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NeuroMolecular Medicine

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04.12.2019 | Review Paper

ACE-Triggered Hypertension Incites Stroke: Genetic, Molecular, and Therapeutic Aspects

verfasst von: Kanika Vasudeva, Renuka Balyan, Anjana Munshi

Erschienen in: NeuroMolecular Medicine | Ausgabe 2/2020

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Abstract

Stroke is the second largest cause of death worldwide. Angiotensin converting enzyme (ACE) gene has emerged as an important player in the pathogenesis of hypertension and consequently stroke. It encodes ACE enzyme that converts the inactive decapeptide angiotensin I to active octapeptide, angiotensin II (Ang II). Dysregulation in the expression of ACE gene, on account of genetic variants or regulation by miRNAs, alters the levels of ACE in the circulation. Variable expression of ACE affects the levels of Ang II. Ang II acts through different signal transduction pathways via various tyrosine kinases (receptor/non-receptor) and protein serine/threonine kinases, initiating a downstream cascade of molecular events. In turn these activated molecular pathways might lead to hypertension and inflammation thereby resulting in cardiovascular and cerebrovascular diseases including stroke. In order to regulate the overexpression of ACE, many ACE inhibitors and blockers have been developed, some of which are still under clinical trials.

Abeywardena, M. Y., Leifert, W. R., Warnes, K. E., Varghese, J. N., & Head, R. J. (2009). Cardiovascular biology of interleukin-6. Current Pharmaceutical Design,15(15), 1809–1821.PubMedCrossRef

Agarwal, D., Dange, R. B., Raizada, M. K., & Francis, J. (2013). Angiotensin II causes imbalance between pro-and anti-inflammatory cytokines by modulating GSK-3β in neuronal culture. British Journal of Pharmacology,169(4), 860–874.PubMedPubMedCentralCrossRef

Allen, A. M. (2002). Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone. Hypertension,39(2), 275–280.PubMedCrossRef

Arnold, J. M. O., Yusuf, S., Young, J., Mathew, J., Johnstone, D., Avezum, A., … Bosch, J. (2003). Prevention of heart failure in patients in the Heart Outcomes Prevention Evaluation (HOPE) study. Circulation, 107(9), 1284–1290.

Barnes, P. J., & Karin, M. (1997). Nuclear factor-κB—A pivotal transcription factor in chronic inflammatory diseases. New England Journal of Medicine,336(15), 1066–1071.PubMedCrossRef

Bátkai, S., & Thum, T. (2012). MicroRNAs in hypertension: Mechanisms and therapeutic targets. Current Hypertension Reports,14(1), 79–87.PubMedCrossRef

Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., … Isasi, C. (2017). Heart disease and stroke statistics-2017 update: A report from the American Heart Association. Circulation, 135(10), e146–e603.

Biancardi, V. C., Bomfim, G. F., Reis, W. L., Al-Gassimi, S., & Nunes, K. P. (2017). The interplay between Angiotensin II, TLR4 and hypertension. Pharmacological Research,120, 88–96.PubMedCrossRef

Boettger, T., Beetz, N., Kostin, S., Schneider, J., Krüger, M., Hein, L., et al. (2009). Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. The Journal of Clinical Investigation,119(9), 2634–2647.PubMedPubMedCentralCrossRef

Böhm, M., Schumacher, H., Teo, K. K., Lonn, E. M., Mahfoud, F., Mann, J. F., … Sliwa, K. (2017). Achieved blood pressure and cardiovascular outcomes in high-risk patients: Results from ONTARGET and TRANSCEND trials. The Lancet, 389(10085), 2226–2237.

Booth, H. D., Hirst, W. D., & Wade-Martins, R. (2017). The role of astrocyte dysfunction in Parkinson’s disease pathogenesis. Trends in Neurosciences,40(6), 358–370.PubMedPubMedCentralCrossRef

Braga, V., Medeiros, I., Ribeiro, T., França-Silva, M., Botelho-Ono, M., & Guimarães, D. (2011). Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: Implications in neurogenic hypertension. Brazilian Journal of Medical and Biological Research,44(9), 871–876.PubMedCrossRef

Brambilla, L., Martorana, F., & Rossi, D. (2013). Astrocyte signaling and neurodegeneration: New insights into CNS disorders. Prion,7(1), 28–36.PubMedPubMedCentralCrossRef

Campese, V. M., Shaohua, Y., & Huiquin, Z. (2005). Oxidative stress mediates angiotensin II–dependent stimulation of sympathetic nerve activity. Hypertension,46(3), 533–539.PubMedCrossRef

Cardinale, J. P., Sriramula, S., Mariappan, N., Agarwal, D., & Francis, J. (2012). Angiotensin II–induced hypertension is modulated by nuclear factor-κB in the paraventricular nucleus. Hypertension,59(1), 113–121.PubMedCrossRef

Carmichael, C. Y., & Wainford, R. D. (2015). Hypothalamic signaling mechanisms in hypertension. Current Hypertension Reports,17(5), 39.PubMedPubMedCentralCrossRef

Castoldi, G., Di Gioia, C. R., Bombardi, C., Catalucci, D., Corradi, B., Gualazzi, M. G., … Condorelli, G. (2012). MiR-133a regulates collagen 1A1: Potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Journal of cellular physiology, 227(2), 850–856.

