Skip to main content
Erschienen in: Journal of Digital Imaging 5/2018

18.05.2018

Andriod Device-Based Cervical Cancer Screening for Resource-Poor Settings

verfasst von: Vidya Kudva, Keerthana Prasad, Shyamala Guruvare

Erschienen in: Journal of Imaging Informatics in Medicine | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

Visual inspection with acetic acid (VIA) is an effective, affordable and simple test for cervical cancer screening in resource-poor settings. But considerable expertise is needed to differentiate cancerous lesions from normal lesions, which is lacking in developing countries. Many studies have attempted automation of cervical cancer detection from cervix images acquired during the VIA process. These studies used images acquired through colposcopy or cervicography. However, colposcopy is expensive and hence is not feasible as a screening tool in resource-poor settings. Cervicography uses a digital camera to acquire cervix images which are subsequently sent to experts for evaluation. Hence, cervicography does not provide a real-time decision of whether the cervix is normal or not, during the VIA examination. In case the cervix is found to be abnormal, the patient may be referred to a hospital for further evaluation using Pap smear and/or biopsy. An android device with an inbuilt app to acquire images and provide instant results would be an obvious choice in resource-poor settings. In this paper, we propose an algorithm for analysis of cervix images acquired using an android device, which can be used for the development of decision support system to provide instant decision during cervical cancer screening. This algorithm offers an accuracy of 97.94%, a sensitivity of 99.05% and specificity of 97.16%.
Literatur
1.
Zurück zum Zitat Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: IARC 2013. Available from: http://globocan.iarc.fr, accessed on 19/09/2017. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: IARC 2013. Available from: http://​globocan.​iarc.​fr, accessed on 19/09/2017.
2.
Zurück zum Zitat Sankaranarayanan R, Wesley R, Somanathan T, Dhakad N: Visual inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma and its precursors. Cancer 83:2150–2156, 1998CrossRefPubMed Sankaranarayanan R, Wesley R, Somanathan T, Dhakad N: Visual inspection of the uterine cervix after the application of acetic acid in the detection of cervical carcinoma and its precursors. Cancer 83:2150–2156, 1998CrossRefPubMed
3.
Zurück zum Zitat Sankaranarayanan R, Shyamalakumary B, Wesley R, Sreedevi Amma N: Visual inspection with acetic acid in the early detection of cervical cancer and precursors. Int. J. Cancer 80:161–163, 1999CrossRefPubMed Sankaranarayanan R, Shyamalakumary B, Wesley R, Sreedevi Amma N: Visual inspection with acetic acid in the early detection of cervical cancer and precursors. Int. J. Cancer 80:161–163, 1999CrossRefPubMed
4.
Zurück zum Zitat Denny L, Kuhn L, Pollack A, Wainwright H: Evaluation of alternative methods of cervical cancer screening for resource-poor settings. Cancer 89:826–833, 2000CrossRefPubMed Denny L, Kuhn L, Pollack A, Wainwright H: Evaluation of alternative methods of cervical cancer screening for resource-poor settings. Cancer 89:826–833, 2000CrossRefPubMed
5.
Zurück zum Zitat Belinson JL, Pretorius RG, Zhang WH, Wu LY, Qiao YL, Elson P: Cervical cancer screening by simple visual inspection after acetic acid. Obstet Gynecol 98:441–444, 2001PubMed Belinson JL, Pretorius RG, Zhang WH, Wu LY, Qiao YL, Elson P: Cervical cancer screening by simple visual inspection after acetic acid. Obstet Gynecol 98:441–444, 2001PubMed
6.
Zurück zum Zitat Sangwa-Lugoma G, Mahmud S, Nasr SH, Liaras J, Kayembe PK, Tozin RR, Drouin P, Lorincz A, Ferenczy A, Franco EL: Visual inspection as a cervical cancer screening method in a primary health-care setting in Africa. Int J Cancer 119:1389–1395, 2006CrossRefPubMed Sangwa-Lugoma G, Mahmud S, Nasr SH, Liaras J, Kayembe PK, Tozin RR, Drouin P, Lorincz A, Ferenczy A, Franco EL: Visual inspection as a cervical cancer screening method in a primary health-care setting in Africa. Int J Cancer 119:1389–1395, 2006CrossRefPubMed
7.
