nach oben

Breast Cancer Research and Treatment

Erschienen in:

28.01.2021 | Epidemiology

Allostatic score and its associations with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA among breast cancer patients

verfasst von: Hua Zhao, Renduo Song, Yuanqing Ye, Wong-Ho Chow, Jie Shen

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2021

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Allostatic load (AL), a composite index, has been used to capture variation in life-course stresses. However, few studies have been carried out among breast cancer patients.

Methods

In this study, we examined the cross-sectional association of AL with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA copy number in breast cancer patients. The study used a sub-sample of 934 women with newly diagnosed breast cancer at M.D. Anderson from 2013 to 2018. To construct the AL score, the study used a battery of seventeen factors that represents the activity of five physiological systems: metabolic, cardiovascular, immunological, renal, and liver.

Results

AL was positively associated with the age of disease diagnosis (P = 0.002), and was higher in Black and Hispanic populations than White (P = 0.001 and 0.032, respectively). AL was also found more abundant in those who experienced marital dissolution (P = 0.006), lacked a college education (P = 0.045), currently smoked (P = 0.011), and had low levels of physical activity (P = 0.037) than their counterparts. The study then found that higher AL was associated with increased odds of having poorly differentiated tumors (Odds ratio (OR): 1.40, 95% confidence interval (CI): 1.28, 1.62). An additional significant association was observed between AL with estrogen receptor negative (ER-) (OR = 1.56, 95%CI: 1.02, 2.36) among Black patients. Finally, we observed a significant positive correlation between AL with leukocyte mitochondrial DNA copy number variation (P < 0.001).

Conclusions

We conclude AL is influenced by selected demographics and healthy behaviors, and further is correlated with tumor characteristics and mitochondrial DNA copy number in breast cancer patients.

Marmot M, Allen J, Bell R, Bloomer E, Goldblatt P, Consortium for the European Review of Social Determinants of H, the Health D (2012) WHO European review of social determinants of health and the health divide. Lancet 380(9846):1011–29

Hossain F, Danos D, Prakash O, Gilliland A, Ferguson TF, Simonsen N, Leonardi C, Yu Q, Wu XC, Miele L, Scribner R (2019) Neighborhood social determinants of triple negative breast cancer. Front Public Health 7:18PubMedPubMedCentral

Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, Simon MS (2017) Influence of clinical, societal, and treatment variables on racial differences in ER-/PR- breast cancer survival. Breast Cancer Res Treat 165(1):163–168PubMedPubMedCentral

Coughlin SS (2019) Social determinants of breast cancer risk, stage, and survival. Breast Cancer Res Treat 177(3):537–548PubMed

Bailey ZD, Krieger N, Agenor M, Graves J, Linos N, Bassett MT (2017) Structural racism and health inequities in the USA: evidence and interventions. Lancet 389(10077):1453–1463PubMed

Krieger N, Smith K, Naishadham D, Hartman C, Barbeau EM (2005) Experiences of discrimination: validity and reliability of a self-report measure for population health research on racism and health. Soc Sci Med 61(7):1576–1596

Plascak JJ, Hohl B, Barrington WE, Beresford SA (2018) Perceived neighborhood disorder, racial-ethnic discrimination and leading risk factors for chronic disease among women: California Behavioral Risk Factor Surveillance System, 2013. SSM Popul Health 5:227–238PubMedPubMedCentral

Seeman T, Epel E, Gruenewald T, Karlamangla A, McEwen BS (2010) Socio-economic differentials in peripheral biology: cumulative allostatic load. Ann N Y Acad Sci 1186:223–239PubMed

Duong MT, Bingham BA, Aldana PC, Chung ST, Sumner AE (2017) Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES. J Racial Ethn Health Disparities 4(3):455–461PubMed

10.

Howard JT, Sparks PJ (2016) Does allostatic load calculation method matter? Evaluation of different methods and individual biomarkers functioning by race/ethnicity and educational level. Am J Hum Biol 28(5):627–635PubMed

11.

