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Sports Medicine
Erschienen in: Sports Medicine 10/2003

01.08.2003 | Leading Article

Abdominal Adipose Tissue Distribution and Metabolic Risk

verfasst von: Suzy L. Wong, Ian Janssen, Dr Robert Ross

Erschienen in: Sports Medicine | Ausgabe 10/2003

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Abstract

It is now established that waist circumference remains a significant predictor of disease and metabolic risk independent of obesity measured by body mass index. These observations are reinforced by a large body of evidence implicating abdominal obesity measured by imaging modalities in the pathogenesis of numerous metabolic risk factors. However, the extent to which abdominal subcutaneous or visceral adipose tissue (AT) independently contribute to the established association between abdominal obesity and metabolic risk remains a subject of considerable research. Discrepancies in the literature may be partially explained by methodological issues, as currently there is no accepted definition for either visceral or abdominal subcutaneous AT. Accordingly, there is confusion concerning how best to measure these depots in metabolic and descriptive studies. Further, despite numerous studies linking abdominal AT depots with metabolic risk factors, the underlying mechanisms remain unclear.
The primary purpose of this review is to examine the independent contribution of visceral and abdominal subcutaneous AT to the aetiology of obesity-related health risk. We begin by considering specific methodological issues with respect to the current classification of abdominal AT as measured by imaging methods. When necessary, we present original data to reinforce important concepts not suitably addressed in the literature. We conclude with a consideration of proposed mechanisms that may link abdominal adiposity and metabolic risk.
Literatur
1.
Chan JM, Rimm EB, Colditz GA, et al. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994; 17(9): 961–9PubMed
2.
Janssen I, Heymsfield SB, Allison DB, et al. Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat. Am J Clin Nutr 2002; 75(4): 683–8PubMed
3.
Rexrode KM, Carey VJ, Hennekens CH, et al. Abdominal adiposity and coronary heart disease in women. JAMA 1998; 280(21): 1843–8PubMed
4.
Hartz AJ, Rupley Jr DC, Kalkhoff RD, et al. Relationship of obesity to diabetes: influence of obesity level and body fat distribution. Prev Med 1983; 12(2): 351–7PubMed
5.
Frayne KN. Visceral fat and insulin resistance: causitive or correlative? Br J Nutr 2000; 83: S71–7
6.
Toth MJ, Sites CK, Cefalu WT, et al. Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women. Am J Physiol Endocrinol Metab 2001; 281(1): E113–21PubMed
7.
Smith SR, Lovejoy JC, Greenway F, et al. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 2001; 50(4): 425–35PubMed
8.
Ross R, Freeman J, Hudson R, et al. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab 2002; 87(11): 5044–51PubMed
9.
Ross R, Aru J, Freeman J, et al. Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 2002; 282(3): E657–63PubMed
10.
Misra A, Garg A, Abate N, et al. Relationship of anterior and posterior subcutaneous abdominal fat to insulin sensitivity in nondiabetic men. Obes Res 1997; 5(2): 93–9PubMed
11.
Kelley DE, Thaete FL, Troost F, et al. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 2000; 278(5): E941–8PubMed
12.
Basu A, Basu R, Shah P, et al. Systemic and regional free fatty acid metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab 2001; 280(6): E1000–6PubMed
13.
Miyazaki Y, Glass L, Triplitt C, et al. Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 2002; 283(6): E1135–43PubMed
14.
Brochu M, Starling RD, Tchernof A, et al. Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 2000; 85(7): 2378–84PubMed
15.
Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14(12): 1132–43PubMed
16.
Bjorntorp P. ‘Portal’ adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990; 10(4): 493–6PubMed
17.
Kirkland JL, Tchikonia T, Giogadze N, et al. Adipose tissue as an endocrine organ: regional differences in adipocyte endocrine function. Obes Res Prog Obes Res. In press
