nach oben

The International Journal of Cardiovascular Imaging

Erschienen in:

27.11.2020 | Original Paper

Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemotherapy for colorectal cancer

verfasst von: Zhen Wang, Wenjuan Qin, Zijing Zhai, Lei Huang, Jia Feng, Xueting Guo, Kuican Liu, Caiyun Zhang, Zhong Wang, Guilin Lu, Shanshan Dong

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

To evaluate the changes in left ventricular myocardial function in patients with colorectal cancer undergoing chemotherapy with mFOLFOX6 (oxaliplatin + 5-fluorouracil + calcium folinate) using three-dimensional speckle-tracking echocardiography (3D-STE). Data were collected from 30 patients diagnosed with colorectal cancer in our hospital treated with mFOLFOX6. We used 3D-STE to measure the following parameters of left ventricle function: global longitudinal strain (GLS), global area strain (GAS), global circumferential strain (GCS), global radial strain (GRS), and left ventricular twist (LVtw). Myocardial composite index (MCI) was calculated from measured values (MCI = GLS × LVtw). The above listed parameters were compared before and after chemotherapy. Receiver operating curves (ROC) were prepared for each parameter and analyzed to identify correlations among MCI, LVEF, GLS, and cTnT. Compared with the pre-chemotherapy state, the absolute values of MCI, LVtw, GLS, GAS, GCS, and GRS decreased with increasing cumulative doses of chemotherapeutic drugs. The absolute values of GAS, GLS, MCI, and LVtw decreased after the first cycle of chemotherapy (P < 0.05). The areas under the ROC curves for MCI and GLS were 0.903 and 0.838, respectively. The correlation observed between MCI and cTnT (r = − 0.7228) was found to be stronger than that between GLS and cTnT (r = − 0.6008). In conclusion, 3D-STE may help detect early changes in left ventricular myocardial function caused by mFOLFOX6 treatment in patients with colorectal cancer. MCI is a relatively sensitive index among the various measurable parameters.

Graphic abstract

Nur mit Berechtigung zugänglich

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB (2019) Colorectal cancer. Lancet (London, England) 394(10207):1467–1480. https://doi.org/10.1016/s0140-6736(19)32319-0CrossRef

Wolf AMD, Fontham ETH, Church TR, Flowers CR, Guerra CE, LaMonte SJ, Etzioni R, McKenna MT, Oeffinger KC, Shih YT, Walter LC, Andrews KS, Brawley OW, Brooks D, Fedewa SA, Manassaram-Baptiste D, Siegel RL, Wender RC, Smith RA (2018) Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA: Cancer J Clin 68(4):250–281. https://doi.org/10.3322/caac.21457CrossRef

Kasi PM, Shahjehan F, Cochuyt JJ, Li Z, Colibaseanu DT, Merchea A (2019) Rising proportion of young individuals with rectal and colon cancer. Clin Colorectal Cancer 18(1):e87–e95. https://doi.org/10.1016/j.clcc.2018.10.002CrossRefPubMed

André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, Bonetti A, Clingan P, Bridgewater J, Rivera F, de Gramont A (2009) Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J ClinOncol 27(19):3109–3116. https://doi.org/10.1200/jco.2008.20.6771CrossRef

Joy G, Eissa H, Al Karoudi R, White SK (2019) Fluorouracil-induced Takotsubo cardiomyopathy causing cardiogenic shock: a case report of clinical and acute cardiac magnetic resonance imaging features. Eur Heart J Case Rep 3(4):1–6. https://doi.org/10.1093/ehjcr/ytz146CrossRefPubMedPubMedCentral

Redman JM, Rhea LP, Brofferio A, Whelpley M, Gulley JL, Gatti-Mays ME, McMahon S, Cordes LM, Strauss J (2019) Successful 5-fluorouracil (5-FU) infusion re-challenge in a metastatic colorectal cancer patient with coronary artery disease who experienced symptoms consistent with coronary vasospasm during first 5-FU infusion. J GastrointestOncol 10(5):1010–1014. https://doi.org/10.21037/jgo.2019.07.04CrossRef