Gruenewald TL, Karlamangla AS, Hu P, Stein-Merkin S, Crandall C, Koretz B, Seeman TE (2012) History of socioeconomic disadvantage and allostatic load in later life. Soc Sci Med 74(1):75–83PubMed

12.

Seeman M, Stein Merkin S, Karlamangla A, Koretz B, Seeman T (2014) Social status and biological dysregulation: the “status syndrome” and allostatic load. Soc Sci Med 118:143–151PubMedPubMedCentral

13.

Delpierre C, Fantin R, Barboza-Solis C, Lepage B, Darnaudery M, Kelly-Irving M (2016) The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort. BMC Public Health 16(1):815PubMedPubMedCentral

14.

McCrory C, Fiorito G, Ni Cheallaigh C, Polidoro S, Karisola P, Alenius H, Layte R, Seeman T, Vineis P, Kenny RA (2019) How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s). Psychoneuroendocrinology 104:64–73PubMed

15.

Karlamangla AS, Singer BH, McEwen BS, Rowe JW, Seeman TE. Allostatic load as a predictor of functional decline. MacArthur studies of successful aging. J Clin Epidemiol. 2002;55(7):696–710

16.

Castagne R, Gares V, Karimi M, Chadeau-Hyam M, Vineis P, Delpierre C, Kelly-Irving M, Lifepath C (2018) Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort. Eur J Epidemiol 33(5):441–458PubMedPubMedCentral

17.

Dibaba DT, Braithwaite D, Akinyemiju T (2018) Metabolic Syndrome and the Risk of Breast Cancer and Subtypes by Race, Menopause and BMI. Cancers (Basel). https://doi.org/10.3390/cancers10090299CrossRef

18.

Li P, Wang T, Zeng C, Yang M, Li G, Han J, Wu W (2020) Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies. Diabetol Metab Syndr 12:10PubMedPubMedCentral

19.

Edechi CA, Ikeogu N, Uzonna JE, Myal Y (2019) Regulation of Immunity in Breast Cancer. Cancers (Basel). https://doi.org/10.3390/cancers11081080CrossRef

20.

Jiang X, Shapiro DJ (2014) The immune system and inflammation in breast cancer. Mol Cell Endocrinol 382(1):673–682PubMed

21.

Baxevanis CN, Fortis SP, Perez SA (2019) The balance between breast cancer and the immune system: Challenges for prognosis and clinical benefit from immunotherapies. Semin Cancer Biol. https://doi.org/10.1016/j.semcancer.2019.12.018CrossRefPubMed

22.

Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM (2017) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA Cancer J Clin 67(5):378–397PubMedPubMedCentral

23.

Xing CY, Doose M, Qin B, Lin Y, Plascak JJ, Omene C, He C, Demissie K, Hong CC, Bandera EV, Llanos AAM (2020) Prediagnostic Allostatic Load as a Predictor of Poorly Differentiated and Larger Sized Breast Cancers among Black Women in the Women’s Circle of Health Follow-Up Study. Cancer Epidemiol Biomarkers Prev 29(1):216–224PubMed

24.

Parente V, Hale L, Palermo T (2013) Association between breast cancer and allostatic load by race: National Health and Nutrition Examination Survey 1999–2008. Psychooncology 22(3):621–628PubMed

25.

Schulz AJ, Mentz G, Lachance L, Johnson J, Gaines C, Israel BA (2012) Associations between socioeconomic status and allostatic load: effects of neighborhood poverty and tests of mediating pathways. Am J Public Health 102(9):1706–1714PubMedPubMedCentral

26.

Chyu L, Upchurch DM (2011) Racial and ethnic patterns of allostatic load among adult women in the United States: findings from the National Health and Nutrition Examination Survey 1999–2004. J Womens Health (Larchmt) 20(4):575–583

27.

