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Erschienen in:
21.08.2023 | Images in Endocrine Pathology
Well-Differentiated Neuroendocrine Tumor of the Gallbladder with Paraganglioma-Like Features: a Potential Mimicker of Gallbladder Paraganglioma
Erschienen in: Endocrine Pathology | Ausgabe 3/2023
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A 42-year-old man, heavy smoker, body mass index: 29.7, presented with dyspnea. Thoracic computed tomography (CT) incidentally showed a 2.5-cm polyp in the gallbladder fundus, which was confirmed by abdominal CT (Fig. 1A), ultrasound and magnetic resonance imaging. He underwent a simple cholecystectomy.
Fig. 1
A CT arterial phase with hyperenhanced polyp in the gallbladder with a peripheral calcification. B Histologically, a mass-forming neoplastic growth of the gallbladder mucosa is seen (H&E). C It is composed of neuroendocrine tumor cells arranged in small solid nests, separated by delicate vasculature, mimicking the paraganglioma (“Zellballen”) architecture (H&E). D–J Tumor cells express chromogranin-A (D) and keratin 8/18 (E), while they are negative for GATA3 (F). They show cytoplasmic and nuclear positivity for S100, while no sustentacular cells are seen (F). Tumor cells express somatostatin (G), and, more focally, pancreatic polypeptide (H). The Ki67 index in the “hot spot” area is 8% (J)
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