18.
Matsuzawa Y. Importance of adipocytokines in obesity-related diseases. Int J Obes 2002; 26Suppl. 1: S63
19.
Randle P, Hales C, Garland P, et al. The glucose fatty acid cycle. Lancet 1963; I: 785–9
20.
Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106(2): 171–6PubMed
21.
Sparrow D, Borkan GA, Gerzof SG, et al. Relationship of fat distribution to glucose tolerance: results of computed tomography in male participants of the Normative Aging Study. Diabetes 1986; 35(4): 411–5PubMed
22.
Gower BA, Nagy TR, Goran MI. Visceral fat, insulin sensitivity, and lipids in prepubertal children. Diabetes 1999; 48(8): 1515–21PubMed
23.
Cruz ML, Bergman RN, Goran MI. Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes. Diabetes Care 2002; 25(9): 1631–6PubMed
24.
Herd SL, Gower BA, Dashti N, et al. Body fat, fat distribution and serum lipids, lipoproteins and apolipoproteins in African-American and Caucasian-American prepubertal children. Int J Obes Relat Metab Disord 2001; 25(2): 198–204PubMed
25.
Pouliot MC, Despres JP, Nadeau A, et al. Visceral obesity in men: associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 1992; 41(7): 826–34PubMed
26.
Ross R, Fortier L, Hudson R. Separate associations between visceral and subcutaneous adipose tissue distribution, insulin and glucose levels in obese women. Diabetes Care 1996; 19(12): 1404–11PubMed
27.
Abate N, Garg A, Peshock RM, et al. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 1996; 45(12): 1684–93PubMed
28.
Abate N, Garg A, Peshock RM, et al. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995; 96(1): 88–98PubMed
29.
DeNino WF, Tchernof A, Dionne IJ, et al. Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women. Diabetes Care 2001; 24(5): 925–32PubMed
30.
Despres JP, Moorjani S, Ferland M, et al. Adipose tissue distribution and plasma lipoprotein levels in obese women: importance of intra-abdominal fat. Arteriosclerosis 1989; 9(2): 203–10PubMed
31.
Despres JP, Nadeau A, Tremblay A, et al. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 1989; 38(3): 304–9PubMed
32.
Ryan AS, Nicklas BJ, Berman DM. Racial differences in insulin resistance and mid-thigh fat deposition in postmenopausal women. Obes Res 2002; 10(5): 336–44PubMed
33.
Okosun IS, Cooper RS, Prewitt TE, et al. The relation of central adiposity to components of the insulin resistance syndrome in a biracial US population sample. Ethn Dis 1999; 9(2): 218–29PubMed
34.
Banerji MA, Faridi N, Atluri R, et al. Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 1999; 84(1): 137–44PubMed
35.
Raji A, Seely EW, Arky RA, et al. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 2001; 86(11): 5366–71PubMed
36.
Kohrt WM, Kirwan JP, Staten MA, et al. Insulin resistance in aging is related to abdominal obesity. Diabetes 1993; 42(2): 273–81PubMed
37.
Abate N, Garg A, Coleman R, et al. Prediction of total subcutaneous abdominal, intraperitoneal, and retroperitoneal adipose tissue masses in men by a single axial magnetic resonance imaging slice. Am J Clin Nutr 1997; 65(2): 403–8PubMed
38.
Ross R, Leger L, Morris D, et al. Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 1992; 72(2): 787–95PubMed
39.
Han TS, Kelly IE, Walsh K, et al. Relationship between volumes and areas from single transverse scans of intra-abdominal fat measured by magnetic resonance imaging. Int J Obes Relat Metab Disord 1997; 21(12): 1161–6PubMed
40.
Ross R, Shaw KD, Rissanen J, et al. Sex differences in lean and adipose tissue distribution by magnetic resonance imaging: anthropometric relationships. Am J Clin Nutr 1994; 59(6): 1277–85PubMed
41.
Rissanen J, Hudson R, Ross R. Visceral adiposity, androgens, and plasma lipids in obese men. Metabolism 1994; 43(10): 1318–23PubMed
42.
Despres JP. Health consequences of visceral obesity. Ann Med 2001; 33(8): 534–41PubMed
43.
Rice B, Janssen I, Hudson R, et al. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999; 22(5): 684–91PubMed
44.
Greenfield JR, Samaras K, Chisholm DJ, et al. Regional intra-subject variability in abdominal adiposity limits usefulness of computed tomography. Obes Res 2002; 10(4): 260–5PubMed
