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Erschienen in:
01.03.2012 | Case report
Unexpected doxorubicin-induced cardiomyopathy in sisters
Erschienen in: International Cancer Conference Journal | Ausgabe 1/2012
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We report the details of two unexpected cases of doxorubicin (DOX)-induced cardiac toxicity in two sisters receiving adjuvant breast cancer therapy. One at age 38 developed a cardiomyopathy resulting in cardiac transplantation 6.5 years after receiving a relatively low total dose of DOX, i.e., 280 mg/m2. The second at age 60 also developed a severe cardiomyopathy (i.e., a ventricular ejection fraction of 22%) 6 years after receiving a total dose of DOX of only 158 mg/m2. Twelve single nucleotide polymorphisms previously associated with doxorubicin cardiotoxicity were assessed by pyrosequencing. None of the genotypes associated with an increased risk of doxorubicin-induced cardiotoxicity were identified in these two patients.