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Erschienen in: Pneumo News 3/2017

19.04.2017 | Amphotericin B | fortbildung

Diagnostik und Therapie pulmonaler Pilzinfektionen

Auf Pilzsuche in der Lunge

verfasst von: Prof. Dr. med. Adrian Gillissen, Dr. med. Maria Paparoupa

Erschienen in: Pneumo News | Ausgabe 3/2017

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Zusammenfassung

Die Lunge immunschwacher Patienten kann von unterschiedlichen Pilzspezies befallen werden. Für die Prognose der Betroffenen ist entscheidend, den Erreger schnell zu identifizieren und zu behandeln. Wichtig dabei ist die Unterscheidung zwischen Kolonisation und akuter Infektion.
Literatur
1.
Zurück zum Zitat Pfaller MA, Andes DR, Diekema DJ et al. Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. PLoS One. 2014;9(7):e101510. doi: 10.1371/journal.pone.0101510CrossRefPubMedPubMedCentral Pfaller MA, Andes DR, Diekema DJ et al. Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. PLoS One. 2014;9(7):e101510. doi: 10.1371/journal.pone.0101510CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Borg-von Zepelin M, Kunz L, Ruchel R et al. Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents: results from a surveillance study on fungaemia in Germany from July 2004 to August 2005. J Antimicrob Chemother. 2007;60:424–8CrossRefPubMed Borg-von Zepelin M, Kunz L, Ruchel R et al. Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents: results from a surveillance study on fungaemia in Germany from July 2004 to August 2005. J Antimicrob Chemother. 2007;60:424–8CrossRefPubMed
4.
Zurück zum Zitat Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503–35CrossRefPubMed Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503–35CrossRefPubMed
5.
Zurück zum Zitat Ostrosky-Zeichner L, Pappas PG. Invasive candidiasis in the intensive care unit. Crit Care Med. 2006;34:857–63CrossRefPubMed Ostrosky-Zeichner L, Pappas PG. Invasive candidiasis in the intensive care unit. Crit Care Med. 2006;34:857–63CrossRefPubMed
6.
Zurück zum Zitat Sims CR, Ostrosky-Zeichner L, Rex JH. Invasive candidiasis in immunocompromised hospitalized patients. Arch Med Res. 2005;36:660–71CrossRefPubMed Sims CR, Ostrosky-Zeichner L, Rex JH. Invasive candidiasis in immunocompromised hospitalized patients. Arch Med Res. 2005;36:660–71CrossRefPubMed
7.
Zurück zum Zitat Tortorano AM, Kibbler C, Peman J et al. Candidaemia in Europe: epidemiology and resistance. Int J Antimicrob Agents. 2006;27:359–66CrossRefPubMed Tortorano AM, Kibbler C, Peman J et al. Candidaemia in Europe: epidemiology and resistance. Int J Antimicrob Agents. 2006;27:359–66CrossRefPubMed
8.
Zurück zum Zitat Tortorano AM, Peman J, Bernhardt H et al. Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis. 2004;23:317–22CrossRefPubMed Tortorano AM, Peman J, Bernhardt H et al. Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis. 2004;23:317–22CrossRefPubMed
9.
Zurück zum Zitat Kousha M, Tadi R, Soubani AO. Pulmonary aspergillosis: a clinical review. Eur Respir Rev. 2011;20:156–74CrossRefPubMed Kousha M, Tadi R, Soubani AO. Pulmonary aspergillosis: a clinical review. Eur Respir Rev. 2011;20:156–74CrossRefPubMed
10.
Zurück zum Zitat Soubani AO, Chandrasekar PH. The clinical spectrum of pulmonary aspergillosis. Chest. 2002;121:1988–99CrossRefPubMed Soubani AO, Chandrasekar PH. The clinical spectrum of pulmonary aspergillosis. Chest. 2002;121:1988–99CrossRefPubMed
11.
Zurück zum Zitat Wiesmuller GA, Heinzow B, Aurbach U et al. Medizinisch klinische Diagnostik bei Schimmelpilzexposition in Innenraumen. Pneumologie. 2016;70:699–741CrossRefPubMed Wiesmuller GA, Heinzow B, Aurbach U et al. Medizinisch klinische Diagnostik bei Schimmelpilzexposition in Innenraumen. Pneumologie. 2016;70:699–741CrossRefPubMed
12.
Zurück zum Zitat Cuenca-Estrella M, Verweij PE, Arendrup MC et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures. Clin Microbiol Infect. 2012;8 Suppl 7:9–18CrossRef Cuenca-Estrella M, Verweij PE, Arendrup MC et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures. Clin Microbiol Infect. 2012;8 Suppl 7:9–18CrossRef
13.
Zurück zum Zitat Blot S, Dimopoulos G, Rello J et al. Is Candida really a threat in the ICU? Curr Opin Crit Care. 2008; 4:600–4CrossRef Blot S, Dimopoulos G, Rello J et al. Is Candida really a threat in the ICU? Curr Opin Crit Care. 2008; 4:600–4CrossRef
