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Virchows Archiv

Erschienen in:

01.12.2010 | Original Article

Warfarin embryopathy: fetal manifestations

verfasst von: Helen Wainwright, Peter Beighton

Erschienen in: Virchows Archiv | Ausgabe 6/2010

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Abstract

During the period 1991–2007, autopsy was undertaken in 13 fetuses with warfarin embryopathy. Pregnancy data and radiographic babygrams were available in each instance. Gestational age ranged from 17 to 37 weeks. Eleven of the fetuses had the characteristic nasal hypoplasia, but only three had radiological epiphyseal stippling. Cerebral hemorrhage was a major feature of autopsy in 8 of the fetuses, and it is evident that bleeding is a significant factor in the pathogenesis of warfarin embryopathy. A wide variety of additional visceral manifestations which were observed at autopsy have been tabulated. There was no obvious correlation between maternal or gestational age and the presence and severity of any specific embryopathic feature. No information was available concerning the dose and timing of warfarin administration in this series.

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Titel: Warfarin embryopathy: fetal manifestations
verfasst von: Helen Wainwright
Peter Beighton
Publikationsdatum: 01.12.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0982-9

Springer Medizin

Warfarin embryopathy: fetal manifestations

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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