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Alzheimer's Research & Therapy

Erschienen in:

01.06.2009 | Review

Angiotensins and Alzheimer's disease: a bench to bedside overview

verfasst von: Patrick G Kehoe

Erschienen in: Alzheimer's Research & Therapy | Ausgabe 1/2009

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Abstract

The pathology of Alzheimer's disease (AD) features amyloid β peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the underlying mechanisms remain unproven. This review proposes angiotensins and associated enzymatic pathways as important mediators of recognised but undefined links between blood pressure and AD. Evidence in support of this involvement translates consistently from the most basic in vitro, in vivo and ex vivo experimental paradigms to more complex human-based observational and experimental studies, which also fortunately offer potential for therapeutic interventions against AD.

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Titel: Angiotensins and Alzheimer's disease: a bench to bedside overview
verfasst von: Patrick G Kehoe
Publikationsdatum: 01.06.2009
Verlag: BioMed Central
Erschienen in: Alzheimer's Research & Therapy / Ausgabe 1/2009
Elektronische ISSN: 1758-9193
DOI: https://doi.org/10.1186/alzrt3

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