14.
Zurück zum Zitat Rello J, Esandi ME, Diaz E et al. The role of Candida sp isolated from bronchoscopic samples in nonneutropenic patients. Chest. 1998;114:146–9CrossRefPubMed Rello J, Esandi ME, Diaz E et al. The role of Candida sp isolated from bronchoscopic samples in nonneutropenic patients. Chest. 1998;114:146–9CrossRefPubMed
15.
Zurück zum Zitat Kauffman CA, Fisher JF, Sobel JD et al. Candida urinary tract infections—diagnosis. Clin Infect Dis. 2011;52 Suppl 6:452–6CrossRef Kauffman CA, Fisher JF, Sobel JD et al. Candida urinary tract infections—diagnosis. Clin Infect Dis. 2011;52 Suppl 6:452–6CrossRef
16.
Zurück zum Zitat Fisher JF, Kavanagh K, Sobel JD et al. Candida urinary tract infection: pathogenesis. Clin Infect Dis. 2011;52 Suppl 6:437–51CrossRef Fisher JF, Kavanagh K, Sobel JD et al. Candida urinary tract infection: pathogenesis. Clin Infect Dis. 2011;52 Suppl 6:437–51CrossRef
17.
Zurück zum Zitat Sobel JD, Fisher JF, Kauffman CA et al. Candida urinary tract infections—epidemiology. Clin Infect Dis. 2011;52 Suppl 6:433–36CrossRef Sobel JD, Fisher JF, Kauffman CA et al. Candida urinary tract infections—epidemiology. Clin Infect Dis. 2011;52 Suppl 6:433–36CrossRef
18.
Zurück zum Zitat Arvanitis M, Anagnostou T, Fuchs BB et al. Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014;27:490–526CrossRefPubMedPubMedCentral Arvanitis M, Anagnostou T, Fuchs BB et al. Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014;27:490–526CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Maertens J, Buve K, Theunissen K et al. Galactomannan serves as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients. Cancer. 2009;115: 355–62CrossRefPubMed Maertens J, Buve K, Theunissen K et al. Galactomannan serves as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients. Cancer. 2009;115: 355–62CrossRefPubMed
20.
Zurück zum Zitat Meersseman W, Lagrou K, Maertens J et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med. 2008;177:27–34CrossRefPubMed Meersseman W, Lagrou K, Maertens J et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med. 2008;177:27–34CrossRefPubMed
21.
Zurück zum Zitat Meersseman W, Lagrou K, Maertens J et al. Invasive aspergillosis in the intensive care unit. Clin Infect Dis. 2007;45:205–16CrossRefPubMed Meersseman W, Lagrou K, Maertens J et al. Invasive aspergillosis in the intensive care unit. Clin Infect Dis. 2007;45:205–16CrossRefPubMed
22.
Zurück zum Zitat Lichtenstern C, Swoboda S, Hirschburger M et al. Update: invasive Pilzinfektionen. Diagnose und Therapie in der operativen Intensivmedizin. Anaesthesist. 2010;59:30–52CrossRefPubMed Lichtenstern C, Swoboda S, Hirschburger M et al. Update: invasive Pilzinfektionen. Diagnose und Therapie in der operativen Intensivmedizin. Anaesthesist. 2010;59:30–52CrossRefPubMed
23.
Zurück zum Zitat Maymind M, Thomas JG, Abrons HL et al. Laboratory implementation of a rapid three-stain technique for detection of microorganisms from lower respiratory specimens. J Clin Lab Anal. 1996;10:104–9CrossRefPubMed Maymind M, Thomas JG, Abrons HL et al. Laboratory implementation of a rapid three-stain technique for detection of microorganisms from lower respiratory specimens. J Clin Lab Anal. 1996;10:104–9CrossRefPubMed
24.
Zurück zum Zitat Mrazek C, Lass-Florl C. Biopsy procedures for molecular tissue diagnosis of invasive fungal infections. Curr Infect Dis Rep. 2011;13:504–9CrossRefPubMed Mrazek C, Lass-Florl C. Biopsy procedures for molecular tissue diagnosis of invasive fungal infections. Curr Infect Dis Rep. 2011;13:504–9CrossRefPubMed
25.
Zurück zum Zitat Soler N, Torres A, Ewig S et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med. 1998;157:1498–505CrossRefPubMed Soler N, Torres A, Ewig S et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med. 1998;157:1498–505CrossRefPubMed
26.
Zurück zum Zitat Rodriguez-Adrian LJ, King RT, Tamayo-Derat LG et al. Retinal lesions as clues to disseminated bacterial and candidal infections: frequency, natural history, and etiology. Medicine (Baltimore). 2003;82:187–202 Rodriguez-Adrian LJ, King RT, Tamayo-Derat LG et al. Retinal lesions as clues to disseminated bacterial and candidal infections: frequency, natural history, and etiology. Medicine (Baltimore). 2003;82:187–202
27.
