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Erschienen in: European Archives of Oto-Rhino-Laryngology 11/2016

11.04.2016 | Head and Neck

Aggressive basal cell carcinoma of the head and neck: challenges in surgical management

verfasst von: Peter J. F. M. Lohuis, Anil Joshi, Pepijn A. Borggreven, Lenka Vermeeren, Biljana Zupan-Kajcovski, Abrahim Al-Mamgani, Alfons J. M. Balm

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 11/2016

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Abstract

With exponentially increasing numbers of basal cell carcinoma (BCC) of the head and neck region, also the locally advanced BCCs are increasing in number. These tumours are associated with aggressive biological behaviour with invasion of soft tissues, organs or bone and present with wide variation in management strategies. The objectives of the study was to describe the biological behaviour of aggressive BCCs and their clinical presentation in the head and neck region with a series of cases treated in our tertiary hospital, discuss management plans of such complex cases in terms of surgical planning and reconstruction. A series of five cases of aggressive BCC in the head and neck region with involvement of organs such as nose, orbit, temporal bone, facial nerve, paranasal sinuses and mandible was studied. Locally advanced, aggressive BCC should be evaluated and treated as head and neck tumours. Multidisciplinary team (MDT) discussion is advisable wherein the strategies on surgical excision, reconstruction options, facial nerve rehabilitation, indications for prosthesis and further adjuvant treatment such as radiotherapy and chemotherapy are carefully planned.
Literatur
1.
Zurück zum Zitat Wu S, Han J, Li WQ, Li T, Quereshi AA (2013) Basal cell carcinoma incidence and associated risk factors in US women and men. A J Epidemiol 178(6):890–897CrossRef Wu S, Han J, Li WQ, Li T, Quereshi AA (2013) Basal cell carcinoma incidence and associated risk factors in US women and men. A J Epidemiol 178(6):890–897CrossRef
2.
Zurück zum Zitat Bath-Hextall F, Leonardi-Bee J, Smith C, Meal A, Hubbard R (2007) Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study. Int J Cancer 121:2105–2108CrossRefPubMed Bath-Hextall F, Leonardi-Bee J, Smith C, Meal A, Hubbard R (2007) Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study. Int J Cancer 121:2105–2108CrossRefPubMed
3.
Zurück zum Zitat Miller DL, Weinstock MA (1994) Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 30:774–778CrossRefPubMed Miller DL, Weinstock MA (1994) Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 30:774–778CrossRefPubMed
4.
Zurück zum Zitat Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ (2004) Aggressive basal cell carcinoma: presentation, pathogenesis and management. Cancer Metastasis Rev 23:389–402CrossRefPubMed Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ (2004) Aggressive basal cell carcinoma: presentation, pathogenesis and management. Cancer Metastasis Rev 23:389–402CrossRefPubMed
5.
Zurück zum Zitat Telfer NR, Colver GB, Morton CA (2008) Guidelines for the management of basal cell carcinoma. Br J Dermatal 159:35–48CrossRef Telfer NR, Colver GB, Morton CA (2008) Guidelines for the management of basal cell carcinoma. Br J Dermatal 159:35–48CrossRef
6.
Zurück zum Zitat Randle H (1996) Basal cell carcinoma: identification and treatment of the high risk patient. Dermatol Surg 22:255–261PubMed Randle H (1996) Basal cell carcinoma: identification and treatment of the high risk patient. Dermatol Surg 22:255–261PubMed
7.