Bingham BA, Duong MT, Ricks M, Mabundo LS, Baker RL Jr, Utumatwishima JN, Udahogora M, Berrigan D, Sumner AE (2016) The Association between Stress Measured by Allostatic Load Score and Physiologic Dysregulation in African Immigrants: The Africans in America Study. Front Public Health 4:265PubMedPubMedCentral

28.

Geronimus AT (1992) The weathering hypothesis and the health of African-American women and infants: evidence and speculations. Ethn Dis 2(3):207–221PubMed

29.

Picard M, McEwen BS (2018) Psychological Stress and Mitochondria: A Systematic Review. Psychosom Med 80(2):141–153PubMedPubMedCentral

30.

Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. Price of adaptation--allostatic load and its health consequences. MacArthur studies of successful aging. Arch Intern Med. 1997;157(19):2259–68

31.

Geronimus AT, Hicken M, Keene D, Bound J (2006) “Weathering” and age patterns of allostatic load scores among blacks and whites in the United States. Am J Public Health 96(5):826–833PubMedPubMedCentral

32.

Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, de Andrade M, Swan GE, Wu X (2008) Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100(15):1104–1112PubMedPubMedCentral

33.

Melkonian SC, Wang X, Gu J, Matin SF, Tannir NM, Wood CG, Wu X (2015) Mitochondrial DNA copy number in peripheral blood leukocytes and the risk of clear cell renal cell carcinoma. Carcinogenesis 36(2):249–255PubMed

34.

Zhao H, Chang D, Ye Y, Shen J, Chow WH, Wu X (2018) Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk: results from the Mano-A-Mano Mexican American Cohort. Oncotarget 9(39):25491–25502PubMedPubMedCentral

35.

Cui B, Luo Y, Tian P, Peng F, Lu J, Yang Y, Su Q, Liu B, Yu J, Luo X, Yin L, Cheng W, An F, He B, Liang D, Wu S, Chu P, Song L, Liu X, Luo H, Xu J, Pan Y, Wang Y, Li D, Huang P, Yang Q, Zhang L, Zhou BP, Liu S, Xu G, Lam EW, Kelley KW, Liu Q (2019) Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells. J Clin Invest 129(3):1030–1046PubMedPubMedCentral

36.

Thomas Tobin CS, Robinson MN, Stanifer K (2019) Does marriage matter? Racial differences in allostatic load among women. Prev Med Rep 15:100948PubMedPubMedCentral

37.

Rote S (2017) Marital Disruption and Allostatic Load in Late Life. J Aging Health 29(4):688–707PubMed

38.

Friedman EM, Hayney MS, Love GD, Urry HL, Rosenkranz MA, Davidson RJ, Singer BH, Ryff CD (2005) Social relationships, sleep quality, and interleukin-6 in aging women. Proc Natl Acad Sci U S A 102(51):18757–18762PubMedPubMedCentral

39.

Salmon P (2001) Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory. Clin Psychol Rev 21(1):33–61PubMed

40.

Crimmins EM, Kim JK, Seeman TE (2009) Poverty and biological risk: the earlier “aging” of the poor. J Gerontol A Biol Sci Med Sci 64(2):286–292PubMed

41.

Robertson T, Benzeval M, Whitley E, Popham F (2015) The role of material, psychosocial and behavioral factors in mediating the association between socioeconomic position and allostatic load (measured by cardiovascular, metabolic and inflammatory markers). Brain Behav Immun 45:41–49PubMedPubMedCentral

42.

Moffatt RJ (1988) Effects of cessation of smoking on serum lipids and high density lipoprotein-cholesterol. Atherosclerosis 74(1–2):85–89PubMed

43.

Tonstad S, Cowan JL (2009) C-reactive protein as a predictor of disease in smokers and former smokers: a review. Int J Clin Pract 63(11):1634–1641PubMedPubMedCentral

44.

Will JC, Galuska DA, Ford ES, Mokdad A, Calle EE (2001) Cigarette smoking and diabetes mellitus: evidence of a positive association from a large prospective cohort study. Int J Epidemiol 30(3):540–546PubMed

45.