45.
Rebuffe-Scrive M, Bronnegard M, Nilsson A, et al. Steroid hormone receptors in human adipose tissues. J Clin Endocrinol Metab 1990; 71(5): 1215–9PubMed
46.
Marin P, Andersson B, Ottosson M, et al. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 1992; 41(11): 1242–8PubMed
47.
Jensen MD. Lipolysis: contribution from regional fat. Annu Rev Nutr 1997; 17: 127–39PubMed
48.
Markman B, Barton Jr FE. Anatomy of the subcutaneous tissue of the trunk and lower extremity. Plast Reconstr Surg 1987; 80(2): 248–54PubMed
49.
Mersmann HJ, Leymaster KA. Differential deposition and utilization of backfat layers in swine. Growth 1984; 48(3): 321–30PubMed
50.
Carey GB. The swine as a model for studying exercise-induced changes in lipid metabolism. Med Sci Sports Exerc 1997; 29(11): 1437–43PubMed
51.
Monzon JR, Basile R, Heneghan S, et al. Lipolysis in adipocytes isolated from deep and superficial subcutaneous adipose tissue. Obes Res 2002; 10(4): 266–9PubMed
52.
Park KS, Rhee BD, Lee KU, et al. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 1991; 40(6): 600–3PubMed
53.
Bonora E, Del Prato S, Bonadonna RC, et al. Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women. Diabetes 1992; 41(9): 1151–9PubMed
54.
Goodpaster BH, Thaete FL, Simoneau JA, et al. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997; 46(10): 1579–85PubMed
55.
Gautier JF, Milner MR, Elam E, et al. Visceral adipose tissue is not increased in Pima Indians compared with equally obese Caucasians and is not related to insulin action or secretion. Diabetologia 1999; 42(1): 28–34PubMed
56.
Ross R, Freeman JA, Janssen I. Exercise alone is an effective strategy for reducing obesity and related comorbidities. Exerc Sport Sci Rev 2000; 28(4): 165–70PubMed
57.
Rendell M, Hulthen UL, Tornquist C, et al. Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women. J Clin Endocrinol Metab 2001; 86(2): 744–9PubMed
58.
Ross R, Dagnone D, Jones PJ, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Intern Med 2000; 133(2): 92–103PubMed
59.
Ryan AS, Nicklas BJ, Berman DM. Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 2002; 25(1): 127–33PubMed
60.
Pouliot MC, Despres JP, Moorjani S, et al. Computed tomography-measured trunk fat and plasma lipoprotein levels in nonobese women. Metabolism 1989; 38(12): 1244–50PubMed
61.
Zamboni M, Armellini F, Milani MP, et al. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord 1992; 16(7): 495–504PubMed
62.
Zamboni M, Armellini F, Turcato E, et al. Relationship between visceral fat, steroid hormones and insulin sensitivity in premenopausal obese women. J Intern Med 1994; 236(5): 521–7PubMed
63.
Cefalu WT, Wang ZQ, Werbel S, et al. Contribution of visceral fat mass to the insulin resistance of aging. Metabolism 1995; 44(7): 954–9PubMed
64.
Albu JB, Murphy L, Frager DH, et al. Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Diabetes 1997; 46(3): 456–62PubMed
65.
Macor C, Ruggeri A, Mazzonetto P, et al. Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity. Metabolism 1997; 46(2): 123–9PubMed
66.
Johnson D, Cormack GC, Abrahams PH, et al. Computed tomographic observations on subcutaneous fat: implications for liposuction. Plast Reconstr Surg 1996; 97(2): 387–96PubMed
67.
Enevoldsen LH, Simonsen L, Stallknecht B, et al. In vivo human lipolytic activity in preperitoneal and subdivisions of subcutaneous abdominal adipose tissue. Am J Physiol Endocrinol Metab 2001; 281(5): E1110–4PubMed
68.
Despres JP, Lamarche B. Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease. Nutr Res Rev 1993; 6: 304–9
69.
Branch LG, Wetle TT, Scherr PA, et al. A prospective study of incident comprehensive medical home care use among the elderly. Am J Public Health 1988; 78(3): 255–9PubMed
70.
Lapidus L, Bengtsson C, Larsson B, et al. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. BMJ (Clin Res Ed) 1984; 289(6454): 1257–61
71.
Larsson B, Svardsudd K, Welin L, et al. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. BMJ (Clin Res Ed) 1984; 288(6428): 1401–4
72.
Ducimetiere P, Richard J, Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Int J Obes 1986; 10(3): 229–40PubMed
73.
Donahue RP, Abbott RD, Bloom E, et al. Central obesity and coronary heart disease in men. Lancet 1987; I(8537): 821–4
74.
Leenen R, van der Kooy K, Seidell JC, et al. Visceral fat accumulation measured by magnetic resonance imaging in relation to serum lipids in obese men and women. Atherosclerosis 1992; 94(2–3): 171–81PubMed
75.
Boyko EJ, Leonetti DL, Bergstrom RW, et al. Visceral adiposity, fasting plasma insulin, and lipid and lipoprotein levels in Japanese Americans. Int J Obes Relat Metab Disord 1996; 20(9): 801–8PubMed
76.
Gautier JF, Mourier A, de Kerviler E, et al. Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus: relationship to insulin resistance. J Clin Endocrinol Metab 1998; 83(4): 1306–11PubMed
77.
Lovejoy JC, Smith SR, Rood JC. Comparison of regional fat distribution and health risk factors in middle-aged white and African American women: the Healthy Transitions Study. Obes Res 2001; 9(1): 10–6PubMed
78.
Taniguchi A, Nakai Y, Sakai M, et al. Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients. Metabolism 2002; 51(5): 544–8PubMed
79.
Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster Study. Am J Cardiol 1992; 70(7): 733–7PubMed
80.
Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study: implications for treatment. Circulation 1992; 85(1): 37–45PubMed
81.
Tchernof A, Lamarche B, Prud’Homme D, et al. The dense LDL phenotype: association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care 1996; 19(6): 629–37PubMed
82.
Pascot A, Lemieux I, Prud’homme D, et al. Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res 2001; 42(12): 2007–14PubMed
83.
Lewis GF, Carpentier A, Adeli K, et al. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002; 23(2): 201–29PubMed
84.
Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 1996; 20(4): 291–302PubMed
85.
Fried SK, Russell CD, Grauso NL, et al. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest 1993; 92(5): 2191–8PubMed
86.
Kraegen EW, Clark PW, Jenkins AB, et al. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991; 40(11): 1397–403PubMed
87.
Bjorntorp P. Liver triglycerides and metabolism. Int J Obes Relat Metab Disord 1995; 19(12): 839–40PubMed
88.
Goto T, Onuma T, Takebe K, et al. The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects. Int J Obes Relat Metab Disord 1995; 19(12): 841–5PubMed
89.
Banerji MA, Buckley MC, Chaiken RL, et al. Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM. Int J Obes Relat Metab Disord 1995; 19(12): 846–50PubMed
90.
Mahmood S, Taketa K, Imai K, et al. Association of fatty liver with increased ratio of visceral to subcutaneous adipose tissue in obese men. Acta Med Okayama 1998; 52(4): 225–31PubMed
91.
Clore JN, Glickman PS, Nestler JE, et al. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol 1991; 261 (4 Pt 1): E425–9PubMed
92.
Svedberg J, Stromblad G, Wirth A, et al. Fatty acids in the portal vein of the rat regulate hepatic insulin clearance. J Clin Invest 1991; 88(6): 2054–8PubMed
93.
Stromblad G, Bjorntorp P. Reduced hepatic insulin clearance in rats with dietary-induced obesity. Metabolism 1986; 35(4): 323–7PubMed
94.
Olefsky JM. Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J Clin Invest 1976; 57(5): 1165–72PubMed
95.
Benthem L, Keizer K, Wiegman CH, et al. Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation. Am J Physiol Endocrinol Metab 2000; 279(6): E1286–93PubMed
96.
Grekin RJ, Dumont CJ, Vollmer AP, et al. Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion. Am J Physiol 1997; 273 (1 Pt 2): R324–30PubMed
97.
Grekin RJ, Vollmer AP, Sider RS. Pressor effects of portal venous oleate infusion: a proposed mechanism for obesity hypertension. Hypertension 1995; 26(1): 193–8PubMed
98.
Arner P, Kriegholm E, Engfeldt P, et al. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 1990; 85(3): 893–8PubMed
99.
Jequier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002; 967: 379–88PubMed
100.
Wilding JP. Leptin and the control of obesity. Curr Opin Pharmacol 2001; 1(6): 656–61PubMed
101.