Zurück zum Zitat Jacobs GH, Rippey JJ, Altini M (1982) Prediction of aggressive behaviour in basal cell carcinoma. Cancer 42:533–537CrossRef Jacobs GH, Rippey JJ, Altini M (1982) Prediction of aggressive behaviour in basal cell carcinoma. Cancer 42:533–537CrossRef
8.
Zurück zum Zitat Vico P, Fourez T, Nemec E, Andry G, Deraemaecker R (1995) Aggressive basal cell carcinoma of head and neck areas. Eur J Surg Oncol 21:490–497CrossRefPubMed Vico P, Fourez T, Nemec E, Andry G, Deraemaecker R (1995) Aggressive basal cell carcinoma of head and neck areas. Eur J Surg Oncol 21:490–497CrossRefPubMed
9.
Zurück zum Zitat Boonchai W, Walsh M, Cummings M, Chenevix-Trench G (2000) Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Arch Dermatol 136:195–198PubMed Boonchai W, Walsh M, Cummings M, Chenevix-Trench G (2000) Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Arch Dermatol 136:195–198PubMed
10.
Zurück zum Zitat Robarge KD, Brunton SA, Castanedo GM (2009) GDC-0449—a potent inhibitor of the Hedgehog pathway. Bioorg Med Chem Lett 60:137–143 Robarge KD, Brunton SA, Castanedo GM (2009) GDC-0449—a potent inhibitor of the Hedgehog pathway. Bioorg Med Chem Lett 60:137–143
11.
Zurück zum Zitat Tsukifuji R, Sakai Y, Hatamochi A, Shinkai H (1997) Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma in in situ hybridization using chondroitin ABC lyase. Histology 29:401–407 Tsukifuji R, Sakai Y, Hatamochi A, Shinkai H (1997) Gene expression of matrix metalloproteinase-1 (interstitial collagenase) and matrix metalloproteinase-3 (stromelysin-1) in basal cell carcinoma in in situ hybridization using chondroitin ABC lyase. Histology 29:401–407
12.
Zurück zum Zitat Christian M, Moy RL, Wagner RF, Yen-Moore A (2001) A correlation of alpha-smooth muscle actin and invasion in micronodular basal cell carcinoma. Dermatol Surg 27:441–445PubMed Christian M, Moy RL, Wagner RF, Yen-Moore A (2001) A correlation of alpha-smooth muscle actin and invasion in micronodular basal cell carcinoma. Dermatol Surg 27:441–445PubMed
13.
Zurück zum Zitat Ciurea ME, Cernea D, Georgescu CC, Cotoi OS, Patrascu V, Parvanescu H et al (2013) Expression of CXCR4, MMP-13 and beta-catenin in different histological subtypes of facial basal cell carcinoma. Romanian J Morphol Embryol (Revue Roum Morphol Embryol) 54:939–951 Ciurea ME, Cernea D, Georgescu CC, Cotoi OS, Patrascu V, Parvanescu H et al (2013) Expression of CXCR4, MMP-13 and beta-catenin in different histological subtypes of facial basal cell carcinoma. Romanian J Morphol Embryol (Revue Roum Morphol Embryol) 54:939–951
14.
Zurück zum Zitat Edge SB, Byrd DR, Compton CC et al (eds) (2010) AJCC—cutaneous squamous cell carcinoma and other cutaneous carcinomas. AJCC cancer staging manual, 7th edn. Springer, New York, pp 301–314 Edge SB, Byrd DR, Compton CC et al (eds) (2010) AJCC—cutaneous squamous cell carcinoma and other cutaneous carcinomas. AJCC cancer staging manual, 7th edn. Springer, New York, pp 301–314
15.
Zurück zum Zitat Farley RL, Manolidis S, Ratner D (2006) Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve and temporal bone. Dermatol Surg 32:307–315PubMed Farley RL, Manolidis S, Ratner D (2006) Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve and temporal bone. Dermatol Surg 32:307–315PubMed
16.
Zurück zum Zitat Brown C, Perry AE (2000) Incidence of perineural invasion in histologically aggressive types of basal cell carcinoma. Am J Dermatopathol 22:123–125CrossRefPubMed Brown C, Perry AE (2000) Incidence of perineural invasion in histologically aggressive types of basal cell carcinoma. Am J Dermatopathol 22:123–125CrossRefPubMed