Zurück zum Zitat Holger Lange: Automatic glare removal in reflectance imagery of the uterine cervix. In Proc. SPIE 5747, Medical Imaging 2005: Image Processing, San Diego, California, United States 2005, pp 2183–2192. Holger Lange: Automatic glare removal in reflectance imagery of the uterine cervix. In Proc. SPIE 5747, Medical Imaging 2005: Image Processing, San Diego, California, United States 2005, pp 2183–2192.
8.
Zurück zum Zitat Othmane EM, Mustapha K, Hakim A, Taouq G, Yassir AB: Automatic detection and inpainting of specular reflections for colposcopic images. Cent. Eur. J. Comp. Sci. 1:341–354, 2011 Othmane EM, Mustapha K, Hakim A, Taouq G, Yassir AB: Automatic detection and inpainting of specular reflections for colposcopic images. Cent. Eur. J. Comp. Sci. 1:341–354, 2011
9.
Zurück zum Zitat Zimmerman-Moreno G, Greenspan H: Automatic detection of specular reflections in uterine cervical images. Proc. of SPIE Medical Imaging 6144, San Diego, California, United States, 2006, pp 2037–2045. Zimmerman-Moreno G, Greenspan H: Automatic detection of specular reflections in uterine cervical images. Proc. of SPIE Medical Imaging 6144, San Diego, California, United States, 2006, pp 2037–2045.
10.
Zurück zum Zitat Wenjing L, Jia G, Daron F, Allen P: Automated image analysis of uterine cervical images. In Proc. SPIE Medical Imaging 6214, San Diego, California, United States 2007, pp 65142P-9P. Wenjing L, Jia G, Daron F, Allen P: Automated image analysis of uterine cervical images. In Proc. SPIE Medical Imaging 6214, San Diego, California, United States 2007, pp 65142P-9P.
11.
Zurück zum Zitat Gali Z, Shiri G, Hayit G: Automatic landmark detection in uterine cervical images for indexing in a content-retrieval system. In Proc. of IEEE International Symposium on Biomedical Imaging, Arlington, VA, USA 2006, pp 1348–1351. Gali Z, Shiri G, Hayit G: Automatic landmark detection in uterine cervical images for indexing in a content-retrieval system. In Proc. of IEEE International Symposium on Biomedical Imaging, Arlington, VA, USA 2006, pp 1348–1351.
12.
Zurück zum Zitat Greenspan H, Gordon S, Zimmerman G, Lotenberg S, Jeronimo J, Antani S, Long R: Automatic detection of anatomical landmarks in uterine cervical images. IEEE Trans Med Imaging 28:454–468, 2009CrossRefPubMed Greenspan H, Gordon S, Zimmerman G, Lotenberg S, Jeronimo J, Antani S, Long R: Automatic detection of anatomical landmarks in uterine cervical images. IEEE Trans Med Imaging 28:454–468, 2009CrossRefPubMed
13.
Zurück zum Zitat Abhishek D, Avijit K, Debasis B: Elimination of specular reflection and identification of ROI: the first step in automated detection of cervical cancer using digital colposcopy. In Proc. 2011 I.E. International Conference on Imaging Systems and Techniques (IST), Penang, Malaysia 2011, pp 237–241. Abhishek D, Avijit K, Debasis B: Elimination of specular reflection and identification of ROI: the first step in automated detection of cervical cancer using digital colposcopy. In Proc. 2011 I.E. International Conference on Imaging Systems and Techniques (IST), Penang, Malaysia 2011, pp 237–241.
14.
Zurück zum Zitat Shelly L, Shiri G, Hayit G: Shape priors for segmentation of the cervix region within uterine cervical images. J. Digit. Imaging 22:286–296, 2009CrossRef Shelly L, Shiri G, Hayit G: Shape priors for segmentation of the cervix region within uterine cervical images. J. Digit. Imaging 22:286–296, 2009CrossRef
15.
