Obligat: histologische Sicherung vor neoadjuvanter Therapie des Pankreaskarzinoms

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Zurück zum Zitat ClinicalTrials.gov. A study evaluating IPI-926 in combination with gemcitabine in patients with metastatic pancreatic cancer. https://clinicaltrials.gov/ct2/show/NCT01130142. Zugegriffen: 20. November 2018 ClinicalTrials.gov. A study evaluating IPI-926 in combination with gemcitabine in patients with metastatic pancreatic cancer. https://​clinicaltrials.​gov/​ct2/​show/​NCT01130142. Zugegriffen: 20. November 2018

Zurück zum Zitat Galia M, Albano D, Picone D, Terranova MC, Agrusa A, Di Buono G, Licata A, Lo Re G, La Grutta L, Midiri M (2018) Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma.Clin Imaging. 2018 Sep Oct;51. Epub 6:76–82. https://doi.org/10.1016/j.clinimag.2018.01.016 CrossRef Galia M, Albano D, Picone D, Terranova MC, Agrusa A, Di Buono G, Licata A, Lo Re G, La Grutta L, Midiri M (2018) Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma.Clin Imaging. 2018 Sep Oct;51. Epub 6:76–82. https://​doi.​org/​10.​1016/​j.​clinimag.​2018.​01.​016 CrossRef

Zurück zum Zitat Garrido-Laguna I, Hidalgo M (2015) Pancreatic cancer: from state-of-the-art treatments to promising novel therapies. Nat Rev Clin Oncol 12(6):319–334. https://doi.org/10.1038/nrclinonc.2015.53. Epub 2015 Mar 31.CrossRef Garrido-Laguna I, Hidalgo M (2015) Pancreatic cancer: from state-of-the-art treatments to promising novel therapies. Nat Rev Clin Oncol 12(6):319–334. https://​doi.​org/​10.​1038/​nrclinonc.​2015.​53. Epub 2015 Mar 31.CrossRef

Zurück zum Zitat Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016) Surgical and molecular pathology of pancreatic neoplasms. Diagn Pathol 11(1):47. https://doi.org/10.1186/s13000-016-0497-z.CrossRefPubMedPubMedCentral Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016) Surgical and molecular pathology of pancreatic neoplasms. Diagn Pathol 11(1):47. https://​doi.​org/​10.​1186/​s13000-016-0497-z.CrossRefPubMedPubMedCentral

Zurück zum Zitat Kim EJ, Sahai V, Abel EV, Griffith KA, Greenson JK, Takebe N, Khan GN, Blau JL, Craig R, Balis UG, Zalupski MM, Simeone DM (2014) Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clin Cancer Res 20(23):5937–5945. https://doi.org/10.1158/1078-0432.CCR-14-1269. Epub 2014 OctCrossRefPubMedPubMedCentral Kim EJ, Sahai V, Abel EV, Griffith KA, Greenson JK, Takebe N, Khan GN, Blau JL, Craig R, Balis UG, Zalupski MM, Simeone DM (2014) Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clin Cancer Res 20(23):5937–5945. https://​doi.​org/​10.​1158/​1078-0432.​CCR-14-1269. Epub 2014 OctCrossRefPubMedPubMedCentral

Zurück zum Zitat Mokdad AA, Minter RM, Zhu H, Augustine MM, Porembka MR, Wang SC, Yopp AC, Mansour JC, Choti MA, Polanco PM (2017) Neoadjuvant therapy followed by resection versus upfront resection for resectable pancreatic cancer: A propensity score matched analysis. J Clin Oncol 35(5):515–522. https://doi.org/10.1200/JCO.2016.68.5081. Epub 2016 Sep 30CrossRef Mokdad AA, Minter RM, Zhu H, Augustine MM, Porembka MR, Wang SC, Yopp AC, Mansour JC, Choti MA, Polanco PM (2017) Neoadjuvant therapy followed by resection versus upfront resection for resectable pancreatic cancer: A propensity score matched analysis. J Clin Oncol 35(5):515–522. https://​doi.​org/​10.​1200/​JCO.​2016.​68.​5081. Epub 2016 Sep 30CrossRef

Zurück zum Zitat Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457–1461. https://doi.org/10.1126/science.1171362. Epub 2009 May 21.CrossRefPubMedPubMedCentral Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457–1461. https://​doi.​org/​10.​1126/​science.​1171362. Epub 2009 May 21.CrossRefPubMedPubMedCentral

Zurück zum Zitat Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ (2014) Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25(6):735–747. https://doi.org/10.1016/j.ccr.2014.04.021. Epub 2014 May 22.CrossRefPubMedPubMedCentral Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ (2014) Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25(6):735–747. https://​doi.​org/​10.​1016/​j.​ccr.​2014.​04.​021. Epub 2014 May 22.CrossRefPubMedPubMedCentral

Zurück zum Zitat S3-Leitlinie zum exokrinen Pankreaskarzinom Version 1.0 – Oktober 2013 AWMF-Registernummer: 032/010O. https://leitlinienprogramm-onkologie.de/uploads/tx_sbdownloader/LL_Pankreas_OL_Langversion.pdf. Zugegriffen: 20. November 2018 S3-Leitlinie zum exokrinen Pankreaskarzinom Version 1.0 – Oktober 2013 AWMF-Registernummer: 032/010O. https://​leitlinienprogra​mm-onkologie.​de/​uploads/​tx_​sbdownloader/​LL_​Pankreas_​OL_​Langversion.​pdf. Zugegriffen: 20. November 2018

Zurück zum Zitat Suh CH, Keraliya A, Shinagare AB, Kim KW, Ramaiya NH, Tirumani SH (2016) Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center. World J Radiol. 8(3):316–321. https://doi.org/10.4329/wjr.v8.i3.316.CrossRefPubMedPubMedCentral Suh CH, Keraliya A, Shinagare AB, Kim KW, Ramaiya NH, Tirumani SH (2016) Multidetector computed tomography features of pancreatic metastases from leiomyosarcoma: Experience at a tertiary cancer center. World J Radiol. 8(3):316–321. https://​doi.​org/​10.​4329/​wjr.​v8.​i3.​316.CrossRefPubMedPubMedCentral

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