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Erschienen in: Brain Structure and Function 3/2016

30.01.2015 | Original Article

Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle

verfasst von: Atsuko Niwa, Masahiro Nishibori, Shinichi Hamasaki, Takuro Kobori, Keyue Liu, Hidenori Wake, Shuji Mori, Tadashi Yoshino, Hideo Takahashi

Erschienen in: Brain Structure and Function | Ausgabe 3/2016

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Abstract

In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.
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Metadaten
Titel
Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle
verfasst von
Atsuko Niwa
Masahiro Nishibori
Shinichi Hamasaki
Takuro Kobori
Keyue Liu
Hidenori Wake
Shuji Mori
Tadashi Yoshino
Hideo Takahashi
Publikationsdatum
30.01.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 3/2016
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-015-0995-x

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