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Current Reviews in Musculoskeletal Medicine
Erschienen in: Current Reviews in Musculoskeletal Medicine 3/2014

01.09.2014 | Knee: Stem Cells (M Ferretti, Section Editor)

Updates in biological therapies for knee injuries: bone

verfasst von: Mauricio Kfuri Jr., Rafael Lara de Freitas, Bruno Bellaguarda Batista, Rodrigo Salim, Marcello Teixeira Castiglia, Ricardo Antonio Tavares, Paulo Henrique Araújo

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2014

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Abstract

Bone is a unique tissue because of its mechanical properties, ability for self-repair, and enrollment in different metabolic processes such as calcium homeostasis and hematopoietic cell production. Bone barely tolerates deformation and tends to fail when overloaded. Fracture healing is a complex process that in particular cases is impaired. Osteoprogenitor cells proliferation, growth factors, and a sound tridimensional scaffold at fracture site are key elements for new bone formation and deposition. Mechanical stability and ample vascularity are also of great importance on providing a proper environment for bone healing. From mesenchymal stem cells delivery to custom-made synthetic scaffolds, many are the biological attempts to enhance bone healing. Impaired fracture healing represents a real burden to contemporary society. Sound basic science knowledge has contributed to newer approaches aimed to accelerate and improve the quality of bone healing.
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Metadaten
Titel
Updates in biological therapies for knee injuries: bone
verfasst von
Mauricio Kfuri Jr.
Rafael Lara de Freitas
Bruno Bellaguarda Batista
Rodrigo Salim
Marcello Teixeira Castiglia
Ricardo Antonio Tavares
Paulo Henrique Araújo
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2014
Elektronische ISSN: 1935-9748
DOI
https://doi.org/10.1007/s12178-014-9225-z

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