Castoldi, G., di Gioia, C., Giollo, F., Carletti, R., Bombardi, C., Antoniotti, M., … Stella, A. (2016). Different regulation of miR-29a-3p in glomeruli and tubules in an experimental model of angiotensin II-dependent hypertension: Potential role in renal fibrosis. Clinical and Experimental Pharmacology and Physiology, 43(3), 335–342.

Celiker, G., Can, U., Verdi, H., Yazici, A. C., Ozbek, N., & Atac, F. B. (2009). Prevalence of thrombophilic mutations and ACE I/D polymorphism in Turkish ischemic stroke patients. Clinical and Applied Thrombosis/Hemostasis,15(4), 415–420.PubMedCrossRef

Chalmers, J., & MacMahon, S. (2003). Perindopril protection against Recurrent Stroke Study (PROGRESS): Interpretation and implementation. Journal of Hypertension,21, S9–S14.PubMedCrossRef

Chan, J. Y., Chen, W.-C., Lee, H.-Y., & Chan, S. H. (1998). Elevated Fos expression in the nucleus tractus solitarii is associated with reduced baroreflex response in spontaneously hypertensive rats. Hypertension,32(5), 939–944.PubMedCrossRef

Chen, Y.-C., Chang, K.-H., & Chen, C.-M. (2018). Genetic polymorphisms associated with spontaneous intracerebral hemorrhage. International Journal of Molecular Sciences,19(12), 3879.PubMedCentralCrossRef

Chen, M. M., Lam, A., Abraham, J. A., Schreiner, G. F., & Joly, A. H. (2000). CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis. Journal of Molecular and Cellular Cardiology,32(10), 1805–1819.PubMedCrossRef

Cheng, W.-H., Lu, P.-J., Ho, W.-Y., Tung, C.-S., Cheng, P.-W., Hsiao, M., et al. (2010). Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure. Circulation Research,106(4), 788.PubMedCrossRef

Chengzhi, L., Li, W., Essackjee, A., Sherpa, N., & Di, L. (2012). Angiotensin-II induced reactive oxygen species: Implications in neurogenic hypertension. Journal of Hypertension,1, 106.

Clark, M. A., & Gonzalez, N. (2007a). Angiotensin II stimulates rat astrocyte mitogen-activated protein kinase activity and growth through EGF and PDGF receptor transactivation. Regulatory Peptides,144(1–3), 115–122.PubMedCrossRef

Clark, M. A., & Gonzalez, N. (2007b). Src and Pyk2 mediate angiotensin II effects in cultured rat astrocytes. Regulatory Peptides,143(1–3), 47–55.PubMedCrossRef

Clark, M. A., Guillaume, G., & Pierre-Louis, H. C. (2008). Angiotensin II induces proliferation of cultured rat astrocytes through c-Jun N-terminal kinase. Brain Research Bulletin,75(1), 101–106.PubMedCrossRef

Clark, M., Landrum, M., & Tallant, E. (2001). Angiotensin II activates mitogen-activated protein kinases and stimulates growth in rat medullary astrocytes. Paper Presented at the Faseb Journal.

Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., … Lederballe-Pedersen, O. (2002). Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol. The Lancet, 359(9311), 995–1003.

Dardiotis, E., Jagiella, J., Xiromerisiou, G., Dardioti, M., Vogiatzi, C., Urbanik, A., … Slowik, A. (2011). Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage. Pharmacogenetics and Genomics, 21(3), 136–141.

Das, S., Roy, S., Sharma, V., Kaul, S., Jyothy, A., & Munshi, A. (2015). Association of ACE gene I/D polymorphism and ACE levels with hemorrhagic stroke: Comparison with ischemic stroke. Neurological Sciences,36(1), 137–142.PubMedCrossRef

Daub, H., Weiss, F. U., Wallasch, C., & Ullrich, A. (1996). Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature,379(6565), 557.PubMedCrossRef

Delaney, J., Chiarello, R., Villar, D., Kandalam, U., Castejon, A. M., & Clark, M. A. (2008). Regulation of c-fos, c-jun and c-myc gene expression by angiotensin II in primary cultured rat astrocytes: Role of ERK1/2 MAP kinases. Neurochemical Research,33(3), 545–550.PubMedCrossRef

Dennis, G. J. (2008). A haplotype analysis of the angiotensin converting enzyme gene in ischaemic stroke. Leicester: University of Leicester.

