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Journal of Natural Medicines

Erschienen in:

01.01.2013 | Note

Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery

verfasst von: Kazumasa Zaima, Jun Deguchi, Yosuke Matsuno, Toshio Kaneda, Yusuke Hirasawa, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2013

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Abstract

A cyclic depsipeptide, FR900359, isolated from Ardisia crenata was evaluated for vasorelaxant effects on rat aortic arteries. FR900359 caused concentration-dependent relaxation (1 nM–10 μM) in phenylephrine-precontracted endothelium-intact aortic rings, which was inhibited by addition of l-NMMA, a NOS inhibitor. In endothelium-denuded rings, the relaxant effect of low concentrations of FR900359 was diminished, but remained at high concentrations. In endothelium-denuded rings, FR900359 at 0.1 μM significantly attenuated high-K⁺-induced contractions and completely inhibited Ca²⁺-induced contractions. These results suggest that the vasorelaxant effect of FR900359 is mediated through the increased release of NO from endothelial cells at low concentrations, and can be attributed to inhibitory effects on voltage-dependent Ca²⁺ channel- and receptor-operated Ca²⁺ channel-dependent Ca²⁺ influx at high concentrations.

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Titel: Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery
verfasst von: Kazumasa Zaima
Jun Deguchi
Yosuke Matsuno
Toshio Kaneda
Yusuke Hirasawa
Hiroshi Morita
Publikationsdatum: 01.01.2013
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2013
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-012-0644-0

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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