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20.06.2018 | Neuro

Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke

verfasst von: Xinfeng Yu, Yeerfan Jiaerken, Xiaojun Xu, Alan Jackson, Peiyu Huang, Linglin Yang, Lixia Yuan, Min Lou, Quan Jiang, Minming Zhang

Erschienen in: European Radiology | Ausgabe 1/2019

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Abstract

Objectives

To test the hypothesis that abnormal corpus callosum (CC) induced by diabetes may impair inter-hemispheric sensorimotor functional connectivity (FC) that is associated with poor clinical outcome after stroke.

Methods

Forty-five patients with acute ischaemic stroke in the middle cerebral artery territory and 14 normal controls participated in the study. CC was divided into five subregions on three-dimensional T1-weighted image. The microstructural integrity of each subregion of CC was analysed by DTI and the inter-hemispheric FCs in primary motor cortex (M1-M1 FC) and primary sensory cortex (S1-S1 FC) were examined by resting-state functional magnetic resonance imaging.

Results

Diabetic patients (n = 26) had significantly lower fractional anisotropy (FA) in the isthmus of CC (CC_isthmus) when compared with non-diabetic patients (n = 19) and normal controls (p < 0.0001). In addition, diabetic patients had the lowest M1-M1 FC (p = 0.015) and S1-S1 FC (p = 0.001). In diabetic patients, reduced FA of CC_isthmus correlated with decreased M1-M1 FC (r = 0.549, p = 0.004) and S1-S1 FC (r = 0.507, p = 0.008). Decreased M1-M1 FC was independently associated with poor outcome after stroke in patients with diabetes (odds ratio = 0.448, p = 0.017).

Conclusions

CC degeneration induced by diabetes impairs sensorimotor connectivity and dysfunction of motor connectivity can contribute to poor recovery after stroke in patients with diabetes.

Key points

• Abnormal isthmus of corpus callosum in stroke patients with diabetes.

• Abnormal isthmus of corpus callosum correlated with decreased inter-hemispheric sensorimotor connectivity.

• Decreased motor connectivity correlated with poor stroke outcome in diabetic patients.

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Titel: Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke
verfasst von: Xinfeng Yu
Yeerfan Jiaerken
Xiaojun Xu
Alan Jackson
Peiyu Huang
Linglin Yang
Lixia Yuan
Min Lou
Quan Jiang
Minming Zhang
Publikationsdatum: 20.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 1/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5576-y

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Abnormal corpus callosum induced by diabetes impairs sensorimotor connectivity in patients after acute stroke