Di Malta, C., Fryer, J. D., Settembre, C., & Ballabio, A. (2012). Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder. Proceedings of the National Academy of Sciences USA,109(35), E2334–E2342.CrossRef

Dive, V., Cotton, J., Yiotakis, A., Michaud, A., Vassiliou, S., Jiracek, J., … Corvol, P. (1999). RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites. Proceedings of the National Academy of Sciences USA, 96(8), 4330–4335.

Domingues-Montanari, S., Fernandez-Cadenas, I., Del Rio-Espinola, A., Mendioroz, M., Ribo, M., Obach, V., … Corbeto, N. (2010). The I/D polymorphism of the ACE1 gene is not associated with ischaemic stroke in Spanish individuals. European Journal of Neurology, 17(11), 1390–1392.

Domingues-Montanari, S., Hernandez-Guillamon, M., Fernandez-Cadenas, I., Mendioroz, M., Boada, M., Munuera, J., … Gutierrez, M. (2011). ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy. Neurobiology of Aging, 32(3), 551. e513–551. e522.

Eguchi, S., & Inagami, T. (2000). Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regulatory Peptides,91(1–3), 13–20.PubMedCrossRef

Eskildsen, T., Jeppesen, P., Schneider, M., Nossent, A., Sandberg, M., Hansen, P., … Rasmussen, L. (2013). Angiotensin II regulates microRNA-132/-212 in hypertensive rats and humans. International Journal of Molecular Sciences, 14(6), 11190–11207.

Fernandes, T., Hashimoto, N. Y., Magalhaes, F. C., Fernandes, F. B., Casarini, D. E., Carmona, A. K., … Oliveira, E. M. (2011). Aerobic exercise training–induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension, 58(2), 182–189.

Ferrari, R. (2004). Preserving bradykinin or blocking angiotensin II: The cardiovascular dilemma. Dialogues in Cardiovascular Medicine,9, 71–92.

Ferrario, C. M. (2002). Use of angiotensin II receptor blockers in animal models of atherosclerosis. American Journal of Hypertension,15(S1), 9S–13S.PubMedCrossRef

Ferrario, C. M. (2011). ACE 2: More of Ang 1-7 or less Ang II? Current Opinion in Nephrology and Hypertension,20(1), 1.PubMedPubMedCentralCrossRef

Frauman, A. G., Johnston, C. I., & Fabiani, M. E. (2001). Angiotensin receptors: Distribution, signalling and function. Clinical Science,100(5), 481–492.PubMedCrossRef

Gao, S., Liu, T.-W., Wang, Z., Jiao, Z.-Y., Cai, J., Chi, H.-J., et al. (2014). Downregulation of MicroRNA-19b contributes to angiotensin II-induced overexpression of connective tissue growth factor in cardiomyocytes. Cardiology,127(2), 114–120.PubMedCrossRef

Gormley, K., Bevan, S., & Markus, H. (2007). Polymorphisms in genes of the renin-angiotensin system and cerebral small vessel disease. Cerebrovascular Diseases,23(2–3), 148–155.PubMedCrossRef

Goyal, R., Goyal, D., Leitzke, A., Gheorghe, C. P., & Longo, L. D. (2010). Brain renin-angiotensin system: Fetal epigenetic programming by maternal protein restriction during pregnancy. Reproductive Sciences,17(3), 227–238.PubMedCrossRef

Group, P. C. (2001). Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. The Lancet,358(9287), 1033–1041.CrossRef

Higuchi, S., Ohtsu, H., Suzuki, H., Shirai, H., Frank, G. D., & Eguchi, S. (2007). Angiotensin II signal transduction through the AT1 receptor: Novel insights into mechanisms and pathophysiology. Clinical Science,112(8), 417–428.PubMedCrossRef

Hu, B., TaoSong, J., YanQu, H., LongBi, C., ZhenHuang, X., XinLiu, X., et al. (2014). Mechanical stretch suppresses microRNA-145 expression by activating extracellular signal-regulated kinase 1/2 and upregulating angiotensin-converting enzyme to alter vascular smooth muscle cell phenotype. PLoS ONE,9(5), e96338.PubMedPubMedCentralCrossRef

Huang, Y., Li, G., Lan, H., Zhao, G., & Huang, C. (2014). Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: A meta-analysis of epidemiologic studies. Journal of the Renin-Angiotensin-Aldosterone System,15(1), 32–38.PubMedCrossRef

Hubert, C., Houot, A.-M., Corvol, P., & Soubrier, F. (1991). Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. Journal of Biological Chemistry, 266(23), 15377-15383.

