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Erschienen in: Current Neurology and Neuroscience Reports 6/2013

01.06.2013 | Movement Disorders (SA Factor, Section Editor)

What is Essential Tremor?

verfasst von: Rodger J. Elble

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 6/2013

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Abstract

Classic essential tremor is a clinical syndrome of action tremor in the upper limbs (at least 95 % of patients) and less commonly the head, face/jaw, voice, tongue, trunk, and lower limbs, in the absence of other neurologic signs. However, the longstanding notion that essential tremor is a monosymptomatic tremor disorder is being challenged by a growing literature describing associated disturbances of tandem walking, personality, mood, hearing, and cognition. There is also epidemiologic, pathologic, and genetic evidence that essential tremor is pathophysiologically heterogeneous. Misdiagnosis of essential tremor is common because clinicians frequently overlook other neurologic signs and because action tremor in the hands is caused by many conditions, including dystonia, Parkinson disease, and drug-induced tremor. Thus, essential tremor is nothing more than a syndrome of idiopathic tremulousness, and the challenge for researchers and clinicians is to find specific etiologies of this syndrome.
Literatur
1.
Zurück zum Zitat Louis ED, Broussolle E, Goetz CG, Krack P, Kaufmann P, Mazzoni P. Historical underpinnings of the term essential tremor in the late 19th century. Neurology. 2008;71:856–9.PubMedCrossRef Louis ED, Broussolle E, Goetz CG, Krack P, Kaufmann P, Mazzoni P. Historical underpinnings of the term essential tremor in the late 19th century. Neurology. 2008;71:856–9.PubMedCrossRef
2.
Zurück zum Zitat • Critchley M. Observations on essential (heredofamial) tremor. Brain. 1949;72:113–39. This is a classic historical review of essential tremor. PubMedCrossRef • Critchley M. Observations on essential (heredofamial) tremor. Brain. 1949;72:113–39. This is a classic historical review of essential tremor. PubMedCrossRef
3.
Zurück zum Zitat Benito-León J, Louis ED, Bermejo-Pareja F. Elderly-onset essential tremor is associated with dementia. Neurology. 2006;66:1500–5.PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Elderly-onset essential tremor is associated with dementia. Neurology. 2006;66:1500–5.PubMedCrossRef
4.
Zurück zum Zitat Benito-León J, Louis ED, Bermejo-Pareja F. Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatry. 2009;80:423–5.PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatry. 2009;80:423–5.PubMedCrossRef
5.
Zurück zum Zitat Louis ED, Benito-Leon J, Ottman R, Bermejo-Pareja F. A population-based study of mortality in essential tremor. Neurology. 2007;69:1982–9.PubMedCrossRef Louis ED, Benito-Leon J, Ottman R, Bermejo-Pareja F. A population-based study of mortality in essential tremor. Neurology. 2007;69:1982–9.PubMedCrossRef
6.
Zurück zum Zitat Louis ED, Faust PL, Vonsattel JP, et al. Older onset essential tremor: more rapid progression and more degenerative pathology. Mov Disord. 2009;24:1606–12.PubMedCrossRef Louis ED, Faust PL, Vonsattel JP, et al. Older onset essential tremor: more rapid progression and more degenerative pathology. Mov Disord. 2009;24:1606–12.PubMedCrossRef
7.
Zurück zum Zitat • Deuschl G, Elble R. Essential tremor - neurodegenerative or nondegenerative disease towards a working definition of ET. Mov Disord. 2009;24:2033–41. This is a recent review of the pathophysiogy of essential tremor. PubMedCrossRef • Deuschl G, Elble R. Essential tremor - neurodegenerative or nondegenerative disease towards a working definition of ET. Mov Disord. 2009;24:2033–41. This is a recent review of the pathophysiogy of essential tremor. PubMedCrossRef
8.
Zurück zum Zitat Marsden CD, Obeso JA, Rothwell JC. Benign essential tremor is not a single entity. In: Yahr MD, editor. Current concepts of parkinson's disease and related disorders. Amsterdam: Excerpta Medica; 1983. p. 31–46. Marsden CD, Obeso JA, Rothwell JC. Benign essential tremor is not a single entity. In: Yahr MD, editor. Current concepts of parkinson's disease and related disorders. Amsterdam: Excerpta Medica; 1983. p. 31–46.
9.
Zurück zum Zitat • Elble RJ, Deuschl G. Tremor. In: Brown WF, Bolton CF, Aminoff M, editors. Neuromuscular function and disease: basic, clinical, and electrodiagnostic aspects. Philadelphia: W. B. Saunders Co; 2002. p. 1759–79. This is a review of the clinical neurophysiology of tremor. • Elble RJ, Deuschl G. Tremor. In: Brown WF, Bolton CF, Aminoff M, editors. Neuromuscular function and disease: basic, clinical, and electrodiagnostic aspects. Philadelphia: W. B. Saunders Co; 2002. p. 1759–79. This is a review of the clinical neurophysiology of tremor.