Zurück zum Zitat Lange H: Automatic detection of multi-level acetowhite regions in RGB color images of the uterine cervix. In Proc. of SPIE Medical Imaging 5747, San Diego, California, United States 2005, pp 1004–1017. Lange H: Automatic detection of multi-level acetowhite regions in RGB color images of the uterine cervix. In Proc. of SPIE Medical Imaging 5747, San Diego, California, United States 2005, pp 1004–1017.
16.
Zurück zum Zitat Park SY, Follen M, Milbourne A, Rhodes H, Malpica A, MacKinnon N, MacAulay C, Markey MK, Richards-Kortum R: Automated image analysis of digital colposcopy for the detection of cervical neoplasia. J. Biomed. Opt 13:014029, 2008CrossRefPubMed Park SY, Follen M, Milbourne A, Rhodes H, Malpica A, MacKinnon N, MacAulay C, Markey MK, Richards-Kortum R: Automated image analysis of digital colposcopy for the detection of cervical neoplasia. J. Biomed. Opt 13:014029, 2008CrossRefPubMed
17.
Zurück zum Zitat Li W, Venkataraman S, Gustafsson U, Oyama JC, Ferris DG, Lieberman RW: Using acetowhite opacity index for detecting cervical intraepithelial neoplasia. J. Biomed. Opt 14:014020, 2009CrossRefPubMed Li W, Venkataraman S, Gustafsson U, Oyama JC, Ferris DG, Lieberman RW: Using acetowhite opacity index for detecting cervical intraepithelial neoplasia. J. Biomed. Opt 14:014020, 2009CrossRefPubMed
18.
Zurück zum Zitat Rama Praba PS, Ranganathan H: Computerized lesion detection in colposcopy cervical images based on statistical features using Bayes classifier. In Proc. of the InConINDIA, AISC 132, Visakhapatnam, India 2012, pp 597–604. Rama Praba PS, Ranganathan H: Computerized lesion detection in colposcopy cervical images based on statistical features using Bayes classifier. In Proc. of the InConINDIA, AISC 132, Visakhapatnam, India 2012, pp 597–604.
19.
Zurück zum Zitat Alush A, Greenspan H, Goldberger J: Automated and interactive lesion detection and segmentation in uterine cervical images. IEEE Trans Med Imaging 29:488–501, 2010CrossRefPubMed Alush A, Greenspan H, Goldberger J: Automated and interactive lesion detection and segmentation in uterine cervical images. IEEE Trans Med Imaging 29:488–501, 2010CrossRefPubMed
20.
Zurück zum Zitat Xu T, Kim E, Huang X: Adjustable adaboost classifier and pyramid features for image-based cervical cancer diagnosis. In Proc. International Symposium on Biomedical Imaging (ISBI), New York, NY, USA 2015, pp 281–285. Xu T, Kim E, Huang X: Adjustable adaboost classifier and pyramid features for image-based cervical cancer diagnosis. In Proc. International Symposium on Biomedical Imaging (ISBI), New York, NY, USA 2015, pp 281–285.
21.
Zurück zum Zitat Sukumar P, Gnanamurthy RK: Computer aided screening of cervical cancer using random forest classifier. RJPBCS 7:1521–1529, 2016 Sukumar P, Gnanamurthy RK: Computer aided screening of cervical cancer using random forest classifier. RJPBCS 7:1521–1529, 2016
22.
Zurück zum Zitat Ji Q, Engel J, Craine E: Texture analysis for classification of cervix lesions. IEEE Trans Med Imaging 19:1144–1149, 2000CrossRefPubMed Ji Q, Engel J, Craine E: Texture analysis for classification of cervix lesions. IEEE Trans Med Imaging 19:1144–1149, 2000CrossRefPubMed
23.
Zurück zum Zitat Yeshwanth S, Brian N, Sunanda M, Sonal B: A unified model-based image analysis framework for automated detection of precancerous lesions in digitized uterine cervical images. IEEE J Select Top Signal Process 3:101–111, 2009CrossRef Yeshwanth S, Brian N, Sunanda M, Sonal B: A unified model-based image analysis framework for automated detection of precancerous lesions in digitized uterine cervical images. IEEE J Select Top Signal Process 3:101–111, 2009CrossRef
24.
