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09.02.2022 | Review

Wnt ligand expression in malignant melanoma: new insights

verfasst von: Khosrow Siamak Houschyar, Mimi R. Borrelli, Susanne Rein, Christian Tapking, Daniel Popp, Behrus Puladi, Mark Ooms, Torsten Schulz, Zeshaan N. Maan, Ludwik K. Branski, Frank Siemers, Wolfgang Gordon Philipp-Dormston, Amir S. Yazdi, Dominik Duscher

Erschienen in: European Journal of Plastic Surgery | Ausgabe 5/2022

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Abstract

Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma.

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Titel: Wnt ligand expression in malignant melanoma: new insights
verfasst von: Khosrow Siamak Houschyar
Mimi R. Borrelli
Susanne Rein
Christian Tapking
Daniel Popp
Behrus Puladi
Mark Ooms
Torsten Schulz
Zeshaan N. Maan
Ludwik K. Branski
Frank Siemers
Wolfgang Gordon Philipp-Dormston
Amir S. Yazdi
Dominik Duscher
Publikationsdatum: 09.02.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Plastic Surgery / Ausgabe 5/2022
Print ISSN: 0930-343X
Elektronische ISSN: 1435-0130
DOI: https://doi.org/10.1007/s00238-022-01941-6

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