Jackson, K. L., Marques, F. Z., Nguyen-Huu, T.-P., Stevenson, E. R., Charchar, F. J., Davern, P. J., & Head, G. A. (2014). MicroRNA-181a mimic inhibits the renin-angiotensin system and attenuates hypertension in a neurogenic model of hypertension. Hypertension, 64(suppl_1), A038-A038.

Jacob, H. J., Lindpaintner, K., Lincoln, S. E., Kusumi, K., Bunker, R. K., Mao, Y.-P., ... Lander, E. S. (1991). Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell,67(1), 213–224.

Jeppesen, P. L., Christensen, G. L., Schneider, M., Nossent, A. Y., Jensen, H. B., Andersen, D. C., ... Sheikh, S. P. (2011). Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes. British Journal of Pharmacology,164(2), 394–404.

Jiang, L., Zhou, X., Yang, H., Guan, R., Xin, Y., Wang, J., ... Wang, J. (2013). ACE2-Ang-(1-7)-Mas axis in brain: A potential target for prevention and treatment of ischemic stroke. Current Neuropharmacology,11(2), 209–217.

Jiang, L., Zhou, X., Yang, H., Guan, R., Xin, Y., Wang, J.,… Wang, J. (2018). Upregulation of AT1 Receptor Mediates a Pressor Effect through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats with Stress-Induced Hypertension. Frontiers in physiology, 9.

Jin, W., Reddy, M. A., Chen, Z., Putta, S., Lanting, L., Kato, M., ... Tangirala, R. K. (2012). Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells. Journal of Biological Chemistry,287(19), 15672–15683.

Kalita, J., Somarajan, B. I., Kumar, B., Mittal, B., & Misra, U. K. (2011). A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke. Clinica Chimica Acta,412(7–8), 642–646.CrossRef

Kandalam, U., & Clark, M. A. (2010). Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes. Regulatory Peptides,159(1–3), 110–116.PubMedCrossRef

Kang, Y.-M., Ma, Y., Zheng, J.-P., Elks, C., Sriramula, S., Yang, Z.-M., et al. (2009). Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovascular Research,82(3), 503–512.PubMedPubMedCentralCrossRef

Kaul, S., & Munshi, A. (2012). Genetics of ischemic stroke: Indian perspective. Neurology India,60(5), 498.PubMedCrossRef

Kemp, J. R., Unal, H., Desnoyer, R., Yue, H., Bhatnagar, A., & Karnik, S. S. (2014). Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin–angiotensin system. Journal of Molecular and Cellular Cardiology,75, 25–39.PubMedPubMedCentralCrossRef

Keramatipour, M., McConnell, R. S., Kirkpatrick, P., Tebbs, S., Furlong, R. A., & Rubinsztein, D. C. (2000). The ACE I allele is associated with increased risk for ruptured intracranial aneurysms. Journal of Medical Genetics,37(7), 498–500.PubMedPubMedCentralCrossRef

Khakh, B. S., Beaumont, V., Cachope, R., Munoz-Sanjuan, I., Goldman, S. A., & Grantyn, R. (2017). Unravelling and exploiting astrocyte dysfunction in Huntington’s disease. Trends in Neurosciences,40(7), 422–437.PubMedPubMedCentralCrossRef

Kim, V. N. (2005). MicroRNA biogenesis: Coordinated cropping and dicing. Nature Reviews Molecular Cell Biology,6(5), 376.PubMedCrossRef

Kim, C. W., Kumar, S., Son, D. J., Jang, I.-H., Griendling, K. K., & Jo, H. (2014). Prevention of abdominal aortic aneurysm by Anti–MicroRNA-712 or Anti–MicroRNA-205 in angiotensin II–infused mice. Arteriosclerosis, Thrombosis, and Vascular Biology,34(7), 1412–1421.PubMedPubMedCentralCrossRef

Kim-Mitsuyama, S., Izumi, Y., Izumiya, Y., Namba, M., Yoshida, K., Wake, R., ... Iwao, H. (2006). Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension. Gene Therapy,13(4), 348.

Kohlstedt, K., Trouvain, C., Boettger, T., Shi, L., Fisslthaler, B., & Fleming, I. (2013). AMP-activated protein kinase regulates endothelial cell angiotensin-converting enzyme expression via p53 and the post-transcriptional regulation of microRNA-143/145. Circulation Research,112(8), 1150–1158.PubMedCrossRef

Kretzschmar, M., & Massagué, J. (1998). SMADs: Mediators and regulators of TGF-β signaling. Current Opinion in Genetics & Development,8(1), 103–111.CrossRef

Krupinski, J., Kumar, P., Kumar, S., & Kaluza, J. (1996). Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans. Stroke,27(5), 852–857.PubMedCrossRef

Kumar, A., Vivekanandhan, S., Srivastava, A., Tripathi, M., Padma Srivastava, M., Saini, N., ... Prasad, K. (2014). Association between angiotensin converting enzyme gene insertion/deletion polymorphism and ischemic stroke in North Indian population: A case–control study and meta-analysis. Neurological Research,36(9), 786–794.

