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01.11.2005 | Original Article

Usefulness of serum mast cell–specific chymase levels for postmortem diagnosis of anaphylaxis

verfasst von: Hajime Nishio, Shinji Takai, Mizuo Miyazaki, Hidekazu Horiuchi, Motoki Osawa, Koichi Uemura, Ken-ichi Yoshida, Masahiro Mukaida, Yasuhiro Ueno, Koichi Suzuki

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2005

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Abstract

Chymase, a serine protease, is stored mainly in secretory granules of human mast cells. Serum chymase concentration was examined in 8 autopsy cases with anaphylaxis as well as in 104 control cases without anaphylaxis. It was detected in all 8 cases with anaphylaxis (range 3–380 ng/ml, mean 89.8 ng/ml), while it was detected in only 2 of the 104 controls and was below a detectable level (<3 ng/ml) in the other 102. Serum tryptase levels are known to be a diagnostic indicator of anaphylaxis, therefore the relationship between serum chymase and tryptase levels was investigated in the 8 cases of anaphylactic death; a significant positive correlation was found (r=0.826, p=0.011). Furthermore, chymase was shown to be quite stable in serum. These results showed that measurement of serum chymase levels might be an additional tool for postmortem diagnosis of anaphylaxis.

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Titel: Usefulness of serum mast cell–specific chymase levels for postmortem diagnosis of anaphylaxis
verfasst von: Hajime Nishio
Shinji Takai
Mizuo Miyazaki
Hidekazu Horiuchi
Motoki Osawa
Koichi Uemura
Ken-ichi Yoshida
Masahiro Mukaida
Yasuhiro Ueno
Koichi Suzuki
Publikationsdatum: 01.11.2005
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 6/2005
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-005-0524-1

Springer Medizin

Usefulness of serum mast cell–specific chymase levels for postmortem diagnosis of anaphylaxis

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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