11.
Zurück zum Zitat Benito-León J, Bermejo-Pareja F, Louis ED. Incidence of essential tremor in 3 elderly populations of central Spain. Neurology. 2005;64:1721–5.PubMedCrossRef Benito-León J, Bermejo-Pareja F, Louis ED. Incidence of essential tremor in 3 elderly populations of central Spain. Neurology. 2005;64:1721–5.PubMedCrossRef
12.
Zurück zum Zitat Dogu O, Louis ED, Sevim S, Kaleagasi H, Aral M. Clinical characteristics of essential tremor in Mersin, Turkey–a population-based door-to-door study. J Neurol. 2005;252:570–4.PubMedCrossRef Dogu O, Louis ED, Sevim S, Kaleagasi H, Aral M. Clinical characteristics of essential tremor in Mersin, Turkey–a population-based door-to-door study. J Neurol. 2005;252:570–4.PubMedCrossRef
13.
Zurück zum Zitat Lorenz D, Poremba C, Papengut F, Schreiber S, Deuschl G. The psychosocial burden of essential tremor in an outpatient- and a community-based cohort. Eur J Neurol. 2011;18:972–9.PubMedCrossRef Lorenz D, Poremba C, Papengut F, Schreiber S, Deuschl G. The psychosocial burden of essential tremor in an outpatient- and a community-based cohort. Eur J Neurol. 2011;18:972–9.PubMedCrossRef
14.
Zurück zum Zitat •• Quinn NP, Schneider SA, Schwingenschuh P, Bhatia KP. Tremor-some controversial aspects. Mov Disord. 2011;26:18–23. The authors summarize many of the uncertainties and controversies regarding the etiology and pathophysiology of essential tremor. PubMedCrossRef •• Quinn NP, Schneider SA, Schwingenschuh P, Bhatia KP. Tremor-some controversial aspects. Mov Disord. 2011;26:18–23. The authors summarize many of the uncertainties and controversies regarding the etiology and pathophysiology of essential tremor. PubMedCrossRef
15.
Zurück zum Zitat Lee MS, Kim YD, Im JH, Kim HJ, Rinne JO, Bhatia KP. 123I-IPT brain SPECT study in essential tremor and Parkinson's disease. Neurology. 1999;52:1422–6.PubMedCrossRef Lee MS, Kim YD, Im JH, Kim HJ, Rinne JO, Bhatia KP. 123I-IPT brain SPECT study in essential tremor and Parkinson's disease. Neurology. 1999;52:1422–6.PubMedCrossRef
16.
Zurück zum Zitat Pellecchia MT, Varrone A, Annesi G, et al. Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2. An FP-CIT SPECT study. Mov Disord. 2007;22:559–63.PubMedCrossRef Pellecchia MT, Varrone A, Annesi G, et al. Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2. An FP-CIT SPECT study. Mov Disord. 2007;22:559–63.PubMedCrossRef
17.
Zurück zum Zitat Rivest J, Marsden CD. Trunk and head tremor as isolated manifestations of dystonia. Mov Disord. 1990;5:60–5.PubMedCrossRef Rivest J, Marsden CD. Trunk and head tremor as isolated manifestations of dystonia. Mov Disord. 1990;5:60–5.PubMedCrossRef
18.
Zurück zum Zitat Schiebler S, Schmidt A, Zittel S, et al. Arm tremor in cervical dystonia-is it a manifestation of dystonia or essential tremor? Mov Disord. 2011;26:1789–92.PubMedCrossRef Schiebler S, Schmidt A, Zittel S, et al. Arm tremor in cervical dystonia-is it a manifestation of dystonia or essential tremor? Mov Disord. 2011;26:1789–92.PubMedCrossRef
19.
Zurück zum Zitat Yanagisawa N, Goto A, Narabayashi H. Familial dystonia musculorum deformans and tremor. J Neurol Sci. 1972;16:125–36.PubMedCrossRef Yanagisawa N, Goto A, Narabayashi H. Familial dystonia musculorum deformans and tremor. J Neurol Sci. 1972;16:125–36.PubMedCrossRef
20.
Zurück zum Zitat Elble RJ. Defining dystonic tremor. Curr Neuropharmacol. 2013;11:in press. Elble RJ. Defining dystonic tremor. Curr Neuropharmacol. 2013;11:in press.
21.
Zurück zum Zitat • Bain PG, Findley LJ, Thompson PD, et al. A study of hereditary essential tremor. Brain. 1994;117:805–24. This paper provides a thorough description of essential tremor in 21 families. PubMedCrossRef • Bain PG, Findley LJ, Thompson PD, et al. A study of hereditary essential tremor. Brain. 1994;117:805–24. This paper provides a thorough description of essential tremor in 21 families. PubMedCrossRef
22.
