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Journal of Bone and Mineral Metabolism

Erschienen in:

30.08.2022 | Invited Review

Wnt signaling: a double-edged sword in protecting bone from cancer

verfasst von: Xun Sun, Kexin Li, Bai-Yan Li, Hiroki Yokota

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 3/2023

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Abstract

Wnt signaling plays a critical role in loading-driven bone formation and bone homeostasis, whereas its activation in cancer cells promotes their progression. Currently, major research efforts in cancer treatment have been directed to the development of Wnt inhibitors. Recent studies on tumor–bone interactions, however, presented multiple lines of evidence that support a tumor-suppressive role of Lrp5, a Wnt co-receptor, and β-catenin, in Wnt signaling. This review describes the action of Wnt signaling as a double-edged sword in the bone microenvironment and suggests the possibility of a novel option for protecting bone from cancer.

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Titel: Wnt signaling: a double-edged sword in protecting bone from cancer
verfasst von: Xun Sun
Kexin Li
Bai-Yan Li
Hiroki Yokota
Publikationsdatum: 30.08.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 3/2023
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-022-01363-1

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