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European Journal of Nutrition

Erschienen in:

01.08.2010 | Original Contribution

A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

verfasst von: C. Razquin, J. A. Martínez, M. A. Martínez-González, J. Salas-Salvadó, R. Estruch, A. Marti

Erschienen in: European Journal of Nutrition | Ausgabe 5/2010

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Abstract

Purpose

Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (−4034A/C, +45T/G, and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients.

Subjects and methods

A total of 737 participants, aged 55–80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the −4034A/C, +45T/G, and +276 G/T polymorphisms was done.

Results

GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B = 1.399; B = 0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction = 0.053).

Conclusion

Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.

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Titel: A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change
verfasst von: C. Razquin
J. A. Martínez
M. A. Martínez-González
J. Salas-Salvadó
R. Estruch
A. Marti
Publikationsdatum: 01.08.2010
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 5/2010
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-009-0090-2

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