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01.04.2006 | Research Article

Visuo-motor pathways in humans revealed by event-related fMRI

verfasst von: Roberto Martuzzi, Micah M. Murray, Philippe P. Maeder, Eleonora Fornari, Jean- Philippe Thiran, Stephanie Clarke, Christoph M. Michel, Reto A. Meuli

Erschienen in: Experimental Brain Research | Ausgabe 4/2006

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Abstract

Whether different brain networks are involved in generating unimanual responses to a simple visual stimulus presented in the ipsilateral versus contralateral hemifield remains a controversial issue. Visuo-motor routing was investigated with event-related functional magnetic resonance imaging (fMRI) using the Poffenberger reaction time task. A 2 hemifield × 2 response hand design generated the “crossed” and “uncrossed” conditions, describing the spatial relation between these factors. Both conditions, with responses executed by the left or right hand, showed a similar spatial pattern of activated areas, including striate and extrastriate areas bilaterally, SMA, and M1 contralateral to the responding hand. These results demonstrated that visual information is processed bilaterally in striate and extrastriate visual areas, even in the “uncrossed” condition. Additional analyses based on sorting data according to subjects’ reaction times revealed differential crossed versus uncrossed activity only for the slowest trials, with response strength in infero-temporal cortices significantly correlating with crossed–uncrossed differences (CUD) in reaction times. Collectively, the data favor a parallel, distributed model of brain activation. The presence of interhemispheric interactions and its consequent bilateral activity is not determined by the crossed anatomic projections of the primary visual and motor pathways. Distinct visuo-motor networks need not be engaged to mediate behavioral responses for the crossed visual field/response hand condition. While anatomical connectivity heavily influences the spatial pattern of activated visuo-motor pathways, behavioral and functional parameters appear to also affect the strength and dynamics of responses within these pathways.

We have partially addressed this issue in a separate pilot study examining simple reaction times to visual, auditory, or simultaneous auditory-visual multisensory pairs. The same subjects first responded with a single finger and several weeks later were re-tested using the piano roll movement used in the present study (both the experiments were conducted within the MR scanner environment). The same pattern of reaction times was observed for both types of motor response, except that the reaction time distribution was simply shifted later in the case of the piano roll

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Titel: Visuo-motor pathways in humans revealed by event-related fMRI
verfasst von: Roberto Martuzzi
Micah M. Murray
Philippe P. Maeder
Eleonora Fornari
Jean- Philippe Thiran
Stephanie Clarke
Christoph M. Michel
Reto A. Meuli
Publikationsdatum: 01.04.2006
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 4/2006
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-005-0232-6

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