Petrovic D, Pivin E, Ponte B, Dhayat N, Pruijm M, Ehret G, Ackermann D, Guessous I, Younes SE, Pechere-Bertschi A, Vogt B, Mohaupt M, Martin PY, Paccaud F, Burnier M, Bochud M, Stringhini S (2016) Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study. Psychoneuroendocrinology 67:76–85PubMed

46.

Gay JL, Salinas JJ, Buchner DM, Mirza S, Kohl HW 3rd, Fisher-Hoch SP, McCormick JB (2015) Meeting physical activity guidelines is associated with lower allostatic load and inflammation in Mexican Americans. J Immigr Minor Health 17(2):574–581PubMedPubMedCentral

47.

Hampson SE, Goldberg LR, Vogt TM, Hillier TA, Dubanoski JP (2009) Using physiological dysregulation to assess global health status: associations with self-rated health and health behaviors. J Health Psychol 14(2):232–241PubMedPubMedCentral

48.

Hu P, Wagle N, Goldman N, Weinstein M, Seeman TE (2007) The associations between socioeconomic status, allostatic load and measures of health in older Taiwanese persons: Taiwan social environment and biomarkers of aging study. J Biosoc Sci 39(4):545–556PubMed

49.

Kusano Y, Crews DE, Iwamoto A, Sone Y, Aoyagi K, Maeda T, Leahy R (2016) Allostatic load differs by sex and diet, but not age in older Japanese from the Goto Islands. Ann Hum Biol 43(1):34–41PubMed

50.

Upchurch DM, Rainisch BW, Chyu L (2015) Greater Leisure Time Physical Activity Is Associated with Lower Allostatic Load in White, Black, and Mexican American Midlife Women: Findings from the National Health and Nutrition Examination Survey, 1999 through 2004. Womens Health Issues 25(6):680–687PubMedPubMedCentral

51.

Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G (2006) Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med 166(22):2437–2445PubMed

52.

Gallo LC, Jimenez JA, Shivpuri S, Espinosa de los Monteros K, Mills PJ. Domains of chronic stress, lifestyle factors, and allostatic load in middle-aged Mexican-American women. Ann Behav Med. 2011;41(1):21–31

53.

O’Keefe JH, Bybee KA, Lavie CJ (2007) Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 50(11):1009–1014PubMed

54.

Tomfohr LM, Pung MA, Dimsdale JE (2016) Mediators of the relationship between race and allostatic load in African and White Americans. Health Psychol 35(4):322–332PubMed

55.

O’Campo P, Schetter CD, Guardino CM, Vance MR, Hobel CJ, Ramey SL, Shalowitz MU (2016) Explaining racial and ethnic inequalities in postpartum allostatic load: Results from a multisite study of low to middle income woment. SSM Popul Health 2:850–858PubMedPubMedCentral

56.

Quinones AR, Botoseneanu A, Markwardt S, Nagel CL, Newsom JT, Dorr DA, Allore HG (2019) Racial/ethnic differences in multimorbidity development and chronic disease accumulation for middle-aged adults. PLoS ONE 14(6):e0218462PubMedPubMedCentral

57.

Howard G, Safford MM, Moy CS, Howard VJ, Kleindorfer DO, Unverzagt FW, Soliman EZ, Flaherty ML, McClure LA, Lackland DT, Wadley VG, Pulley L, Cushman M (2017) Racial Differences in the Incidence of Cardiovascular Risk Factors in Older Black and White Adults. J Am Geriatr Soc 65(1):83–90PubMed

58.

Philbin MM, Flake M, Hatzenbuehler ML, Hirsch JS (2018) State-level immigration and immigrant-focused policies as drivers of Latino health disparities in the United States. Soc Sci Med 199:29–38PubMed

59.

Nguyen GC, Thuluvath PJ (2008) Racial disparity in liver disease: biological, cultural, or socioeconomic factors. Hepatology 47(3):1058–1066PubMed

60.