Zurück zum Zitat Louis ED, Hernandez N, Alcalay RN, Tirri DJ, Ottman R, Clark LN. Prevalence and features of unreported dystonia in a family study of "pure" essential tremor. Parkinsonism Relat Disord. 2012;[Epub ahead of print]. Louis ED, Hernandez N, Alcalay RN, Tirri DJ, Ottman R, Clark LN. Prevalence and features of unreported dystonia in a family study of "pure" essential tremor. Parkinsonism Relat Disord. 2012;[Epub ahead of print].
23.
Zurück zum Zitat Shatunov A, Sambuughin N, Jankovic J, et al. Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23. Brain. 2006;129:2318–31.PubMedCrossRef Shatunov A, Sambuughin N, Jankovic J, et al. Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23. Brain. 2006;129:2318–31.PubMedCrossRef
24.
Zurück zum Zitat Chouinard S, Louis ED, Fahn S. Agreement among movement disorder specialists on the clinical diagnosis of essential tremor. Mov Disord. 1997;12:973–6.PubMedCrossRef Chouinard S, Louis ED, Fahn S. Agreement among movement disorder specialists on the clinical diagnosis of essential tremor. Mov Disord. 1997;12:973–6.PubMedCrossRef
25.
Zurück zum Zitat Poston KL, Rios E, Louis ED. Action tremor of the legs in essential tremor: prevalence, clinical correlates, and comparison with age-matched controls. Parkinsonism Relat Disord. 2009;15:602–5.PubMedCrossRef Poston KL, Rios E, Louis ED. Action tremor of the legs in essential tremor: prevalence, clinical correlates, and comparison with age-matched controls. Parkinsonism Relat Disord. 2009;15:602–5.PubMedCrossRef
26.
Zurück zum Zitat Hsu YD, Chang MK, Sung SC, Hsein HH, Deng JC. Essential tremor: clinical, electromyographical, and pharmacological studies in 146 Chinese patients. Chung Hua I Hsueh Tsa Chih. 1990;45:93–9.PubMed Hsu YD, Chang MK, Sung SC, Hsein HH, Deng JC. Essential tremor: clinical, electromyographical, and pharmacological studies in 146 Chinese patients. Chung Hua I Hsueh Tsa Chih. 1990;45:93–9.PubMed
27.
Zurück zum Zitat Whaley NR, Putzke JD, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord. 2007;13:333–9.PubMedCrossRef Whaley NR, Putzke JD, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord. 2007;13:333–9.PubMedCrossRef
28.
Zurück zum Zitat Louis ED, Ford B, Wendt KJ, Cameron G. Clinical characteristics of essential tremor: data from a community- based study. Mov Disord. 1998;13:803–8.PubMedCrossRef Louis ED, Ford B, Wendt KJ, Cameron G. Clinical characteristics of essential tremor: data from a community- based study. Mov Disord. 1998;13:803–8.PubMedCrossRef
29.
Zurück zum Zitat Elble RJ. Characteristics of physiologic tremor in young and elderly adults. Clin Neurophysiol. 2003;114:624–35.PubMedCrossRef Elble RJ. Characteristics of physiologic tremor in young and elderly adults. Clin Neurophysiol. 2003;114:624–35.PubMedCrossRef
30.
Zurück zum Zitat Elble RJ, Higgins C, Elble S. Electrophysiologic transition from physiologic tremor to essential tremor. Mov Disord. 2005;20:1038–42.PubMedCrossRef Elble RJ, Higgins C, Elble S. Electrophysiologic transition from physiologic tremor to essential tremor. Mov Disord. 2005;20:1038–42.PubMedCrossRef
31.
Zurück zum Zitat Louis ED, Ford B, Bismuth B. Reliability between two observers using a protocol for diagnosing essential tremor. Mov Disord. 1998;13:287–93.PubMedCrossRef Louis ED, Ford B, Bismuth B. Reliability between two observers using a protocol for diagnosing essential tremor. Mov Disord. 1998;13:287–93.PubMedCrossRef
32.
Zurück zum Zitat Lorenz D, Papengut F, Frederiksen H, et al. Evaluation of a screening instrument for essential tremor. Mov Disord. 2008;23:1006–12.PubMedCrossRef Lorenz D, Papengut F, Frederiksen H, et al. Evaluation of a screening instrument for essential tremor. Mov Disord. 2008;23:1006–12.PubMedCrossRef
33.
Zurück zum Zitat Louis ED, Pullman SL. Comparison of clinical vs electrophysiological methods of diagnosing of essential tremor. Mov Disord. 2001;16:668–73.PubMedCrossRef Louis ED, Pullman SL. Comparison of clinical vs electrophysiological methods of diagnosing of essential tremor. Mov Disord. 2001;16:668–73.PubMedCrossRef
34.
Zurück zum Zitat •• Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord. 1998;13:2–23. This paper summarizes the TRIG and MDS criteria for essential tremor. PubMedCrossRef •• Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord. 1998;13:2–23. This paper summarizes the TRIG and MDS criteria for essential tremor. PubMedCrossRef
35.
