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Angiogenesis

Erschienen in:

01.06.2007 | Original Paper

Vascular permeability in ocular disease and the role of tight junctions

verfasst von: Kathryn K. Erickson, Jeffrey M. Sundstrom, David A. Antonetti

Erschienen in: Angiogenesis | Ausgabe 2/2007

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Abstract

Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.

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Titel: Vascular permeability in ocular disease and the role of tight junctions
verfasst von: Kathryn K. Erickson
Jeffrey M. Sundstrom
David A. Antonetti
Publikationsdatum: 01.06.2007
Verlag: Kluwer Academic Publishers
Erschienen in: Angiogenesis / Ausgabe 2/2007
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-007-9067-z

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