Norton JM, Moxey-Mims MM, Eggers PW, Narva AS, Star RA, Kimmel PL, Rodgers GP (2016) Social determinants of racial disparities in CKD. J Am Soc Nephrol 27(9):2576–2595PubMedPubMedCentral

61.

Simons RL, Lei MK, Klopack E, Beach SRH, Gibbons FX, Philibert RA (2020) The effects of social adversity, discrimination, and health risk behaviors on the accelerated aging of African Americans: Further support for the weathering hypothesis. Soc Sci Med 113169

62.

Forde AT, Crookes DM, Suglia SF, Demmer RT (2019) The weathering hypothesis as an explanation for racial disparities in health: a systematic review. Ann Epidemiol 33(1–18):e3

63.

Tan M, Mamun A, Kitzman H, Mandapati SR, Dodgen L (2017) Neighborhood disadvantage and allostatic load in African American women at risk for obesity-related diseases. Prev Chronic Dis 14:E119PubMedPubMedCentral

64.

Anna Bellatorre BKF, Phuong Do D, Chloe E, Bird and Audrey N. Beck. (2011) Contextual predictors of cumulative biological risk: segregation and allostatic load. JSTOR 92(5):1338–1362

65.

Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Richardson AL, Schnitt SJ, Schmitt FC, Tan PH, Tse GM, Badve S, Ellis IO (2010) Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res 12(4):207PubMedPubMedCentral

66.

Braun L, Tsai J, Ucik L (2015) Racial and ethnic differences in breast cancer diagnosis and survival. JAMA 313(14):1475PubMed

67.

Warner ET, Tamimi RM, Hughes ME, Ottesen RA, Wong YN, Edge SB, Theriault RL, Blayney DW, Niland JC, Winer EP, Weeks JC, Partridge AH (2015) Racial and ethnic differences in breast cancer survival: mediating effect of tumor characteristics and sociodemographic and treatment factors. J Clin Oncol 33(20):2254–2261PubMedPubMedCentral

68.

Cai N, Li Y, Chang S, Liang J, Lin C, Zhang X, Liang L, Hu J, Chan W, Kendler KS, Malinauskas T, Huang GJ, Li Q, Mott R, Flint J (2015) Genetic control over mtDNA and its relationship to major depressive disorder. Curr Biol 25(24):3170–3177PubMedPubMedCentral

69.

Tyrka AR, Parade SH, Price LH, Kao HT, Porton B, Philip NS, Welch ES, Carpenter LL (2016) Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology. Biol Psychiatry 79(2):78–86PubMed

70.

Trichopoulos D, Adami HO, Ekbom A, Hsieh CC, Lagiou P (2008) Early life events and conditions and breast cancer risk: from epidemiology to etiology. Int J Cancer 122(3):481–485PubMed

Titel: Allostatic score and its associations with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA among breast cancer patients
verfasst von: Hua Zhao
Renduo Song
Yuanqing Ye
Wong-Ho Chow
Jie Shen
Publikationsdatum: 28.01.2021
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2021
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-021-06102-0

Springer Medizin

Allostatic score and its associations with demographics, healthy behaviors, tumor characteristics, and mitochondrial DNA among breast cancer patients

Abstract

Introduction

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2021

Who is managing menopausal symptoms, sexual problems, mood and sleep disturbance after breast cancer and is it working? Findings from a large community-based survey of breast cancer survivors

FASN inhibition as a potential treatment for endocrine-resistant breast cancer

Early postoperative outcomes in implant, pedicled, and free flap reconstruction for breast cancer: an analysis of 23,834 patients from the ACS-NSQIP datasets

Shall patients’ anxiety influence surgical decisions for atypical breast lesions? A substudy of the prospective NOMAT trial

SETD2 alterations and histone H3K36 trimethylation in phyllodes tumor of breast

Comparison of the performance of four staging systems in determining the prognosis of breast cancer among women undergoing neoadjuvant chemotherapy

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie