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Archives of Gynecology and Obstetrics

Erschienen in:

01.05.2010 | Gynecologic Oncology

Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery

verfasst von: Won Joon Seong, Douk Hun Yoon, Gun Oh Chong, Dae Gy Hong, Tae Bon Koo, Taek Hoo Lee, Sang Sik Chun

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2010

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Abstract

Purpose

To evaluate cord blood amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels according to the mode of delivery.

Method

Between 1 March and 31 May 2007, 106 blood samples were drawn from the umbilical vein at the time of delivery. Eighty-four NT-proBNP levels [63 term (34 cesarean sections and 29 vaginal deliveries) and 21 preterm births] were analyzed with respect to gestational age, birth weight, Apgar score, newborn gender, and cord blood pH.

Results

There was no statistical significance on comparison of the mean NT-proBNP values between the cesarean and vaginal delivery groups (801.9 ± 537.7 vs. 724.3 ± 542.4 pg/ml, respectively; P = 0.572). The correlation of NT-proBNP with gestational age, birth weight, and cord blood pH was −0.616, −0.585, and −0.202, respectively. The mean values for NT-proBNP levels were compared according to the newborn gender (male vs. female; P = 0.926), and Apgar score at 1 min [>6 (N = 71) vs. ≤6 (N = 13); P = 0.001].

Conclusion

Vaginal delivery did not result in increased cord blood NT-proBNP levels reflecting cardiovascular stress to the fetal heart. NT-proBNP was inversely correlated with gestational age. Low Apgar score and umbilical cord blood pH appeared to induce the fetus to produce increased amounts of NT-proBNP.

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Titel: Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery
verfasst von: Won Joon Seong
Douk Hun Yoon
Gun Oh Chong
Dae Gy Hong
Tae Bon Koo
Taek Hoo Lee
Sang Sik Chun
Publikationsdatum: 01.05.2010
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 5/2010
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-009-1253-3

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Umbilical cord blood amino-terminal pro-brain natriuretic peptide levels according to the mode of delivery