Erschienen in:
02.02.2023 | Hepatobiliary Tumors
Where are We with Liver Transplant for Unresectable Colorectal Metastases? Its Early, but Some Initial Insights are Evident
verfasst von:
S. Whitney Zingg, MD, Shimul A. Shah, MD, MHCM
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 5/2023
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Excerpt
Liver transplantation for unresectable colorectal metastases (CRLM) has been increasing in recent years, with an almost tenfold increase in cases between 2017 and 2022. While historically CRLM has been a contraindication to liver transplant, modern chemotherapy has allowed a re-analysis of patients with unresectable CRLM. In 2012, the University of Oslo group demonstrated a significantly improved overall survival (OS) in patients who underwent liver transplantation when compared with chemotherapy alone for unresectable CRLM.
1,2 As transplantation for these patients began to garner favor, the International Hepato-Pancreato-Biliary Association (IHPBA) published a consensus guideline in 2021 to provide a better framework for liver transplantation for unresectable CRLM.
3 …