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Neurosurgical Review

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04.01.2019 | Review

Weak direct current (DC) electric fields as a therapy for spinal cord injuries: review and advancement of the oscillating field stimulator (OFS)

verfasst von: Jianming Li

Erschienen in: Neurosurgical Review | Ausgabe 4/2019

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Abstract

Traumatic injury to the spinal cord remains a catastrophic event that has lifelong consequences. While decades of research have elucidated much of the pathophysiology associated with spinal cord injury (SCI), there still remains no clinically approved treatments for restoring lost sensorimotor function. The traditional dogma suggests central nervous system (CNS) neurons do not regenerate after injury but active areas of research aim to overcome this biological bottleneck. One particular approach using low-level direct current electric fields (DC EFs) appears especially promising based on a rich set of experimental data. This review highlights the biological basis for EF-induced regeneration and discusses the pre-clinical and clinical trials using the oscillating field stimulator (OFS)—a medical device designed to deliver DC EFs in vivo. I further report ongoing developments in our laboratory that refreshes the OFS concept with the hope of renewing interest in conducting additional clinical trials.

The NASCIS trials were a series of clinical trials beginning in 1984 that investigated the use of high-dose methylprednisolone to mitigate cellular oxidative stress and inflammation after acute SCI [52, 53]. The NASCIS II and III trials claimed some modest benefit of using MP following spinal injury. In retrospect, these studies have been widely criticized for poor experimental design, data reporting and suspect post-hoc statistical analysis [54, 55]. Nonetheless, the trials were the first of its kind and reported data that can be used as historical controls, especially in assessing the effects of spontaneous recovery

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Titel: Weak direct current (DC) electric fields as a therapy for spinal cord injuries: review and advancement of the oscillating field stimulator (OFS)
verfasst von: Jianming Li
Publikationsdatum: 04.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Neurosurgical Review / Ausgabe 4/2019
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-018-01068-y

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