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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.12.2013 | Retinal Disorders

Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy

verfasst von: Tomoaki Shiba, Hideaki Bujo, Mao Takahashi, Yukihiro Sato, Meizi Jiang, Yuichi Hori, Takatoshi Maeno, Kohji Shirai

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 12/2013

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Abstract

Background

To evaluate the vitreous fluid levels of soluble LR11 (sLR11), a novel circulating marker for proliferative diabetic retinopathy (PDR), in patients with PDR and non-PDR (NPDR) in comparison to those in patients with non-diabetic ocular diseases.

Method

Twenty NPDR and 60 PDR cases were included. Twenty-four subjects with a macular hole were served as a control group. The sLR11 levels of vitreous fluid and serum were determined by sandwich enzyme-linked immunosorbent assay.

Results

The serum sLR11 levels in the PDR and NPDR groups were 12.3 ± 5.0 ng/ml and 10.0 ± 2.7 ng/ml, respectively. The sLR11 levels in the vitreous fluid in the PDR (17.8 ± 6.2 ng/ml) and NPDR (17.4 ± 7.1 ng/ml) groups were significantly higher than those in the control subjects (12.3 ± 4.5 ng /ml) (P = 0.0003 and P = 0.006, respectively). The vitreous fluid levels of sLR11 were not significantly different between the PDR and NPDR groups, and the levels were not significantly correlated with the serum levels of sLR11 in the patients with PDR or NPDR.

Conclusion

Vitreous fluid sLR11 level may be a novel risk factor for the early development of PDR prior to the increase in circulating levels in diabetic patients.

Bujo H, Saito Y (2006) Modulation of smooth muscle cell migration by members of the low-density lipoprotein receptor family. Arterioscler Thromb Vasc Biol 26:1246–1252PubMedCrossRef

Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI (2007) Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res 100:381–390PubMedCrossRef

Takahashi M, Bujo H, Jiang M, Noike H, Saito Y, Shirai K (2010) Enhanced circulating soluble LR11 in patients with coronary organic stenosis. Atherosclerosis 210:581–584PubMedCrossRef

Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, Shibasaki M, Azuma K, Harigaya K, Schneider WJ, Saito Y (2008) AngII-stimulated migration of vascular SMC is dependent on LR11. J Clin Invest 118:2733–2746PubMedCentralPubMed

Henricsson M, Nilsson A, Heijl A, Janzon L, Groop L (1997) Mortality in diabetic patients participating in an ophthalmological control and screening programme. Diabet Med 14:576–583PubMedCrossRef

Klein R, Klein BE, Moss SE, Cruickshanks KJ (1999) Association of ocular disease and mortality in a diabetic population. Arch Ophthalmol 117:1487–1495PubMedCrossRef

Rajala U, Koskela P, Pajumppaa H, Keinanen-Kiukaannieemi S (2000) High cardiovascular disease mortality in subjects with visual impairment caused by diabetic retinopathy. Diabetes Care 23:957–961PubMedCrossRef

Sundell J, Janatuinen T, Rönnemaa T, Raitakari OT, Toikka J, Nuutila P, Knuuti J (2004) Diabetic background retinopathy is associated with impaired coronary vasoreactivity on people with type 1 diabetes. Diabetologia 47:725–731PubMedCrossRef

Ohno T, Takamoto S, Motomura N, Ono M, Ando J, Morita T, Fujita H, Hirata Y, Nagai R, Shigeeda T, Hirose A (2007) Coronary artery by-pass grafting versus coronary implantation of sirolimus-eluting stents in patients with diabetic retinopathy. Ann Thorax Surg 84:1474–1478CrossRef

10.

Ohno T, Takamoto S, Motomura N (2008) Diabetic retinopathy and coronary artery disease from the cardiac surgeon’s perspective. Ann Thorax Surg 85:681–689CrossRef

11.

Takahashi M, Bujo H, Shiba T, Jiang M, Maeno T, Shirai K (2012) Enhanced circulating soluble lr11 in patients with diabetic retinopathy. Am J Ophthalmol 154:187–192PubMedCrossRef

12.

Matsuo M, Ebinuma H, Fukamachi I, Jiang M, Bujo H, Saito Y (2009) Development of an immunoassay for the quantification of soluble LR11, a circulating marker of atherosclerosis. Clin Chem 55:1801–1808PubMedCrossRef

13.

Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT, Global Diabetic Retinopathy Project Group (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110:1677–1682PubMedCrossRef

14.

Imai E, Horio M, Nitta K, Yamagata K, Iseki K, Hara S, Ura N, Kiyohara Y, Hirakata H, Watanabe T, Moriyama T, Ando Y, Inaguma D, Narita I, Iso H, Wakai K, Yasuda Y, Tsukamoto Y, Ito S, Makino H, Hishida A, Matsuo S (2007) Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease. Clin Exp Nephrol 11:41–50PubMedCrossRef

15.

Miida T, Takahashi A, Ikeuchi T (2007) Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects. Pharmacol Ther 113:378–393PubMedCrossRef

16.

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39:168–177PubMedCentralPubMedCrossRef

17.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE (2005) Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci USA 102:13461–13466PubMedCentralPubMedCrossRef

18.

Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ (2006) The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 26:1596–1603PubMedCentralPubMedCrossRef

19.

Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ (2004) Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 61:1200–1205PubMed

20.

Ikeuchi T, Hirayama S, Miida T, Fukamachi I, Tokutake T, Ebinuma H, Takubo K, Kaneko H, Kasuga K, Kakita A, Takahashi H, Bujo H, Saito Y, Nishizawa M (2010) Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease. Dement Geriatr Cogn Disord 30:28–32PubMedCrossRef

21.

Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480–1487PubMedCrossRef

22.

Castellon R, Hamdi HK, Sacerio I, Aoki AM, Kenney MC, Ljubimov AV (2002) Effects of angiogenic growth factor combinations on retinal endothelial cells. Exp Eye Res 74:523–535PubMedCrossRef

23.

Wilkinson-Berka JL (2006) Angiotensin and diabetic retinopathy. Int J Biochem Cell Biol 38:752–765PubMedCrossRef

24.

McLeod DS, Lefer DJ, Merges C, Lutty GA (1995) Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol 147:642–653PubMedCentralPubMed

25.

Goldberg RB (2009) Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 94:3171–3182PubMedCrossRef

26.

Kilpatrick ES, Rigby AS, Atkin SL (2009) Effect of glucose variability on the long-term risk of microvascular complications in type 1 diabetes. Diabetes Care 32:1901–1903PubMedCentralPubMedCrossRef

Titel: Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy
verfasst von: Tomoaki Shiba
Hideaki Bujo
Mao Takahashi
Yukihiro Sato
Meizi Jiang
Yuichi Hori
Takatoshi Maeno
Kohji Shirai
Publikationsdatum: 01.12.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 12/2013
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-013-2373-9

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Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy

Abstract

Background

Method

Results

Conclusion

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Springer Medizin

Abstract

Background

Method

Results

Conclusion

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