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Pediatric Nephrology

Erschienen in:

01.09.2011 | Review

Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect

verfasst von: Inga J. Murawski, Christine L. Watt, Indra R. Gupta

Erschienen in: Pediatric Nephrology | Ausgabe 9/2011

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Abstract

Vesico-ureteric reflux (VUR) is a common congenital urinary tract defect in which urine flows retrogradely from the bladder to the kidneys because of an abnormally formed uretero-vesical junction. It is associated with recurrent urinary tract infections, renal hypo/dysplasia, reflux nephropathy, hypertension, and end-stage renal disease. In humans, VUR is genetically and phenotypically heterogeneous, encompassing diverse renal and urinary tract phenotypes. To understand the significance of these phenotypes, we and others have used the mouse as a model organism and this has led to the identification of new candidate genes. Through careful phenotypic analysis of these models, a new understanding of the genetics and biology of VUR is now underway.

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Titel: Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect
verfasst von: Inga J. Murawski
Christine L. Watt
Indra R. Gupta
Publikationsdatum: 01.09.2011
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 9/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1821-1

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Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect

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