Lambert, D. W., Lambert, L. A., Clarke, N. E., Hooper, N. M., Porter, K. E., & Turner, A. J. (2014). Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421. Clinical Science,127(4), 243–249.PubMedCrossRef

Lanz, T. V., Ding, Z., Ho, P. P., Luo, J., Agrawal, A. N., Srinagesh, H., ... Wyss-Coray, T. (2010). Angiotensin II sustains brain inflammation in mice via TGF-β. The Journal of Clinical Investigation,120(8), 2782–2794.

Lassègue, B., & Griendling, K. K. (2010). NADPH oxidases: Functions and pathologies in the vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology,30(4), 653–661.PubMedCrossRef

Lee, Y., Kim, M., Han, J., Yeom, K. H., Lee, S., Baek, S. H., et al. (2004). MicroRNA genes are transcribed by RNA polymerase II. The EMBO journal,23(20), 4051–4060.PubMedPubMedCentralCrossRef

Li, Z., Bains, J. S., & Ferguson, A. V. (1993). Functional evidence that the angiotensin antagonist losartan crosses the blood-brain barrier in the rat. Brain Research Bulletin,30(1–2), 33–39.PubMedCrossRef

Lin, H., Pan, S., Meng, L., Zhou, C., Jiang, C., Ji, Z., ... Guo, H. (2017). MicroRNA-384-mediated Herpud1 upregulation promotes angiotensin II-induced endothelial cell apoptosis. Biochemical and Biophysical Research Communications,488(3), 453–460.

Lonn, E. M., Bosch, J., López-Jaramillo, P., Zhu, J., Liu, L., Pais, P., ... Dans, A. (2016). Blood-pressure lowering in intermediate-risk persons without cardiovascular disease. New England Journal of Medicine,374(21), 2009–2020.

Lyle, A. N., & Griendling, K. K. (2006). Modulation of vascular smooth muscle signaling by reactive oxygen species. Physiology,21(4), 269–280.PubMedCrossRef

Malueka, R. G., Dwianingsih, E. K., Sutarni, S., Bawono, R. G., Bayuangga, H. F., Gofir, A., et al. (2018). The D allele of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is associated with worse functional outcome of ischaemic stroke. International Journal of Neuroscience,128(8), 697–704.PubMedCrossRef

Malueka, R. G., Dwianingsih, E. K., Sutarni, S., Gofir, A., & Setyopranoto, I. (2017). Association between ace gene polymorphism and functional outcome of ischemic stroke. Journal of the Neurological Sciences,381, 618.CrossRef

Markoula, S., Giannopoulos, S., Kostoulas, C., Tatsioni, A., Bouba, I., Maranis, S.,… Kyritsis, A. P. (2011). Gender association of the angiotensin-converting enzyme gene with ischaemic stroke. Journal of the Renin-Angiotensin-Aldosterone System, 12(4), 510-515.

Martínez-Rodríguez, N., Posadas-Romero, C., Villarreal-Molina, T., Vallejo, M., Del-Valle-Mondragón, L., Ramírez-Bello, J., ... Vargas-Alarcón, G. (2013). Single nucleotide polymorphisms of the angiotensin-converting enzyme (ACE) gene are associated with essential hypertension and increased ACE enzyme levels in Mexican individuals. PLoS ONE,8(5), e65700.

Matarin, M., Brown, W. M., Dena, H., Britton, A., De Vrieze, F. W., Brott, T. G., ... Chanock, S. J. (2009). Candidate gene polymorphisms for ischemic stroke. Stroke,40(11), 3436–3442.

Mengesha, H. G., Petrucka, P., Spence, C., & Tafesse, T. B. (2019). Effects of angiotensin converting enzyme gene polymorphism on hypertension in Africa: A meta-analysis and systematic review. PLoS ONE,14(2), e0211054.PubMedPubMedCentralCrossRef

Miller, A. J., & Arnold, A. C. (2019). The renin–angiotensin system in cardiovascular autonomic control: Recent developments and clinical implications. Clinical Autonomic Research,29(2), 231–243.PubMedCrossRef

Moore, J. P., Vinh, A., Tuck, K. L., Sakkal, S., Krishnan, S. M., Chan, C. T., ... Kemp-Harper, B. K. (2015). M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure. American Journal of Physiology-Heart and Circulatory Physiology,309(5), H906–H917.