Zurück zum Zitat Gerasimou G, Costa DC, Papanastasiou E, et al. SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson's disease? Ann Nucl Med. 2012;26:337–44.PubMedCrossRef Gerasimou G, Costa DC, Papanastasiou E, et al. SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson's disease? Ann Nucl Med. 2012;26:337–44.PubMedCrossRef
36.
Zurück zum Zitat Schwingenschuh P, Ruge D, Edwards MJ, et al. Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: a clinical and electrophysiological study. Mov Disord. 2010;25:560–9.PubMedCrossRef Schwingenschuh P, Ruge D, Edwards MJ, et al. Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: a clinical and electrophysiological study. Mov Disord. 2010;25:560–9.PubMedCrossRef
37.
Zurück zum Zitat Kagi G, Bhatia KP, Tolosa E. The role of DAT-SPECT in movement disorders. J Neurol Neurosurg Psychiatry. 2010;81:5–12.PubMedCrossRef Kagi G, Bhatia KP, Tolosa E. The role of DAT-SPECT in movement disorders. J Neurol Neurosurg Psychiatry. 2010;81:5–12.PubMedCrossRef
38.
Zurück zum Zitat Jain S, Lo SE, Louis ED. Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor? Arch Neurol. 2006;63:1100–4.PubMedCrossRef Jain S, Lo SE, Louis ED. Common misdiagnosis of a common neurological disorder: how are we misdiagnosing essential tremor? Arch Neurol. 2006;63:1100–4.PubMedCrossRef
39.
Zurück zum Zitat Schrag A, Münchau A, Bhatia KP, Quinn NP, Marsden CD. Essential tremor: an overdiagnosed condition? J Neurol. 2000;247:955–9.PubMedCrossRef Schrag A, Münchau A, Bhatia KP, Quinn NP, Marsden CD. Essential tremor: an overdiagnosed condition? J Neurol. 2000;247:955–9.PubMedCrossRef
40.
Zurück zum Zitat Mostile G, Jankovic J. Alcohol in essential tremor and other movement disorders. Mov Disord. 2010;25:2274–84.PubMedCrossRef Mostile G, Jankovic J. Alcohol in essential tremor and other movement disorders. Mov Disord. 2010;25:2274–84.PubMedCrossRef
41.
Zurück zum Zitat Rajput AH, Jamieson H, Hirsh S, Quraishi A. Relative efficacy of alcohol and propranolol in action tremor. Can J Neurol Sci. 1975;2:31–5.PubMed Rajput AH, Jamieson H, Hirsh S, Quraishi A. Relative efficacy of alcohol and propranolol in action tremor. Can J Neurol Sci. 1975;2:31–5.PubMed
42.
Zurück zum Zitat Louis ED, Dogu O. Isolated head tremor: part of the clinical spectrum of essential tremor? data from population-based and clinic-based case samples. Mov Disord. 2009;24:2281–5.PubMedCrossRef Louis ED, Dogu O. Isolated head tremor: part of the clinical spectrum of essential tremor? data from population-based and clinic-based case samples. Mov Disord. 2009;24:2281–5.PubMedCrossRef
43.
Zurück zum Zitat Louis ED, Ferreira JJ. How common is the most common adult movement disorder? update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534–41.PubMedCrossRef Louis ED, Ferreira JJ. How common is the most common adult movement disorder? update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25:534–41.PubMedCrossRef
44.
Zurück zum Zitat Wolraich D, Vasile Marchis-Crisan C, Redding N, Khella SL, Mirza N. Laryngeal tremor: co-occurrence with other movement disorders. ORL J Otorhinolaryngol Relat Spec. 2010;72:291–4.PubMedCrossRef Wolraich D, Vasile Marchis-Crisan C, Redding N, Khella SL, Mirza N. Laryngeal tremor: co-occurrence with other movement disorders. ORL J Otorhinolaryngol Relat Spec. 2010;72:291–4.PubMedCrossRef
45.
Zurück zum Zitat Silverdale MA, Schneider SA, Bhatia KP, Lang AE. The spectrum of orolingual tremor—a proposed classification system. Mov Disord. 2008;23:159–67.PubMedCrossRef Silverdale MA, Schneider SA, Bhatia KP, Lang AE. The spectrum of orolingual tremor—a proposed classification system. Mov Disord. 2008;23:159–67.PubMedCrossRef
46.
Zurück zum Zitat Bain P, Brin M, Deuschl G, et al. Criteria for the diagnosis of essential tremor. Neurology. 2000;54:S7.PubMed Bain P, Brin M, Deuschl G, et al. Criteria for the diagnosis of essential tremor. Neurology. 2000;54:S7.PubMed
47.
48.
Zurück zum Zitat Fasano A, Herzog J, Raethjen J, et al. Gait ataxia in essential tremor is differentially modulated by thalamic stimulation. Brain. 2010;133:3635–48.PubMedCrossRef Fasano A, Herzog J, Raethjen J, et al. Gait ataxia in essential tremor is differentially modulated by thalamic stimulation. Brain. 2010;133:3635–48.PubMedCrossRef
49.
