the hemodynamic and quality of life outcome of balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a retrospective study

Kazutoshi Hirose, Shun Minatsuki, Akihito Saito, Hiroki Yagi, Norifumi Takeda, Masaru Hatano, Issei Komuro

Open Access Correspondence

How often do healthy people cough?

Kimberley J. Holt, Jaclyn A. Smith

Open Access Research

Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression

Jie Zhou, Peiwei Li, Xiaogang Zhao, Yuanhao Zhao, Junwen Luo, Yupeng Deng, Ning Jiang, Zhaohua Xiao, Wenhao Zhang, Yongjia Zhou, Jiangfeng Zhao, Peichao Li, Yuliang Li, Zhongxian Tian

Open Access Research

Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer

Guangyao Shan, Guoshu Bi, Guangyin Zhao, Jiaqi Liang, Yunyi Bian, Huan Zhang, Xing Jin, Zhengyang Hu, Guangyu Yao, Hong Fan, Cheng Zhan

Open Access Review

The impact of SARS-CoV-2 infection in patients with cystic fibrosis undergoing CFTR channel modulators treatment: a literature review

Antonio Vitiello, Michela Sabbatucci, Andrea Silenzi, Annalisa Capuano, Francesco Rossi, Andrea Zovi, Francesco Blasi, Giovanni Rezza

Open Access Research

Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis

Theodoros Karampitsakos, Apostolos Galaris, Serafeim Chrysikos, Ourania Papaioannou, Ioannis Vamvakaris, Ilianna Barbayianni, Paraskevi Kanellopoulou, Sofia Grammenoudi, Nektarios Anagnostopoulos, Grigoris Stratakos, Matthaios Katsaras, Fotios Sampsonas, Katerina Dimakou, Effrosyni D. Manali, Spyridon Papiris, Bochra Tourki, Brenda M Juan-Guardela, Petros Bakakos, Demosthenes Bouros, Jose D Herazo-Maya, Vassilis Aidinis, Argyris Tzouvelekis

Open Access Research

Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis

Wei-Ching Huang, Chi-Fen Chuang, Yung-Tsang Huang, I-Che Chung, Mao-Lin Chen, Tung-Yueh Chuang, Xiu-Li Yang, Yu-Yau Chou, Chih-Hsin Liu, Nai-Yu Chen, Chun-Jen Chen, Ta-Tung Yuan

Open Access Research

COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Ellen Caroline Toledo do Nascimento, Jôse Mara de Brito, Leila Antonangelo, Caroline Silvério Faria, Jhonatas Sirino Monteiro, João Carlos Setubal, João Renato Rebello Pinho, Roberta Verciano Pereira, Marilia Seelaender, Gabriela Salim de Castro, Joanna D. C. C. Lima, Renata Aparecida de Almeida Monteiro, Amaro Nunes Duarte-Neto, Paulo Hilário Nascimento Saldiva, Luiz Fernando Ferraz da Silva, Marisa Dolhnikoff, Thais Mauad

Open Access Research

Cough and sputum in long COVID are associated with severe acute COVID-19: a Japanese cohort study

Mayuko Watase, Jun Miyata, Hideki Terai, Keeya Sunata, Emiko Matsuyama, Takanori Asakura, Ho Namkoong, Katsunori Masaki, Kazuma Yagi, Keiko Ohgino, Shotaro Chubachi, Ichiro Kawada, Takao Mochimaru, Ryosuke Satomi, Yoshitaka Oyamada, Keigo Kobayashi, Toshiyuki Hirano, Takashi Inoue, Ho Lee, Kai Sugihara, Nao Omori, Koichi Sayama, Shuko Mashimo, Yasushi Makino, Tatsuya Kaido, Makoto Ishii, Koichi Fukunaga

Open Access Research

Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper

Alvaro G. Moreira, Tanima Arora, Shreyas Arya, Caitlyn Winter, Charles T. Valadie, Przemko Kwinta

Open Access Research

Metagenomics for the microbiological diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia (HAP/VAP) in intensive care unit (ICU): a proof-of-concept study