Munshi, A., Das, S., & Kaul, S. (2015). Genetic determinants in ischaemic stroke subtypes: Seven year findings and a review. Gene,555(2), 250–259.PubMedCrossRef

Munshi, A., & Kaul, S. (2010). Genetic basis of stroke: An overview. Neurology India,58(2), 185.PubMedCrossRef

Munshi, A., Sultana, S., Kaul, S., Reddy, B. P., Alladi, S., & Jyothy, A. (2008). Angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population. Journal of the Neurological Sciences,272(1–2), 132–135.PubMedCrossRef

Nemecz, M., Alexandru, N., Tanko, G., & Georgescu, A. (2016). Role of microRNA in endothelial dysfunction and hypertension. Current Hypertension Reports,18(12), 87.PubMedPubMedCentralCrossRef

Ning, Q., & Jiang, X. (2013). Angiotensin II upregulated the expression of microRNA-224 but not microRNA-21 in adult rat cardiac fibroblasts. Biomedical reports,1(5), 776–780.PubMedPubMedCentralCrossRef

Ohkuma, T., Jun, M., Rodgers, A., Cooper, M. E., Glasziou, P., Hamet, P., ... Neal, B. (2019). Acute increases in serum creatinine after starting angiotensin-converting enzyme inhibitor-based therapy and effects of its continuation on major clinical outcomes in Type 2 diabetes mellitus: The ADVANCE Trial. Hypertension,73(1), 84–91.

Pannu, H., Kim, D. H., Seaman, C. R., Van Ginhoven, G., Shete, S., & Milewicz, D. M. (2005). Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States. Journal of Neurosurgery,103(1), 92–96.PubMedCrossRef

Peck, G., Smeeth, L., Whittaker, J., Casas, J. P., Hingorani, A., & Sharma, P. (2008). The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS ONE,3(11), e3691.PubMedPubMedCentralCrossRef

Peña-Silva, R. A., & Heistad, D. D. (2015). Stages in discovery: ACE2 and stroke. Hypertension,66(1), 15.PubMedPubMedCentralCrossRef

Pera, J., Slowik, A., Dziedzic, T., Wloch, D., & Szczudlik, A. (2006). ACE I/D polymorphism in different etiologies of ischemic stroke. Acta Neurologica Scandinavica,114(5), 320–322.PubMedCrossRef

Peterson, M. C. (2005). Circulating transforming growth factor ß-1: A partial molecular explanation for associations between hypertension, diabetes, obesity, smoking and human disease involving fibrosis. Medical Science Monitor, 11(7), RA229–RA232.

Peterson, J. R., Burmeister, M. A., Tian, X., Zhou, Y., Guruju, M. R., Stupinski, J. A., ... Davisson, R. L. (2009). Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension,54(5), 1106–1114.

Prabhakar, P., De, T., Nagaraja, D., & Christopher, R. (2014). Angiotensin-converting enzyme gene insertion/deletion polymorphism and small vessel cerebral stroke in Indian population. International Journal of Vascular Medicine, 1–4.

Ruilope, L. M., Redón, J., & Schmieder, R. (2007). Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? Expectations from the ONTARGET Trial Programme. Vascular Health and Risk Management,3(1), 1.PubMedPubMedCentral

Saavedra, J. M. (2005). Brain angiotensin II: New developments, unanswered questions and therapeutic opportunities. Cellular and Molecular Neurobiology,25(3–4), 485–512.PubMedCrossRef

Sacco, R. L., Kasner, S. E., Broderick, J. P., Caplan, L. R., Connors, J., Culebras, A., … Higashida, R. T. (2013). An updated definition of stroke for the 21st century: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 44(7), 2064–2089.

Saito, Y., & Berk, B. C. (2001). Transactivation: A novel signaling pathway from angiotensin II to tyrosine kinase receptors. Journal of Molecular and Cellular Cardiology,33(1), 3–7.PubMedCrossRef

Santos, R. A., de Silva, A. C. S., Maric, C., Silva, D. M., Machado, R. P., de Buhr, I., … Bader, M. (2003). Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas. Proceedings of the National Academy of Sciences USA, 100(14), 8258–8263.

Sayed-Tabatabaei, F., Oostra, B., Isaacs, A., Van Duijn, C., & Witteman, J. (2006). ACE polymorphisms. Circulation Research,98(9), 1123–1133.PubMedCrossRef

Schrader, J., Lüders, S., Kulschewski, A., Hammersen, F., Plate, K., Berger, J. r., … Group, M. S. (2005). Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: Principal results of a prospective randomized controlled study (MOSES). Stroke, 36(6), 1218–1224.

