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International Ophthalmology

Erschienen in:

19.06.2018 | Original Paper

YKL-40 expression in pterygium: a potential role in the pathogenesis

verfasst von: Ali Kurt, Raşit Kılıç, Murat Tad, Osman Ahmet Polat

Erschienen in: International Ophthalmology | Ausgabe 7/2019

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Abstract

Purpose

The aim of the study was to evaluate whether YKL-40 (chitinase 3-like 1 protein) plays a role in pterygium pathogenesis.

Methods

We included 42 primary pterygium patients and 24 control subjects with normal bulbar conjunctiva in the study. The pterygium patients were classified into the atrophic, fleshy, and intermediate groups according to the Tan classification. We then surgically removed the primary nasal pterygium and normal bulbar conjunctiva from the patients and immunohistochemically investigated YKL-40 expression.

Results

YKL-40 expression was statistically significantly higher in the epithelial, endothelial, and stromal cells of the pterygium tissues than in the control tissues (P = 0.009, P = 0.003, P = 0.002, respectively). There was no significant correlation between the pterygium subgroups and YKL-40 expression (P > 0.05).

Conclusions

We believe YKL-40 may play a significant role in pterygium pathogenesis.

Bianchi E, Scarinci F, Grande C et al (2012) Immunohistochemical profile of VEGF, TGF-β and PGE₂ in human pterygium and normal conjunctiva: experimental study and review of the literature. Int J Immunopathol Pharmacol 25:607–615CrossRefPubMed

Bradley JC, Yang W, Bradley RH, Reid TW, Schwab IR (2010) The science of pterygia. Br J Ophthalmol 94:815–820CrossRefPubMed

Di Girolamo N, Wakefield D, Coroneo MT (2006) UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci 47:2430–2437CrossRefPubMed

Kria L, Ohira A, Amemiya T (1996) Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium. Acta Histochem 98:195–201CrossRefPubMed

Shao R, Taylor SL, Oh DS et al (2015) Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization. Oncotarget 6:40507–40518PubMedPubMedCentral

Lee CG, Da Silva CA, Dela Cruz CS et al (2011) Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol 73:479–501CrossRefPubMed

Łata E, Gisterek I, Matkowski R et al (2010) The importance of determining the prognostic marker YKL-40 in serum and tissues. Pol Merkur Lekarski 28:505–508PubMed

Libreros S, Iragavarapu-Charyulu V (2015) YKL-40/CHI3L1 drives inflammation on the road of tumor progression. J Leukoc Biol 98:931–936CrossRefPubMedPubMedCentral

Kang EJ, Jung H, Woo OH et al (2014) YKL-40 expression could be a poor prognostic marker in the breast cancer tissue. Tumour Biol 35:277–286CrossRefPubMed

10.

Tan DT, Chee SP, Dear KB et al (1997) Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol 115:1235–1240CrossRefPubMed

11.

Aspiotis M, Tsanou E, Gorezis S et al (2007) Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1. Eye (Lond) 21:1095–1101CrossRef

12.

Zhou WP, Zhu YF, Zhang B et al (2016) The role of ultraviolet radiation in the pathogenesis of pterygia. Mol Med Rep 14:3–15CrossRefPubMed

13.

Kim KW, Park SH, Kim JC (2016) Fibroblast biology in pterygia. Exp Eye Res 142:32–39CrossRefPubMed

14.

Kim KW, Park SH, Lee SH et al (2013) Upregulated stromal cell-derived factor 1 (SDF-1) expression and its interaction with CXCR4 contribute to the pathogenesis of severe pterygia. Invest Ophthalmol Vis Sci 54:7198–7206CrossRefPubMed

15.

Hosseini H, Nejabat M, Khalili MR (2007) Bevacizumab (Avastin) as a potential novel adjunct in the management of pterygia. Med Hypotheses 69:925–927CrossRefPubMed

16.

Bahar I, Kaiserman I, McAllum P et al (2008) Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium. Curr Eye Res 33:23–28CrossRefPubMed

17.

Mak RK, Chan TC, Marcet MM et al (2017) Use of anti-vascular endothelial growth factor in the management of pterygium. Acta Ophthalmol 95:20–27CrossRefPubMed

18.

Alsmman AH, Radwan G, Abozaid MA et al (2017) Preoperative subconjunctival combined injection of bevacizumab and mitomycin C before the surgical excision of primary pterygium: clinical and histological results. Clin Ophthalmol 11:493–501CrossRefPubMedPubMedCentral

19.

Liu W, Sha X, Wen Y et al (2014) Effect of Avastin on the migration and invasion of pterygium fibroblasts. Eye Sci 29:214–218PubMed

20.

Wang Y, Lin J, Chen L et al (2017) Expression of Peroxiredoxin 2 and vascular endothelial growth factor receptor 2 in pterygium. Cornea 36:841–844CrossRefPubMed

21.

Karadag R, Bayram N, Oguztuzun S et al (2016) Investigation of glutathione S-transferase isoenzyme protein expression in patients with pterygium. Cornea 35:1089–1092CrossRefPubMed

22.

Xue C, Chen Y, Huang Z et al (2014) EphB4 expression in pterygium is associated with microvessel density. Int J Clin Exp Med 7:4008–4015PubMedPubMedCentral

23.

Kiliç R, Kurt A, Tad M et al (2017) Endocan overexpression in pterygium. Cornea 36:696–699CrossRefPubMed

24.

Roslind A, Johansen JS (2009) YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation. Methods Mol Biol 511:159–184CrossRefPubMed

25.

Faibish M, Francescone R, Bentley B et al (2011) A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers. Mol Cancer Ther 10:742–751CrossRefPubMedPubMedCentral

26.

Francescone RA, Scully S, Faibish M et al (2011) Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. J Biol Chem 286:15332–15343CrossRefPubMedPubMedCentral

27.

Kawada M, Seno H, Kanda K et al (2012) Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer. Oncogene 31:3111–3123CrossRefPubMed

28.

Gumus K, Karakucuk S, Mirza GE et al (2014) Overexpression of vascular endothelial growth factor receptor 2 in pterygia may have a predictive value for a higher postoperative recurrence rate. Br J Ophthalmol 98:796–800CrossRefPubMed

Titel: YKL-40 expression in pterygium: a potential role in the pathogenesis
verfasst von: Ali Kurt
Raşit Kılıç
Murat Tad
Osman Ahmet Polat
Publikationsdatum: 19.06.2018
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 7/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-018-0957-4

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Springer Medizin

YKL-40 expression in pterygium: a potential role in the pathogenesis

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

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Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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