Morgane Heitz, Albrice Levrat, Vladimir Lazarevic, Olivier Barraud, Stéphane Bland, Emmanuelle Santiago-Allexant, Karen Louis, Jacques Schrenzel, Sébastien Hauser

Open Access Research

Clinical nomogram assisting in discrimination of juvenile dermatomyositis-associated interstitial lung disease

Minfei Hu, Chencong Shen, Fei Zheng, Yun Zhou, Liping Teng, Rongjun Zheng, Bin Hu, Chaoying Wang, Meiping Lu, Xuefeng Xu

Open Access Research

Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis

Rachel Z. Blumhagen, Jonathan S. Kurche, Carlyne D. Cool, Avram D. Walts, David Heinz, Tasha E. Fingerlin, Ivana V. Yang, David A. Schwartz

Open Access Research

Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice

Jiang Yu, Boying Zhao, Qiangzhong Pi, Guoxiang Zhou, Zhe Cheng, Can Qu, Xiaowen Wang, Lingwen Kong, Suxin Luo, Dingyuan Du, Yongzheng Guo

Open Access Research

Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model

Congke Zhao, Xiangyang Le, Mengqi Li, Yuanbo Hu, Xiaohui Li, Zhuo Chen, Gaoyun Hu, Liqing Hu, Qianbin Li

Open Access Research

Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study

James D. Crapo, Abhya Gupta, David A. Lynch, Alice M. Turner, Robert M. Mroz, Wim Janssens, Andrea Ludwig-Sengpiel, Harald Koegler, Anastasia Eleftheraki, Frank Risse, Claudia Diefenbach

Open Access Research

The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study

Wanyang Lei, Mei Yang, Ziyu Yuan, Runlin Feng, Xiao Kuang, Zhiqiang Liu, Zongqi Deng, Xianglin Hu, Wenlin Tai

Open Access Research

Impact of sex differences on cardiac injury in critically ill patients with COVID-19

Mathieu Jozwiak, Denis Doyen, Pierre Denormandie, Antoine Goury, Jonathan Marey, Frédéric Pène, Alain Cariou, Jean-Paul Mira, Jean Dellamonica, Lee S. Nguyen

Open Access Research

Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands

Karin M. A. Swart, Brenda N. Baak, Louise Lemmens, Fernie J. A. Penning-van Beest, Camilla Bengtsson, Muriel Lobier, Fabian Hoti, Dina Vojinovic, Lindy van Burk, Kirsty Rhodes, Edeltraut Garbe, Ron M. C. Herings, Clementine Nordon, Sami O. Simons

Open Access Research

S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty

Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andréanne Côté, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou, Jamila Chakir

Open Access Review

Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target

Heena Kansal, Vishal Chopra, Kranti Garg, Siddharth Sharma

Open Access Review

Animal models of acute exacerbation of pulmonary fibrosis

Xu Ye, Mingrui Zhang, Huimin Gu, Mengying Liu, Yichao Zhao, Yanchen Shi, Shufei Wu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang, Mengshu Cao

Open Access Research

Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9

Wensi Zhu, Linxiao Han, Yuanyuan Wu, Lin Tong, Ludan He, Qin Wang, Yu Yan, Ting Pan, Jie Shen, Yuanlin Song, Yao Shen, Qiaoliang Zhu, Jian Zhou

Open Access Review

In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis

Fama Thiam, Sakshi Phogat, Filsan Ahmed Abokor, Emmanuel Twumasi Osei

Open Access Research

Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening

Bin Chen, Ziyi Liu, Jinjuan Lu, Zhihao Li, Kaiming Kuang, Jiancheng Yang, Zengmao Wang, Yingli Sun, Bo Du, Lin Qi, Ming Li

Open Access Research

METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway

Yi Lu, Zeyu Liu, Yunjiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang, Tao Ren

Open Access Research

CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD

Congping Li, Fei Chen, Liangfen Lin, Jiwei Li, Yamei Zheng, Qingyun Chen

Open Access Research

Prediction of the number of asthma patients using environmental factors based on deep learning algorithms