Zurück zum Zitat Fasano A, Herzog J, Raethjen J, et al. Lower limb joints kinematics in essential tremor and the effect of thalamic stimulation. Gait Posture. 2012;36:187–93.PubMedCrossRef Fasano A, Herzog J, Raethjen J, et al. Lower limb joints kinematics in essential tremor and the effect of thalamic stimulation. Gait Posture. 2012;36:187–93.PubMedCrossRef
50.
Zurück zum Zitat Pifl C, Kish SJ, Hornykiewicz O. Thalamic noradrenaline in Parkinson's disease: deficits suggest role in motor and non-motor symptoms. Mov Disord. 2012;27:1618–24.PubMedCrossRef Pifl C, Kish SJ, Hornykiewicz O. Thalamic noradrenaline in Parkinson's disease: deficits suggest role in motor and non-motor symptoms. Mov Disord. 2012;27:1618–24.PubMedCrossRef
51.
Zurück zum Zitat • Raethjen J, Deuschl G. The oscillating central network of essential tremor. Clin Neurophysiol. 2012;123:61–4. This is a recent study of the so-called tremor network. PubMedCrossRef • Raethjen J, Deuschl G. The oscillating central network of essential tremor. Clin Neurophysiol. 2012;123:61–4. This is a recent study of the so-called tremor network. PubMedCrossRef
52.
Zurück zum Zitat Schnitzler A, Munks C, Butz M, Timmermann L, Gross J. Synchronized brain network associated with essential tremor as revealed by magnetoencephalography. Mov Disord. 2009;24:1629–35.PubMedCrossRef Schnitzler A, Munks C, Butz M, Timmermann L, Gross J. Synchronized brain network associated with essential tremor as revealed by magnetoencephalography. Mov Disord. 2009;24:1629–35.PubMedCrossRef
53.
Zurück zum Zitat Dupuis MJ, Evrard FL, Jacquerye PG, Picard GR, Lermen OG. Disappearance of essential tremor after stroke. Mov Disord. 2010;25:2884–7.PubMedCrossRef Dupuis MJ, Evrard FL, Jacquerye PG, Picard GR, Lermen OG. Disappearance of essential tremor after stroke. Mov Disord. 2010;25:2884–7.PubMedCrossRef
54.
Zurück zum Zitat Hellwig B, Häussler S, Schelter B, et al. Tremor-correlated cortical activity in essential tremor. Lancet. 2001;357:519–23.PubMedCrossRef Hellwig B, Häussler S, Schelter B, et al. Tremor-correlated cortical activity in essential tremor. Lancet. 2001;357:519–23.PubMedCrossRef
55.
Zurück zum Zitat Hua SE, Lenz FA. Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits. J Neurophysiol. 2005;93:117–27.PubMedCrossRef Hua SE, Lenz FA. Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits. J Neurophysiol. 2005;93:117–27.PubMedCrossRef
57.
Zurück zum Zitat Timmermann L, Gross J, Dirks M, Volkmann J, Freund HJ, Schnitzler A. The cerebral oscillatory network of parkinsonian resting tremor. Brain. 2003;126:199–212.PubMedCrossRef Timmermann L, Gross J, Dirks M, Volkmann J, Freund HJ, Schnitzler A. The cerebral oscillatory network of parkinsonian resting tremor. Brain. 2003;126:199–212.PubMedCrossRef
58.
Zurück zum Zitat Sudmeyer M, Pollok B, Hefter H, et al. Synchronized brain network underlying postural tremor in Wilson's disease. Mov Disord. 2006;21:1935–40.PubMedCrossRef Sudmeyer M, Pollok B, Hefter H, et al. Synchronized brain network underlying postural tremor in Wilson's disease. Mov Disord. 2006;21:1935–40.PubMedCrossRef
59.
Zurück zum Zitat Timmermann L, Gross J, Kircheis G, Haussinger D, Schnitzler A. Cortical origin of mini-asterixis in hepatic encephalopathy. Neurology. 2002;58:295–8.PubMedCrossRef Timmermann L, Gross J, Kircheis G, Haussinger D, Schnitzler A. Cortical origin of mini-asterixis in hepatic encephalopathy. Neurology. 2002;58:295–8.PubMedCrossRef
60.
Zurück zum Zitat Pollok B, Gross J, Dirks M, Timmermann L, Schnitzler A. The cerebral oscillatory network of voluntary tremor. J Physiol. 2004;554:871–8.PubMedCrossRef Pollok B, Gross J, Dirks M, Timmermann L, Schnitzler A. The cerebral oscillatory network of voluntary tremor. J Physiol. 2004;554:871–8.PubMedCrossRef
61.
Zurück zum Zitat Timmermann L, Gross J, Butz M, Kircheis G, Haussinger D, Schnitzler A. Pathological oscillatory coupling within the human motor system in different tremor syndromes as revealed by magnetoencephalography. Neurol Clin Neurophysiol. 2004;2004:26.PubMed Timmermann L, Gross J, Butz M, Kircheis G, Haussinger D, Schnitzler A. Pathological oscillatory coupling within the human motor system in different tremor syndromes as revealed by magnetoencephalography. Neurol Clin Neurophysiol. 2004;2004:26.PubMed
62.