Bouloumie A, Drexler HC, Lafontan M, et al. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998; 83(10): 1059–66PubMed
102.
Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281(5383): 1683–6PubMed
103.
Sivitz WI, Walsh SA, Morgan DA, et al. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138(8): 3395–401PubMed
104.
Rossetti L, Massillon D, Barzilai N, et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 1997; 272(44): 27758–63PubMed
105.
Zhang Y, Guo KY, Diaz PA, et al. Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol 2002; 282(1): R226–34PubMed
106.
Zhang HH, Kumar S, Barnett AH, et al. Intrinsic site-specific differences in the expression of leptin in human adipocytes and its autocrine effects on glucose uptake. J Clin Endocrinol Metab 1999; 84(7): 2550–6PubMed
107.
Van Harmelen V, Reynisdottir S, Eriksson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998; 47(6): 913–7PubMed
108.
Bennett FI, McFarlane-Anderson N, Wilks R, et al. Leptin concentration in women is influenced by regional distribution of adipose tissue. Am J Clin Nutr 1997; 66(6): 1340–4PubMed
109.
Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2(7): 800–3PubMed
110.
Bastelica D, Morange P, Berthet B, et al. Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits. Arterioscler Thromb Vasc Biol 2002; 22(1): 173–8PubMed
111.
Halleux CM, Declerck PJ, Tran SL, et al. Hormonal control of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: stimulation by glucocorticoids and inhibition by catecholamines. J Clin Endocrinol Metab 1999; 84(11): 4097–105PubMed
112.
Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002; 13(2): 84–9PubMed
113.
Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis: the missing link of adipo-vascular axis. J Biol Chem 2002; 277(40): 37487–91PubMed
114.
Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998; 83(3): 847–50PubMed
115.
Skurk T, Hauner H. Cytokine expression in cultured human adipocytes after ANG II stimulation. Int J Obes 2002; 26Suppl. 1: S120
116.
Dusserre E, Moulin P, Vidal H. Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta 2000; 1500(1): 88–96PubMed
117.
Bastard JP, Maachi M, Van Nhieu JT, et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab 2002; 87(5): 2084–9PubMed
118.
Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280(5): E745–51PubMed
119.
Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women’s health and aging study. Circulation 2001; 103(7): 947–53PubMed
120.
Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286(3): 327–34PubMed
121.
Porter MH, Cutchins A, Fine JB, et al. Effects of TNF-alpha on glucose metabolism and lipolysis in adipose tissue and isolated fat-cell preparations. J Lab Clin Med 2002; 139(3): 140–6PubMed
122.
Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994; 43(11): 1271–8PubMed
123.
Samad F, Uysal KT, Wiesbrock SM, et al. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A 1999; 96(12): 6902–7PubMed
124.
Niesler CU, Prins JB, O’Rahilly% S, et al. Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFalpha. Int J Obes Relat Metab Disord 2001; 25(7): 1027–33PubMed
125.
Frederich Jr RC, Kahn BB, Peach MJ, et al. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 1992; 19(4): 339–44PubMed
126.
Paul M, Wagner J, Dzau VJ. Gene expression of the renin-angiotensin system in human tissues: quantitative analysis by the polymerase chain reaction. J Clin Invest 1993; 91(5): 2058–64PubMed
127.
van Harmelen V, Elizalde M, Ariapart P, et al. The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity. Int J Obes Relat Metab Disord 2000; 24(6): 673–8PubMed
Metadaten
Titel
Abdominal Adipose Tissue Distribution and Metabolic Risk
verfasst von
Suzy L. Wong
Ian Janssen
Dr Robert Ross
Publikationsdatum
01.08.2003
Verlag
Springer International Publishing
Erschienen in
Sports Medicine / Ausgabe 10/2003
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI
https://doi.org/10.2165/00007256-200333100-00001

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Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

Update Orthopädie und Unfallchirurgie

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