Sharma, N. M., & Patel, K. P. (2017). Post-translational regulation of neuronal nitric oxide synthase: Implications for sympathoexcitatory states. Expert opinion on therapeutic targets,21(1), 11–22.PubMedCrossRef

Sica, D. A. (2010). The evolution of renin-angiotensin blockade: Angiotensin-converting enzyme inhibitors as the starting point. Current Hypertension Reports,12(2), 67–73.PubMedCrossRef

Sica, D. A. (2016). A Review of antihypertensive drugs and choosing the right antihypertensive for recurrent stroke prevention hypertension and stroke (pp. 245–257). New York: Springer.

Slowik, A., Borratynska, A., Pera, J., Betlej, M., Dziedzic, T., Krzyszkowski, T., … Szczudlik, A. (2004). II genotype of the angiotensin-converting enzyme gene increases the risk for subarachnoid hemorrhage from ruptured aneurysm. Stroke, 35(7), 1594–1597.

Smeda, J. S., VanVliet, B. N., & King, S. R. (1999). Stroke-prone spontaneously hypertensive rats lose their ability to auto-regulate cerebral blood flow prior to stroke. Journal of Hypertension,17(12), 1697–1705.PubMedCrossRef

Sriramula, S., Cardinale, J. P., Lazartigues, E., & Francis, J. (2011). ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovascular Research,92(3), 401–408.PubMedPubMedCentralCrossRef

Sriramula, S., Xia, H., Xu, P., & Lazartigues, E. (2015). Brain-targeted ACE2 overexpression attenuates neurogenic hypertension by inhibiting COX mediated inflammation. Hypertension,65(3), 577.PubMedCrossRef

Staalsø, J. M., Nielsen, M., Edsen, T., Koefoed, P., Springborg, J. B., Moltke, F. B., … Olsen, N. V. (2011). Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: A case-control study. Journal of Neurosurgical Anesthesiology, 23(4), 304–309.

Sun, Y., Liu, Y., Watts, L. T., Sun, Q., Zhong, Z., Yang, G.-Y., & Bian, L. (2014). Correction: Genetic Associations of Angiotensin-Converting Enzyme with Primary Intracerebral Hemorrhage: A Meta-analysis. PloS one, 9(1).

Taddei, S., & Bortolotto, L. (2016). Unraveling the pivotal role of bradykinin in ACE inhibitor activity. American Journal of Cardiovascular Drugs,16(5), 309–321.PubMedCrossRef

Tascilar, N., Dursun, A., Ankarali, H., Mungan, G., Ekem, S., & Baris, S. (2009). Angiotensin-converting enzyme insertion/deletion polymorphism has no effect on the risk of atherosclerotic stroke or hypertension. Journal of the Neurological Sciences,285(1–2), 137–141.PubMedCrossRef

ten Dijke, P., & Hill, C. S. (2004). New insights into TGF-β–Smad signalling. Trends in Biochemical Sciences,29(5), 265–273.PubMedCrossRef

Tsuda, K. (2012). Renin-angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension. International journal of hypertension, 2012.

Tuncer, N., Tuglular, S., Kılıç, G., Sazcı, A., Us, Ö., & Kara, İ. (2006). Evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischaemic stroke. Journal of Clinical Neuroscience,13(2), 224–227.PubMedCrossRef

Villard, E., & Soubrier, F. (1996). Molecular biology and genetics of the angiotensin-I-converting enzyme: Potential implications in cardiovascular diseases. Cardiovascular Research,32(6), 999–1007.PubMedCrossRef

Villard, E., Tiret, L., Visvikis, S., Rakotovao, R., Cambien, F., & Soubrier, F. (1996). Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis. American Journal of Human Genetics,58(6), 1268.PubMedPubMedCentral

Wang, X., & Abdel-Rahman, A. A. (2004). An association between ethanol-evoked enhancement of c-jun gene expression in the nucleus tractus solitarius and the attenuation of baroreflexes. Alcoholism: Clinical and Experimental Research,28(8), 1264–1272.CrossRef

Wei, L. K., Au, A., Menon, S., Griffiths, L. R., Kooi, C. W., Irene, L., … Hassan, M. R. A. (2017). Polymorphisms of MTHFR, eNOS, ACE, AGT, ApoE, PON1, PDE4D, and ischemic stroke: Meta-analysis. Journal of Stroke and Cerebrovascular Diseases, 26(11), 2482–2493.