Dyhl-Polk A, Vaage-Nilsen M, Schou M, Vistisen KK, Lund CM, Kümler T, Appel JM, Nielsen DL (2020) Incidence and risk markers of 5-fluorouracil and capecitabinecardiotoxicity in patients with colorectal cancer. ActaOncol (Stockholm, Sweden) 59(4):475–483. https://doi.org/10.1080/0284186x.2019.1711164CrossRef

Polk A, Shahmarvand N, Vistisen K, Vaage-Nilsen M, Larsen FO, Schou M, Nielsen DL (2016) Incidence and risk factors for capecitabine-induced symptomatic cardiotoxicity: a retrospective study of 452 consecutive patients with metastatic breast cancer. BMJ Open 6(10):e012798. https://doi.org/10.1136/bmjopen-2016-012798CrossRefPubMedPubMedCentral

Labianca R, Beretta G, Clerici M, Fraschini P, Luporini G (1982) Cardiac toxicity of 5-fluorouracil: a study on 1083 patients. Tumori 68(6):505–510CrossRef

10.

Meyer CC, Calis KA, Burke LB, Walawander CA, Grasela TH (1997) Symptomatic cardiotoxicity associated with 5-fluorouracil. Pharmacotherapy 17(4):729–736PubMed

11.

Ray JC, Cho P, Dragon M, Graham CG (2016) A case of 5-fluorouracil-induced cardiac arrest. J Emerg Med 50(1):e1-6. https://doi.org/10.1016/j.jemermed.2015.09.001CrossRefPubMed

12.

McDonald JP, MacNamara JP, Zaha VG (2019) Challenges in implementing optimal echocardiographic screening in cardio-oncology. Curr Treat Options Cardiovasc Med 21(8):39. https://doi.org/10.1007/s11936-019-0740-5CrossRefPubMed

13.

He J, Yang L (2019) Value of three-dimensional speckle-tracking imaging in detecting left ventricular systolic function in patients with dilated cardiomyopathy. Echocardiography (Mount Kisco, NY) 36(8):1492–1495. https://doi.org/10.1111/echo.14427CrossRef

14.

Reant P, Barbot L, Touche C, Dijos M, Arsac F, Pillois X, Landelle M, Roudaut R, Lafitte S (2012) Evaluation of global left ventricular systolic function using three-dimensional echocardiography speckle-tracking strain parameters. J Am SocEchocardiogr 25(1):68–79. https://doi.org/10.1016/j.echo.2011.10.009CrossRef

15.

Mornoş C, Petrescu L (2013) Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist. Can J PhysiolPharmacol 91(8):601–607. https://doi.org/10.1139/cjpp-2012-0398CrossRef

16.

Shiga T, Hiraide M (2020) Cardiotoxicities of 5-fluorouracil and other fluoropyrimidines. Curr Treat Options Oncol 21(4):27. https://doi.org/10.1007/s11864-020-0719-1CrossRefPubMedPubMedCentral

17.

Südhoff T, Enderle MD, Pahlke M, Petz C, Teschendorf C, Graeven U, Schmiegel W (2004) 5-Fluorouracil induces arterial vasocontractions. Ann Oncol 15(4):661–664. https://doi.org/10.1093/annonc/mdh150CrossRefPubMed

18.

Jensen SA, Sørensen JB (2012) 5-Fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicity. Cancer ChemotherPharmacol 69(1):57–64. https://doi.org/10.1007/s00280-011-1669-xCrossRef

19.

Polk A, Vaage-Nilsen M, Vistisen K, Nielsen DL (2013) Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors. Cancer Treat Rev 39(8):974–984. https://doi.org/10.1016/j.ctrv.2013.03.005CrossRefPubMed

20.