Zurück zum Zitat Park SY, Sargent D, Liebeman R, Gustafsson U: Domain-specific image analysis for cervical neoplasia detection based on conditional random fields. IEEE Trans Med Imaging 30:867–878, 2011CrossRefPubMed Park SY, Sargent D, Liebeman R, Gustafsson U: Domain-specific image analysis for cervical neoplasia detection based on conditional random fields. IEEE Trans Med Imaging 30:867–878, 2011CrossRefPubMed
25.
Zurück zum Zitat Zhiyun X, Rodney LL, Sameer A, George RT: Automatic extraction of mosaic patterns in uterine cervical images. Computer-Based Medical Systems (CBMS) 2010 I.E. 23rd International Symposium, Perth, WA, 2000, pp 273–278. Zhiyun X, Rodney LL, Sameer A, George RT: Automatic extraction of mosaic patterns in uterine cervical images. Computer-Based Medical Systems (CBMS) 2010 I.E. 23rd International Symposium, Perth, WA, 2000, pp 273–278.
26.
Zurück zum Zitat Song D, Edward K, Xiaolei H, Joseph P, Hctor MA, Je H: Multimodal entity coreference for cervical dysplasia diagnosis. IEEE Trans Med Imaging 34:229–245, 2015CrossRefPubMed Song D, Edward K, Xiaolei H, Joseph P, Hctor MA, Je H: Multimodal entity coreference for cervical dysplasia diagnosis. IEEE Trans Med Imaging 34:229–245, 2015CrossRefPubMed
27.
Zurück zum Zitat Quinley KE, Gormley RH, Ratclie SJ, Shih T, Szep Z, Steiner A, Ramogola-Masire D, Kovarik CL: Use of mobile telemedicine for cervical cancer screening. J Telemed Telecare 17:203–209, 2011CrossRefPubMedPubMedCentral Quinley KE, Gormley RH, Ratclie SJ, Shih T, Szep Z, Steiner A, Ramogola-Masire D, Kovarik CL: Use of mobile telemedicine for cervical cancer screening. J Telemed Telecare 17:203–209, 2011CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Catarino R, Vassilakos P, Scaringella S, Undurraga-Malinverno M, Meyer-Hamme U, Ricard-Gauthier D, Matute JC, Petignat P: Smartphone use for cervical cancer screening in low-resource countries: a pilot study conducted in Madagascar. PLoS ONE 10:1–10, 2015 Catarino R, Vassilakos P, Scaringella S, Undurraga-Malinverno M, Meyer-Hamme U, Ricard-Gauthier D, Matute JC, Petignat P: Smartphone use for cervical cancer screening in low-resource countries: a pilot study conducted in Madagascar. PLoS ONE 10:1–10, 2015
29.
Zurück zum Zitat Ricard-Gauthier D, Wisniak A, Catarino R, van Rossum AF, Meyer-Hamme U, Negulescu R, Scaringella S, Jinoro J, Vassilakos P, Petignat P: Use of smartphones as adjuvant tools for cervical cancer screening in low-resource settings. J Lower Genit Tract Dis 19:295–300, 2015CrossRef Ricard-Gauthier D, Wisniak A, Catarino R, van Rossum AF, Meyer-Hamme U, Negulescu R, Scaringella S, Jinoro J, Vassilakos P, Petignat P: Use of smartphones as adjuvant tools for cervical cancer screening in low-resource settings. J Lower Genit Tract Dis 19:295–300, 2015CrossRef
30.
Zurück zum Zitat Rashmi B, Vanita S, Radhika S, Niranjan K, Payal K, Sarif KN, Vidya C, Lovi G, Soubhik P: Feasibility of using mobile smartphone camera as an imaging device for screening of cervical cancer in a low-resource setting. J Postgrad Med Edu Res 50:69–74, 2016CrossRef Rashmi B, Vanita S, Radhika S, Niranjan K, Payal K, Sarif KN, Vidya C, Lovi G, Soubhik P: Feasibility of using mobile smartphone camera as an imaging device for screening of cervical cancer in a low-resource setting. J Postgrad Med Edu Res 50:69–74, 2016CrossRef
31.