Weigert, C., Brodbeck, K., Klopfer, K., Häring, H., & Schleicher, E. (2002). Angiotensin II induces human TGF-β1 promoter activation: Similarity to hyperglycaemia. Diabetologia,45(6), 890–898.PubMedCrossRef

Weir, M. R., & Dzau, V. J. (1999). The renin-angiotensin-aldosterone system: A specific target for hypertension management. American Journal of Hypertension,12(S9), 205S–213S.PubMedCrossRef

Wu, W.-H., Hu, C.-P., Chen, X.-P., Zhang, W.-F., Li, X.-W., Xiong, X.-M., et al. (2011). MicroRNA-130a mediates proliferation of vascular smooth muscle cells in hypertension. American Journal of Hypertension,24(10), 1087–1093.PubMedCrossRef

Yang, L.-x., Liu, G., Zhu, G.-f., Liu, H., Guo, R.-w., Qi, F., & Zou, J.-h. (2014). MicroRNA-155 inhibits angiotensin II-induced vascular smooth muscle cell proliferation. Journal of the Renin-Angiotensin-Aldosterone System, 15(2), 109-116.

Yang, Y., Ago, T., Zhai, P., Abdellatif, M., & Sadoshima, J. (2011). Thioredoxin 1 negatively regulates angiotensin II–induced cardiac hypertrophy through upregulation of miR-98/let-7. Circulation Research,108(3), 305–313.PubMedCrossRef

Yang, X., Long, L., Southwood, M., Rudarakanchana, N., Upton, P. D., Jeffery, T. K., … Morrell, N. W. (2005). Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circulation Research, 96(10), 1053–1063.

Yang, Y., Zhou, Y., Cao, Z., Tong, X. Z., Xie, H. Q., Luo, T., … Wang, H. Q. (2016). miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy. Experimental and Therapeutic Medicine, 12(3), 1556–1562.

Yazawa, H., Miyachi, M., Furukawa, M., Takahashi, K., Takatsu, M., Tsuboi, K., … Kato, Y. (2011). Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats. Journal of Cardiac Failure, 17(12), 1041–1050.

Yin, J.-X., Yang, R.-F., Li, S., Renshaw, A. O., Li, Y.-L., Schultz, H. D., et al. (2010). Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. American Journal of Physiology-Cell Physiology,298(4), C857–C865.PubMedPubMedCentralCrossRef

Yusuf, S., Sleight, P., Pogue, J. F., Bosch, J., Davies, R., & Dagenais, G. (2000). Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The New England Journal of Medicine,342(3), 145–153.PubMedCrossRef

Zhang, Y., Huang, X.-R., Wei, L.-H., Chung, A. C., Yu, C.-M., & Lan, H.-Y. (2014). miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling. Molecular Therapy,22(5), 974–985.PubMedPubMedCentralCrossRef

Zhang, Z., Xu, G., Liu, D., Fan, X., Zhu, W., & Liu, X. (2012). Angiotensin-converting enzyme insertion/deletion polymorphism contributes to ischemic stroke risk: A meta-analysis of 50 case-control studies. PLoS ONE,7(10), e46495.PubMedPubMedCentralCrossRef

Zhao, J., Qin, X., Li, S., & Zeng, Z. (2014). Association between the ACE I/D polymorphism and risk of ischemic stroke: An updated meta-analysis of 47,026 subjects from 105 case–control studies. Journal of the Neurological Sciences,345(1–2), 37–47.PubMedCrossRef

Zhao, Y., Wu, J., Zhang, M., Zhou, M., Xu, F., Zhu, X. ,… Yun, S. (2017). Angiotensin II induces calcium/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members. Journal of Molecular Medicine, 95(8), 887–898.

Zheng, L., Xu, C.-C., Chen, W.-D., Shen, W.-L., Ruan, C.-C., Zhu, L.-M., … Gao, P.-J. (2010). MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts. Biochemical and Biophysical Research Communications, 400(4), 483–488.

Zhu, N., Zhang, D., Chen, S., Liu, X., Lin, L., Huang, X., … Yuan, W. (2011). Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis, 215(2), 286–293.

Zimmerman, M. C., Lazartigues, E., Lang, J. A., Sinnayah, P., Ahmad, I. M., Spitz, D. R., et al. (2002). Superoxide mediates the actions of angiotensin II in the central nervous system. Circulation Research,91(11), 1038–1045.PubMedCrossRef

Zimmerman, M. C., Lazartigues, E., Sharma, R. V., & Davisson, R. L. (2004). Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circulation Research,95(2), 210–216.PubMedCrossRef

Titel: ACE-Triggered Hypertension Incites Stroke: Genetic, Molecular, and Therapeutic Aspects
verfasst von: Kanika Vasudeva
Renuka Balyan
Anjana Munshi
Publikationsdatum: 04.12.2019
Verlag: Springer US
Erschienen in: NeuroMolecular Medicine / Ausgabe 2/2020
Print ISSN: 1535-1084
Elektronische ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-019-08583-1

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