Jin X, Bai Y, Gao L, Wu S (2019) Incidence of and risk factors for cardiotoxicity after fluorouracil-based chemotherapy in locally advanced or metastatic gastric cancer patients. Cancer ChemotherPharmacol 84(3):599–607. https://doi.org/10.1007/s00280-019-03888-1CrossRef

21.

Lestuzzi C, Vaccher E, Talamini R, Lleshi A, Meneguzzo N, Viel E, Scalone S, Tartuferi L, Buonadonna A, Ejiofor L, Schmoll HJ (2014) Effort myocardial ischemia during chemotherapy with 5-fluorouracil: an underestimated risk. Ann Oncol 25(5):1059–1064. https://doi.org/10.1093/annonc/mdu055CrossRefPubMed

22.

Bergamini C, Dolci G, Truong S, Zanolla L, Benfari G, Fiorio E, Rossi A, Ribichini FL (2019) Role of speckle tracking echocardiography in the evaluation of breast cancer patients undergoing chemotherapy: review and meta-analysis of the literature. CardiovascToxicol 19(6):485–492. https://doi.org/10.1007/s12012-019-09523-yCrossRef

23.

Yanagimoto K, Okamoto Y, Kodama Y, Nishikawa T, Tanabe T, Kawano Y (2017) Decrease of cardiac base rotation in 2D speckle tracking indicates drug-induced cardiomyopathy after chemotherapy in children with cancer. J PediatrHematolOncol 39(1):10–14. https://doi.org/10.1097/mph.0000000000000683CrossRef

24.

Muraru D, Niero A, Rodriguez-Zanella H, Cherata D, Badano L (2018) Three-dimensional speckle-tracking echocardiography: benefits and limitations of integrating myocardial mechanics with three-dimensional imaging. CardiovascDiagnTher 8(1):101–117. https://doi.org/10.21037/cdt.2017.06.01CrossRef

25.

Coutinho Cruz M, MouraBranco L, Portugal G, Galrinho A, Timóteo AT, Rio P, Ilhão Moreira R, Mendonça T, Leal A, Gameiro F, Duarte Oliveira S, Luz R, Cruz Ferreira R (2020) Three-dimensional speckle-tracking echocardiography for the global and regional assessments of left ventricle myocardial deformation in breast cancer patients treated with anthracyclines. Clin Res Cardiol 109(6):673–684. https://doi.org/10.1007/s00392-019-01556-1CrossRefPubMed

26.

Chen J, Wang L, Wu FF, Sun G (2019) Early detection of cardiotoxicity by 3D speckle tracking imaging of area strain in breast cancer patients receiving chemotherapy. Echocardiography (Mount Kisco, NY) 36(9):1682–1688. https://doi.org/10.1111/echo.14467CrossRef

27.

Potter E, Marwick TH (2018) Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging 11(2 Pt 1):260–274. https://doi.org/10.1016/j.jcmg.2017.11.017CrossRefPubMed

28.

Ong G, Yan AT, Connelly KA (2019) Clinical application of echocardiographic-derived myocardial strain imaging in subclinical disease: a primer for cardiologists. CurrOpinCardiol 34(2):147–155. https://doi.org/10.1097/hco.0000000000000592CrossRef

29.

Neilan TG, Jassal DS, Perez-Sanz TM, Raher MJ, Pradhan AD, Buys ES, Ichinose F, Bayne DB, Halpern EF, Weyman AE, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M (2006) Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury. Eur Heart J 27(15):1868–1875. https://doi.org/10.1093/eurheartj/ehl013CrossRefPubMed

30.

Kosmas C, Kallistratos MS, Kopterides P, Syrios J, Skopelitis H, Mylonakis N, Karabelis A, Tsavaris N (2008) Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study. J Cancer Res ClinOncol 134(1):75–82. https://doi.org/10.1007/s00432-007-0250-9CrossRef

31.

