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Graefe's Archive for Clinical and Experimental Ophthalmology

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19.07.2019 | Retinal Disorders

Vitreo-macular interface disorders in retinitis pigmentosa

verfasst von: Serena Fragiotta, Tommaso Rossi, Carmela Carnevale, Alessandro Cutini, Stefano Tricarico, Lorenzo Casillo, Gianluca Scuderi, Enzo Maria Vingolo

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2019

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Abstract

Purpose

To investigate the prevalence and progression of vitreo-macular interface disorders (VMID) phenotypes and their natural history in retinitis pigmentosa (RP).

Methods

A total of 257 eyes of 145 RP patients with VMID were retrospectively evaluated. Patients were divided according to the VMID subtypes into epiretinal membranes (ERMs), vitreo-macular traction (VMT) group, and macular hole (MH). Serial eye-tracked spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA) changes were analyzed for a mean follow-up of 36.95 months. The status of posterior vitreous cortex was also considered. A control group of 65 eyes belonging to 65 RP patients with no macular changes was also recruited.

Results

VMID and control groups had the same baseline BCVA (0.50 vs 0.44 LogMAR) and did not differ in terms of phakic status. Different VMID groups had similar BCVA at baseline (p = 0.98). ERM represented the most prevalent disorder (207/257 eyes, 80.5%), followed by 35/257 (13.6%) VMT, and 15/257 Lamellar MH (LMH) eyes (5.8%). There were no cases of full thickness MH. Throughout the 36.9 months of follow-up, BCVA decreased an average 0.09 LogMAR from 0.31 to 0.4 in VMID patients and 0.01 in controls. VMID subgroup analysis showed a significant BCVA decrease in ERM patients (− 20.29%, p < 0.001), while VMT and LMH did not change significantly. Foveal thickness also remained stable over time. Complete PVD was present in 11 eyes in ERM, VMT, and LMH.

Conclusions

Our study confirms the high prevalence of VMID in RP patients; however, only ERMs determined a significant loss of vision over 24 months. The high prevalence of VMID in RP patients suggests that macular alteration other than edema represents part of disease spectrum.

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Titel: Vitreo-macular interface disorders in retinitis pigmentosa
verfasst von: Serena Fragiotta
Tommaso Rossi
Carmela Carnevale
Alessandro Cutini
Stefano Tricarico
Lorenzo Casillo
Gianluca Scuderi
Enzo Maria Vingolo
Publikationsdatum: 19.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04418-8

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Vitreo-macular interface disorders in retinitis pigmentosa

Abstract

Purpose

Methods

Results

Conclusions

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