Zurück zum Zitat Ascioglu S, Rex JH, de Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34:7–14CrossRefPubMed Ascioglu S, Rex JH, de Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34:7–14CrossRefPubMed
28.
Zurück zum Zitat Ascioglu S, de Pauw BE, Meis JF. Prophylaxis and treatment of fungal infections associated with haematological malignancies. Int J Antimicrob Agents. 2000;15:159–68CrossRefPubMed Ascioglu S, de Pauw BE, Meis JF. Prophylaxis and treatment of fungal infections associated with haematological malignancies. Int J Antimicrob Agents. 2000;15:159–68CrossRefPubMed
29.
Zurück zum Zitat Limper AH, Knox KS, Sarosi GA et al. An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med. 2011;183:96–128CrossRefPubMed Limper AH, Knox KS, Sarosi GA et al. An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med. 2011;183:96–128CrossRefPubMed
31.
Zurück zum Zitat Kalil AC, Metersky ML, Klompas M et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:575–82CrossRefPubMed Kalil AC, Metersky ML, Klompas M et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:575–82CrossRefPubMed
32.
Zurück zum Zitat Haron E, Vartivarian S, Anaissie E et al. Primary Candida pneumonia. Experience at a large cancer center and review of the literature. Medicine (Baltimore). 1993;72:137–42CrossRef Haron E, Vartivarian S, Anaissie E et al. Primary Candida pneumonia. Experience at a large cancer center and review of the literature. Medicine (Baltimore). 1993;72:137–42CrossRef
33.
Zurück zum Zitat Limper AH. Clinical approach and management for selected fungal infections in pulmonary and critical care patients. Chest. 2014;146:1658–66CrossRefPubMed Limper AH. Clinical approach and management for selected fungal infections in pulmonary and critical care patients. Chest. 2014;146:1658–66CrossRefPubMed
34.
Zurück zum Zitat Tissot F, Agrawal S, Pagano L et al. ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients. Haematologica 2016, doi: 10.3324/haematol.2016.152900 Tissot F, Agrawal S, Pagano L et al. ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients. Haematologica 2016, doi: 10.3324/haematol.2016.152900
35.
Zurück zum Zitat Tarpatzi A, Avlamis A, Papaparaskevas J et al. Incidence and risk factors for central vascular catheter-related bloodstream infections in a tertiary care hospital. New Microbiol. 2012;35:429–37PubMed Tarpatzi A, Avlamis A, Papaparaskevas J et al. Incidence and risk factors for central vascular catheter-related bloodstream infections in a tertiary care hospital. New Microbiol. 2012;35:429–37PubMed
36.
Zurück zum Zitat Chabi ML, Goracci A, Roche N et al. Pulmonary aspergillosis. Diagn Interv Imaging. 2015;96:435–42CrossRefPubMed Chabi ML, Goracci A, Roche N et al. Pulmonary aspergillosis. Diagn Interv Imaging. 2015;96:435–42CrossRefPubMed
37.
Zurück zum Zitat Tasci S, Schafer H, Ewig S et al. Erfolgreiche Behandlung einer chronisch nekrotisierenden pulmonalen Aspergillose mit einer oralen Itraconazol-Langzeittherapie. Dtsch Med Wochenschr. 1999;124:1419–22CrossRefPubMed Tasci S, Schafer H, Ewig S et al. Erfolgreiche Behandlung einer chronisch nekrotisierenden pulmonalen Aspergillose mit einer oralen Itraconazol-Langzeittherapie. Dtsch Med Wochenschr. 1999;124:1419–22CrossRefPubMed
38.
Zurück zum Zitat Denning DW, Cadranel J, Beigelman-Aubry C et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47:45–68CrossRefPubMed Denning DW, Cadranel J, Beigelman-Aubry C et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47:45–68CrossRefPubMed
39.
Zurück zum Zitat Patterson TF, Thompson GR, 3rd, Denning DW et al. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:433–42CrossRefPubMed Patterson TF, Thompson GR, 3rd, Denning DW et al. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:433–42CrossRefPubMed
40.
Zurück zum Zitat Alanio A, Hauser PM, Lagrou K et al. ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2386–96CrossRefPubMed Alanio A, Hauser PM, Lagrou K et al. ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2386–96CrossRefPubMed
41.
Zurück zum Zitat Maschmeyer G, Helweg-Larsen J, Pagano L et al. ECIL guidelines for treatment of Pneumocystis jirovecii pneumonia in non-HIV-infected haematology patients. J Antimicrob Chemother. 2016;71:2405–13CrossRefPubMed Maschmeyer G, Helweg-Larsen J, Pagano L et al. ECIL guidelines for treatment of Pneumocystis jirovecii pneumonia in non-HIV-infected haematology patients. J Antimicrob Chemother. 2016;71:2405–13CrossRefPubMed