Chong JH, Ghosh AK (2019) Coronary artery vasospasm induced by 5-fluorouracil: proposed mechanisms, existing management options and future directions. IntervCardiol (London, England) 14(2):89–94. https://doi.org/10.15420/icr.2019.12CrossRef

32.

Kim SM, Kwak CH, Lee B, Kim SB, Sir JJ, Cho WH, Choi SK (2012) A case of severe coronary spasm associated with 5-fluorouracil chemotherapy. Korean J Intern Med 27(3):342–345. https://doi.org/10.3904/kjim.2012.27.3.342CrossRefPubMedPubMedCentral

33.

Buckberg G, Hoffman JI, Mahajan A, Saleh S, Coghlan C (2008) Cardiac mechanics revisited: the relationship of cardiac architecture to ventricular function. Circulation 118(24):2571–2587. https://doi.org/10.1161/circulationaha.107.754424CrossRefPubMed

34.

Seo Y, Ishizu T, Enomoto Y, Sugimori H, Aonuma K (2011) Endocardial surface area tracking for assessment of regional LV wall deformation with 3D speckle tracking imaging. JACC Cardiovasc Imaging 4(4):358–365. https://doi.org/10.1016/j.jcmg.2010.12.007CrossRefPubMed

35.

Li SN, Wong SJ, Cheung YF (2011) Novel area strain based on three-dimensional wall motion analysis for assessment of global left ventricular performance after repair of tetralogy of Fallot. J Am SocEchocardiogr 24(8):819–825. https://doi.org/10.1016/j.echo.2011.03.020CrossRef

36.

Sengupta PP, Krishnamoorthy VK, Korinek J, Narula J, Vannan MA, Lester SJ, Tajik JA, Seward JB, Khandheria BK, Belohlavek M (2007) Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging. J Am SocEchocardiogr 20(5):539–551. https://doi.org/10.1016/j.echo.2006.10.013CrossRef

37.

Pokharel P, Yoon AJ, Bella JN (2014) Noninvasive measurement and clinical relevance of myocardial twist and torsion. Expert Rev CardiovascTher 12(11):1305–1315. https://doi.org/10.1586/14779072.2014.970179CrossRef

38.

Mehta L, Watson K, Barac A, Beckie T, Bittner V, Cruz-Flores S, Dent S, Kondapalli L, Ky B, Okwuosa T, Piña I, Volgman A (2018) Cardiovascular disease and breast cancer: where these entities intersect: a scientific statement from the American Heart Association. Circulation 137(8):e30–e66CrossRef

39.

Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z (2004) Two-dimensional strain—a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr 17(10):1021–1029. https://doi.org/10.1016/j.echo.2004.06.019CrossRef

Titel: Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemotherapy for colorectal cancer
verfasst von: Zhen Wang
Wenjuan Qin
Zijing Zhai
Lei Huang
Jia Feng
Xueting Guo
Kuican Liu
Caiyun Zhang
Zhong Wang
Guilin Lu
Shanshan Dong
Publikationsdatum: 27.11.2020
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 4/2021
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-020-02103-0

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

21.05.2024 TAVI Nachrichten

Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemotherapy for colorectal cancer

Abstract

Graphic abstract

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

Update Kardiologie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Graphic abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2021

Multiclass machine learning vs. conventional calculators for stroke/CVD risk assessment using carotid plaque predictors with coronary angiography scores as gold standard: a 500 participants study

Prognostic importance of coincidental coronary artery calcification on FDG-PET/CT oncology studies

Accuracy of global and regional longitudinal strain at peak of dobutamine stress echocardiography to detect significant coronary artery disease

Diagnosis of patent foramen ovale using maximum intensity T-projection imaging

Imaging in COVID-19-related myocardial injury

The cardiovascular determinants of physical function in patients with end-stage kidney disease on haemodialysis

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

Update Kardiologie