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European Archives of Psychiatry and Clinical Neuroscience

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29.01.2019 | Original Paper

White matter microstructure in schizophrenia patients with a history of violence

verfasst von: Natalia Tesli, Lars T. Westlye, Guttorm B. Storvestre, Tiril P. Gurholt, Ingrid Agartz, Ingrid Melle, Ole A. Andreassen, Unn K. Haukvik

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 4/2021

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Abstract

Schizophrenia (SCZ) is associated with increased risk of violence compared to the general population. Neuroimaging research suggests SCZ to be a disorder of disrupted connectivity, with diffusion tensor imaging (DTI) indicating white matter (WM) abnormalities. It has been hypothesized that SCZ patients with a history of violence (SCZ-V) have brain abnormalities distinguishing them from SCZ patients with no history of violence (SCZ-NV). Yet, a thorough investigation of the neurobiological underpinnings of state and trait measures of violence and aggression in SCZ derived from DTI indices is lacking. Using tract-based spatial statistics, we compared DTI-derived microstructural indices: fractional anisotropy (FA), mean, axial (AD) and radial diffusivity across the brain; (1) between SCZ-V (history of murder, attempted murder, or severe assault towards other people, n = 24), SCZ-NV (n = 52) and healthy controls (HC, n = 94), and (2) associations with current aggression scores among both SCZ groups. Then, hypothesis-driven region of interest analyses of the uncinate fasciculus and clinical characteristics including medication use were performed. SCZ-V and SCZ-NV showed decreased FA and AD in widespread regions compared to HC. There were no significant differences on any DTI-based measures between SCZ-V and SCZ-NV, and no significant associations between state or trait measures of aggression and any of the DTI metrics in the ROI analyses. The DTI-derived WM differences between SCZ and HC are in line with previous findings, but the results do not support the hypothesis of specific brain WM microstructural correlates of violence or aggression in SCZ.

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Titel: White matter microstructure in schizophrenia patients with a history of violence
verfasst von: Natalia Tesli
Lars T. Westlye
Guttorm B. Storvestre
Tiril P. Gurholt
Ingrid Agartz
Ingrid Melle
Ole A. Andreassen
Unn K. Haukvik
Publikationsdatum: 29.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 4/2021
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-019-00988-0

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