17.
Zurück zum Zitat Hanke CW, Wolf RL, Hochman SA, O’Brian JJ (1983) Chemosurgical reports: perineural spread of basal cell carcinoma. J Dermatol Surg Oncol 9:742–747CrossRefPubMed Hanke CW, Wolf RL, Hochman SA, O’Brian JJ (1983) Chemosurgical reports: perineural spread of basal cell carcinoma. J Dermatol Surg Oncol 9:742–747CrossRefPubMed
18.
Zurück zum Zitat Dreier J, Cheng PF, Alleman IB, Gugger A, Hafner J, Tschopp A, Goldinger SM, Levesque MP, Dummer R (2014) Basal cell carcinomas in a tertiary referral centre: a systematic analysis. Br J Dermatol 171:1066–1072CrossRefPubMed Dreier J, Cheng PF, Alleman IB, Gugger A, Hafner J, Tschopp A, Goldinger SM, Levesque MP, Dummer R (2014) Basal cell carcinomas in a tertiary referral centre: a systematic analysis. Br J Dermatol 171:1066–1072CrossRefPubMed
19.
Zurück zum Zitat Van den Brekel MWM, Castelijns JA, Stel HV et al (1991) Occult metastatic neck disease: detection with US and US-guided fine needle aspiration cytology. Radiology 178:457–461CrossRef Van den Brekel MWM, Castelijns JA, Stel HV et al (1991) Occult metastatic neck disease: detection with US and US-guided fine needle aspiration cytology. Radiology 178:457–461CrossRef
20.
Zurück zum Zitat Chang ALS, Solomon JA, Hainsworth JD et al (2014) Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. J Am Acad Dermatol 70:60–69CrossRefPubMed Chang ALS, Solomon JA, Hainsworth JD et al (2014) Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. J Am Acad Dermatol 70:60–69CrossRefPubMed
21.
Zurück zum Zitat Orouji A, Goerdt S, Utikal J et al (2014) Multiple highly and moderately differentiated squamous cell carcinomas of the skin during vismodegib treatment of inoperable basal cell carcinoma. Br J Dermatol 171:431–433CrossRefPubMed Orouji A, Goerdt S, Utikal J et al (2014) Multiple highly and moderately differentiated squamous cell carcinomas of the skin during vismodegib treatment of inoperable basal cell carcinoma. Br J Dermatol 171:431–433CrossRefPubMed
22.
Zurück zum Zitat Tavin E, Persky MS, Jacobs J (1995) Metastatic basal cell carcinoma of the head and neck. Laryngoscope 105:814–817CrossRefPubMed Tavin E, Persky MS, Jacobs J (1995) Metastatic basal cell carcinoma of the head and neck. Laryngoscope 105:814–817CrossRefPubMed
23.
Zurück zum Zitat Snow S, Saul WJ, Lo J, Mohs FE, Warner T, Dekkingo JA, Feyzi J (1994) Metastatic basal cell carcinoma: report of 5 cases. Cancer 73:328–335CrossRefPubMed Snow S, Saul WJ, Lo J, Mohs FE, Warner T, Dekkingo JA, Feyzi J (1994) Metastatic basal cell carcinoma: report of 5 cases. Cancer 73:328–335CrossRefPubMed
24.
Zurück zum Zitat Levy RM, Hanke CW (2010) Mohs micrographic surgery: facts and controversies. Clin Dermatol 28:269–274CrossRefPubMed Levy RM, Hanke CW (2010) Mohs micrographic surgery: facts and controversies. Clin Dermatol 28:269–274CrossRefPubMed
25.
Zurück zum Zitat Miller P, Roenigk RK, Brodland DG, Randle HW (1992) Cutaneous micrographic surgery: Moh’s procedure. Mayo Clin Proc 67:971–980CrossRefPubMed Miller P, Roenigk RK, Brodland DG, Randle HW (1992) Cutaneous micrographic surgery: Moh’s procedure. Mayo Clin Proc 67:971–980CrossRefPubMed
Metadaten
Titel
Aggressive basal cell carcinoma of the head and neck: challenges in surgical management
verfasst von
Peter J. F. M. Lohuis
Anil Joshi
Pepijn A. Borggreven
Lenka Vermeeren
Biljana Zupan-Kajcovski
Abrahim Al-Mamgani
Alfons J. M. Balm
Publikationsdatum
11.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 11/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4039-9

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