Background
Materials and methods
Data collection
Study population
Data processing
Weighted gene co-expression network construction
Module clinical feature associations
Identification of DEGs
Validation of candidate genes
Functional enrichment analysis
Results
Expression value analysis of microarray data
Weighted gene co-expression network construction
Module clinical feature associations
Identification of DEGs
DEGs | Genes |
---|---|
Up-regulated |
MGP, ASB9, FCDH7, FXYD3, SORL1, PCSK6, MGST2, ITGB3, CORO2B
|
Down-regulated |
MME, CYR61, CXCL1, MYL9, FOS, MICAL2, MFAP2, ID3, TXNIP, TNFAIP3, COX7A1, DUSP1, RNASE4, GALC, ANGPTL4, IFI6, NCRNA00312, FHOD3, ZSCAN18, PTEN, WSB1, SOD2, NID2, ANG, FERMT2, DACT1, FAM69A
|
Validation of candidate genes
Functional enrichment analysis
ID | Term | Count | p-value | Genes |
---|---|---|---|---|
GO:0016788 | hydrolase activity, acting on ester bonds | 2 | 0.00465 |
CYR61, RNASE4
|
GO:0090304 | nucleic acid metabolic process | 3 | 0.02260 |
CYR61, DUSP1, RNASE4
|
GO:0008219 | cell death | 2 | 0.03509 |
CYR61, DUSP1
|
GO:0071495 | cellular response to endogenous stimulus | 2 | 0.01713 |
CYR61, DUSP1
|
GO:0071310 | cellular response to organic substance | 2 | 0.04895 |
CYR61, DUSP1
|
GO:0009790 | embryo development | 2 | 0.008327 |
CYR61, DUSP1
|
GO:0048598 | embryonic morphogenesis | 2 | 0.00303 |
CYR61, DUSP1
|
GO:0019838 | growth factor binding | 2 | 0.00014 |
CYR61, DUSP1
|
GO:0006915 | apoptotic process | 2 | 0.03095 |
CYR61, DUSP1
|
GO:0043066 | negative regulation of apoptotic process | 2 | 0.00673 |
CYR61, DUSP1
|
GO:0060548 | negative regulation of cell death | 2 | 0.007915 |
CYR61, DUSP1
|
GO:0043069 | negative regulation of programmed cell death | 2 | 0.00688 |
CYR61, DUSP1
|
GO:0048646 | anatomical structure formation involved in morphogenesis | 2 | 0.01169 |
CYR61, DUSP1
|
GO:0016310 | phosphorylation | 2 | 0.04169 |
CYR61, DUSP1
|
GO:0043065 | positive regulation of apoptotic process | 2 | 0.00311 |
CYR61, DUSP1
|
GO:0010942 | positive regulation of cell death | 2 | 0.00354 |
CYR61, DUSP1
|
GO:0043068 | positive regulation of programmed cell death | 2 | 0.00316 |
CYR61, DUSP1
|
GO:0012501 | programmed cell death | 2 | 0.03166 |
CYR61, DUSP1
|
GO:0006468 | protein phosphorylation | 2 | 0.02993 |
CYR61, DUSP1
|
GO:0006508 | proteolysis | 2 | 0.02311 |
CYR61, DUSP1
|
GO:0070372 | regulation of ERK1 and ERK2 cascade | 2 | 0.00054 |
CYR61, DUSP1
|
GO:0043408 | regulation of MAPK cascade | 2 | 0.00578 |
CYR61, DUSP1
|
GO:0042981 | regulation of apoptotic process | 2 | 0.01902 |
CYR61, DUSP1
|
GO:0050790 | regulation of catalytic activity | 2 | 0.04813 |
CYR61, DUSP1
|
GO:0010941 | regulation of cell death | 2 | 0.02167 |
CYR61, DUSP1
|
GO:0051128 | regulation of cellular component organization | 2 | 0.04404 |
CYR61, DUSP1
|
GO:1902531 | regulation of intracellular signal transduction | 2 | 0.02427 |
CYR61, DUSP1
|
GO:0043549 | regulation of kinase activity | 2 | 0.00783 |
CYR61, DUSP1
|
GO:0019220 | regulation of phosphate metabolic process | 2 | 0.02663 |
CYR61, DUSP1
|
GO:0051174 | regulation of phosphorus metabolic process | 2 | 0.02702 |
CYR61, DUSP1
|
GO:0042325 | regulation of phosphorylation | 2 | 0.02016 |
CYR61, DUSP1
|
GO:0043067 | regulation of programmed cell death | 2 | 0.01933 |
CYR61, DUSP1
|
GO:0070371 | ERK1 and ERK2 cascade | 2 | 0.00060 |
CYR61, DUSP1
|
GO:0000165 | MAPK cascade | 2 | 0.00687 |
CYR61, DUSP1
|
GO:0009888 | tissue development | 2 | 0.02669 |
CYR61, DUSP1
|
GO:0044702 | single organism reproductive process | 2 | 0.01329 |
CYR61, DUSP1
|
GO:0023014 | signal transduction by protein phosphorylation | 2 | 0.00735 |
CYR61, DUSP1
|
GO:0009719 | response to endogenous stimulus | 2 | 0.02830 |
CYR61, DUSP1
|
GO:0022414 | reproductive process | 2 | 0.01641 |
CYR61, DUSP1
|
GO:0000003 | reproduction | 2 | 0.01646 |
CYR61, DUSP1
|
GO:0051338 | regulation of transferase activity | 2 | 0.01001 |
CYR61, DUSP1
|
GO:0030162 | regulation of proteolysis | 2 | 0.00476 |
CYR61, DUSP1
|
GO:0001932 | regulation of protein phosphorylation | 2 | 0.01783 |
CYR61, DUSP1
|
GO:0031399 | regulation of protein modification process | 2 | 0.02839 |
CYR61, DUSP1
|
GO:0045859 | regulation of protein kinase activity | 2 | 0.00701 |
CYR61, DUSP1
|