Zurück zum Zitat Lorenz D, Frederiksen H, Moises H, Kopper F, Deuschl G, Christensen K. High concordance for essential tremor in monozygotic twins of old age. Neurology. 2004;62:208–11.PubMedCrossRef Lorenz D, Frederiksen H, Moises H, Kopper F, Deuschl G, Christensen K. High concordance for essential tremor in monozygotic twins of old age. Neurology. 2004;62:208–11.PubMedCrossRef
63.
Zurück zum Zitat Gulcher JR, Jonsson P, Kong A, et al. Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet. 1997;17:84–7.PubMedCrossRef Gulcher JR, Jonsson P, Kong A, et al. Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet. 1997;17:84–7.PubMedCrossRef
64.
Zurück zum Zitat Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord. 1997;12:859–64.PubMedCrossRef Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord. 1997;12:859–64.PubMedCrossRef
65.
66.
Zurück zum Zitat Kovach MJ, Ruiz J, Kimonis K, et al. Genetic heterogeneity in autosomal dominant essential tremor. Genet Med. 2001;3:197–9.PubMedCrossRef Kovach MJ, Ruiz J, Kimonis K, et al. Genetic heterogeneity in autosomal dominant essential tremor. Genet Med. 2001;3:197–9.PubMedCrossRef
67.
Zurück zum Zitat Ma S, Davis TL, Blair MA, et al. Familial essential tremor with apparent autosomal dominant inheritance: should we also consider other inheritance modes? Mov Disord. 2006;21:1368–74.PubMedCrossRef Ma S, Davis TL, Blair MA, et al. Familial essential tremor with apparent autosomal dominant inheritance: should we also consider other inheritance modes? Mov Disord. 2006;21:1368–74.PubMedCrossRef
68.
Zurück zum Zitat Pasini E, Busolin G, Nobile C, Michelucci R. Autosomal dominant essential tremor: a novel family with anticipation. Neurol Sci. 2012;[Epub ahead of print]. Pasini E, Busolin G, Nobile C, Michelucci R. Autosomal dominant essential tremor: a novel family with anticipation. Neurol Sci. 2012;[Epub ahead of print].
69.
Zurück zum Zitat Yoo YM, Lee CJ, Lee U, Kim YJ. Mitochondrial DNA in patients with essential tremor. Neurosci Lett. 2008;434:29–34.PubMedCrossRef Yoo YM, Lee CJ, Lee U, Kim YJ. Mitochondrial DNA in patients with essential tremor. Neurosci Lett. 2008;434:29–34.PubMedCrossRef
70.
Zurück zum Zitat Zimprich A. Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers. Parkinsonism Relat Disord. 2012;18:711–6.PubMedCrossRef Zimprich A. Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers. Parkinsonism Relat Disord. 2012;18:711–6.PubMedCrossRef
71.
Zurück zum Zitat •• Jiménez-Jiménez FJ, Garrrcia-Martin E, Lorenzo-Betancor O, Pastor P, Alonso-Navarro H, Agundez JA. LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808. J Neurol Sci. 2012;317:52–7. This is a recent meta-analysis and review of the data supporting LINGO1 variants as risk factors for essential tremor. PubMedCrossRef •• Jiménez-Jiménez FJ, Garrrcia-Martin E, Lorenzo-Betancor O, Pastor P, Alonso-Navarro H, Agundez JA. LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808. J Neurol Sci. 2012;317:52–7. This is a recent meta-analysis and review of the data supporting LINGO1 variants as risk factors for essential tremor. PubMedCrossRef
72.
Zurück zum Zitat Stefansson H, Steinberg S, Petursson H, et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet. 2009;41:277–9.PubMedCrossRef Stefansson H, Steinberg S, Petursson H, et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet. 2009;41:277–9.PubMedCrossRef
73.
Zurück zum Zitat Wu YW, Rong TY, Li HH, et al. Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians. Acta Neurol Scand. 2011;124:264–8.PubMedCrossRef Wu YW, Rong TY, Li HH, et al. Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians. Acta Neurol Scand. 2011;124:264–8.PubMedCrossRef
74.
Zurück zum Zitat Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson's disease. Acta Neurol Scand. 2012;125:1–7.PubMedCrossRef Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson's disease. Acta Neurol Scand. 2012;125:1–7.PubMedCrossRef
75.
Zurück zum Zitat Yu M, Ma K, Faust PL, et al. Increased number of Purkinje cell dendritic swellings in essential tremor. Eur J Neurol. 2012;19:625–30.PubMedCrossRef Yu M, Ma K, Faust PL, et al. Increased number of Purkinje cell dendritic swellings in essential tremor. Eur J Neurol. 2012;19:625–30.PubMedCrossRef
76.