Hyemin Hwang, Jae-Hyuk Jang, Eunyoung Lee, Hae-Sim Park, Jae Young Lee

Open Access Research

Characterization and inhibition of inflammasome responses in severe and non-severe asthma

Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson

Open Access Research

PTK2-associated gene signature could predict the prognosis of IPF

Anlin Feng, Yesenia Moreno Caro, Colin Gardner, Garrett Grischo, Ying Liang, Praveen D. Wickremasinghe, Michaela Polmann, Mrinalini Kala, Timothy Marlowe, Stephen M. Black, Kenneth S. Knox, Ting Wang

Open Access Research

Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction

Shunwang Li, Xiangwu Ju, Qiang Liu, Yiwu Yan, Cong Zhang, Yuhao Qin, Xingyu Deng, Chang Li, Mingyao Tian, Yanli Zhang, Ningyi Jin, Chengyu Jiang

Open Access Research

Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation

Hyeon Hwa Kim, Ho Cheol Kim, Tae Sun Shim, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Geun Dong Lee, Dong Kwan Kim, Seung-Il Park, Sehoon Choi

Open Access Research

An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma

Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens

Open Access Research

Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function

Jungnam Lee, Naweed Mohammad, Yuanqing Lu, Regina Oshins, Alek Aranyos, Mark Brantly

Open Access Research

Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension

Lei Ma, Yanxia Wang, Xiaoqian Li, Zefang Wang, Bo Zhang, Ying Luo, Yousheng Wu, Zhichao Li, Wen Niu

Open Access Research

Deep learning prediction of hospital readmissions for asthma and COPD

Kevin Lopez, Huan Li, Zachary Lipkin-Moore, Shannon Kay, Haseena Rajeevan, J. Lucian Davis, F. Perry Wilson, Carolyn L. Rochester, Jose L. Gomez

Open Access Research

Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice

Lin Liu, Haiyang Fan, Liang Li, Yunping Fan

Open Access Research

Prognostic implications of obstructive sleep apnea in patients with acute coronary syndrome stratified by homocysteine level: a prospective cohort study

Xiuhuan Chen, Lei Zhen, Hui Ai, Bin Que, Jingyao Fan, Xiao Wang, Yan Yan, Siyi Li, Zekun Zhang, Yun Zhou, Wei Gong, Shaoping Nie

Open Access Research

CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid

Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson, Kevin K. Kim

Open Access Research

Genetic and observational associations of lung function with gastrointestinal tract diseases: pleiotropic and mendelian randomization analysis

Minghui Jiang, Xingjie Hao, Yi Jiang, Si Li, Chaolong Wang, Shanshan Cheng

Open Access Review

Treatable traits and challenges in the clinical management of non-tuberculous mycobacteria lung disease in people with cystic fibrosis

Andrea Gramegna, Sofia Misuraca, Andrea Lombardi, Chiara Premuda, Ivan Barone, Margherita Ori, Francesco Amati, Mariangela Retucci, Erica Nazzari, Gianfranco Alicandro, Maurizio Ferrarese, Luigi Codecasa, Alessandra Bandera, Stefano Aliberti, Valeria Daccò, Francesco Blasi

Open Access Research

Longitudinal microbial and molecular dynamics in the cystic fibrosis lung after Elexacaftor–Tezacaftor–Ivacaftor therapy

Christian Martin, Douglas V. Guzior, Cely T. Gonzalez, Maxwell Okros, Jenna Mielke, Lienwil Padillo, Gabriel Querido, Marissa Gil, Ryan Thomas, Marc McClelland, Doug Conrad, Stefanie Widder, Robert A. Quinn

Open Access Research

Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly

Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li, Ivan Rosas, Lan Wang, Guoying Yu

Open Access Research

Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang, Feng Li

Open Access Research

Bronchoalveolar cytokine profile differentiates Pulmonary Langerhans cell histiocytosis patients from other smoking-related interstitial lung diseases

Silvia Barril, Paloma Acebo, Paloma Millan-Billi, Alfonso Luque, Oriol Sibila, Carlos Tarín, Abdellatif Tazi, Diego Castillo, Sonsoles Hortelano

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Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

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25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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