42.
44.
Zurück zum Zitat Wheat J, Sarosi G, McKinsey D et al. Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America. Clin Infect Dis. 2000;30:688–95CrossRefPubMed Wheat J, Sarosi G, McKinsey D et al. Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America. Clin Infect Dis. 2000;30:688–95CrossRefPubMed
45.
Zurück zum Zitat Galgiani JN, Ampel NM, Blair JE et al. Executive Summary: 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:717–22CrossRefPubMed Galgiani JN, Ampel NM, Blair JE et al. Executive Summary: 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:717–22CrossRefPubMed
46.
Zurück zum Zitat Galgiani JN, Ampel NM, Blair JE et al. 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:e112–146CrossRefPubMed Galgiani JN, Ampel NM, Blair JE et al. 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:e112–146CrossRefPubMed
47.
Zurück zum Zitat Lortholary O, Petrikkos G, Akova M et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS. Clin Microbiol Infect. 2012;18 Suppl 7:68–77CrossRefPubMed Lortholary O, Petrikkos G, Akova M et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS. Clin Microbiol Infect. 2012;18 Suppl 7:68–77CrossRefPubMed
48.
Zurück zum Zitat Ullmann AJ, Akova M, Herbrecht R et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin Microbiol Infect. 2012;18 Suppl 7:53–67CrossRefPubMed Ullmann AJ, Akova M, Herbrecht R et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin Microbiol Infect. 2012;18 Suppl 7:53–67CrossRefPubMed
49.
Zurück zum Zitat Cornely OA, Bohme A, Buchheidt D et al. Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tufortbildung mors—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2003;82 Suppl 2:S186–200CrossRefPubMed Cornely OA, Bohme A, Buchheidt D et al. Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tufortbildung mors—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2003;82 Suppl 2:S186–200CrossRefPubMed
50.
Zurück zum Zitat El Zakhem A, Saad H, Tayyar R et al. Controversies in Candida management. Int J Antimicrob Agents. 2015;46 Suppl 1:S43–46CrossRefPubMed El Zakhem A, Saad H, Tayyar R et al. Controversies in Candida management. Int J Antimicrob Agents. 2015;46 Suppl 1:S43–46CrossRefPubMed
51.
Zurück zum Zitat Albert M, Williamson D, Muscedere J et al. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med. 2014;40:1313–22CrossRefPubMed Albert M, Williamson D, Muscedere J et al. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med. 2014;40:1313–22CrossRefPubMed
52.
Zurück zum Zitat Maertens J, Cesaro S, Maschmeyer G et al. ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2397–404CrossRefPubMed Maertens J, Cesaro S, Maschmeyer G et al. ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2397–404CrossRefPubMed
53.
Zurück zum Zitat Tacke D, Buchheidt D, Karthaus M et al. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014;93:1449–56CrossRefPubMed Tacke D, Buchheidt D, Karthaus M et al. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014;93:1449–56CrossRefPubMed
54.
Zurück zum Zitat Fleming S, Yannakou CK, Haeusler GM et al. Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014. Intern Med J. 2014;44:1283–97CrossRefPubMed Fleming S, Yannakou CK, Haeusler GM et al. Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014. Intern Med J. 2014;44:1283–97CrossRefPubMed
55.
Zurück zum Zitat Kruger WH, Bohlius J, Cornely OA et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the infectious diseases working party (AGIHO) of the german society of haematology and oncology. Ann Oncol. 2005;16:1381–90CrossRefPubMed Kruger WH, Bohlius J, Cornely OA et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the infectious diseases working party (AGIHO) of the german society of haematology and oncology. Ann Oncol. 2005;16:1381–90CrossRefPubMed
Metadaten
Titel
Diagnostik und Therapie pulmonaler Pilzinfektionen
Auf Pilzsuche in der Lunge
verfasst von
Prof. Dr. med. Adrian Gillissen
Dr. med. Maria Paparoupa
Publikationsdatum
19.04.2017
Verlag
Springer Medizin
Erschienen in
Pneumo News / Ausgabe 3/2017
Print ISSN: 1865-5467
Elektronische ISSN: 2199-3866
DOI
https://doi.org/10.1007/s15033-017-0668-y

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