Zurück zum Zitat Thier S, Lorenz D, Nothnagel M, et al. Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor. Neurology. 2012;79:243–8.PubMedCrossRef Thier S, Lorenz D, Nothnagel M, et al. Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor. Neurology. 2012;79:243–8.PubMedCrossRef
77.
Zurück zum Zitat Garcia-Martin E, Martinez C, Alonso-Navarro H, et al. Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor. Pharmacogenet Genomics. 2011;21:436–9.PubMedCrossRef Garcia-Martin E, Martinez C, Alonso-Navarro H, et al. Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor. Pharmacogenet Genomics. 2011;21:436–9.PubMedCrossRef
78.
Zurück zum Zitat Garcia-Martin E, Martinez C, Alonso-Navarro H, et al. Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor. J Neurol. 2011;258:203–11.PubMedCrossRef Garcia-Martin E, Martinez C, Alonso-Navarro H, et al. Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor. J Neurol. 2011;258:203–11.PubMedCrossRef
79.
Zurück zum Zitat Thier S, Kuhlenbaumer G, Lorenz D, et al. GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor. Eur J Neurol. 2011;18:1098–100.PubMedCrossRef Thier S, Kuhlenbaumer G, Lorenz D, et al. GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor. Eur J Neurol. 2011;18:1098–100.PubMedCrossRef
80.
Zurück zum Zitat •• Louis ED. Essential tremors: a family of neurodegenerative disorders? Arch Neurol. 2009;66:1202–8. This review summarizes the epidemiologic and pathologic evidence for essential tremor being a heterogeneous group of disorders. PubMedCrossRef •• Louis ED. Essential tremors: a family of neurodegenerative disorders? Arch Neurol. 2009;66:1202–8. This review summarizes the epidemiologic and pathologic evidence for essential tremor being a heterogeneous group of disorders. PubMedCrossRef
81.
Zurück zum Zitat •• Louis ED, Faust PL, Vonsattel JP. Purkinje cell loss is a characteristic of essential tremor. Parkinsonism Relat Disord. 2011;17:406–9. This paper and reference 80 summarize the argument that essential tremor is a neurodegenerative disorder. PubMedCrossRef •• Louis ED, Faust PL, Vonsattel JP. Purkinje cell loss is a characteristic of essential tremor. Parkinsonism Relat Disord. 2011;17:406–9. This paper and reference 80 summarize the argument that essential tremor is a neurodegenerative disorder. PubMedCrossRef
82.
Zurück zum Zitat Louis ED, Faust PL, Ma KJ, Yu M, Cortes E, Vonsattel JP. Torpedoes in the cerebellar vermis in essential tremor cases vs controls. Cerebellum. 2011;10:812–9.PubMedCrossRef Louis ED, Faust PL, Ma KJ, Yu M, Cortes E, Vonsattel JP. Torpedoes in the cerebellar vermis in essential tremor cases vs controls. Cerebellum. 2011;10:812–9.PubMedCrossRef
83.
Zurück zum Zitat Louis ED, Ma K, Babij R, et al. Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Neurosci Lett. 2012;518:49–54.PubMedCrossRef Louis ED, Ma K, Babij R, et al. Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Neurosci Lett. 2012;518:49–54.PubMedCrossRef
84.
Zurück zum Zitat Louis ED, Mazzoni P, Ma KJ, et al. Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration. Clin Neuropathol. 2012;31:119–26.PubMed Louis ED, Mazzoni P, Ma KJ, et al. Essential tremor with ubiquitinated intranuclear inclusions and cerebellar degeneration. Clin Neuropathol. 2012;31:119–26.PubMed
85.
Zurück zum Zitat •• Rajput AH, Adler CH, Shill HA, Rajput A. Essential tremor is not a neurodegenerative disease. Neurodegener Dis Manag. 2012;2:259–68. This paper summarizes the evidence against the hypothesis that essential tremor is a neurodegenerative disorder. PubMedCrossRef •• Rajput AH, Adler CH, Shill HA, Rajput A. Essential tremor is not a neurodegenerative disease. Neurodegener Dis Manag. 2012;2:259–68. This paper summarizes the evidence against the hypothesis that essential tremor is a neurodegenerative disorder. PubMedCrossRef
86.
Zurück zum Zitat Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent upon cerebellar Purkinje cell loss. Parkinsonism Relat Disord. 2012;18:626–8. Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent upon cerebellar Purkinje cell loss. Parkinsonism Relat Disord. 2012;18:626–8.
87.
Zurück zum Zitat Louis ED, Faust PL, Vonsattel JP, et al. Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains. Mov Disord. 2009;24:1600–5.PubMedCrossRef Louis ED, Faust PL, Vonsattel JP, et al. Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains. Mov Disord. 2009;24:1600–5.PubMedCrossRef
88.
