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01.12.2011 | Original Article

Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients

verfasst von: Dilek Gogas Yavuz, Lezan Keskin, Sinem Kıyıcı, Murat Sert, Dilek Yazıcı, İbrahim Şahin, Meral Yüksel, Oğuzhan Deyneli, Hasan Aydın, Ercan Tuncel, Sema Akalın

Erschienen in: Acta Diabetologica | Ausgabe 4/2011

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Abstract

Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 ± 7.3 y duration of diabetes 8.1 ± 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 ± 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 ± 0.2 g/cm² vs. 0.97 ± 0.2 g/cm² (P = 0.0001) for the femur, 1.0 ± 0.1 g/cm² vs. 1.13 ± 0.1 g/cm² (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.

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Titel: Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients
verfasst von: Dilek Gogas Yavuz
Lezan Keskin
Sinem Kıyıcı
Murat Sert
Dilek Yazıcı
İbrahim Şahin
Meral Yüksel
Oğuzhan Deyneli
Hasan Aydın
Ercan Tuncel
Sema Akalın
Publikationsdatum: 01.12.2011
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 4/2011
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-011-0284-y

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