Zurück zum Zitat Kudva V, Prasad K, Guruvare S: Detection of specular reflection and segmentation of cervix region in uterine cervix images for cervical cancer screening. IRBM 38:218–291, 2017CrossRef Kudva V, Prasad K, Guruvare S: Detection of specular reflection and segmentation of cervix region in uterine cervix images for cervical cancer screening. IRBM 38:218–291, 2017CrossRef
32.
Zurück zum Zitat Claude I, Pouletaut P: Integrated color and texture tools for colposcopic image segmentation. In Proc. IEEE International Conference on Image Processing, Thessaloniki, Greece 2001, pp 311–314. Claude I, Pouletaut P: Integrated color and texture tools for colposcopic image segmentation. In Proc. IEEE International Conference on Image Processing, Thessaloniki, Greece 2001, pp 311–314.
33.
Zurück zum Zitat Haralick RM, Shanmugan K, Dinstein I: Textural features for image classification. IEEE Trans. Syst., Man, Cybern, SMC 3:610–621, 1973CrossRef Haralick RM, Shanmugan K, Dinstein I: Textural features for image classification. IEEE Trans. Syst., Man, Cybern, SMC 3:610–621, 1973CrossRef
34.
Zurück zum Zitat Amadasun M, King R: Textural features corresponding to textural properties. IEEE Trans. Syst., Man, Cybern 19:1264–1274, 1989CrossRef Amadasun M, King R: Textural features corresponding to textural properties. IEEE Trans. Syst., Man, Cybern 19:1264–1274, 1989CrossRef
35.
Zurück zum Zitat Sun C, Wee WG: Neighbouring gray level dependence matrix. Comput. Vision, Graphics Image Processing 23:341–352, 1982CrossRef Sun C, Wee WG: Neighbouring gray level dependence matrix. Comput. Vision, Graphics Image Processing 23:341–352, 1982CrossRef
36.
Zurück zum Zitat Ojala T, Pietikainen M, Maenpaa T: Multiresolution gray scale and rotation invariant texture classification with local binary patterns. IEEE Trans. Pattern Anal. Mach. Intell. 24:971–987, 2002CrossRef Ojala T, Pietikainen M, Maenpaa T: Multiresolution gray scale and rotation invariant texture classification with local binary patterns. IEEE Trans. Pattern Anal. Mach. Intell. 24:971–987, 2002CrossRef
37.
Zurück zum Zitat Jouni P, Okko R, Serdar K: Feature selection methods and their combinations in high-dimensional classification of speaker likability, intelligibility and personality traits. Comput Speech Lang. 29:145–171, 2015CrossRef Jouni P, Okko R, Serdar K: Feature selection methods and their combinations in high-dimensional classification of speaker likability, intelligibility and personality traits. Comput Speech Lang. 29:145–171, 2015CrossRef
38.
Zurück zum Zitat Ross Quinlan J: Induction of decision trees. Machine Learning 1:81–106, 1986 Ross Quinlan J: Induction of decision trees. Machine Learning 1:81–106, 1986
39.
Zurück zum Zitat Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108, 2015CrossRefPubMed Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108, 2015CrossRefPubMed
40.
Zurück zum Zitat Mishra GA, Pimple SA, Shastri SS: An overview of prevention and early detection of cervical cancers. Indian J. Med. Paediatr. Oncol 32:125–132, 2011CrossRefPubMedPubMedCentral Mishra GA, Pimple SA, Shastri SS: An overview of prevention and early detection of cervical cancers. Indian J. Med. Paediatr. Oncol 32:125–132, 2011CrossRefPubMedPubMedCentral
Metadaten
Titel
Andriod Device-Based Cervical Cancer Screening for Resource-Poor Settings
verfasst von
Vidya Kudva
Keerthana Prasad
Shyamala Guruvare
Publikationsdatum
18.05.2018
Verlag
Springer International Publishing
Erschienen in
Journal of Imaging Informatics in Medicine / Ausgabe 5/2018
Print ISSN: 2948-2925
Elektronische ISSN: 2948-2933
DOI
https://doi.org/10.1007/s10278-018-0083-x

Weitere Artikel der Ausgabe 5/2018

Journal of Digital Imaging 5/2018 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.