Zurück zum Zitat Ma K, Babij R, Cortes E, Vonsattel JP, Louis ED. Cerebellar pathology of a dual clinical diagnosis: patients with essential tremor and dystonia. Tremor and other Hyperkinetic Movements. 2012;2. Ma K, Babij R, Cortes E, Vonsattel JP, Louis ED. Cerebellar pathology of a dual clinical diagnosis: patients with essential tremor and dystonia. Tremor and other Hyperkinetic Movements. 2012;2.
89.
Zurück zum Zitat Benito-León J, Louis ED, Bermejo-Pareja F. Population-based case–control study of cognitive function in essential tremor. Neurology. 2006;66:69–74.PubMedCrossRef Benito-León J, Louis ED, Bermejo-Pareja F. Population-based case–control study of cognitive function in essential tremor. Neurology. 2006;66:69–74.PubMedCrossRef
90.
Zurück zum Zitat Bermejo-Pareja F, Louis ED, Benito-Leon J. Risk of incident dementia in essential tremor: a population-based study. Mov Disord. 2007;22:1573–80.PubMedCrossRef Bermejo-Pareja F, Louis ED, Benito-Leon J. Risk of incident dementia in essential tremor: a population-based study. Mov Disord. 2007;22:1573–80.PubMedCrossRef
91.
Zurück zum Zitat Thawani SP, Schupf N, Louis ED. Essential tremor is associated with dementia: prospective population-based study in New York. Neurology. 2009;73:621–5.PubMedCrossRef Thawani SP, Schupf N, Louis ED. Essential tremor is associated with dementia: prospective population-based study in New York. Neurology. 2009;73:621–5.PubMedCrossRef
92.
Zurück zum Zitat Benito-León J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in 3 elderly populations of central Spain. Mov Disord. 2003;18:389–94.PubMedCrossRef Benito-León J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in 3 elderly populations of central Spain. Mov Disord. 2003;18:389–94.PubMedCrossRef
93.
Zurück zum Zitat Louis ED. Factor analysis of motor and nonmotor signs in essential tremor: are these signs all part of the same underlying pathogenic process? Neuroepidemiology. 2009;33:41–6.PubMedCrossRef Louis ED. Factor analysis of motor and nonmotor signs in essential tremor: are these signs all part of the same underlying pathogenic process? Neuroepidemiology. 2009;33:41–6.PubMedCrossRef
94.
Zurück zum Zitat Adler CH, Shill HA, Beach TG. Essential tremor and Parkinson's disease: lack of a link. Mov Disord. 2011;26:372–7.PubMedCrossRef Adler CH, Shill HA, Beach TG. Essential tremor and Parkinson's disease: lack of a link. Mov Disord. 2011;26:372–7.PubMedCrossRef
95.
Zurück zum Zitat Elble RJ, Dubinsky RM, Ala T. Alzheimer's disease and essential tremor finally meet. Mov Disord. 2007;22:1525–7.PubMedCrossRef Elble RJ, Dubinsky RM, Ala T. Alzheimer's disease and essential tremor finally meet. Mov Disord. 2007;22:1525–7.PubMedCrossRef
96.
Zurück zum Zitat Shill HA, Adler CH, Beach TG, et al. Brain biochemistry in autopsied patients with essential tremor. Mov Disord. 2012;27:113–7.PubMedCrossRef Shill HA, Adler CH, Beach TG, et al. Brain biochemistry in autopsied patients with essential tremor. Mov Disord. 2012;27:113–7.PubMedCrossRef
97.
Zurück zum Zitat Deuschl G. Locus coeruleus dysfunction: a feature of essential or senile tremor? Mov Disord. 2012;27:1–2.PubMedCrossRef Deuschl G. Locus coeruleus dysfunction: a feature of essential or senile tremor? Mov Disord. 2012;27:1–2.PubMedCrossRef
98.
Zurück zum Zitat Benito-Leon J. Essential tremor: from a monosymptomatic disorder to a more complex entity. Neuroepidemiology. 2008;31:191–2.PubMedCrossRef Benito-Leon J. Essential tremor: from a monosymptomatic disorder to a more complex entity. Neuroepidemiology. 2008;31:191–2.PubMedCrossRef
99.
Zurück zum Zitat Johnson WG, Hodge SE, Duvoisin R. Twin studies and the genetics of Parkinson's disease—a reappraisal. Mov Disord. 1990;5:187–94.PubMedCrossRef Johnson WG, Hodge SE, Duvoisin R. Twin studies and the genetics of Parkinson's disease—a reappraisal. Mov Disord. 1990;5:187–94.PubMedCrossRef
100.
Zurück zum Zitat Fugger L, McVean G, Bell JI. Genomewide association studies and common disease–realizing clinical utility. N Engl J Med. 2012;367:2370–1.PubMedCrossRef Fugger L, McVean G, Bell JI. Genomewide association studies and common disease–realizing clinical utility. N Engl J Med. 2012;367:2370–1.PubMedCrossRef
Metadaten
Titel
What is Essential Tremor?
verfasst von
Rodger J. Elble
Publikationsdatum
01.06.2013
Verlag
Current Science Inc.
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 6/2013
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-013-0353-4

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